Las epífitas vasculares del estado de Hidalgo, México: diversidad y distribución

Based on the recollection of botanical specimens in different regions of the state of Hidalgo and the study of herbarium material deposited in several institutional collections, supplemented by a literature review, we obtained records of 17 families (nine of them belonging to Pteridophytes and the rest to Angiosperms), 64 genera and 163 species. We also provide data about the municipal distribution of taxa and an analysis of their representation by vegetation type and altitudinal range. We report from Hidalgo, for the first time the following taxa: Tillandsia filifolia Schltdl. & Cham., T. heterophylla E. Morren, Pleurothallis sp.1 and Pleurothallis sp. 2. Only Laelia gouldiana Rchb. f., Dignathe pygmaeum Lindl., and one undescribed species of the genus Goodyera, are endemic to the state.Con base en la recolección de ejemplares botánicos en diferentes regiones del estado de Hidalgo y en el estudio de material herborizado depositado en diversas colecciones institucionales, complementado con una revisión bibliográfica, obtuvimos el inventario de la flora epifítica vascular de la entidad. Como resultado de lo anterior se registran para el área de estudio 17 familias (nueve de ellas pertenecientes a las Pteridofitas y el resto a las Magnoliofitas), 64 géneros y 163 especies. Asimismo, se aportan datos sobre la distribución municipal de los taxa y un análisis sobre su representación por tipo de vegetación y por intervalo altitudinal. Se registran por primera vez para el estado los siguientes taxa: Tillandsia filifolia Schltdl. & Cham., T. heterophylla E. Morren, Pleurothallis sp. 1 y Pleurothallis sp. 2. Sólo Laelia gouldiana Rchb. f., Dignathe pygmaeum Lindl. y una especie no descrita del género Goodyera son endémicos del estado

Una propuesta de Modelamiento para los Sistemas de Recompensa

One of the most important subjects of interest, in nearly any human activity, is the perception of salary. It could even be said that the decision of following a career depends deeply on the perspective that the individual may have about the future income. In this work we propose a general model for its computation. We define an employee’s reward system as a function that depends on monetary and non monetary parameters; hence, the reward system can be stated as a multiobjective system to be optimized. In the article we present a rationale of the proposed reward system, as a general model of solution, and we present come examples.En todos los tiempos uno de los temas de mayor interés a todos los niveles de la actividad humana es el referente a las percepciones salariales que se tienen. Incluso se podría decir que la decisión de seguir ciertos estudios ha dependido en gran manera sobre las perspectivas que el individuo tiene sobre el futuro de sus ingresos, por lo que en este trabajo se propone un modelo general para su cálculo. Se plantea el sistema de recompensa de un empleado como una función que depende de par´ametros tanto monetarios como no monetarios, por lo que se puede plantear el sistema de recompensa como un sistema multiobjetivo a optimizar. En el trabajo se presenta una justificación del sistema de recompensa propuesto como un modelo general de solución a éste y se presentan algunos ejemplos

Thrombolisis in acute Myocardial Infarction. Celia Sánchez Manduley Hospital, October-December 2017

Se realizó un estudio descriptivo retrospectivo transversal mediante la revisión de los expedientes clínicos de los 54 pacientes que estuvieron ingresados en el Hospital “Celia Sánchez Manduley” con el diagnóstico de Infarto Agudo del Miocardio (IMA) en el período octubre-diciembre del 2017, para conocer los beneficios más relevantes del tratamiento trombolítico. Se comprobó que los principales factores que retardan el tratamiento trombolítico con eficacia en las enfermedades coronarias (IMA) fueron: la llegada del paciente fuera del tiempo establecido (29,2 %); la hipotensión arterial (9,75 %) y las arritmias (14,6 %); además se observaron signos relevantes de reperfusión y una evolución excelente en los pacientes con óptimo tiempo dolor-aguja (< 2 horas), donde los pacientes trombolizados respondieron favorablemente (23,00 %); mientras que la evolución favorable de los que fueron trombolizados y su tiempo dolor-aguja se comportó al 31,48 %. La información obtenida se procesó en una base de datos mediante el paquete estadístico SPSS 11.5 y se expuso en tablas para su mejor análisis y discusión de los resultados.A descriptive cross sectional, retrospective study was carried out by reviewing the clinical histories of 54 patients who were admitted to Celia Sánchez Manduley hospital with acute Myocardial Infarction diagnosis (AMI) in the period October-December 2017, to know the most relevant benefits of. Thrombolytic treatment with efficacy in coronary diseases were: the arrival of the patient outside the established time (29,2 %); the  arterial hypotension (9,75 %) and the arrhythmias (14,6 %); also relevants signs of  reperfusion were observed and an excellent evolution in patient with optimal pain-needle time (2 hours) where the thrombolyzed patients answered favorably (23,00 %) while the favorable evolution of those who were thrombolyzed and their pain-needle time was behaved to (31,48%). The information was processed in a data by means of statistical package SPSS 11,5 and it was presented in tables for a better analysis and discussion of the results

