725 research outputs found
Computationally designed libraries of fluorescent proteins evaluated by preservation and diversity of function
To determine which of seven library design algorithms best introduces new protein function without destroying it altogether, seven combinatorial libraries of green fluorescent protein variants were designed and synthesized. Each was evaluated by distributions of emission intensity and color compiled from measurements made in vivo. Additional comparisons were made with a library constructed by error-prone PCR. Among the designed libraries, fluorescent function was preserved for the greatest fraction of samples in a library designed by using a structure-based computational method developed and described here. A trend was observed toward greater diversity of color in designed libraries that better preserved fluorescence. Contrary to trends observed among libraries constructed by error-prone PCR, preservation of function was observed to increase with a library's average mutation level among the four libraries designed with structure-based computational methods
Turbulent Gas Flows in the Rosette and G216-2.5 Molecular Clouds: Assessing Turbulent Fragmentation Descriptions of Star Formation
The role of turbulent fragmentation in regulating the efficiency of star
formation in interstellar clouds is examined from new wide field imaging of
12CO and 13CO J=1-0 emission from the Rosette and G216-2.5 molecular clouds.
The Rosette molecular cloud is a typical star forming giant molecular cloud and
G215-2.5 is a massive molecular cloud with no OB stars and very little low mass
star formation. The properties of the turbulent gas flow are derived from the
set of eigenvectors and eigenimages generated by Principal Component Analysis
of the spectroscopic data cubes. While the two clouds represent quite divergent
states of star formation activity, the velocity structure functions for both
clouds are similar. The sonic scale, lambda_S, defined as the spatial scale at
which turbulent velocity fluctuations are equivalent to the local sound speed,
and the turbulent Mach number evaluated at 1 pc, M_{1pc}, are derived for an
ensemble of clouds including the Rosette and, G216-2.5 regions that span a
large range in star formation activity. We find no evidence for the positive
correlations between these quantities and the star formation efficiency, that
are predicted by turbulent fragmentation models. A correlation does exist
between the star formation efficiency and the sonic scale for a subset of
clouds with L_{FIR}/M(H_2) > 1 that are generating young stellar clusters.
Turbulent fragmentation must play a limited and non-exclusive role in
determining the yield of stellar masses within interstellar clouds.Comment: Accepted by ApJ, 22 pages, 7 figure
Self-reported health, perceived racial discrimination, and skin color in african americans in the CARDIA study
http://deepblue.lib.umich.edu/bitstream/2027.42/61518/1/Borrell_Self-reported-health,-perceived-racial-discrimination,-and-skin-color-in-African-Americans-in-the-CARDIA-study_2006.pd
Keck Spectroscopy of 3<z<7 Faint Lyman Break Galaxies: The Importance of Nebular Emission in Understanding the Specific Star Formation Rate and Stellar Mass Density
The physical properties inferred from the SEDs of z>3 galaxies have been
influential in shaping our understanding of early galaxy formation and the role
galaxies may play in cosmic reionization. Of particular importance is the
stellar mass density at early times which represents the integral of earlier
star formation. An important puzzle arising from the measurements so far
reported is that the specific star formation rates (sSFR) evolve far less
rapidly than expected in most theoretical models. Yet the observations
underpinning these results remain very uncertain, owing in part to the possible
contamination of rest-optical broadband light from strong nebular emission
lines. To quantify the contribution of nebular emission to broad-band fluxes,
we investigate the SEDs of 92 spectroscopically-confirmed galaxies in the
redshift range 3.8<z<5.0 chosen because the H-alpha line lies within the
Spitzer/IRAC 3.6 um filter. We demonstrate that the 3.6 um flux is
systematically in excess of that expected from stellar continuum, which we
derive by fitting the SED with population synthesis models. No such excess is
