CARD8 rs2043211 (p.C10X) polymorphism is not associated with disease susceptibility or cardiovascular events in Spanish rheumatoid arthritis patients

Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis, which is the main cause of increased cardiovascular (CV) morbidity and mortality in RA patients. CARD8 is a constituent of inflammasome, which regulates interleukin 1-beta production, and has been associated with a worse disease course in early RA. One thousand six hundred twenty-one patients fulfilling the 1987 ACR classification criteria for RA and 1300 matched controls, were genotyped for the CARD8 rs2043211 (30T > A, p.C10X) single-nucleotide polymorphism (SNP) using predesigned TaqMan SNP genotyping assay. The genotyping success rate in our study was greater than 94%. We assessed CARD8 rs2043211 gene polymorphism results in 1530 Spanish RA patients in whom information on CV disease and CV risk factors was available at the time of the study. Also, a subgroup of patients with no history of CV events (n = 276) was assessed for the potential influence of the rs2043211 variant in the development of subclinical atherosclerosis, by measurement of carotid intima-media thickness (IMT) and presence of carotid plaques. No statistically significant differences in allele or genotype frequencies for the rs2043211 CARD8 gene variant between patients with RA and controls were seen. Similarly, CARD8 rs2043211 (30T > A, p.C10X) SNP did not influence the development of CV events or the risk of CV events throughout the time. Likewise, no significant association between this gene variant and carotid IMT or the presence of plaques was found. In summary, our results do not support a role of the CARD8 rs2043211 gene variant in susceptibility to RA or in the development of CV disease in patients with RA

JASON-1 CALVAL experiences in Cape of Begur and Ibiza island

The direct and indirect calibration experiences made at the Cape of Begur area in 1999, 2000 and 2002, for Topex/Poseidon and at the Ibiza island in 2003 have contributed to the international campaigns made at Harvest (USA), Corsica (France) and Bass (Australia). The main objective of IBIZA 2003 campaign has been the determination of the instantaneous sea surface/marine geoid gradient along Jason-1 tracks using a GPS catamaran and a network of GPS located in Portinatx and Ibiza and San Antonio harbours. The marine geoid will be used to relate the tide gauge coastal data with the altimeter data. We present the first results obtained with static and kinematic analysis of the data using different softwares.Peer ReviewedPostprint (published version

Proyecto de emprendimiento para la creación de la micro empresa Piensa En Verde, dedicada a la elaboración y comercialización del jarabe Digestin Plus, ubicada en el municipio de Jinotepe, departamento de Carazo, durante el segundo semestre del año 2019

Proyecto de emprendimiento para la micro empresa Piensa En Verde dedicada a la elaboración y comercialización del jarabe Digestin Plus. Digestin plus, nombre asignado al jarabe de marañón y miel, innovado por el grupo multidisciplinario de la FAREM, Carazo, que está conformado por diferentes carreras como es mercadotecnia, contabilidad y administración de empresa, al realizarse un conjunto de ideas para al proyecto se tomó una decisión por mayoría de votos. Este es un jarabe 100% natural, ya que no contiene ningún tipo de conservante químico, puesto que una de las tantas funciones que tiene la miel es esa. La combinación de estos 2 componentes como es el marañón y la miel han creado un poderoso jarabe que tiene como propósito estimular al organismo luego que las personas ingieran comidas con muchos condimentos que causan espasmos estomacales y problemas gastrointestinales, este ayudara a que el sistema digestivo pueda facilitar la digestión de estos alimento

Adição de OptiLisina® à dieta de juvenis do axolote Ambystoma velasci para o seu crescimento e sobrevivência