Obsolescence in the neighbourhood of Nuestra Señora del Carmen

Actualmente, áreas urbanas donde habita un importantísimo sector poblacional están afectadas por una compleja problemática que se materializa en cuestiones arquitectónicas (desencaje tipológico, deficiencias técnicas, deterioro físico), urbanísticas (aislamiento, carencias funcionales, degradación del espacio público) y sociales (desempleo, segregación, conflictividad). El análisis del estado de obsolescencia de la barriada de El Carmen ha sido el punto de inicio de este trabajo de investigación. A partir de indicadores de obsolescencia socioeconómicos y físicos, anteriormente definidos por el proyecto de investigación «Intervención en barriadas residenciales obsoletas: manual de buenas prácticas» (G-GI3001/IDIH), financiado por la Unión Europea –Fondos FEDER– y gestionado por la Consejería de Fomento y Vivienda de la Junta de Andalucía, se ha establecido la situación de la barriada con referencia a valores máximos y mínimos, hallados a través del estudio de un número representativo de barriadas andaluzas. Tras la valoración del estado de obsolescencia de la barriada, se profundizó en su estudio a través de la comparación del cumplimiento de las recomendaciones establecidas como buenas prácticas en la publicación Intervención en barriadas residenciales obsoletas. Manual de buenas prácticas. Esta verificación permitió la elaboración de un diagnóstico pormenorizado basado en el análisis de los diferentes aspectos atendidos por las buenas prácticas, donde se evaluaban las deficiencias de El Carmen a escala urbana y arquitectónica, y dentro de estas, en diferentes categorías, siendo las urbanas: compacidad, conectividad, zonas verdes, funcionalidad, seguridad e inclusividad; y las arquitectónicas: hibridación, diversidad y flexibilidad, comunidad y accesibilidad. Esta evaluación detallada de las deficiencias y potencialidades de la barriada establecía los fundamentos para la definición de criterios y estrategias de intervención. Estos criterios de intervención tenían como base una selección de las buenas prácticas más adecuadas de acuerdo con las circunstancias halladas en la barriada, sistematizando las actuaciones que priorizan la atención de aspectos primordiales o que actúan mitigando carencias graves. Los criterios que se establecen son: sostenibilidad, la mejora de la calidad de vida de sus residentes y la atracción de nueva población a la barriada. Respondiendo a este estudio y la definición de criterios se proponen actuaciones estratégicas englobadas en cuatro líneas de trabajo: relación con la ciudad y su contexto, cualificación del espacio público y dotaciones existentes, cualificación de edificios existentes y actualización tipológica.Today, a number of high-occupancy urban areas are being affected by a complex problem that materialises in architectural issues (typological mismatch, technical deficiencies, physical deterioration), urban planning issues (isolation, functional inadequacies, deterioration of public space) and social issues (unemployment, segregation, conflict). Analysing the state of obsolescence of the neighbourhood of El Carmen was the starting point of this research project. Using socio-economic and physical obsolescence indicators established in an earlier research project–“Intervention in Obsolete Residential Neighbourhoods: Manual of Best Practices” (G-GI3001/IDIH), funded by the ERDF and managed by the Regional Ministry of Public Works and Housing of Andalusia–the situation of this neighbourhood was defined with reference to minimum and maximum values identified by studying a representative number of Andalusian neighbourhoods. After assessing the neighbourhood’s state of obsolescence, it was then studied to determine the degree of compliance with the best practices recommended in the publication Intervención en barriadas residenciales obsoletas. Manual de buenas prácticas. This verification made it possible to come up with a detailed diagnosis based on the analysis of different aspects addressed in that manual of best practices, evaluating the urban and architectural deficiencies of El Carmen and subdividing each into different categories. Urban deficiencies included compactness, connectivity, green areas, functionality, safety and inclusiveness; and architectural deficiencies were hybridisation, diversity, flexibility, community and accessibility. This detailed analysis of the neighbourhood’s shortcomings and potential improvements provided a solid foundation for defining intervention criteria and strategies. Those intervention criteria were based on a selection of the best practices deemed most appropriate in light of the neighbourhood’s current situation, systematising actions that address the most important aspects or attempt to mitigate serious deficiencies. The established criteria are as follows: sustainability, improving the residents’ quality of life, and bringing new residents to the neighbourhood. Based on this study and the defined criteria, strategic courses of action were proposed in four general areas: relationship with the city and its context, qualification of existing facilities and public spaces, qualification of existing buildings, and typological modernisation

Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications

ESRETNET Study Group, The ERDC Study Group, The Associated Clinical Study Group.Inherited retinal diseases (IRDs), defined by dysfunction or progressive loss of photoreceptors, are disorders characterized by elevated heterogeneity, both at the clinical and genetic levels. Our main goal was to address the genetic landscape of IRD in the largest cohort of Spanish patients reported to date. A retrospective hospital-based cross-sectional study was carried out on 6089 IRD affected individuals (from 4403 unrelated families), referred for genetic testing from all the Spanish autonomous communities. Clinical, demographic and familiar data were collected from each patient, including family pedigree, age of appearance of visual symptoms, presence of any systemic findings and geographical origin. Genetic studies were performed to the 3951 families with available DNA using different molecular techniques. Overall, 53.2% (2100/3951) of the studied families were genetically characterized, and 1549 different likely causative variants in 142 genes were identified. The most common phenotype encountered is retinitis pigmentosa (RP) (55.6% of families, 2447/4403). The most recurrently mutated genes were PRPH2, ABCA4 and RS1 in autosomal dominant (AD), autosomal recessive (AR) and X-linked (XL) NON-RP cases, respectively; RHO, USH2A and RPGR in AD, AR and XL for non-syndromic RP; and USH2A and MYO7A in syndromic IRD. Pathogenic variants c.3386G > T (p.Arg1129Leu) in ABCA4 and c.2276G > T (p.Cys759Phe) in USH2A were the most frequent variants identified. Our study provides the general landscape for IRD in Spain, reporting the largest cohort ever presented. Our results have important implications for genetic diagnosis, counselling and new therapeutic strategies to both the Spanish population and other related populations.This work was supported by the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Health (FIS; PI16/00425 and PI19/00321), Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER, 06/07/0036), IIS-FJD BioBank (PT13/0010/0012), Comunidad de Madrid (CAM, RAREGenomics Project, B2017/BMD-3721), European Regional Development Fund (FEDER), the Organización Nacional de Ciegos Españoles (ONCE), Fundación Ramón Areces, Fundación Conchita Rábago and the University Chair UAM-IIS-FJD of Genomic Medicine. Irene Perea-Romero is supported by a PhD fellowship from the predoctoral Program from ISCIII (FI17/00192). Ionut F. Iancu is supported by a grant from the Comunidad de Madrid (CAM, PEJ-2017-AI/BMD7256). Marta del Pozo-Valero is supported by a PhD grant from the Fundación Conchita Rábago. Berta Almoguera is supported by a Juan Rodes program from ISCIII (JR17/00020). Pablo Minguez is supported by a Miguel Servet program from ISCIII (CP16/00116). Marta Corton is supported by a Miguel Servet program from ISCIII (CPII17/00006)

Brentuximab vedotin in the treatment of cutaneous T-cell lymphomas: Data from the Spanish Primary Cutaneous Lymphoma Registry

[Background] Brentuximab vedotin (BV) has been approved for CD30-expressing cutaneous T-cell lymphoma (CTCL) after at least one previous systemic treatment. However, real clinical practice is still limited.[Objectives] To evaluate the response and tolerance of BV in a cohort of patients with CTCL.[Methods] We analysed CTCL patients treated with BV from the Spanish Primary Cutaneous Lymphoma Registry (RELCP).[Results] Sixty-seven patients were included. There were 26 females and the mean age at diagnosis was 59 years. Forty-eight were mycosis fungoides (MF), 7 Sézary syndrome (SS) and 12 CD30+ lymphoproliferative disorders (CD30 LPD). Mean follow-up was 18 months. Thirty patients (45%) showed at least 10% of CD30+ cells among the total lymphocytic infiltrate. The median number of BV infusions received was 7. The overall response rate (ORR) was 67% (63% in MF, 71% in SS and 84% in CD30 LPD). Ten of 14 patients with folliculotropic MF (FMF) achieved complete or partial response (ORR 71%). The median time to response was 2.8 months. During follow-up, 36 cases (54%) experienced cutaneous relapse or progression. The median progression free survival (PFS) was 10.3 months. The most frequent adverse event was peripheral neuropathy (PN) (57%), in most patients (85%), grades 1 or 2.[Conclusions] These results confirm the efficacy and safety of BV in patients with advanced-stage MF, and CD30 LPD. In addition, patients with FMF and SS also showed a favourable response. Our data suggest that BV retreatment is effective in a proportion of cases.The Spanish Primary Cutaneous Lymphoma Registry (RELCP) is promoted by the Fundación Piel Sana Academia Española de Dermatología y Venereología, which received an unrestricted grant support from Kyowa Kirin.Peer reviewe