seen in a control sample at 3.1<z<3.6 in which there is no nebular
contamination in the IRAC filters. From the distribution of our 3.6 um flux
excesses, we derive an H-alpha equivalent width (EW) distribution. The mean
rest-frame H-alpha EW we infer at 3.8<z<5.0 (270 A) indicates that nebular
emission contributes at least 30% of the 3.6 um flux. Via our
empirically-derived EW distribution we correct the available stellar mass
densities and show that the sSFR evolves more rapidly at z>4 than previously
thought, supporting up to a 5x increase between z~2 and 7. Such a trend is much
closer to theoretical expectations. Given our findings, we discuss the
prospects for verifying quantitatively the nebular emission line strengths
prior to the launch of the James Webb Space Telescope.Comment: 16 pages, 9 figures, submitted to Ap
Heterogenized Pyridine-Substituted Cobalt(II) Phthalocyanine Yields Reduction of CO2 by Tuning the Electron Affinity of the Co Center
Conversion of CO2 to reduced products is a promising route to alleviate irreversible climate change. Here we report the synthesis of a Co-based phthalocyanine with pyridine moieties (CoPc-Pyr), which is supported on a carbon electrode and shows Faradaic efficiency âŒ90% for CO at 490 mV of overpotential (-0.6 V vs reversible hydrogen electrode (RHE)). In addition, its catalytic activity at -0.7 V versus RHE surpasses other Co-based molecular and metal-organic framework catalysts for CO2 reduction at this bias. Density functional theory calculations show that pyridine moieties enhance CO2 adsorption and electron affinity of the Co center by an inductive effect, thus lowering the overpotential necessary for CO2 conversion. Our study shows that CoPc-Pyr reduces CO2 at lower overpotential and with higher activity than noble metal electrodes, such as silver
Training of Instrumentalists and Development of New Technologies on SOFIA
This white paper is submitted to the Astronomy and Astrophysics 2010 Decadal
Survey (Astro2010)1 Committee on the State of the Profession to emphasize the
potential of the Stratospheric Observatory for Infrared Astronomy (SOFIA) to
contribute to the training of instrumentalists and observers, and to related
technology developments. This potential goes beyond the primary mission of
SOFIA, which is to carry out unique, high priority astronomical research.
SOFIA is a Boeing 747SP aircraft with a 2.5 meter telescope. It will enable
astronomical observations anywhere, any time, and at most wavelengths between
0.3 microns and 1.6 mm not accessible from ground-based observatories. These
attributes, accruing from the mobility and flight altitude of SOFIA, guarantee
a wealth of scientific return. Its instrument teams (nine in the first
generation) and guest investigators will do suborbital astronomy in a
shirt-sleeve environment. The project will invest $10M per year in science
instrument development over a lifetime of 20 years. This, frequent flight
opportunities, and operation that enables rapid changes of science instruments
and hands-on in-flight access to the instruments, assure a unique and extensive
potential - both for training young instrumentalists and for encouraging and
deploying nascent technologies. Novel instruments covering optical, infrared,
and submillimeter bands can be developed for and tested on SOFIA by their
developers (including apprentices) for their own observations and for those of
guest observers, to validate technologies and maximize observational
effectiveness.Comment: 10 pages, no figures, White Paper for Astro 2010 Survey Committee on
State of the Professio
A forgotten figure in Siouan and Caddoan linguistics: Samuel Stehman Haldeman.
The Siouan family comprises some twenty languages, historically spoken across a broad swath of the central North American plains and woodlands, as well as in parts of the southeastern United States. In spite of its geographical extent and diversity, and the size and importance of several Siouan-speaking tribes, this family has received relatively little attention in the linguistic literature and many of the individual Siouan languages are severely understudied. This volume aims to make work on Siouan languages more broadly available and to encourage deeper investigation of the myriad typological, theoretical, descriptive, and pedagogical issues they raise.
