The economic feasibility of combined heat and power as a utility producer for the residential sector

Combined heat and power (CHP) plants are a very promising prospect to reducing CO₂ emissions and increasing efficiency in the power generation sector, especially when combined with residential solar photovoltaic (PV) power generation. By utilizing natural gas, a cleaner fuel than coal, CHP plants can reduce CO₂ emissions, while exploiting the waste heat from electricity production to generate a useful thermal energy, increasing the overall efficiency of the plant. While incorporating residential solar PV power generation has important environmental benefits, it can - if not properly managed - lead to an over-generation situation with very high power plant ramp rates. Most current power plants are unlikely to be able to withstand such rapid changes in generation rates. If PV generation is incorporated into the design and operation of the CHP plant, both thermal and electrical energy storage systems can be included, opening the door to more strategies for controlling photovoltaic generation and increased PV power generation. The ability to combine thermal and electrical energy generation in an efficient manner, on a medium to large scale, suggests that CHP plants with rooftop PV panels and energy storage are an appealing choice as an integrated utility supplier for the neighborhood of the future. Yet, there are currently no CHP plants that serve exclusively residential neighborhoods in the United States. Thus, the objective of this research was to determine the most economical design and operation of a CHP plant with integrated residential solar PV power generation to meet all the energy demands of a residential neighborhood. After determining that a CHP plant could meet all the electricity, heating, and cooling demands of a residential neighborhood, a multi-scale economical optimization formulation to simultaneously determine the design and operation of a CHP plant with PV generation was constructed. The optimal CHP plant produced extra energy, so the optimization formulation was updated to include both thermal and electrical energy storage. Utilizing the results from these optimizations, the monetary values of PV generation and energy storage were evaluated, giving a guide for future economic targets for these technologies.Chemical Engineerin

Court of International Trade Deference to International Trade Commission and International Trade Administration Antidumping Determinations: An Empirical Look

Article published in the Law and Policy in International Business

Effects of Material Characteristics and Equipment Configuration on Profilometry Scanning Results for Error Mitigation in Automated Fiber Placement

The Automated Fiber Placement manufacturing process is a method for constructing layered composite parts. This is done by placing tapes of material on a tool using a compaction roller and heat to tackify the material [1]. This manufacturing process is not new, but latest equipment generations can still introduce randomly occurring defects, presenting often as tow twists, gaps, unintentional overlaps and even missing tows during the layup process. These defects deviate the manufactured structure from the as-designed structure, and have been proven to introduce stress concentration sources, which can ultimately undermine the performance of a structure [2]. To detect and avert these defects during manufacturing, a profilometry driven topology analysis system can be used to scan the placed tows, check for layup defects, and record a history of the part [3,4]. However, for certain materials and environmental conditions, it has been shown that the utilized profilometers do not currently return reliable readings of the material topology. An experimental investigation into the feasibility of improving scan results of specific thermoset composite materials is summarized by investigating settings on commercially available profilometry scanners. Additionally, the impacts of material characteristics including surface quality are explored. Presented are the challenges, analysis, and potential solutions discovered to improve scanning results

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins.

Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high stability and ease of production. Here, we investigate the structures and the neutralization mechanisms for six unique VHHs targeting BoNT/A1 or BoNT/B1. These studies reveal diverse neutralizing mechanisms by which VHHs prevent host receptor binding or block transmembrane delivery of the BoNT protease domain. Guided by this knowledge, we design heterodimeric VHHs by connecting two neutralizing VHHs via a flexible spacer so they can bind simultaneously to the toxin. These bifunctional VHHs display much greater potency in a mouse co-intoxication model than similar heterodimers unable to bind simultaneously. Taken together, our studies offer insight into antibody neutralization of BoNTs and advance our ability to design multivalent anti-pathogen VHHs with improved therapeutic properties

Control Optimization of Combined Cooling and Power System with Prime Mover of Solid Oxide Fuel Cell-gas Turbine for Building Application

© 2017 The Authors. This paper presents a control strategy for a combined cooling and power (CCP) system using a prime mover of solid oxide fuel cell (SOFC) with bottoming cycle of gas turbine (GT) for building application. Dynamic simulation model of the CCP system was developed in TRNSYS 17, and the control strategy was developed for year-round operation in response to the changing climatic and loading conditions. The capacity ratio of cells in operation; the ratio of exhaust heat delivered to GT; and the ratio of cooling load shared between absorption and compression chillers were chosen as the decision variables in the control strategy. In order to minimize the system energy consumption, particle swarm optimization (PSO) was constructed in MATLAB and coupled with TRNSYS 17 for control optimization. It was found that with the proposed control strategy, the yearly energy saving of the SOFC-GT CCP system would be 6.89% compared to the reference case

Neuromuscular recovery from botulism involves multiple forms of compensatory plasticity

