Effect of Kramecyne on the Inflammatory Response in Lipopolysaccharide-Stimulated Peritoneal Macrophages

Kramecyne is a new peroxide, it was isolated from Krameria cytisoides, methanol extract, and this plant was mostly found in North and South America. This compound showed potent anti-inflammatory activity; however, the mechanisms by which this compound exerts its anti-inflammatory effect are not well understood. In this study, we examined the effects of kramecyne on inflammatory responses in mouse lipopolysaccharide- (LPS-) induced peritoneal macrophages. Our findings indicate that kramecyne inhibits LPS-induced production of tumor necrosis factor (TNF-α) and interleukin- (IL-) 6. During the inflammatory process, levels of cyclooxygenase- (COX-) 2, nitric oxide synthase (iNOS), and nitric oxide (NO) increased in mouse peritoneal macrophages; however, kramecyne suppressed them significantly. These results provide novel insights into the anti-inflammatory actions and support its potential use in the treatment of inflammatory diseases

DETERMINAÇÃO DE PARÂMETROS NA RELAÇÃO ENTRE O REGULADOR E OS CONCESSIONÁRIOS DE TRANSMISSÃO DE ENERGIA ELÉTRICA: UMA ABORDAGEM PRINCIPAL-AGENTE

In order to stimulate the quality of the service, ANEEL introduced penalties in the contracts with the concessionaires of public services of transmission of electric energy in the case which the transmission facilities are turned off, be for accident or for maintenance. In this sense, a variable value was instituted whose amount is discounted of the transmission revenue. The value of this parcel is not of easy determination, and ANEEL, based on observations, established a formula for calculation. High penalties can result in bad incentives to the entry of companies in the sector; otherwise, low penalties can induce to the offer of service of bad quality. By using the Theory Principal-agent, this work search to determine this formula so that the true objective is reached. in a rational way. In the present work we analyze the relationship ANEEL - Concessionaires by using the Theory Principalagent. The main conclusion of the work, besides the rising of the costs and of the analysis of the behavior of the concessionaires, refers to the fact that the values of the parameters used by the regulator can be established in smaller values than the now adopted, with larger economic efficiency.

The boson peak in structural and orientational glasses of simple alcohols: Specific heat at low temperatures

We review in this work specific-heat experiments, that we have conducted on different hydrogen-bonded glasses during last years. Specifically, we have measured the low-temperature specific heat Cp for a set of glassy alcohols: normal and fully-deuterated ethanol, 1- and 2- propanol, and glycerol. Ethanol exhibits a very interesting polymorphism presenting three different solid phases at low temperature: a fully-ordered (monoclinic) crystal, an orientationally-disordered (cubic) crystal or 'orientational glass', and the ordinary structural glass. By measuring and comparing the low-temperature specific heat of the three phases, in the 'boson peak' range 2-10 K as well as in the tunneling-states range below 1K, we are able to provide a quantitative confirmation that ''glassy behavior'' is not an exclusive property of amorphous solids. On the other hand, propanol is the simplest monoalcohol with two different stereoisomers (1- and 2-propanol), what allows us to study directly the influence of the spatial rearrangement of atoms on the universal properties of glasses. We have measured the specific heat of both isomers, finding a noteworthy quantitative difference between them. Finally, low-temperature specific-heat data of glassy glycerol have also been obtained. Here we propose a simple method based upon the soft-potential model to analyze low-temperature specific-heat measurements, and we use this method for a quantitative comparison of all these data of glassy alcohols and as a stringent test of several universal correlations and scaling laws suggested in the literature. In particular, we find that the interstitialcy model for the boson peak [A. V. Granato, Phys. Rev. Lett. 68 (1992) 974] gives a very good account of the temperature at which the maximum in Cp/T^3 occurs.Comment: 16 pages, 2 figures, Proceedings of the 4th International Discussion Meeting on Relaxations in Complex Systems, Hersonissos (Crete), June 2001. Journal of Non-Crystalline Solids (accepted for publication

On the product of two π-decomposable soluble groups

Let the group G = AB be a product of two π-decomposable sub-groups A = Oπ(A) × Oπ' (A) and B = Oπ(B) × Oπ' (B) where π is a set of primes. The authors conjecture that Oπ(A)Oπ(B) = Oπ(B)Oπ(A) if π is a set of odd primes. In this paper it is proved that the conjecture is true if A and B are soluble. A similar result with certain additional restrictions holds in the case 2 ∈ π. Moreover, it is shown that the conjecture holds if Oπ '(A) and Oπ'(B) have coprime orders

Medium-modified DGLAP evolution of fragmentation functions from large to small x

The unified description of fragmentation function evolution from large to small x which was developed for the vacuum in previous publications is now generalized to the medium, and is studied for the case in which the complete contribution from the largest class of soft gluon logarithms, the double logarithms, are accounted for and with the fixed order part calculated to leading order. In this approach it proves possible to choose the remaining degrees of freedom related to the medium such that the distribution of produced hadrons is suppressed at large momenta while the production of soft radiation-induced charged hadrons at small momenta is enhanced, in agreement with experiment. Just as for the vacuum, our approach does not require further assumptions concerning fragmentation and is more complete than previous computations of evolution in the medium

Finite trifactorized groups and pi-decomposability

The first author would like to thank the Universitat de Valencia for its warm hospitality and financial support during the preparation of this paper.Kazarin, LS.; Martínez-Pastor, A.; Perez Ramos, MD. (2018). Finite trifactorized groups and pi-decomposability. Bulletin of the Australian Mathematical Society. 97(2):218-228. https://doi.org/10.1017/S0004972717001034S21822897