The 17 chapters in this volume present a broad range of current Siouan research, focusing on various Siouan languages, from a variety of linguistic perspectives: historical-genetic, philological, applied, descriptive, formal/generative, and comparative/typological. The editors' preface summarizes characteristic features of the Siouan family, including head-final and "verb-centered" syntax, a complex system of verbal affixes including applicatives and subject-possessives, head-internal relative clauses, gendered speech markers, stop-systems including ejectives, and a preference for certain prosodic and phonotactic patterns.
The volume is dedicated to the memory of Professor Robert L. Rankin, a towering figure in Siouan linguistics throughout his long career, who passed away in February of 2014
Advances in the study of Siouan languages and linguistics
The Siouan family comprises some twenty languages, historically spoken across a broad swath of the central North American plains and woodlands, as well as in parts of the southeastern United States. In spite of its geographical extent and diversity, and the size and importance of several Siouan-speaking tribes, this family has received relatively little attention in the linguistic literature and many of the individual Siouan languages are severely understudied. This volume aims to make work on Siouan languages more broadly available and to encourage deeper investigation of the myriad typological, theoretical, descriptive, and pedagogical issues they raise.
The 17 chapters in this volume present a broad range of current Siouan research, focusing on various Siouan languages, from a variety of linguistic perspectives: historical-genetic, philological, applied, descriptive, formal/generative, and comparative/typological. The editors' preface summarizes characteristic features of the Siouan family, including head-final and "verb-centered" syntax, a complex system of verbal affixes including applicatives and subject-possessives, head-internal relative clauses, gendered speech markers, stop-systems including ejectives, and a preference for certain prosodic and phonotactic patterns.
The volume is dedicated to the memory of Professor Robert L. Rankin, a towering figure in Siouan linguistics throughout his long career, who passed away in February of 2014
Advances in the study of Siouan languages and linguistics
The Siouan family comprises some twenty languages, historically spoken across a broad swath of the central North American plains and woodlands, as well as in parts of the southeastern United States. In spite of its geographical extent and diversity, and the size and importance of several Siouan-speaking tribes, this family has received relatively little attention in the linguistic literature and many of the individual Siouan languages are severely understudied. This volume aims to make work on Siouan languages more broadly available and to encourage deeper investigation of the myriad typological, theoretical, descriptive, and pedagogical issues they raise.
The 17 chapters in this volume present a broad range of current Siouan research, focusing on various Siouan languages, from a variety of linguistic perspectives: historical-genetic, philological, applied, descriptive, formal/generative, and comparative/typological. The editors' preface summarizes characteristic features of the Siouan family, including head-final and "verb-centered" syntax, a complex system of verbal affixes including applicatives and subject-possessives, head-internal relative clauses, gendered speech markers, stop-systems including ejectives, and a preference for certain prosodic and phonotactic patterns.
The volume is dedicated to the memory of Professor Robert L. Rankin, a towering figure in Siouan linguistics throughout his long career, who passed away in February of 2014
Advances in the study of Siouan languages and linguistics
The Siouan family comprises some twenty languages, historically spoken across a broad swath of the central North American plains and woodlands, as well as in parts of the southeastern United States. In spite of its geographical extent and diversity, and the size and importance of several Siouan-speaking tribes, this family has received relatively little attention in the linguistic literature and many of the individual Siouan languages are severely understudied. This volume aims to make work on Siouan languages more broadly available and to encourage deeper investigation of the myriad typological, theoretical, descriptive, and pedagogical issues they raise.
The 17 chapters in this volume present a broad range of current Siouan research, focusing on various Siouan languages, from a variety of linguistic perspectives: historical-genetic, philological, applied, descriptive, formal/generative, and comparative/typological. The editors' preface summarizes characteristic features of the Siouan family, including head-final and "verb-centered" syntax, a complex system of verbal affixes including applicatives and subject-possessives, head-internal relative clauses, gendered speech markers, stop-systems including ejectives, and a preference for certain prosodic and phonotactic patterns.
The volume is dedicated to the memory of Professor Robert L. Rankin, a towering figure in Siouan linguistics throughout his long career, who passed away in February of 2014
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