Do traditional livestock systems fit into contemporary landscapes? Integrating social perceptions and values on landscape change

European traditional cultural landscapes are increasingly modified by rural abandonment and urban growth processes. Acknowledged as of High Nature Value for providing multiple ecosystem services while contributing to human well-being, the future of these social-ecological systems is uncertain. Here we aim to (1) explore dominant land use and cover (LULC) changes linked to extensive livestock farming across an urban-rural gradient defined by a large city (Madrid) over the last three decades; (2) identify and classify the main driving forces shaping these landscape trajectories and; (3) acknowledge the main landscape values for promoting landscape stewardship under participatory governance frameworks. For doing so, we combine mapping analyses (CORINE Land cover) with stakeholder perceptions and positions. Our results show a dual process of progressive abandonment of agroecosystems linked to traditional livestock farming and an ever-increasing urban growth over the last three decades as the most important driving forces. The growing urban sprawl in areas close to Madrid begins to be perceived as problematic for interviewees. The decline of extensive livestock farming in detriment of tourism, particularly evident in rural areas far from Madrid, is perceived as a threat to the cultural heritage and traditions of rural people. This decline is also perceived as a worrying increase of wildfire risk. Stakeholders stressed the need of valuing extensive livestock farming to prevent rural-urban migration, dynamizing rural economies, conserving landscapes and traditions while producing food-quality products. Interviewees advocated for science-based, stakeholder-inclusive and participatory landscape planning and co-management, leading to more context-specific, regionalized policymakin

Multifunctional device for bicycles

This paper aims at designing a "Multifunctional device composed of load support and anti-theft lock for standard bicycles". A previous study has been developed in order to justify and validate the final design of the unmet needs of people in their daily lives, with an emphasis on satisfying those that imply specific savings, whether economic, energy or time. As a result, the use of bicycles as a means of transport in Spain is promoted taking as a frame of reference countries such as the Netherlands or France. This means economic and energy savings (by replacing the car) and an improvement in people's health and quality of life. Following the steps of the design methodology, once the need was detected, an information search was carried out in order to identify and prioritize the design specifications that meet the demands of potential customers. For this reason, various sources were used, The boost to use bicycles has allowed to establish a set of measurements and specifications in the design of the device with a double functionality, the transport of merchandise and an anti-theft system. In addition to meeting the needs of the client, the design must comply with a set of reference regulations both, at the level of security devices and the transport of merchandise at retail. The result of the work has given rise to patent application with prior examination at a national level, in a first phase, and subsequently, at an international level.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Inversion of accommodation zones in salt-bearing extensional systems: insights from analog modeling

This work uses sandbox analog models to analyze the formation and subsequent inversion of a decoupled extensional system comprised of two segmented half-grabens separated by a diffuse accommodation zone with thick early syn-rift salt. The segmented half-grabens strike perpendicular to the direction of extension and subsequent shortening. Rifting first created a basement topography that was infilled by model salt, followed by a second phase of extension and sedimentation, followed afterwards by inversion. During the second phase of extension, syn-rift syncline minibasins developed above the basement extensional system and extended beyond the confines of the fault blocks. Sedimentary downbuilding and extension initiated the migration of model salt to the basement highs, forming salt anticlines, reactive diapirs, and salt walls perpendicular to the direction of extension, except for along the intervening accommodation zone where a slightly oblique salt anticline developed. Inversion resulted in decoupled cover and basement thrust systems. Thrusts in the cover system nucleated along squeezed salt structures and along primary welds. New primary welds developed where the cover sequence touched down on basement thrust tips due to uplift, salt extrusion, and syn-contractional downbuilding caused by the loading of syn-contractional sedimentation. Model geometries reveal the control imposed by the basement configuration and distribution of salt in the development of a thrust front from the inversion of a salt-bearing extensional system. In 3D, the interaction of salt migrating from adjacent syn-rift basins can modify the expected salt structure geometry, which may in turn influence the location and style of thrust in the cover sequence upon inversion. Results are compared to the Northern Lusitanian Basin, offshore Portugal, and the Isábena area of the South-Central Pyrenees, Spain

Aportaciones a la flora vascular de la provincia de Córdoba, II (Andalucía, España)

En el presente estudio corológico se aportan 25 taxones que son raros o suponen novedad para alguna comarca o toda la provincia de Córdoba (Andalucía, España). Los taxones más interesantes son Campanula decumbens subsp. baetica Cano-Maqueda & Talavera, Narcissus × susannae Fern. Casas y Plumbago auriculata Lam., ya que son citados por primera vez para esta provincia.Twenty-five taxa are recorded as rare and new localities either in some areas or the whole province of Cordoba (Andalusia, Spain). Campanula decumbens subsp. baetica Cano-Maqueda & Talavera, Narcissus × susannae Fern. Casas and Plumbago auriculata Lam. are the most interesting taxa found, being the first record for this province

The Northern Calcareous Alps revisited: Formation of a hyperextended margin and mantle exhumation in the Northern Calcareous Alps sector of the Neo-Tethys (Eastern Alps, Austria)