IntroductionBotulinum neurotoxin (BoNT) causes neuroparalytic disease and death by blocking neuromuscular transmission. There are no specific therapies for clinical botulism and the only treatment option is supportive care until neuromuscular function spontaneously recovers, which can take weeks or months after exposure. The highly specialized neuromuscular junction (NMJ) between phrenic motor neurons and diaphragm muscle fibers is the main clinical target of BoNT. Due to the difficulty in eliciting respiratory paralysis without a high mortality rate, few studies have characterized the neurophysiological mechanisms involved in diaphragm recovery from intoxication. Here, we develop a mouse model of botulism that involves partial paralysis of respiratory muscles with low mortality rates, allowing for longitudinal analysis of recovery.Methods and resultsMice challenged by systemic administration of 0.7 LD50 BoNT/A developed physiological signs of botulism, such as respiratory depression and reduced voluntary running activity, that persisted for an average of 8–12 d. Studies in isolated hemidiaphragm preparations from intoxicated mice revealed profound reductions in nerve-elicited, tetanic and twitch muscle contraction strengths that recovered to baseline 21 d after intoxication. Despite apparent functional recovery, neurophysiological parameters remained depressed for 28 d, including end plate potential (EPP) amplitude, EPP success rate, quantal content (QC), and miniature EPP (mEPP) frequency. However, QC recovered more quickly than mEPP frequency, which could explain the discrepancy between muscle function studies and neurophysiological recordings. Hypothesizing that differential modulation of voltage-gated calcium channels (VGCC) contributed to the uncoupling of QC from mEPP frequency, pharmacological inhibition studies were used to study the contributions of different VGCCs to neurophysiological function. We found that N-type VGCC and P/Q-type VGCC partially restored QC but not mEPP frequency during recovery from paralysis, potentially explaining the accelerated recovery of evoked release versus spontaneous release. We identified additional changes that presumably compensate for reduced acetylcholine release during recovery, including increased depolarization of muscle fiber resting membrane potential and increased quantal size.DiscussionIn addition to identifying multiple forms of compensatory plasticity that occur in response to reduced NMJ function, it is expected that insights into the molecular mechanisms involved in recovery from neuromuscular paralysis will support new host-targeted treatments for multiple neuromuscular diseases

Millennials in the Workplace: A Communication Perspective on Millennials’ Organizational Relationships and Performance

Stereotypes about Millennials, born between 1979 and 1994, depict them as self-centered, unmotivated, disrespectful, and disloyal, contributing to widespread concern about how communication with Millennials will affect organizations and how they will develop relationships with other organizational members. We review these purported characteristics, as well as Millennials’ more positive qualities—they work well in teams, are motivated to have an impact on their organizations, favor open and frequent communication with their supervisors, and are at ease with communication technologies. We discuss Millennials’ communicated values and expectations and their potential effect on coworkers, as well as how workplace interaction may change Millennials

Surface modification of P dl LGA microspheres with gelatine methacrylate: Evaluation of adsorption, entrapment, and oxygen plasma treatment approaches

Injectable poly (dl-lactic-co-glycolic acid) (PdlLGA) microspheres are promising candidates as biodegradable controlled release carriers for drug and cell delivery applications; however, they have limited functional groups on the surface to enable dense grafting of tissue specific biocompatible molecules. In this study we have evaluated surface adsorption, entrapment and oxygen plasma treatment as three approaches to modify the surfaces of PdlLGA microspheres with gelatine methacrylate (gel-MA) as a biocompatible and photo cross-linkable macromolecule. Time of flight secondary ion mass spectroscopy (TOF SIMS) and X-ray photoelectron spectroscopy (XPS) were used to detect and quantify gel-MA on the surfaces. Fluorescent and scanning electron microscopies (SEM) were used to image the topographical changes. Human mesenchymal stem cells (hMSCs) of immortalised cell line were cultured on the surface of gel-MA modified PdlLGA microspheres and Presto-Blue assay was used to study the effect of different surface modifications on cell proliferation. Data analysis showed that the oxygen plasma treatment approach resulted in the highest density of gel-MA deposition. This study supports oxygen plasma treatment as a facile approach to modify the surface of injectable PdlLGA microspheres with macromolecules such as gel-MA to enhance proliferation rate of injected cells and potentially enable further grafting of tissue specific molecules

Impact of comorbidity on the short- and medium-term risk of revision in total hip and knee arthroplasty

Background: The impact of comorbidity on the risk of revision in patients undergoing Total Knee arthroplasty (TKA) and Total Hip Arthroplasty (THA) is not currently well known. The aim of this study was to analyze the impact of comorbidity on the risk of revision in TKA and THA. Methods: Patients recorded in the Catalan Arthroplasty Register (RACat) between 01/01/2005 and 31/12/2016 undergoing TKA (n = 49,701) and THA (n = 17,923) caused by osteoarthritis were included. As main explanatory factors, comorbidity burden was assessed by the Elixhauser index, categorized, and specific comorbidities from the index were taken into account. Descriptive analyses for comorbidity burden and specific conditions were done. Additionally, incidence at 1 and 5 years' follow-up was calculated, and adjusted Competing Risks models were fitted. Results: A higher incidence of revision was observed when the number of comorbidities was high, both at 1 and 5 years for THA, but only at 1 year for TKA. Of the specific conditions, only obesity was related to the incidence of revision at 1 year in both joints, and at 5 years in TKA. The risk of revision was related to deficiency anemia and liver diseases in TKA, while in THA, it was related to peripheral vascular disorders, metastatic cancer and psychoses. Conclusions: Different conditions, depending on the joint, might be related to higher revision rates. This information could be relevant for clinical decision-making, patient-specific information and improving the results of both TKA and THA.This article is freely available via Open Access. Click on the Publisher URL to access it via the publisher's site.The present study was funded by CIBER Epidemiology and Public Health (CIBERESP) as part of the aid for short internships granted to Jorge Arias-de la Torre in 2017 and 2018.published version, accepted versio