Quinoidization of regioregular oligo(THIENO[3,4-b]THIOPHENE)s

Caracterización de oligotiofenosUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics

Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly mutated in hereditary spastic paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To investigate how the physiological roles of the ER might be affected by such disruption, we developed tools to interrogate its Ca2+ signaling function. We generated GAL4-driven Ca2+ sensors targeted to the ER lumen, to record ER Ca2+ fluxes in identified Drosophila neurons. Using GAL4 lines specific for Type Ib or Type Is larval motor neurons, we compared the responses of different lumenal indicators to electrical stimulation, in axons and presynaptic terminals. The most effective sensor, ER-GCaMP6-210, had a Ca2+ affinity close to the expected ER lumenal concentration. Repetitive nerve stimulation generally showed a transient increase of lumenal Ca2+ in both the axon and presynaptic terminals. Mutants lacking neuronal reticulon and REEP proteins, homologs of human HSP proteins, showed a larger ER lumenal evoked response compared to wild type; we propose mechanisms by which this phenotype could lead to neuronal dysfunction or degeneration. Our lines are useful additions to a Drosophila Ca2+ imaging toolkit, to explore the physiological roles of ER, and its pathophysiological roles in HSP and in axon degeneration more broadly

Análisis y ejecución de estrategias en la industria de sensores mediante la simulación CAPSIM

Documento en el que se muestra el trabajo realizado en la dirección de una empresa de la industria de sensores dentro del simulador de negocios Capsim. Se presenta un análisis de la industria de los sensores, se describe la empresa en la que se trabajó, las estrategias de negocio y el proceso de su implementación, así como los resultados finales

Applicability of magnetic fabrics in rocks associated with the emplacement of salt structures (the Bicorb-Quesa and Navarrés salt walls, Prebetics, SE Spain)

This work assesses the applicability of the analysis of the anisotropy of magnetic susceptibility (AMS) to rocks associated with salt structures.Magnetic fabrics from16 sites sampled on Upper Triassic clays (Keuper facies) interbedded within the salt layers of the Bicorb-Quesa and Navarrés saltwalls (Prebetic Zone, SE Spain) aremostly characterized by oblate magnetic ellipsoids with theirmagnetic foliation parallel to the bedding andmagnetic lineation contained in the bedding plane but without a constant relationship with dip direction. To evaluate the quality and significance of the low-field AMS, several experiments were carried out to characterize the magnetic mineralogy of representative samples and enable separation of the contributions from paramagnetic and ferromagnetic (s.l.) minerals. The comparison between the orientation of the observed magnetic lineation and that of the structural elements characterizing the internal geometry of the studied salt structures (antiforms, minor folds, faults and shear zones) and flanks indicates that the magnetic fabric is controlled by deformation processes affecting the salt walls during their growth and/or evolution. Samples were also analyzed from sixteen sites from Miocene rocks outcropping in several syn-diapiric Miocene half-grabens related to the salt walls studied. Their magnetic fabric is interpreted to reflect the dominant stretching direction at the syn-diapiric half grabens during and/or shortly after deposition. Our results indicate that caution is required in interpreting magnetic lineations related to salt flow mechanics from rocks associated with salt structures

The 2011 October Draconids outburst. I. Orbital elements, meteoroid fluxes and 21P/Giacobini-Zinner delivered mass to Earth

