Variation for health-enhancing compounds and traits in onion (Allium cepa L.) germplasm

Consumption of onion has been associated with reduced incidence of chronic diseases. Phenolic, organosulfur and carbohydrate compounds present are largely responsible for these effects. This study examined compositional variation for health-enhancing compounds in a genetically diverse collection of onion cultivars. Total antioxidant activity and aroma profiles were characterized. Significant variation in bulb concentration for total and individual phenolic compounds, thiosulfinates, carbohydrates, and total and soluble solids was found. The range of variation was particularly large (>50-fold difference between the cultivars with the highest and lowest content) for fructo-oligosaccharides (FOS) and the polyphenols quercetin, epigallocatechin gallate and epicatechin gallate. Amino acid profiles varied significantly as well with substantial variation (~10 fold) observed in both total and essential amino acids. Total antioxidant activity was positively correlated with polyphenols content, and quercetin in particular (r = 0.83), suggesting a major contribution from phenolic compounds to onion antioxidant properties. Significant positive correlation was also found between solids and thiosulfinates content (r = 0.74) and between solids and FOS (r = 0.81), suggesting a dilution/concentration effect for organosulfur compounds and FOS in onion bulbs. The present study revealed broad variation for health-enhancing compounds content in onion germplasm, which can be exploited in breeding programs aiming at increasing onion nutraceutical value.Fil: Insani, Ester Marina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Agroindustria. Instituto de Tecnología de los Alimentos; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Nacional de Investigaciones Agropecuarias Castelar. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Cavagnaro, Pablo Federico. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Departamento de Producción Agropecuaria. Cátedra de Horticultura y Floricultura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Salomón, Virginia María. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Agroindustria. Instituto de Tecnología de los Alimentos; ArgentinaFil: Langman, Leandro Ezequiel. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Agroindustria. Instituto de Tecnología de los Alimentos; ArgentinaFil: Sance, Maria Mirta. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Pazos, Adriana Alejandra. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Agroindustria. Instituto de Tecnología de los Alimentos; ArgentinaFil: Carrari, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria. Centro Nacional de Investigaciones Agropecuarias Castelar. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Filippini de Delfino, Olga Susana. Universidad Nacional de Luján; ArgentinaFil: Vignera, Laura. Universidad Nacional de Luján; ArgentinaFil: Galmarini, Claudio Romulo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Mendoza-San Juan. Estación Experimental Agropecuaria La Consulta; Argentina. Universidad Nacional de Cuyo; Argentin

DISTRETTO CULTURALE EVOLUTO FLAMINIA NEXT ONE: INNOVAZIONE TECNOLOGICA PER L’ARCHEOLOGIA E LA VALORIZZAZIONE DIGITALE DELLA VIA FLAMINIA E DI FORUM SEMPRONII

none4noThe Via Flaminia DCE project starts from the recognition of the uniqueness and the identity value of the territory crossed by the Roman road which, since ancient times, has represented an important communication axis and seat of economic ferment. This system, unique in its specific features and vocations, can become an incubator for the “production of a new culture”, thus allowing us to integrate new knowledge, new technologies and new professional skills in order to enhance the existing heritage, giving it new life. In this feature the Cultural heritage can be the fertile ground in which the productive system can look for new ideas, capable of activating a process of innovation and economic and social development. In this respect we planned four pilot projects, the first of which, The Flaminia Museum, was built in the San Michele Church of Fano and aims to virtually reconnect the Roman archaeological heritage scattered along the Via Flaminia, through immersive technologies for communication and monitoring. The other three pilots are planned at the sites of the Furlo Gorge, the Cagli Museum and the Forum Sempronii Archaeological Park, key points along the route of the ancient consular road in the Marche region.mixedOscar Mei, Paolo Clini, Gabriele Filippini, Laura Invernizzi,Mei, Oscar; Clini, Paolo; Filippini, Gabriele; Invernizzi, Laur

Distretto Culturale Evoluto Flaminia NextOne : innovazione tecnologica per l’archeologia e la valorizzazione digitale della Via Flaminia e di Forum Sempronii

