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Protein kinase C is a calcium sensor for presynaptic short-term plasticity
In presynaptic boutons, calcium (Ca2+) triggers both neurotransmitter release and short-term synaptic plasticity. Whereas synaptotagmins are known to mediate vesicle fusion through binding of high local Ca2+ to their C2 domains, the proteins that sense smaller global Ca2+ increases to produce short-term plasticity have remained elusive. Here, we identify a Ca2+ sensor for post-tetanic potentiation (PTP), a form of plasticity thought to underlie short-term memory. We find that at the functionally mature calyx of Held synapse the Ca2+-dependent protein kinase C isoforms α and β are necessary for PTP, and the expression of PKCβ in PKCαβ double knockout mice rescues PTP. Disruption of Ca2+ binding to the PKCβ C2 domain specifically prevents PTP without impairing other PKCβ-dependent forms of synaptic enhancement. We conclude that different C2-domain-containing presynaptic proteins are engaged by different Ca2+ signals, and that Ca2+ increases evoked by tetanic stimulation are sensed by PKCβ to produce PTP. DOI: http://dx.doi.org/10.7554/eLife.03011.00
Cooling Flow Star Formation and the Apparent Stellar Ages of Elliptical Galaxies
Observational constraints and theoretical arguments indicate that cooled
interstellar gas in bright elliptical galaxies forms into a young stellar
population throughout the region within the half-light radius. The young
population has a bottom-heavy, but optically luminous IMF extending to 1 - 2
M_sun. When the colors and spectral features of this young population are
combined with those of the underlying old stellar population, the apparent ages
are significantly reduced, similar to the relatively young apparent ages
observed in many ellipticals. Galactic mergers are not required to resupply
young stars. The sensitivity of continuous star formation to L_B and L_x/L_B is
likely to account for the observed spread in apparent ages among elliptical
galaxies. Local star formation is accompanied by enhanced stellar H_beta
equivalent widths, stronger optical emission lines, enhanced thermal X-ray
emission and lower apparent temperatures in the hot gas. The young stars should
cause M/L to vary with galactic radius, perturbing the fundamental plane
occupied by the old stars.Comment: 6 pages with 2 figures; accepted by Astrophysical Journal Letter
BVRI Surface Photometry of Isolated Spiral Galaxies
A release of multicolor broad band (BVRI) photometry for a subsample of 44
isolated spirals drawn from the Catalogue of Isolated Galaxies (CIG) is
presented. Total magnitudes and colors at various circular apertures, as well
as some global structural/morphological parameters are estimated. Morphology is
reevaluated through optical and sharp/filtered R band images, (B-I) color index
maps, and archive near-IR JHK images from the Two-Micron Survey. The CAS
structural parameters (Concentration, Asymmetry, and Clumpiness) were
calculated from the images in each one of the bands. The fraction of galaxies
with well identified optical/near-IR bars (SB) is 63%, while a 17% more shows
evidence of weak or suspected bars (SAB). The sample average value of the
maximum bar ellipticity is 0.4. Half of the galaxies in the sample shows rings.
We identify two candidates for isolated galaxies with disturbed morphology. The
structural CAS parameters change with the observed band, and the tendencies
they follow with the morphological type and global color are more evident in
the redder bands. In any band, the major difference between our isolated
spirals and a sample of interacting spirals is revealed in the A-S plane. A
deep and uniformly observed sample of isolated galaxies is intended for various
purposes including (i) comparative studies of environmental effects, (ii)
confronting model predictions of galaxy evolution and (iii) evaluating the
change of galaxy properties with redshift.Comment: 44 pages, 9 figures and 7 tables included. To appear in The
Astronomical Journal. For the 43 appendix figures 4.1-4.43 see
http://www.astroscu.unam.mx/~avila/Figs4.1_4.43.tar.gz (7.2 Mb tar.gz file
Radial Distribution of the Mass-to-Luminosity Ratio in Spiral Galaxies and Massive Dark Cores
We derive radial profiles of the surface-mass-density for 19 spiral galaxies
directly from their high-resolution rotation curves. Using the corresponding
luminosity profiles, we obtain the radial distribution of the
mass-to-luminosity ratios () from the inner bulge ( a few 100 pc) to
the outer disk ( 2-10 kpc) for 11 galaxies (with inclination <
in order to reduce the influence of the interstellar extinction.