On October 8th, 2011 the Earth crossed the dust trails left by comet 21P/Giacobini-Zinner during its XIX and XX century perihelion approaches with the comet being close to perihelion. The geometric circumstances of that encounter were thus favorable to produce a meteor storm, but the trails were much older than in the 1933 and 1946 historical encounters. As a consequence the 2011 October Draconid display exhibited several activity peaks with Zenithal Hourly Rates of about 400 meteors per hour. In fact, if the display had been not forecasted, it could have passed almost unnoticed as was strongly attenuated for visual observers due to the Moon. This suggests that most meteor storms of a similar nature could have passed historically unnoticed under unfavorable weather and Moon observing conditions. The possibility of obtaining information on the physical properties of cometary meteoroids penetrating the atmosphere under low-geocentric velocity encounter circumstances motivated us to set up a special observing campaign. Added to the Spanish Fireball Network wide-field all-sky and CCD video monitoring, other high-sensitivity 1/2" black and white CCD video cameras were attached to modified medium-field lenses for obtaining high resolution orbital information. The trajectory, radiant, and orbital data of 16 October Draconid meteors observed at multiple stations are presented. The results show that the meteors appeared from a geocentric radiant located at R.A.=263.0+-0.4 deg. and Dec.=+55.3+-0.3 deg. that is in close agreement with the radiant predicted for the 1873-1894 and the 1900 dust trails. The estimated mass of material from 21P/Giacobini-Zinner delivered to Earth during the six-hours outburst was around 950+-150 kg.Comment: Manuscript in press in Monthly Notices of the Royal Astronomical Society, submitted to MNRAS on November 16th, 2012 Accepted for publication in MNRAS on April 28th, 2013 Manuscript Pages: 21 Tables: 8 Figures: 4 Manuscript associated: "The 2011 October Draconids outburst. II. Meteoroid chemical abundances from fireball spectroscopy" by J.M. Madiedo is also in press in the same journa

Corrigendum to ‘Dietary aflatoxin B1 (AFB1) reduces growth performance, impacting growth axis, metabolism, and tissue integrity in juvenile gilthead sea bream (Sparus aurata)’. Aquaculture, volume 533, 25 February 2021, 736189

The authors regret the errors in a few table references within the text. Specifically, it should reads as follows within the following subsections/ page: 3.2. Blood analysis (page 5)info:eu-repo/semantics/publishedVersio

Influence of sociodemographic characteristics on human mobility

Human mobility has been traditionally studied using surveys that deliver snapshots of population displacement patterns. The growing accessibility to ICT information from portable digital media has recently opened the possibility of exploring human behavior at high spatio-temporal resolutions. Mobile phone records, geolocated tweets, check-ins from Foursquare or geotagged photos, have contributed to this purpose at different scales, from cities to countries, in different world areas. Many previous works lacked, however, details on the individuals' attributes such as age or gender. In this work, we analyze credit-card records from Barcelona and Madrid and by examining the geolocated credit-card transactions of individuals living in the two provinces, we find that the mobility patterns vary according to gender, age and occupation. Differences in distance traveled and travel purpose are observed between younger and older people, but, curiously, either between males and females of similar age. While mobility displays some generic features, here we show that sociodemographic characteristics play a relevant role and must be taken into account for mobility and epidemiological modelization.Comment: 13 pages, 11 figures + Supplementary informatio

Analysis of the Effect of Scarification Process on Papaya (<em>Carica papaya</em> Lin.) Seeds Germination

The presence of the aril (sarcotesta) in the papaya causes a slow and low germination, being necessary to break the state of dormancy. Calcium hydroxide that was applied in order to evaluate its scarifying effect was the objective. The sample consisted of 60 randomly selected fruits of hermaphrodite plants in a commercial production batch of approximately 1 ha (2222 plants) showing commercial maturity, of homogeneous size (±2 kg). The treatments were calcium hydroxide Ca(OH)2 at three doses, dipping the seed for a period of 24 h; the standardized sodium hydroxide (NaOH) at 25% with a 15 min immersion time. The highest germination and vigor seeds were obtained applied Ca(OH)2 with highly significant differences respect to the rest treatment, especially for the dose of 60 g l−1 of water for reasons of diminishing expenses. Significant correlations were found, with direct relations (aril and mechanical damage) and inverse relations (abnormal seeds) between the variables evaluated related to the vigor and germination of the seeds. It can be an ecological and not expensive methodology to improve the germination and vigor of papaya seeds in relation to other chemical compounds to scarify

