204 research outputs found

    Decomposition of Differences

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    This paper examines methods of decomposing a difference in levels between groups for a dependent variable such as income. Applied to regression equations, this technique estimates the contribution to the difference from divergent characteristics and divergent rates of converting characteristics into the dependent variable. The consequences of an "interaction" component being present in the decomposition is examined. The paper, using data from the 1960 Census, shows how ignoring the interaction term can influence results.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68707/2/10.1177_004912417500300306.pd

    Large-N supersymmetric beta-functions

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    We present calculations of the leading and O(1/N) terms in a large-N expansion of the \beta-functions for various supersymmetric theories: a Wess-Zumino model, supersymmetric QED and a non-abelian supersymmetric gauge theory. In all cases N is the number of a class of the chiral superfields in the theory.Comment: 9 pages, tex, five figures. Uses harvmac and epsf. Revised to include a discussion of higher loop DRED ambiguities. Some references added, and notation clarifie

    Impact of mutant beta-catenin on ABCB1 expression and therapy response in colon cancer cells

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    Background: Colorectal cancers are often chemoresistant toward antitumour drugs that are substrates for ABCB1-mediated multidrug resistance (MDR). Activation of the Wnt/beta-catenin pathway is frequently observed in colorectal cancers. This study investigates the impact of activated, gain-of-function beta-catenin on the chemoresistant phenotype. Methods: The effect of mutant (mut) beta-catenin on ABCB1 expression and promoter activity was examined using HCT116 human colon cancer cells and isogenic sublines harbouring gain-of-function or wild-type beta-catenin, and patients' tumours. Chemosensitivity towards 24 anticancer drugs was determined by high throughput screening. Results: Cell lines with mut beta-catenin showed high ABCB1 promoter activity and expression. Transfection and siRNA studies demonstrated a dominant role for the mutant allele in activating ABCB1 expression. Patients' primary colon cancer tumours shown to express the same mut beta-catenin allele also expressed high ABCB1 levels. However, cell line chemosensitivities towards 24 MDR-related and non-related antitumour drugs did not differ despite different beta-catenin genotypes. Conclusion: Although ABCB1 is dominantly regulated by mut beta-catenin, this did not lead to drug resistance in the isogenic cell line model studied. In patient samples, the same beta-catenin mutation was detected. The functional significance of the mutation for predicting patients' therapy response or for individualisation of chemotherapy regimens remains to be established

    Initial State Interactions for KK^--Proton Radiative Capture

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    The effects of the initial state interactions on the KpK^--p radiative capture branching ratios are examined and found to be quite sizable. A general coupled-channel formalism for both strong and electromagnetic channels using a particle basis is presented, and applied to all the low energy KpK^--p data with the exception of the {\it 1s} atomic level shift. Satisfactory fits are obtained using vertex coupling constants for the electromagnetic channels that are close to their expected SU(3) values.Comment: 16 pages, uses revte

    SUSY-QCD Decays of Squarks and Gluinos

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    The partial widths are determined for squark decays to gluinos and quarks, and gluino decays to squarks and quarks, respectively. The widths are calculated including one-loop SUSY-QCD corrections. The corrections amount to ++30\% to ++50\% for squark decays and -10\% to ++10\% for gluino decays. We have derived the results in the \DR ~and \MS ~renormalization schemes, and we have demonstrated explicitly that the one-loop effective qqgqqg and q\sq\gl couplings are equal in the limit of exact supersymmetry.Comment: 11 pages, Latex2e, 2 figures (uses epsfig). Complete postscript file available at http://www.desy.de/pub/preprints/desy/1996/desy96-022.p

    Soft parton radiation in polarized vector boson production: theoretical issues

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    Accurate measurement of spin-dependent parton distributions in production of electroweak bosons with polarized proton beams at the Relativistic Heavy Ion Collider depends on good understanding of QCD radiation at small transverse momenta qTq_T of vector bosons. We present a theoretical formalism for small-qTq_T resummation of the cross sections for production of virtual photons, W, and Z bosons, with the subsequent decay of these bosons into lepton pairs, for arbitrary longitudinal polarizations of the proton beams.Comment: 35 pages, 2 figures; minor modifications; bibliography references adde

    Vibrational Properties of Nanoscale Materials: From Nanoparticles to Nanocrystalline Materials

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    The vibrational density of states (VDOS) of nanoclusters and nanocrystalline materials are derived from molecular-dynamics simulations using empirical tight-binding potentials. The results show that the VDOS inside nanoclusters can be understood as that of the corresponding bulk system compressed by the capillary pressure. At the surface of the nanoparticles the VDOS exhibits a strong enhancement at low energies and shows structures similar to that found near flat crystalline surfaces. For the nanocrystalline materials an increased VDOS is found at high and low phonon energies, in agreement with experimental findings. The individual VDOS contributions from the grain centers, grain boundaries, and internal surfaces show that, in the nanocrystalline materials, the VDOS enhancements are mainly caused by the grain-boundary contributions and that surface atoms play only a minor role. Although capillary pressures are also present inside the grains of nanocrystalline materials, their effect on the VDOS is different than in the cluster case which is probably due to the inter-grain coupling of the modes via the grain-boundaries.Comment: 10 pages, 7 figures, accepted for publication in Phys. Rev.

    Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy

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    We review HB stars in a broad astrophysical context, including both variable and non-variable stars. A reassessment of the Oosterhoff dichotomy is presented, which provides unprecedented detail regarding its origin and systematics. We show that the Oosterhoff dichotomy and the distribution of globular clusters (GCs) in the HB morphology-metallicity plane both exclude, with high statistical significance, the possibility that the Galactic halo may have formed from the accretion of dwarf galaxies resembling present-day Milky Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the second-parameter problem is presented. A technique is proposed to estimate the HB types of extragalactic GCs on the basis of integrated far-UV photometry. The relationship between the absolute V magnitude of the HB at the RR Lyrae level and metallicity, as obtained on the basis of trigonometric parallax measurements for the star RR Lyrae, is also revisited, giving a distance modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are studied. Finally, the conductive opacities used in evolutionary calculations of low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and Space Scienc
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