The Neo-Tethys margin evolution is preserved in the Northern Calcareous Alps (Eastern Alps), from Late Permian crustal stretching to Late Triassic oceanization. The Northern Calcareous Alps represent the salt-floored fold-and-thrust belt developed from the salt-influenced Triassic carbonate sedimentary cover of the ancestral European margin of the Neo-Tethys Ocean. A crustal scale model for the margin has been obtained by restoration of regional cross-sections of the Northern Calcareous Alps carbonate platforms. Lithospheric break-up was investigated from remnants of exhumed mantle found within an evaporitic melange, suggesting hyperextended crust underneath the distal Triassic platforms of the Northern Calcareous Alps preceding breakup. By modelling the thermal evolution of the margin in combination with excellent stratigraphic control, a detailed timeline has been established for the evolution of the Neo-Tethys margin, especially around the period of rapid mantle exhumation. Our study indicates that salt-floored carbonate shelfs can be used as a proxy to characterize the margins evolution, from crustal stretching to continental breakup. Diagnostic stratigraphic records are preserved in the carbonate platforms: pre- mantle exhumation carbonates are represented by aggrading isolated carbonate platforms first, followed by expanding and margin wide prograding carbonate shelfs once thermal subsidence dominates. In addition, a distinct clastic sequence is deposited as an immediate response to mantle exhumation, in between the pre- and post-mantle exhumation carbonate factory. Our study proposes a new refined model for the formation of the Neo-Tethys margin and provides new insights for the dynamic coupling of salt-controlled carbonate shelfs and the underlying lithosphere during continental breakup

Lupinus mariae-josephii (Leguminosae) en la comarca de Camp de Turia (Valencia)

Se aporta para la comarca valenciana de Camp de Túria una nueva población de Lupinus mariae-josephae (Leguminosae), especie endémica de la Comunidad Valenciana (España), catalogada como Vulnerable en el Catálogo Valenciano de Especies de Flora Amenazadas. La población se localiza en el término municipal de Riba-roja de Túria y representa hasta el momento la más septentrional de su área de distribución.A new population of Lupinus mariae-josephae (Leguminosae) from Camp de Túria region is provided. This species is an endemic plant of Valencian Community (Spain) and it is listed as Vulnerable in the Valencian Catalog of Threatened Plant Species. This population is located in Riba-roja de Túria and constitutes the most northern of this species

c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity

Plitidepsin is an antitumor drug of marine origin currently in Phase III clinical trials in multiple myeloma. In cultured cells, plitidepsin induces cell cycle arrest or an acute apoptotic process in which sustained activation of c-Jun N-terminal kinase (JNK) plays a crucial role. With a view to optimizing clinical use of plitidepsin, we have therefore evaluated the possibility of using JNK activation as an in vivo biomarker of response. In this study, we show that administration of a single plitidepsin dose to mice xenografted with human cancer cells does indeed lead to increased phosphorylation of JNK in tumors at 4 to 12 h. By contrast, no changes were found in other in vitro plitidepsin targets such as the levels of phosphorylated-ERK, -p38MAPK or the protein p27KIP1. Interestingly, plitidepsin also increased JNK phosphorylation in spleens from xenografted mice showing similar kinetics to those seen in tumors, thereby suggesting that normal tissues might be useful for predicting drug activity. Furthermore, plitidepsin administration to rats at plasma concentrations comparable to those achievable in patients also increased JNK phosphorylation in peripheral mononuclear blood cells. These findings suggest that changes in JNK activity provide a reliable biomarker for plitidepsin activity and this could be useful for designing clinical trials and maximizing the efficacy of plitidepsin.This work has been partially supported by grants (Programa Cenit, CEN-20091016, SAF2010-18302 and Fondo Europeo de Desarrollo Regional-Instituto de Salud Carlos III, RD12/0036/0021) from Ministerio de Economíay Competitividad of Spain.S

Folding of cytosine-based nucleolipid monolayer by guanine recognition at the air-water interface

Monolayers of a cytosine-based nucleolipid (1,2-dipalmitoyl-sn-glycero-3-(cytidine diphosphate) (ammonium salt), CDP-DG) at basic subphase have been prepared at the air-water interface both in absence and presence of guanine. The formation of the complementary base pairing is demonstrated by combining surface experimental techniques, i.e., surface pressure (π)–area (A), Brewster angle microscopy (BAM), infrared spectroscopy (PM-IRRAS) and computer simulations. A folding of the cytosine-based nucleolipid molecules forming monolayer at the air-water interface occurs during the guanine recognition as absorbate host and is kept during several compression-expansion processes under set experimental conditions. The specificity between nitrogenous bases has been also registered. Finally, mixed monolayers of CDP-DG and a phospholipid (1,2-dimyristoyl-sn-glycero-3-phosphate (sodium salt), DMPA) has been studied and a molecular segregation of the DMPA molecules has been inferred by the additivity rule

Transverse jointing in foreland fold-and-thrust belts: a remote sensing analysis in the eastern Pyrenees

Joint systems in the eastern portion of the Ebro Basin of the eastern Pyrenees enjoy near continuous exposure from the frontal portion of the belt up to the external portion of its associated foredeep. Utilizing orthophoto mosaics of these world-class exposures, we have manually digitized over 30 000 joints within a 16 km×50 km study area. The mapped traces exhibit orientations that are dominantly perpendicular to the trend of the belt (transverse) and, subordinately, parallel to the belt (longitudinal). In particular, joints systematically orient perpendicular to the trend of the belt both in the frontal folds and in the inner and central portion of the foredeep basin. Longitudinal joints occur rarely with a disordered spatial distribution, exhibiting null difference in abundance between the belt and the foredeep. Joint orientations in the external portion of the foredeep become less clustered, with adjacent areas dominated by either transverse or oblique joints. Our data indicate that joints in the studied area formed in the foredeep in response to a foredeep-parallel stretching, which becomes progressively less intense within the external portion of the foredeep. There, the minimum stress direction becomes more variable, providing evidence of the poor contribution of the forebulge-perpendicular stretching on stress organization