The s in the bulges of two galaxies with sufficient resolution, NGC 4527
and NGC 6946, are found to increase steeply toward the center at radii
100-500 pc at rates of 153 and 72 times per kpc, respectively. Some
other galaxies with fairly high resolution also show signs of an increase
toward the center. Such an increase may indicate the existence of a new
component, a ``massive dark core'', which may be an object linking the bulge
and a central black hole. Based on radial variations of the , we further
discuss the variation of the dark-mass fraction in spiral galaxies.Comment: Latex 19 pages, 30 ps figures. ApJ in pres
Spin accumulation induced resistance in mesoscopic ferromagnet/ superconductor junctions
We present a description of spin-polarized transport in mesoscopic
ferromagnet-superconductor (F/S) systems, where the transport is diffusive, and
the interfaces are transparent. It is shown that the spin reversal associated
with Andreev reflection generates an excess spin density close to the F/S
interface, which leads to a spin contact resistance. Expressions for the
contact resistance are given for two terminal and four terminal geometries. In
the latter the sign depends on the relative magnetization of the ferromagnetic
electrodes.Comment: RevTeX 10 pages, 4 figures, submitted to Phys.Rev. Let
Quantum shot-noise at local tunneling contacts on mesoscopic multiprobe conductors
New experiments that measure the low-frequency shot-noise spectrum at local
tunneling contacts on mesoscopic structures are proposed. The current
fluctuation spectrum at a single tunneling tip is determined by local partial
densities of states. The current-correlation spectrum between two tunneling
tips is sensitive to non-diagonal density of states elements which are
expressed in terms of products of scattering states of the conductor. Thus such
an experiment permits to investigate correlations of electronic wave functions.
We present specific results for a clean wire with a single barrier and for
metallic diffusive conductors.Comment: 4 pages REVTeX, 2 figure
Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications
OBJECTIVES: DISH has been associated with increased coronary artery calcifications and incident ischaemic stroke. The formation of bone along the spine may share pathways with calcium deposition in the aorta. We hypothesized that patients with DISH have increased vascular calcifications. Therefore we aimed to investigate the presence and extent of DISH in relation to thoracic aortic calcification (TAC) severity. METHODS: This cross-sectional study included 4703 patients from the Second Manifestation of ARTerial disease cohort, consisting of patients with cardiovascular events or risk factors for cardiovascular disease. Chest radiographs were scored for DISH using the Resnick criteria. Different severities of TAC were scored arbitrarily from no TAC to mild, moderate or severe TAC. Using multivariate logistic regression, the associations between DISH and TAC were analysed with adjustments for age, sex, BMI, diabetes, smoking status, non-high-density lipoprotein cholesterol, cholesterol lowering drug usage, renal function and blood pressure. RESULTS: A total of 442 patients (9.4%) had evidence of DISH and 1789 (38%) patients had TAC. The prevalence of DISH increased from 6.6% in the no TAC group to 10.8% in the mild, 14.3% in the moderate and 17.1% in the severe TAC group. After adjustments, DISH was significantly associated with the presence of TAC [odds ratio (OR) 1.46 [95% CI 1.17, 1.82)]. In multinomial analyses, DISH was associated with moderate TAC [OR 1.43 (95% CI 1.06, 1.93)] and severe TAC [OR 1.67 (95% CI 1.19, 2.36)]. CONCLUSIONS: Subjects with DISH have increased TACs, providing further evidence that patients with DISH have an increased burden of vascular calcifications
Internal medicine specialists' attitudes towards working part-time: a comparison between 1996 and 2004
BACKGROUND: Although medical specialists traditionally hold negative views towards working part-time, the practice of medicine has evolved. Given the trend towards more part-time work and that there is no evidence that it compromises the quality of care, attitudes towards part-time work may have changed as well in recent years. The aim of this paper was to examine the possible changes in attitudes towards part-time work among specialists in internal medicine between 1996 and 2004. Moreover, we wanted to determine whether these attitudes were associated with individual characteristics (age, gender, investments in work) and whether attitudes of specialists within a partnership showed more resemblance than specialists' attitudes from