The axolotl Ambystoma velasci is an endemic amphibian of Mexico, due to different environmental and anthropogenic pressures the wild populations have decreased, for which it is listed in NOM-059-SEMARNAT-2010 as a species subject to special protection. An important aspect for their well-being, development, and adaptation in captivity is offering a varied diet; however, there are no studies on the nutritional requirements of this genus of salamanders. In captivity, one of the favorite foods of this amphibian is the mudworm Tubifex spp., but live food does not always cover the nutritional requirements, therefore, strategies are sought to improve the quality of the food, one of them is its enrichment, incorporating supplements, such is the case of the OptiLisina® formula, which is an herbal supplement characterized by being a source of lysine, which when added to the diet has a positive influence as a growth promoter. The objective of this study was to evaluate the parameters of growth, food consumption and survival with the addition of OptiLisina® to the diet of A. velasci juveniles under captive conditions. The experimental design consisted of a trial with 120 individuals of 110 days of age distributed in three levels of OptiLisina® (0, 0.5 and 1.0 g/kg) added to the Tubifex spp., with four repetitions each. The growth in weight and height was recorded to calculate the productive parameters and to be analyzed in a Completely Random Design using orthogonal linear and quadratic polynomials to evaluate the effect of the herbal supplement (P<0.05) in the Software, R. The results of the diet did not show linear or quadratic effects on productive parameters (P> 0.05). More studies are needed on the nutritional requirements of this amphibian, in order to carry out better feeding strategies for the species and favor its maintenance in captivity.El ajolote Ambystoma velasci es un anfibio endémico de México, debido a las presiones ambientales y antropogénicas sus poblaciones silvestres han disminuido, por lo cual se encuentra enlistado como especie sujeta a protección especial (NOM-059-SEMARNAT-2010). Un aspecto importante para su bienestar, desarrollo y adaptación en cautiverio es ofrecer una dieta variada; sin embargo, no existen estudios acerca de los requerimientos nutricionales en este género de salamandras. En cautiverio, uno de los alimentos de predilección de este anfibio es el gusano de fango Tubifex spp., aunque no siempre el alimento vivo cubre los requerimientos nutricionales, por ende, se buscan estrategias para mejorar la calidad del alimento, una de ellas es su enriquecimiento, incorporando suplementos, tal es el caso de la fórmula OptiLisina® que es un complemento herbal que se caracteriza por ser fuente de lisina, que adicionado a la dieta influye positivamente como promotor de crecimiento. El objetivo del presente estudio fue evaluar los parámetros de crecimiento, consumo de alimento y supervivencia con la adición de OptiLisina® a la dieta de juveniles de A. velasci en condiciones de cautiverio. El diseño experimental  consistió en un ensayo con 120 individuos de 110 días de edad distribuidos en tres niveles de OptiLisina® (0, 0,5 y 1,0 g/kg) adicionado al Tubifex spp., con cuatro repeticiones cada uno. Se registró el crecimiento en peso y talla para calcular los parámetros productivos y ser analizados en un Diseño Completamente al Azar empleando polinomios lineales y cuadráticos ortogonales para evaluar el efecto del complemento herbal (P<0.05) en el Software, R. Los resultados de la dieta no mostraron efectos lineales ni cuadráticos en los parámetros productivos (P> 0,05). Se necesitan realizar más estudios sobre los requerimientos nutricionales de este anfibio, para así realizar mejores estrategias de alimentación para la especie y favorecer su mantenimiento en cautiverio.O axolote Ambystoma velasci é um anfíbio endêmico do México, devido a diferentes pressões ambientais e antrópicas as populações selvagens diminuíram, pelo que está listado no NOM-059-SEMARNAT-2010 como uma espécie sujeita a proteção especial. Um aspecto importante para seu bem-estar, desenvolvimento e adaptação em cativeiro é oferecer uma dieta variada, porém não existem estudos sobre as exigências nutricionais desse gênero de salamandras. Em cativeiro, um dos alimentos preferidos deste anfíbio é a minhoca Tubifex spp., porém a alimentação viva nem sempre cobre as exigências nutricionais, por isso, buscam-se estratégias para melhorar a qualidade da alimentação, uma delas é o seu enriquecimento, incorporando suplementos, como é o caso da fórmula OptiLisina®, que é um suplemento fitoterápico caracterizado por ser fonte de lisina, que quando adicionado à dieta tem influência positiva como promotor de crescimento. O objetivo deste estudo foi avaliar os parâmetros de crescimento, consumo alimentar e sobrevivência com a adição de OptiLisina® à dieta de juvenis de A. velasci em cativeiro. O delineamento experimental consistiu em um ensaio com 120 indivíduos de 110 dias de idade distribuídos em três níveis de OptiLisina® (0, 0,5 e 1,0 g/kg) adicionado ao Tubifex spp., com quatro repetições cada. O crescimento em peso e altura foi registrado para calcular os parâmetros produtivos e para ser analisado em um Projeto Completamente Aleatório usando polinômios ortogonais lineares e quadráticos para avaliar o efeito do suplemento de ervas (P<0,05) no Software, R. Os resultados de a dieta não apresentou efeitos lineares ou quadráticos nos parâmetros produtivos (P>0,05). Mais estudos são necessários sobre as exigências nutricionais deste anfíbio, a fim de realizar melhores estratégias alimentares para a espécie e favorecer sua manutenção em cativeiro

