9 research outputs found

    Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry

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    Differential clinical characteristics and prognosis of intraventricular conduction defects in patients with chronic heart failure

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    Intraventricular conduction defects (IVCDs) can impair prognosis of heart failure (HF), but their specific impact is not well established. This study aimed to analyse the clinical profile and outcomes of HF patients with LBBB, right bundle branch block (RBBB), left anterior fascicular block (LAFB), and no IVCDs. Clinical variables and outcomes after a median follow-up of 21 months were analysed in 1762 patients with chronic HF and LBBB (n = 532), RBBB (n = 134), LAFB (n = 154), and no IVCDs (n = 942). LBBB was associated with more marked LV dilation, depressed LVEF, and mitral valve regurgitation. Patients with RBBB presented overt signs of congestive HF and depressed right ventricular motion. The LAFB group presented intermediate clinical characteristics, and patients with no IVCDs were more often women with less enlarged left ventricles and less depressed LVEF. Death occurred in 332 patients (interannual mortality = 10.8%): cardiovascular in 257, extravascular in 61, and of unknown origin in 14 patients. Cardiac death occurred in 230 (pump failure in 171 and sudden death in 59). An adjusted Cox model showed higher risk of cardiac death and pump failure death in the LBBB and RBBB than in the LAFB and the no IVCD groups. LBBB and RBBB are associated with different clinical profiles and both are independent predictors of increased risk of cardiac death in patients with HF. A more favourable prognosis was observed in patients with LAFB and in those free of IVCDs. Further research in HF patients with RBBB is warranted

    Review on magnetic devices development for terrestrial and planetary rock characterization during field surveys

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    The characterization of rocks magnetic signature, via the magnetic field and its spatial gradient, and the magnetic properties of natural samples, such as the complex magnetic susceptibility, are useful tools not only to understand the composition and structure of the rock but also its geological history, with important implication on paleomagnetism and the magnetic fields involved in the early history of the planets. The determination of this important magnetic information often requires large and complex laboratory set-ups that measure different magnetic properties and sample collection (and tools for the extraction of the rocks) on field campaigns. Our most recent research in this discipline has been focused on the design and construction of devices that, complemented with magnetic field measurements, could enhance the in-situ magnetic characterization of rocks and soils extracted from the field campaigns and prior to laboratory characterization. In this work we present the development of magnetic devices for a complete in-situ and non-destructive characterization of the magnetic signature and other magnetic properties of natural samples and soils, with designs compatible with rover architectures for planetary exploration. This work comprises the development of a magnetic gradiometer prototype for the complete characterization of the magnetic field, and the evolution of a magnetic susceptometer with the capability of measuring the complex magnetic susceptibility (with a sweep of frequencies between 10 and 100 kHz) in a wide range representative for natural samples. It has to be taken into account that one of the important parameters in such devices is robustness, and thus, great part of our effort has been focused to achieve high robustness devices maintaining a high maturity level (technology readiness level – TRL)

    Revisiting the age and palaeoenvironments of the Upper Jurassic–Lower Cretaceous? dinosaur-bearing sedimentary record of eastern Spain: implications for Iberian palaeogeography

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    Differential clinical characteristics and prognosis of intraventricular conduction defects in patients with chronic heart failure

    No full text
    Intraventricular conduction defects (IVCDs) can impair prognosis of heart failure (HF), but their specific impact is not well established. This study aimed to analyse the clinical profile and outcomes of HF patients with LBBB, right bundle branch block (RBBB), left anterior fascicular block (LAFB), and no IVCDs. Clinical variables and outcomes after a median follow-up of 21 months were analysed in 1762 patients with chronic HF and LBBB (n = 532), RBBB (n = 134), LAFB (n = 154), and no IVCDs (n = 942). LBBB was associated with more marked LV dilation, depressed LVEF, and mitral valve regurgitation. Patients with RBBB presented overt signs of congestive HF and depressed right ventricular motion. The LAFB group presented intermediate clinical characteristics, and patients with no IVCDs were more often women with less enlarged left ventricles and less depressed LVEF. Death occurred in 332 patients (interannual mortality = 10.8%): cardiovascular in 257, extravascular in 61, and of unknown origin in 14 patients. Cardiac death occurred in 230 (pump failure in 171 and sudden death in 59). An adjusted Cox model showed higher risk of cardiac death and pump failure death in the LBBB and RBBB than in the LAFB and the no IVCD groups. LBBB and RBBB are associated with different clinical profiles and both are independent predictors of increased risk of cardiac death in patients with HF. A more favourable prognosis was observed in patients with LAFB and in those free of IVCDs. Further research in HF patients with RBBB is warranted
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