Preliminary structural and seismic performance assessment of the Mosque-Cathedral of Cordoba: The Abd al-Rahman I sector

This manuscript discusses some preliminary results on the structural and the seismic performance of the Mosque-Cathedral of Cordoba, a UNESCO World Heritage. The area is characterized by a moderate seismic hazard. The building was built from the 8th to the 16th century and it has undergone several transformations. Owing to the complexity of the building, this work has focused on the assessment of the Abd al-Rahman I sector, which is the most aged part of the complex. For that, first, a 3D numerical finite element model of the sector has been done in the OpenSees framework and calibrated. To do so, an experimental non-destructive campaign has been carried out. Second, the model has been used to evaluate the structural behaviour, under vertical and horizontal loads, considering different scenarios. Finally, the crack patterns and the seismic safety have been obtained. The results showed that the numerical damage obtained for the gravitational loads is in good agreement with the data collected from the in situ surveys. Also, particular attention should be paid to the cymatiums, as they are the most demanded part of the system. Regarding its seismic performance, the building presents a higher capacity in the direction of the arcades. For the seismic demand, slight damage is expected in both principal directions of the building, which could be easily repaired. Damage concentration is expected in the contact between the perimetral wall and the arcades. This work has expanded the study of the features of the Mosque-Cathedral of Cordoba to the structural and seismic analysis with advanced numerical FE computing, which has not been done to date. To the authors’ knowledge, this is the first time that a macro-modelling approach with solid elements is presented for the seismic assessment of heritage buildings using the OpenSees framework. The methodology to do so is also presented. Apart from showing how advanced numerical analyses can provide useful information to assess the existing damage on monumental buildings, this work aims at contributing to the assessment of the vulnerability and the safety of one of the most emblematic mosque-like buildings of the world.20 página

A 3D joint interpretation of magnetotelluric and seismic tomographic models: the case of the volcanic island of Tenerife

In this work we have done a 3D joint interpretation of magnetotelluric and seismic tomography models. Previously we have described different techniques to infer the inner structure of the Earth. We have focused on volcanic regions, specifically on Tenerife Island volcano (Canary Islands, Spain). In this area, magnetotelluric and seismic tomography studies have been done separately. The novelty of the present work is the combination of both techniques in Tenerife Island. For this aim we have applied Fuzzy Clusters Method at different depths obtaining several clusters or classes. From the results, a geothermal system has been inferred below Teide volcano, in the center of Tenerife Island. An edifice hydrothermally altered and full of fluids is situated below Teide, ending at 600 m below sea level. From this depth the resistivity and VP values increase downwards. We also observe a clay cap structure, a typical feature in geothermal systems related with low resistivity and low VP values.Comment: Preprint of the published paper without figure

WALLABY Pilot Survey: An 'Almost' Dark Cloud near the Hydra Cluster

We explore the properties of an 'almost' dark cloud of neutral hydrogen (HI) using data from the Widefield ASKAP L-band Legacy All-sky Survey (WALLABY). Until recently, WALLABY J103508-283427 (also known as H1032-2819 or LEDA 2793457) was not known to have an optical counterpart, but we have identified an extremely faint optical counterpart in the DESI Legacy Imaging Survey Data Release 10. We measured the mean g-band surface brightness to be $27.0\pm0.3$ mag arcsec$^{-2}$. The WALLABY data revealed the cloud to be closely associated with the interacting group Klemola 13 (also known as HIPASS J1034-28 and the Tol 9 group), which itself is associated with the Hydra cluster. In addition to WALLABY J103508-283427/H1032-2819, Klemola 13 contains ten known significant galaxies and almost half of the total HI gas is beyond the optical limits of the galaxies. By combining the new WALLABY data with archival data from the Australia Telescope Compact Array (ATCA), we investigate the HI distribution and kinematics of the system. We discuss the relative role of tidal interactions and ram pressure stripping in the formation of the cloud and the evolution of the system. The ease of detection of this cloud and intragroup gas is due to the sensitivity, resolution and wide field of view of WALLABY, and showcases the potential of the full WALLABY survey to detect many more examples.Comment: 13 pages, 7 figures, accepted for publication in MNRA

SEN1990 is a predicted winged helix-turn-helix protein involved in the pathogenicity of Salmonella enterica serovar Enteritidis and the expression of the gene oafB in the SPI-17