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

Introduction: A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery phase. We aimed to identify previously overlooked susceptibility variants by using a follow-up strategy.<p></p> Methods: Sixty-six non-HLA SNPs showing a P value <10-4 in the discovery phase of the French SSc GWAS were analyzed in the first step of this study, performing a meta-analysis that combined data from the two published SSc GWASs. A total of 2,921 SSc patients and 6,963 healthy controls were included in this first phase. Two SNPs, PPARG rs310746 and CHRNA9 rs6832151, were selected for genotyping in the replication cohort (1,068 SSc patients and 6,762 healthy controls) based on the results of the first step. Genotyping was performed by using TaqMan SNP genotyping assays. Results: We observed nominal associations for both PPARG rs310746 (PMH = 1.90 × 10-6, OR, 1.28) and CHRNA9 rs6832151 (PMH = 4.30 × 10-6, OR, 1.17) genetic variants with SSc in the first step of our study. In the replication phase, we observed a trend of association for PPARG rs310746 (P value = 0.066; OR, 1.17). The combined overall Mantel-Haenszel meta-analysis of all the cohorts included in the present study revealed that PPARG rs310746 remained associated with SSc with a nominal non-genome-wide significant P value (PMH = 5.00 × 10-7; OR, 1.25). No evidence of association was observed for CHRNA9 rs6832151 either in the replication phase or in the overall pooled analysis.<p></p> Conclusion: Our results suggest a role of PPARG gene in the development of SSc

Scientific output on transsexuality in the Spanish biomedical literature: Bibliometric and content analysis (1973-2011)

Objetivo: Explorar la evolución del conocimiento científico sobre transexualidad durante los últimos 40 años, a través de un análisis bibliométrico y de contenido de la producción de la literatura biomédica española sobre la transexualidad entre los años 1973 y 2011. Método: Descriptivo y transversal. Universo: artículos biomédicos españoles sobre transexualidad publicados entre 1973 y 2011. Fuente: ÍndiceMédico Español e ISOC-Ciencias Sociales y Humanidades. Análisis: bibliométrico y de contenido de las publicaciones biomédicas. Resultados: 65 artículos biomédicos analizados. Entre 1973 y 1984, en España, el conocimiento sobre transexualidad se produce y circula en revistas médicas. En 1996 se inicia una década de gran productividad, y en los años siguientes el número de revistas que publican sobre transexualidad se multiplica. Hasta 2006, año de mayor productividad biomédica, los discursos biomédicos reproducen representaciones de la transexualidad ancladas en el determinismo biológico. En el período 2008-2011, los y las profesionales incorporan teorías feministas y perspectivas sociales en sus discursos. Conclusiones: En el último cuarto del siglo xx, el discurso médico dominante ha considerado las manifestaciones de las personas transexuales desde una perspectiva biologicista que concibe la transexualidad como un error de correspondencia sexo/género. En los últimos años, la aparición de nuevas categorías de identidad y la reflexión desde posturas no esencialistas y normativas del género favorece la gestión clínica de la transexualidad.Objective: To explore the scientific output on transsexuality in the Spanish biomedical literature between 1973 and 2011, through bibliometric and content analyses. Methods: We carried out a descriptive, cross-sectional study of Spanish biomedical articles on transsexuality published between 1973 and 2011. The data sources consisted of Índice Médico Español and ISOC-Ciencias Sociales y Humanidades. Bibliometric and content analyses were performed. Results: A total of 65 papers were analyzed. Knowledge on transsexuality in Spain began to appear in medical journals between 1973 and 1984. A decade of intense productivity began in 1996 and the number of journals publishing articles on transsexuality multiplied in the following years. Until 2006, the year with the most biomedical productivity, biomedical discourses reproduced representations of transsexuality anchored in biological determinism. From 2008-2011, professionals writing on the topic incorporated feminist theories and social perspectives in their discourses. Conclusions: In the last quarter of the twentieth century, the dominant medical discourse considered manifestations of transsexual people from a biologist perspective that conceives transsexuality as a configuration mismatch between sex and gender. The emergence of new identity categories and medical reflection from non-essentialist and non-normative gender perspectives has improved the clinical management of transsexuality

