The milliped family Tingupidae (Chordeumatida) on Kodiak Island, Alaska, USA, a geographically remote record of indigenous Diplopoda

With documentation of an unidentifiable adult female and juvenile Tingupidae (Chordeumatida), Kodiak Island, Alaska, becomes the westernmost indigenous diplopod locality in North America including continental islands. The northernmost and most proximate locality, Yakutat, lies ca. 935 mi (1,496 km) to the eastnortheast, while Haines, the type locality of Tingupa tlingitorum Shear and Shelley, some 1,196 mi (1,914 km) in this direction, is the most proximate familial site. Kodiak is also one of the most remote indigenous milliped localities in the Pacific, the most proximate ones to the west and south, Kamchatka, Russia, and the Hawaiian Islands, United States, being over 3,300 mi (5, 280 km) distant. Tingupidae is recorded for the first time from Canada excluding the Queen Charlotte Islands, and geographically remote, ostensibly indigenous records from the North Pacific Ocean and environs are tabulated

Waste fish oil as an alternative renewable fuel for IC engines

Received: January 31st, 2021 ; Accepted: April 10th, 2021 ; Published: April 30th, 2021 ; Correspondence: [email protected] are potential fuels for internal combustion engines because of they have advantageous properties such as biodegradability, renewability, high oxygen content and low sulphur. However, the high viscosity, surface tension, and density of crude bio-oils pose challenges for engine use. Those properties affect fuel spray characteristics, mixture formation and combustion. In turn, these impact engine, efficiency, power and emissions. This study investigated the use of crude fish oil (FO) at medium and low engine-loads at two engine speeds in an off-road engine. The injectors had 6-hole high flow rate tips. The results were compared with those of fossil diesel fuel oil (DFO). Fish oil increased hydrocarbon (HC), carbon monoxide (CO) and partly oxides of nitrogen (NOx) emissions. Smoke number, however, decreased. Crude fish oil also showed lowered total particle number (TPN) at low load at low engine-speed compared with DFO

Avalanches in Wood Compression

Wood is a multiscale material exhibiting a complex viscoplastic response. We study avalanches in small wood samples in compression. “Woodquakes” measured by acoustic emission are surprisingly similar to earthquakes and crackling noise in rocks and laboratory tests on brittle materials. Both the distributions of event energies and of waiting (silent) times follow power laws. The stress-strain response exhibits clear signatures of localization of deformation to “weak spots” or softwood layers, as identified using digital image correlation. Even though material structure-dependent localization takes place, the avalanche behavior remains scale-free.Peer reviewe

A Mild and Efficient Synthesis of Oxindoles: Progress Towards the Synthesis of Welwitindolinone A Isonitrile

The complete carbon skeleton of welwitindolinone A isonitrile has been prepared by using a [2+2] cycloaddition to establish the bicyclo[4.2.0]octane core and a SmI2-mediated intramolecular reductive cyclization between an enone and an aryl isocyanate to stereoselectively install the spiro-oxindole (see scheme; DBU=1,8-diazabicyclo[5.4.0]undec-7-ene)

Unpacking the circular economy: A problematizing review

Transitioning to a circular economy(CE) model has been proposed to solve many grand environmental challenges. While research on CE has been extensivelyreviewed, less is known about the implicit underlying assumptions of this work.Understanding these assumptions is critical as they typically go unchallengedyet play a significant role in shaping research fields. In this paper we conduct a problematizing review to critically analyse and make explicit the in-house, root metaphor and ideological assumptions that inform the framing of CE. Firstly, we demonstrate various in-house assumptions about CE, such as an emphasis on the business case for CE and the relationship between CE and corporate sustain-ability. Secondly, root metaphor assumptions include circularity and industrial relationships resembling biological metabolisms. Finally, the dominant ideo-logical assumptions-neoliberalism and ecological modernization-guide scholarly thinking about growth, consumption and profit maximization. Based on our analysis and drawing on the ongoing CE debates within broader environmental studies, we suggest new agendas for future research. We contribute to the growing literature on CE in business, management and organization studies by identifying assumptions that may be misleading or limiting for future CE research, as well as to the conversations on grand challenges by discussing the implications of how challenges and solutions are framed

Design, development, and verification of the Planck Low Frequency Instrument 70 GHz Front-End and Back-End Modules

Peer reviewe

VisHiC—hierarchical functional enrichment analysis of microarray data

Measuring gene expression levels with microarrays is one of the key technologies of modern genomics. Clustering of microarray data is an important application, as genes with similar expression profiles may be regulated by common pathways and involved in related functions. Gene Ontology (GO) analysis and visualization allows researchers to study the biological context of discovered clusters and characterize genes with previously unknown functions. We present VisHiC (Visualization of Hierarchical Clustering), a web server for clustering and compact visualization of gene expression data combined with automated function enrichment analysis. The main output of the analysis is a dendrogram and visual heatmap of the expression matrix that highlights biologically relevant clusters based on enriched GO terms, pathways and regulatory motifs. Clusters with most significant enrichments are contracted in the final visualization, while less relevant parts are hidden altogether. Such a dense representation of microarray data gives a quick global overview of thousands of transcripts in many conditions and provides a good starting point for further analysis. VisHiC is freely available at http://biit.cs.ut.ee/vishic

Evolution of a Synthetic Strategy: Total Synthesis of (±)-Welwitindolinone A Isonitrile

An efficient and highly stereoselective total synthesis of the natural product (±)-welwitindolinone A isonitrile (1) is described. The bicyclo[4.2.0]octane core of 1 was established by a regio- and diastereoselective [2+2] ketene cycloaddition. The C12 quaternary center and vicinal stereogenic chlorine were installed in a single operation with excellent stereocontrol via a chloronium ion mediated semipinacol rearrangement. Described strategies for construction of the spiro-oxinole include a SmI_2−LiCl mediated reductive cyclization and a novel anionic cyclization that simultaneously constructs the spiro-oxindole and vinyl isonitrile moieties

Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer

Microsatellite instability (MSI) leads to accumulation of an excessive number of mutations in the genome, mostly small insertions and deletions. MSI colorectal cancers (CRCs), however, also contain more point mutations than microsatellite-stable (MSS) tumors, yet they have not been as comprehensively studied. To identify candidate driver genes affected by point mutations in MSI CRC, we ranked genes based on mutation significance while correcting for replication timing and gene expression utilizing an algorithm, MutSigCV. Somatic point mutation data from the exome kit-targeted area from 24 exome-sequenced sporadic MSI CRCs and respective normals, and 12 whole-genome-sequenced sporadic MSI CRCs and respective normals were utilized. The top 73 genes were validated in 93 additional MSI CRCs. The MutSigCV ranking identified several well-established MSI CRC driver genes and provided additional evidence for previously proposed CRC candidate genes as well as shortlisted genes that have to our knowledge not been linked to CRC before. Two genes, SMARCB1 and STK38L, were also functionally scrutinized, providing evidence of a tumorigenic role, for SMARCB1 mutations in particular. © 2018 The Authors. Published under the terms of the CC BY 4.0 licensePeer reviewe