The Via Flaminia DCE project starts from the recognition of the uniqueness and the identity value of the territory crossed by the Roman road which, since ancient times, has represented an important communication axis and seat of economic ferment. This system, unique in its specific features and vocations, can become an incubator for the “production of a new culture”, thus allowing us to integrate new knowledge, new technologies and new professional skills in order to enhance the existing heritage, giving it new life. In this feature the Cultural heritage can be the fertile ground in which the productive system can look for new ideas, capable of activating a process of innovation and economic and social development. In this respect we planned four pilot projects, the first of which, The Flaminia Museum, was built in the San Michele Church of Fano and aims to virtually reconnect the Roman archaeological heritage scattered along the Via Flaminia, through immersive technologies for communication and monitoring. The other three pilots are planned at the sites of the Furlo Gorge, the Cagli Museum and the Forum Sempronii Archaeological Park, key points along the route of the ancient consular road in the Marche region

Dress syndrome and fulminant hepatic failure induced by lamotrigine

Lamotrigine is a non-aromatic antiepileptic drug. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe idiosyncratic reaction to drugs, especially anti-epileptic drugs. Associated clinical features include cutaneous eruption, fever, multiple peripheral lymphadenopathies, and potentially life-threatening damage of one or more organs. We report a case of DRESS syndrome induced by lamotrigine presenting with a hypersensitivity syndrome and fulminant hepatic failure requiring liver transplant. A 21-year old female patient presented an episode of seizure with loss of conscience. CT and EEG studies performed were normal. Treatment with lamotrigine was prescribed. In the course of 30 days, the patient developed skin lesions, pruritus, cholestatic hepatitis, and systemic symptoms-fever, lymphadenopathies, extensive exfoliative erythematous maculopapular rash, and jaundice. Serologic and laboratory tests showed no other causes responsible for the clinical spectrum. Hematologic tests revealed peripheral eosinophilia. Fulminant hepatic failure was diagnosed and an orthotopic liver transplant was performed. Histologic sections of the ex-planted liver demonstrated submassive hepatic necrosis, with the remnant portal spaces and lobules showing a mixed inflammatory infiltrate with lymphocytes and eosinophils. Lamotrigine treatment has been associated with multiorgan failure, DRESS syndrome, acute hepatic failure, and disseminated intravascular coagulation. In conclusion, we suggest that these potentially fatal side effects should be considered in any patient with clinical deterioration following administration of this drug

Pixel or Paper? Validation of a Mobile Technology for Collecting Patient-Reported Outcomes in Rheumatoid Arthritis

none12Background: In the management of chronic disease, new models for telemonitoring of patients combined with the choice of electronic patient-reported outcomes (ePRO) are being encouraged, with a clear improvement of both patients' and parents' quality of life. An Italian study demonstrated that ePRO were welcome in patients with rheumatoid arthritis (RA), with excellent matching data.Objective: The aim of this study is to evaluate the level of agreement between electronic and paper-and-pencil questionnaire responses.Methods: This is an observational prospective study. Patients were randomly assigned to first complete the questionnaire by paper and pencil and then by tablet or in the opposite order. The questionnaire consisted of 3 independent self-assessment visual rating scales (Visual Analog Scale, Global Health score, Patient Global Assessment of Disease Activity) commonly used in different adult patients, including those with rheumatic diseases.Results: A total of 185 consecutive RA patients were admitted to hospital and were enrolled and completed the questionnaire both on paper and on electronic versions. For all the evaluated items, the intrarater degree of agreement between 2 approaches was found to be excellent (intraclass correlation coefficient>0.75, P<.001).Conclusions: An electronic questionnaire is uploaded in a dedicated Web-based tool that could implement a telemonitoring system aimed at improving the follow-up of RA patients. High intrarater reliability between paper and electronic methods of data collection encourage the use of a new digital app with consequent benefit for the overall health care system.noneEpis, Oscar Massimiliano; Casu, Cinzia; Belloli, Laura; Schito, Emanuela; Filippini, Davide; Muscarà, Marina; Gentile, Maria Giovanna; Perez Cagnone, Paula Carina; Venerelli, Chiara; Sonnati, Massimo; Schiavetti, Irene; Bruschi, EleonoraEpis, Oscar Massimiliano; Casu, Cinzia; Belloli, Laura; Schito, Emanuela; Filippini, Davide; Muscarà, Marina; Gentile, Maria Giovanna; Perez Cagnone, Paula Carina; Venerelli, Chiara; Sonnati, Massimo; Schiavetti, Irene; Bruschi, Eleonor