re-habitar El Carmen : Un proyecto sobre patrimonio contemporáneo

El proyecto _re-HABITAR suponía para el propio proceder de la institución un avance más allá del reconocimiento, registro, inventario o protección patrimonial de la arquitectura del siglo XX y del Movimiento Moderno para posicionarse en la acción preventiva y conservativa de ese legado contemporáneo. Para ello, la praxis patrimonial se aferraba a un modelo: el de la vivienda social en España en la segunda mitad del siglo XX; a un caso concreto: el de la barriada de Nuestra Señora del Carmen (Recasens Méndez-Queipo de Llano, 1958); y a un requisito fundamental: analizar un objeto vivo y en uso, aún con la presencia de quienes lo vivieron y usaron desde su origen

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Jardins per a la salut

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia. Assignatura: Botànica farmacèutica. Curs: 2014-2015. Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són el recull de les fitxes botàniques de 128 espècies presents en el Jardí Ferran Soldevila de l’Edifici Històric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de l’assignatura Botànica Farmacèutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte d’Innovació Docent «Jardins per a la salut: aprenentatge servei a Botànica farmacèutica» (codi 2014PID-UB/054). Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pels professors de l’assignatura. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica. També s’ha pretès motivar els estudiants a través del retorn de part del seu esforç a la societat a través d’una experiència d’Aprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a través d’una Web pública amb la possibilitat de poder-ho fer in-situ en el propi jardí mitjançant codis QR amb un smartphone

Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications

Inherited retinal diseases (IRDs), defined by dysfunction or progressive loss of photoreceptors, are disorders characterized by elevated heterogeneity, both at the clinical and genetic levels. Our main goal was to address the genetic landscape of IRD in the largest cohort of Spanish patients reported to date. A retrospective hospital-based cross-sectional study was carried out on 6089 IRD affected individuals (from 4403 unrelated families), referred for genetic testing from all the Spanish autonomous communities. Clinical, demographic and familiar data were collected from each patient, including family pedigree, age of appearance of visual symptoms, presence of any systemic findings and geographical origin. Genetic studies were performed to the 3951 families with available DNA using different molecular techniques. Overall, 53.2% (2100/3951) of the studied families were genetically characterized, and 1549 different likely causative variants in 142 genes were identified. The most common phenotype encountered is retinitis pigmentosa (RP) (55.6% of families, 2447/4403). The most recurrently mutated genes were PRPH2, ABCA4 and RS1 in autosomal dominant (AD), autosomal recessive (AR) and X-linked (XL) NON-RP cases, respectively; RHO, USH2A and RPGR in AD, AR and XL for non-syndromic RP; and USH2A and MYO7A in syndromic IRD. Pathogenic variants c.3386G > T (p.Arg1129Leu) in ABCA4 and c.2276G > T (p.Cys759Phe) in USH2A were the most frequent variants identified. Our study provides the general landscape for IRD in Spain, reporting the largest cohort ever presented. Our results have important implications for genetic diagnosis, counselling and new therapeutic strategies to both the Spanish population and other related populations.This work was supported by the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Health (FIS; PI16/00425 and PI19/00321), Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER, 06/07/0036), IIS-FJD BioBank (PT13/0010/0012), Comunidad de Madrid (CAM, RAREGenomics Project, B2017/BMD-3721), European Regional Development Fund (FEDER), the Organización Nacional de Ciegos Españoles (ONCE), Fundación Ramón Areces, Fundación Conchita Rábago and the University Chair UAM-IIS-FJD of Genomic Medicine. Irene Perea-Romero is supported by a PhD fellowship from the predoctoral Program from ISCIII (FI17/00192). Ionut F. Iancu is supported by a grant from the Comunidad de Madrid (CAM, PEJ-2017-AI/BMD7256). Marta del Pozo-Valero is supported by a PhD grant from the Fundación Conchita Rábago. Berta Almoguera is supported by a Juan Rodes program from ISCIII (JR17/00020). Pablo Minguez is supported by a Miguel Servet program from ISCIII (CP16/00116). Marta Corton is supported by a Miguel Servet program from ISCIII (CPII17/00006). The funders played no role in study design, data collection, data analysis, manuscript preparation and/or publication decisions