Principales indicadores bibliométricos de la actividad científica peruana. 2012-2017

La actividad científica, como uno de los principales motores de desarrollo económico, implica la participación de diversos sectores e instituciones. Para ello, el Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica (CONCYTEC), como institución rectora del Sistema Nacional de Ciencia, Tecnología e Innovación Tecnológica (SINACYT), desarrolla diversas actividades orientadas no solo a generar las condiciones necesarias para el desarrollo de la investigación, sino también para su promoción, fomento y orientación. En este contexto, la elaboración de análisis sobre los resultados de investigación que se generan en el país es fundamental para la evaluación que hacen las diferentes instancias gubernamentales implicadas en el desarrollo de la política nacional de Ciencia, Tecnología e Innovación (CTeI) y en el planteamiento de estrategias que contribuyan a consolidar la actividad investigadora en el país.Por ello, el objetivo principal de este informe es caracterizar la investigación científica desarrollada en Perú, mediante la determinación del grado de visibilidad, colaboración, impacto, excelencia y liderazgo, que alcanzaron los investigadores peruanos, durante el sexenio de 2012-2017. Para lo cual, se usaron como fuente de datos bibliométricos Scopus de Elsevier y la metodología de SCImago Research Group.Peer reviewe

FaSt-SWOT 2023 Cruise Report

DISPONIBLE PRÓXIMAMENTEThe SWOT satellite mission (Surface Water and Ocean Topography), launched in December 2022, is measuring sea surface height with a resolution an order of magnitude higher than conventional altimeters, providing an unprecedented view of the variability of the sea surface topography. This document reports the activities carried out at sea during the two campaigns of the FaSt-SWOT project (PID2021-122417NB-I00 funded by MCIN/AEI/10.13039/501100011033/ FEDER,UE). These campaigns had two main objectives: 1) participate to the SWOT satellite cal/val activities by collecting in-situ observations of fine-scale structures in the area covered by the satellite during its initial fast-sampling phase, and 2) improve the characterization and understanding of these structures by combining in-situ multi-platform and satellite data with numerical models and other computational techniques. The FaSt-SWOT experiments were conducted in the Balearic Sea (Western Mediterranean Sea) between 25-28 April and 7-10 May 2023, using R/V SOCIB. The experiments consisted in 2 legs both using multi-scale ship-based instruments (CTD, Moving Vessel Profiler, thermosalinograph, ADCP and GoPro action cameras), autonomous platforms (surface drifters and gliders), and satellite observations (SST, ocean color and altimetry). In addition, 2km-resolution data-assimilative modelling simulations were produced to provide a complementary representation of the fine-scale ocean variability. Finally, machine-learning-based optimization algorithms were also tested to define adaptive sampling strategies during the experiment. The sampling first focused on a small anticyclonic eddy, with a diameter around 20-25km. Several cross-sections of the Moving Vessel Profiler and underwater gliders provided insights into the vertical structure of temperature and salinity fields and the associated signals in chlorophyll and dissolved oxygen. Two gliders were programmed to perform back-and-forth sections during a 3-week time with a 1-day delay between them, allowing to evaluate the temporal variability of the ocean fields at the period of repetitivity of the satellite. The second leg started 9 days after the end of the first one. A 48-hour dense radiator-like pattern was performed by R/V SOCIB, allowing to characterize the evolution of the small eddy observed during the first leg. A total of 45 surface drifters were deployed during the two phases to evaluate in-situ surface currents and their associated convergence and divergence in the vicinity of the eddy. This report presents the details of the sampling strategy and collected measurements, also including data management aspects and description of the supporting numerical simulations and external communication activities associated with these field campaigns.FaSt-SWOT project; PID2021-122417NB-I00 funded by MCIN/AEI/10.13039/501100011033/ FEDER,UE.Peer reviewe