500 research outputs found
Deadly Carousel or Difficult Interpretation of New Diagnostic Tools for Whipple's Disease: Case Report and Review of the Literature
Abstract : Whipple's disease is a rare systemic disorder classically presenting with weight loss, arthralgias, and diarrhea, which was first described in 1907. The causative bacterium Tropheryma whipplei, is a fastidious organism not growing on conventional media. Before the introduction of polymerase chain reaction (PCR)-based methods, the diagnostic gold standard was histological detection of diastase-resistant periodic acid Schiff (PAS)-positive macrophages or electron microscopy. As in the present case, contradictory results between the former and new diagnostic methods may obscure the correct diagnosis. We critically summarize the performance of the different diagnostic methods and discuss their impact on the clinical management of patients with suspected Whipple's diseas
A protosolar nebula origin for the ices agglomerated by Comet 67P/Churyumov-Gerasimenko
The nature of the icy material accreted by comets during their formation in
the outer regions of the protosolar nebula is a major open question in
planetary science. Some scenarios of comet formation predict that these bodies
agglomerated from crystalline ices condensed in the protosolar nebula.
Concurrently, alternative scenarios suggest that comets accreted amorphous ice
originating from the interstellar cloud or from the very distant regions of the
protosolar nebula. On the basis of existing laboratory and modeling data, we
find that the N/CO and Ar/CO ratios measured in the coma of the Jupiter
family comet 67P/Churyumov-Gerasimenko by the ROSINA instrument aboard the
European Space Agency's Rosetta spacecraft match those predicted for gases
trapped in clathrates. If these measurements are representative of the bulk
N/CO and Ar/CO ratios in 67P/Churyumov-Gerasimenko, it implies that the
ices accreted by the comet formed in the nebula and do not originate from the
interstellar medium, supporting the idea that the building blocks of outer
solar system bodies have been formed from clathrates and possibly from pure
crystalline ices. Moreover, because 67P/Churyumov-Gerasimenko is impoverished
in Ar and N, the volatile enrichments observed in Jupiter's atmosphere
cannot be explained solely via the accretion of building blocks with similar
compositions and require an additional delivery source. A potential source may
be the accretion of gas from the nebula that has been progressively enriched in
heavy elements due to photoevaporation.Comment: The Astrophysical Journal Letters, in pres
Origin of molecular oxygen in Comet 67P/Churyumov-Gerasimenko
Molecular oxygen has been detected in the coma of comet
67P/Churyumov-Gerasimenko with abundances in the 1-10% range by the ROSINA-DFMS
instrument on board the Rosetta spacecraft. Here we find that the radiolysis of
icy grains in low-density environments such as the presolar cloud may induce
the production of large amounts of molecular oxygen. We also show that
molecular oxygen can be efficiently trapped in clathrates formed in the
protosolar nebula, and that its incorporation as crystalline ice is highly
implausible because this would imply much larger abundances of Ar and N2 than
those observed in the coma. Assuming that radiolysis has been the only O2
production mechanism at work, we conclude that the formation of comet
67P/Churyumov-Gerasimenko is possible in a dense and early protosolar nebula in
the framework of two extreme scenarios: (1) agglomeration from pristine
amorphous icy grains/particles formed in ISM and (2) agglomeration from
clathrates that formed during the disk's cooling. The former scenario is found
consistent with the strong correlation between O2 and H2O observed in 67P/C-G's
coma while the latter scenario requires that clathrates formed from ISM icy
grains that crystallized when entering the protosolar nebula.Comment: The Astrophysical Journal Letters, in pres
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High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging
Progress in neuroscience relies on new techniques for investigating the complex dynamics of neuronal networks. An ongoing challenge is to achieve minimally invasive and high-resolution observations of neuronal activity in vivo inside deep brain areas. Recently introduced methods for holographic control of light propagation in complex media enable the use of a hair-thin multimode optical fibre as an ultranarrow imaging tool. Compared to endoscopes based on graded-index lenses or fibre bundles, this new approach offers a footprint reduction exceeding an order of magnitude, combined with a significant enhancement in resolution. We designed a compact and high-speed system for fluorescent imaging at the tip of a fibre, achieving a resolution of 1.18 ± 0.04 µm across a 50-µm field of view, yielding 7-kilopixel images at a rate of 3.5 frames/s. Furthermore, we demonstrate in vivo observations of cell bodies and processes of inhibitory neurons within deep layers of the visual cortex and hippocampus of anaesthetised mice. This study paves the way for modern microscopy to be applied deep inside tissues of living animal models while exerting a minimal impact on their structural and functional properties