Excisable genomic islands (EGIs) are horizontally acquired genetic elements that harbor an array of genes with diverse functions. ROD21 is an EGI found integrated in the chromosome of Salmonella enterica serovar Enteritidis (Salmonella ser. Enteritidis). While this island is known to be involved in the capacity of Salmonella ser. Enteritidis to cross the epithelial barrier and colonize sterile organs, the role of most ROD21 genes remains unknown, and thus, the identification of their function is fundamental to understanding the impact of this EGI on bacterium pathogenicity. Therefore, in this study, we used a bioinformatical approach to evaluate the function of ROD21-encoded genes and delve into the characterization of SEN1990, a gene encoding a putative DNA-binding protein. We characterized the predicted structure of SEN1990, finding that this protein contains a three-stranded winged helix-turn-helix (wHTH) DNA-binding domain. Additionally, we identified homologs of SEN1990 among other members of the EARL EGIs. Furthermore, we deleted SEN1990 in Salmonella ser. Enteritidis, finding no differences in the replication or maintenance of the excised ROD21, contrary to what the previous Refseq annotation of the protein suggests. High-throughput RNA sequencing was carried out to evaluate the effect of the absence of SEN1990 on the bacterium’s global transcription. We found a downregulated expression of oafB, an SPI-17-encoded acetyltransferase involved in O-antigen modification, which was restored when the deletion mutant was complemented ectopically. Additionally, we found that strains lacking SEN1990 had a reduced capacity to colonize sterile organs in mice. Our findings suggest that SEN1990 encodes a wHTH domain-containing protein that modulates the transcription of oafB from the SPI-17, implying a crosstalk between these pathogenicity islands and a possible new role of ROD21 in the pathogenesis of Salmonella ser. Enteritidis

Maíces con alto contenido de antocianina, biofortificados con zinc, provitamina A y de alta calidad de proteína en Perú

Más de 2000 millones de personas en el mundo padecen “hambre oculta” por insuficiencia de minerales y/o vitaminas en la dieta diaria. La situación del hambre en Perú pasó de 17.7 a 19.6 puntos de 2021 a 2022. La biofortificación de cultivos surgió como una iniciativa para ayudar a solucionar este problema mediante la producción de plantas con mayor contenido de zinc (Zn), hierro (Fe) y provitamina A (ProA) en el grano utilizando métodos de mejoramiento convencional (no transgénicos). Los resultados obtenidos en el Perú nos muestran que existen híbridos de maíz biofortificado, con alto contenido de Zn y ProA, y con muy buen potencial de rendimiento. Para el caso del maíz morado, con alto contenido de antocianinas, un fitoquímico que tiene efectos beneficiosos para la salud de las personas, se está estudiando la adaptación de las variedades en todo el país tanto para el rendimiento del grano como para el contenido de antocianinas. Resultados preliminares indican que hay claras diferencias entre variedades para rendimiento y contenido de antocianina en la coronta, brácteas y grano. La producción de maíz morado se ha cuadruplicado en los últimos 20 años por un mayor consumo interno y por el incremento en las exportaciones. Sin embargo, su contribución al Producto Bruto Interno (PBI) es muy baja: menor al 1 %; lo que es un reto y una oportunidad para desarrollar y transferir tecnología que incremente la producción y vincule al productor de maíz morado con el consumidor. En el caso de maíz de alta calidad de proteína (QPM), se ha liberado en el Perú un híbrido simple (QPM) de color amarillo intenso, con alto potencial de rendimiento y amplia adaptación

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Actas de las V Jornadas ScienCity 2022. Fomento de la Cultura Científica, Tecnológica y de Innovación en Ciudades Inteligentes

ScienCity es una actividad que viene siendo continuada desde 2018 con el objetivo de dar a conocer los conocimientos y tecnologías emergentes siendo investigados en las universidades, informar de experiencias, servicios e iniciativas puestas ya en marcha por instituciones y empresas, llegar hasta decisores políticos que podrían crear sinergias, incentivar la creación de ideas y posibilidades de desarrollo conjuntas, implicar y provocar la participación ciudadana, así como gestar una red internacional multidisciplinar de investigadores que garantice la continuación de futuras ediciones. En 2022 se recibieron un total de 48 trabajos repartidos en 25 ponencias y 24 pósteres pertenecientes a 98 autores de 14 instituciones distintas de España, Portugal, Polonia y Países Bajos.Fundación Española para la Ciencia y la Tecnología-Ministerio de Ciencia, Innovación y Universidades; Consejería de la Presidencia, Administración Pública e Interior de la Junta de Andalucía; Estrategia de Política de Investigación y Transferencia de la Universidad de Huelva; Cátedra de Innovación Social de Aguas de Huelva; Cátedra de la Provincia; Grupo de investigación TEP-192 de Control y Robótica; Centro de Investigación en Tecnología, Energía y Sostenibilidad (CITES