85 research outputs found
ESTUDO Benchmarking do Cfd Gratuito Openfoam na Modelagem e Simulação da Transferência de Calor em Não-equilÃbrio Térmico Local e Transiente Numa Frente de Combustão Smouldering
Com o constante aumento da demanda energética é necessário o estudo de fontes alternativas de energia bem como técnicas para sua conversão em trabalho útil em diferentes escalas de consumo. Outro fator importante é que a humanidade esta produzindo cada vez mais resÃduos sólidos, e neste, existe um potencial energético que não pode ser negligenciado. Neste contexto, a combustão se mostra uma boa alternativa para o reaproveitamento energético desses resÃduos, no entanto, é indispensável um entendimento do processo, bem como das variáveis de operação.
Portanto, este trabalho tem como objetivo apresentar uma modelagem para as equações de energia que governam a transferência de calor em um meio poroso reativo das fases sólida e gasosa e, ao mesmo tempo, simular o processo de combustão smouldering em meio poroso utilizando um software de simulação gratuito, o OpenFOAM, principal ferramenta utilizada neste trabalho.
É apresentado para o leitor uma concisa descrição do pacote de simulação utilizado juntamente com suas principais caracterÃsticas. Os resultados simulados são comparados com resultados experimentais obtidos pela célula de combustão instrumentada desenvolvida no Laboratório de CombustÃveis e Combustão da Universidade Federal do EspÃrito Santo para estudos da combustão em meio poroso.
Por último, apresenta-se a influência de parâmetros fÃsicos, como espessura da frente, fração volumétrica de sólido e velocidade de resfriamento, na evolução da temperatura simulada no interior do leito
Cooperative Behavior of Kinetically Constrained Lattice Gas Models of Glassy Dynamics
Kinetically constrained lattice models of glasses introduced by Kob and
Andersen (KA) are analyzed. It is proved that only two behaviors are possible
on hypercubic lattices: either ergodicity at all densities or trivial
non-ergodicity, depending on the constraint parameter and the dimensionality.
But in the ergodic cases, the dynamics is shown to be intrinsically cooperative
at high densities giving rise to glassy dynamics as observed in simulations.
The cooperativity is characterized by two length scales whose behavior controls
finite-size effects: these are essential for interpreting simulations. In
contrast to hypercubic lattices, on Bethe lattices KA models undergo a
dynamical (jamming) phase transition at a critical density: this is
characterized by diverging time and length scales and a discontinuous jump in
the long-time limit of the density autocorrelation function. By analyzing
generalized Bethe lattices (with loops) that interpolate between hypercubic
lattices and standard Bethe lattices, the crossover between the dynamical
transition that exists on these lattices and its absence in the hypercubic
lattice limit is explored. Contact with earlier results are made via analysis
of the related Fredrickson-Andersen models, followed by brief discussions of
universality, of other approaches to glass transitions, and of some issues
relevant for experiments.Comment: 59 page
On the cavity method for decimated random constraint satisfaction problems and the analysis of belief propagation guided decimation algorithms
We introduce a version of the cavity method for diluted mean-field spin
models that allows the computation of thermodynamic quantities similar to the
Franz-Parisi quenched potential in sparse random graph models. This method is
developed in the particular case of partially decimated random constraint
satisfaction problems. This allows to develop a theoretical understanding of a
class of algorithms for solving constraint satisfaction problems, in which
elementary degrees of freedom are sequentially assigned according to the
results of a message passing procedure (belief-propagation). We confront this
theoretical analysis to the results of extensive numerical simulations.Comment: 32 pages, 24 figure
Environmental damage and public health threat caused by cemeteries: a proposal of ideal cemeteries for the growing urban sprawl
MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network.
The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities
Integrated genomic characterization of oesophageal carcinoma
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies
Integrated genomic characterization of pancreatic ductal adenocarcinoma
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple KRAS mutations, with some showing evidence of biallelic mutations. Protein profiling identified a favorable prognosis subset with low epithelial-mesenchymal transition and high MTOR pathway scores. Associations of non-coding RNAs with tumor-specific mRNA subtypes were also identified. Our integrated multi-platform analysis reveals a complex molecular landscape of PDAC and provides a roadmap for precision medicine
Report of a phase II study of sphingosomal vincristine (SV) in patients with relapsed or refractory Hodgkin’s disease
Identification of Streptococcus gallolyticus subsp. macedonicus as the etiological agent in a case of culture-negative multivalve infective endocarditis by 16S rDNA PCR analysis of resected valvular tissue
Today, PCR using broad-range primers is being used increasingly to detect pathogens from resected heart valves. Herein is described the first case of multivalve infective endocarditis where 16S rDNA PCR was used to detect a single pathogen from two affected valves in a 61-year-old man. Triple heart valve replacement was required despite six weeks of appropriate antimicrobial therapy. The organism was confirmed as Streptococcus gallolyticus subsp. macedonicus, a member of the 'S. equinus/S. bovis' complex. To date, only one report has been made of human infection due to this organism. This may be due to the limited resolution of the routine diagnostic methods used and/or as a consequence of the complex nomenclature associated with this group of organisms
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