Necesidades de formación continua del profesorado de educación básica para el diseño de programas de posgrado

This paper shows the results of an exploratory study with a quantitative approach in which the continuous training needs of basic education teachers are identified: preschool, primary and secondary, in order to design a relevant and contextualized postgraduate proposal. The main objective is based on the diagnosis of training needs felt by teachers for the design and implementation of continuous training educational programs, based on the areas of opportunity expressed by teachers in service in the northern region of the state of Zacatecas, Mexico, in contrast to the professional competences for the exercise of teaching. For the collection of information, a questionnaire instrument with a Likert-type scale was used, made up of 48 items in six categories of analysis: continuous training needs, teaching and continuous improvement, educational research, professional ethics, didactic use of ICTs and English. This study shows a diagnosis of the training needs most felt by in-service teachers, from which Higher Education Institutions (HEIs) could base their proposals for continuous training programs.Estudio exploratorio con enfoque cuantitativo en el que se identifican las necesidades de formación continua de docentes de educación básica: preescolar, primaria y secundaria, a fin de diseñar una propuesta de posgrado pertinente y contextualizada. El objetivo principal se basa en el diagnóstico de necesidades de formación sentidas por el profesorado para el diseño e implementación de programas educativos de formación continua, a partir de las áreas de oportunidad expresadas por los profesores en servicio de la región norte del estado de Zacatecas, México, en contraste con las competencias profesionales para el ejercicio de la docencia. Para la recogida de información se utilizó un instrumento de cuestionario con escala tipo Likert, conformado por 48 ítems en seis categorías de análisis: necesidades de formación continua, docencia y mejora continua, investigación educativa, ética profesional, uso didáctico de TIC´s e inglés. Este estudio muestra un diagnóstico de las necesidades de formación más sentidas por los docentes en servicio, a partir de las cuales las Instituciones de Educación Superior (IES) podrían fundamentar sus propuestas de programas de formación continua

Health-related Quality of Life in Type 1 Diabetes Mellitus Pediatric Patients and Their Caregivers in Spain: An Observational Cross-Sectional Study

Objectives: This study assessed the health-related quality of life (HRQOL) of pediatric patients with type 1 diabetes mellitus (T1DM) and their caregivers.Methods: CHRYSTAL was an observational cross-sectional study conducted in Spain in 2014 on 275 patients under 18 years old diagnosed with T1DM. Patient/caregiver pairs were stratified by patients' HbA1c level (?7.5% versus <7.5%) and by presence or absence of T1DM complications and/or comorbidities. EQ-5D and PedsQL questionnaires were administered to patients and caregivers.Results: On the EQ-5D, according to caregivers' perception, 17.7% of children experienced moderate pain or discomfort, 9.7% suffered problems performing usual activities, and 13.2% demonstrated moderate anxiety or depression. Mean EQ-5D index score was 0.95 and mean visual analog scale (VAS) score was 86.1. By HbA1c level (?7.5% versus <7.5%), mean index scores were 0.94 and 0.95, and mean VAS scores were 82.8 and 89.2, respectively. Mean index scores were 0.91 for children with complications and/or comorbidities and 0.96 for children without. Mean VAS scores were 83.7 and 87.2, respectively. HRQOL per the PedsQL tool ranged from 68.1 (ages 2-4) to 73.1 (ages 13-18). EQ-5D index and VAS scores were significantly correlated (rho = 0.29-0.43) with several age groups of the PedsQL. EQ-5D scales showed significant moderate correlation between EQ-5D-Y and EQ-5D-3L proxy VAS score (rho = 0.45; p < .001).Conclusions: Patients with few complications and controlled HbA1c reported a relatively high HRQOL. The results suggest that parent-proxy EQ-5D ratings are valid for use as part of an overall health outcomes assessment in clinical studies of T1DM in pediatric patients