The <i>Rosetta</i> Mission and the Chemistry of Organic Species in Comet 67P/Churyumov–Gerasimenko
Comets are regarded as probably the most primitive of solar system objects, preserving a record of the materials from which the solar system aggregated. Key amongst their components are organic compounds – molecules that may trace their heritage to the interstellar medium from which the protosolar nebula eventually emerged. The most recent cometary space mission, Rosetta, carried instruments designed to characterize, in unprecedented detail, the organic species in comet 67P/Churyumov–Gerasimenko (67P). Rosetta was the first mission to match orbits with a comet and follow its evolution over time, and also the first mission to land scientific instruments on a comet surface. Results from the mission revealed a greater variety of molecules than previously identified and indicated that 67P contained both primitive and processed organic entities
Future thruster application: combination of numerical simulation of ECR zone and plasma X-ray Bremsstrahlung measurement of the SWISSCASE ECR ion source
We present the combination of the numerical 3D magnetic field simulation of SWISSCASE, the new 10 GHz ECR ion source at the University of Bern in Switzerland, and the experimental X-ray Bremsstrahlung measurement of the same ion source, to determine the hot electron and the total electron number densities of its ECR plasma. The results, which are in excellent agreement with literature, demonstrate the quality of the numerical simulation, the X-ray Bremsstrahlung measurement and the method of combination to calculate these particle densities. The revealed key parameters of the ECR plasma such as geometry, particle densities and Bremsstrahlung emission, may enable the development of a microwave ECR plasma model, yet to be defined, which can be integrated into a Finite Difference Time Domain (FDTD) simulation to reproduce realistic microwave-plasma interaction. The presented method of 3D magnetic field modeling, X-ray Bremsstrahlung measurement and the subsequent determination of the electron densities is not limited to the SWISSCASE ion source but can further be used for detailed investigation and optimization of current and future electric propulsion concepts
Observation of a New Type of Low Frequency Waves at Comet 67P/Churyumov-Gerasimenko
We report on magnetic field measurements made in the innermost coma of
67P/Churyumov-Gerasimenko in its low activity state. Quasi-coherent,
large-amplitude (), compressional magnetic field
oscillations at 40 mHz dominate the immediate plasma environment of the
nucleus. This differs from previously studied comet-interaction regions where
waves at the cometary ion gyro-frequencies are the main feature. Thus classical
pick-up ion driven instabilities are unable to explain the observations. We
propose a cross-field current instability associated with newborn cometary ion
currents as a possible source mechanism.Comment: 6 pages, 3 Figure
Características clínico-epidemiológicas do hiperadrenocorticismo na região de Botucatu - SP
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Complex organosulfur molecules on comet 67P: Evidence from the ROSINA measurements and insights from laboratory simulations.
The ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) instrument aboard the Rosetta mission revolutionized our understanding of cometary material composition. One of Rosetta's key findings is the complexity of the composition of comet 67P/Churyumov-Gerasimenko. Here, we used ROSINA data to analyze dust particles that were volatilized during a dust event in September 2016 and report the detection of large organosulfur species and an increase in the abundances of sulfurous species previously detected in the coma. Our data support the presence of complex sulfur-bearing organics on the surface of the comet. In addition, we conducted laboratory simulations that show that this material may have formed from chemical reactions that were initiated by the irradiation of mixed ices containing H2S. Our findings highlight the importance of sulfur chemistry in cometary and precometary materials and the possibility of characterizing organosulfur materials in other comets and small icy bodies using the James Webb Space Telescope
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