Almost Periodic and Asymptotically Almost Periodic Solutions of Liénard Equations

The aim of this paper is to study the almost periodic and asymptotically almost periodic solutions on (0,+1) of the Li´enard equation x′′ + f(x)x′ + g(x) = F(t), where F : T ! R (T = R+ or R) is an almost periodic or asymptotically almost periodic function and g : (a, b) ! R is a strictly decreasing function. We study also this problem for the vectorial Li´enard equation. We analyze this problem in the framework of general non-autonomous dynamical systems (cocycles). We apply the general results obtained in our early papers [3, 7] to prove the existence of almost periodic (almost automorphic, recurrent, pseudo recurrent) and asymptotically almost periodic (asymptotically almost automorphic, asymptotically recurrent, asymptotically pseudo recurrent) solutions of Li´enard equations (both scalar and vectorial)

Interim 2017/18 influenza seasonal vaccine effectiveness: Combined results from five European studies

Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Neogene Basin Inversion and Recent Slip Rate Distribution of the Northern Termination of the Alhama de Murcia Fault (Eastern Betic Shear Zone, SE Spain)

The Alhama de Murcia Fault is one of the main active structures of the Eastern Betic Shear Zone (SE Spain), characterized by the presence, along its trace, of Neogene basins developed under Early to Late Miocene extensional tectonics. A dominant NNW‐SSE shortening direction is active from Late Miocene driven by the present‐day plate convergence. We present the structural analysis of the northeastern section of this fault, where reliable estimations of slip rates were unknown due to the lack of geomorphological evidence of recent activity. The recent tectonic evolution and reactivation of the northeastern section is closely related to the Fortuna basin development and tectonic inversion. We approach the structural analysis through the interpretation of seismic reflection profiles, well data, fieldwork and 3D geological modeling. We estimated a maximum long‐term slip‐rate of (0.32 +0.18/‐0.13) mm/yr in the Librilla sector (last 4.8‐7.6 Ma), based on cross‐section restorations and assuming current motion trends from GPS data. According to the results from the cross‐sections restored along the section and a vertical displacement analysis based on a 3D model, the slip‐rate distribution shows a decrease of activity toward the northeastern tip of the studied fault section. This supports a transference of deformation between the Alhama de Murcia Fault and the Carrascoy Fault, which seems to absorb part of the shortening during the Plio‐Quaternary, explaining the lower relief created by the activity of the northeastern section. The slip rates obtained have important implications in seismic hazard assessments and in the distribution of deformation along the region

Highly dense linkage maps from 31 full-sibling families of turbot (Scophthalmus maximus) provide insights into recombination patterns and chromosome rearrangements throughout a newly refined genome assembly

Highly dense linkage maps enable positioning thousands of landmarks useful for anchoring the whole genome and for analysing genome properties. Turbot is the most important cultured flatfish worldwide and breeding programs in the fifth generation of selection are targeted to improve growth rate, obtain disease resistant broodstock and understand sex determination to control sex ratio. Using a Restriction-site Associated DNA approach, we genotyped 18,214 single nucleotide polymorphism in 1,268 turbot individuals from 31 full-sibling families. Individual linkage maps were combined to obtain a male, female and species consensus maps. The turbot consensus map contained 11,845 markers distributed across 22 linkage groups representing a total normalised length of 3,753.9 cM. The turbot genome was anchored to this map, and scaffolds representing 96% of the assembly were ordered and oriented to obtain the expected 22 megascaffolds according to its karyotype. Recombination rate was lower in males, especially around centromeres, and pairwise comparison of 44 individual maps suggested chromosome polymorphism at specific genomic regions. Genome comparison across flatfish provided new evidence on karyotype reorganisations occurring across the evolution of this fish group