different partnerships. METHODS: Two samples were used in this study: data of a survey conducted in 1996 and in 2004. After selecting internal medicine specialists working in general hospitals in The Netherlands, the sample consisted of 219 specialists in 1996 and 363 specialists in 2004. They were sent a questionnaire, including topics on the attitudes towards part-time work. RESULTS: Internal medicine specialists' attitudes towards working part-time became slightly more positive between 1996 and 2004. Full-time working specialists in 2004 still expressed concerns regarding the investments of part-timers in overhead tasks, the flexibility of task division, efficiency, communication and continuity of care. In 1996 gender was the only predictor of the attitude, in 2004 being a full- or a part-timer, age and the time invested in work were associated with this attitude. Furthermore, specialists' attitudes were not found to cluster much within partnerships. CONCLUSION: In spite of the increasing number of specialists working or preferring to work part-time, part-time practice among internal medicine specialists seems not to be fully accepted. The results indicate that the attitudes are no longer gender based, but are associated with age and work aspects such as the number of hours worked. Though there is little evidence to support them, negative ideas about the consequences of part-time work for the quality of care still exist. Policy should be aimed at removing the organisational difficulties related to part-time work and create a system in which part-time practice is fully integrated and accepted
The POINT-AGAPE survey II: An Unrestricted Search for Microlensing Events towards M31
An automated search is carried out for microlensing events using a catalogue
of 44554 variable superpixel lightcurves derived from our three-year monitoring
program of M31. Each step of our candidate selection is objective and
reproducible by a computer. Our search is unrestricted, in the sense that it
has no explicit timescale cut. So, it must overcome the awkward problem of
distinguishing long-timescale microlensing events from long-period stellar
variables. The basis of the selection algorithm is the fitting of the
superpixel lightcurves to two different theoretical models, using variable star
and blended microlensing templates. Only if microlensing is preferred is an
event retained as a possible candidate. Further cuts are made with regard to
(i) sampling, (ii) goodness of fit of the peak to a Paczynski curve, (iii)
consistency of the microlensing hypothesis with the absence of a resolved
source, (iv) achromaticity, (v) position in the colour-magnitude diagram and
(vi) signal-to-noise ratio. Our results are reported in terms of first-level
candidates, which are the most trustworthy, and second-level candidates, which
are possible microlensing but have lower signal-to-noise and are more
questionable. The pipeline leaves just 3 first-level candidates, all of which
have very short full-width half-maximum timescale (<5 days) and 3 second-level
candidates, which have timescales of 31, 36 and 51 days respectively. We also
show 16 third-level lightcurves, as an illustration of the events that just
fail the threshold for designation as microlensing candidates. They are almost
certainly mainly variable stars. Two of the 3 first-level candidates correspond
to known events (PA 00-S3 and PA 00-S4) already reported by the POINT-AGAPE
project. The remaining first-level candidate is new.Comment: 22 pages, 18 figures, MNRAS, to appea
Microlensing towards LMC: a study of the LMC halo contribution
We carry on a new analysis of the sample of MACHO microlensing candidates
towards the LMC. Our main purpose is to determine the lens population to which
the events may belong. We give particular emphasis to the possibility of
characterizing the Milky Way dark matter halo population with respect to the
LMC one. Indeed, we show that only a fraction of the events have
characteristics that match those expected for lenses belonging to the MACHO
population of the Milky Way halo. This suggests that this component cannot
explain all the candidates. Accordingly, we challenge the view that the dark
matter halo fraction of both the Milky Way and the LMC halos are equal, and
indeed we show that, for a MACHO mass in the range 0.1-0.3 M, the LMC
halo fraction can be significantly larger than the Milky Way one. In this
perspective, our main conclusion is that up to about half of the observed
events could be attributed to the LMC MACHO dark matter halo.Comment: Accepted for publication in Astronomy & Astrophysic
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