Ефективність застосування альфасорбу у годівлі поросят

Mycotoxins cause severe diseases in organisms of human and animals. They are difficult to diagnose, cause great economic damage. Sorbents are able to effectively bind and remove from the body through the digestive tract with a therapeutic or prophylactic purpose various endogenous and ekzogenous substances, microorganisms and they toxins, supermolecular structures and cells. The aim of the work is to study the effectiveness of use of Alfasorb for the neutralization of mixed fodders affected by mycotoxins and they impact on blood’s indexes and productive qualities of piglets of Large White Breed. Experience was conducted on 30 ty piglets. Animals of the control group received mixed feed that was produced in the conditions of the farm. The pigs of experimental group in addition to the basic diet received Alfasorb. We determined blood’s indexes for study the effect of feed additive Alfasorb on the physiological state of animals at 4 months of age. A morphological and histological study of liver was carried out. The analysis of the average daily weight gain of piglets showed that it was higher in period of growth in the animals of experimental group. In the animals of the experimental groups there was an increase in the number of red blood cells in comparison with the control. An unreliable decrease in blood serum levels which characterize the level of intermediate metabolism of proteins in the body (content of urea, creatinine and common bilirubin) was established in the animals of the experimental group as compared to the control group respectively by 22.83% ( td = 0.98, P ≤ 0.05), 7.12% (td = 1.92, P ≤ 0.05) and by 20.54% (td = 0.86, P ≤ 0.05). Most hepatocytes had large nucleus and intense color of the cytoplasm. This indicates the absence of alterative processes in the body. The results of the studies make it possible to assert that the inclusion the 0.2% Alfasorb to the compound of feed which contaminated with mycotoxins significantly reduces their negative effect on the piglets organism, has a positive effect on the growth rate, on the course of metabolic processes, also it promotes an increase in the liver of medium-sized hepatocyte nuclei, stimulates biosynthetic processes in that cells and ensures the formation of a full structure of histohematological barriers in the organism.Мікотоксини спричиняють різні захворювання в організмі людини та тварин. Вони важко діагностуються та призводять до великих економічних збитків. Сорбенти здатні ефективно зв’язувати та виводити з організму через травний тракт з профілактичною чи терапевтичною метою різні ендогенні та екзогенні субстанції, мікроорганізми та їх токсини, складні молекулярні структури та клітини. Мета роботи – дослідити ефективність застосування альфасорбу для нейтралізації комбікормів, уражених мікотоксинами, та їх вплив на показники крові та продуктивні якості поросят великої білої породи. Дослід проводили на 30-ти поросятах. Тварини контрольної групи отримували комбікорм, що виробляється в умовах ферми. Поросята дослідної групи у додаток до основного раціону одержували альфасорб. Ми вивчали показники крові для визначення впливу кормової добавки альфасорб та фізіологічний стан тварин 4-місячного віку. Було проведено морфологічне і гістологічне дослідження печінки. Аналіз середньодобових приростів поросят показав, що вони були більшими у період росту тварин експериментальної групи. У тварин дослідної групи була більшою кількість еритроцитів, у порівнянні з контролем. Встановлено зниження у сироватці крові тварин дослідної групи показників, що характеризують проміжний обмін (вміст сечовини, креатиніну та загального білірубіну), у порівнянні з контрольною групою відповідно 22,83% (td = 0,98, P ≤ 0,05), 7,12% (td = 1,92, P ≤ 0,05) and by 20,54% (td = 0,86, P ≤ 0,05). Більшість гепатоцитів мали великі ядра та інтенсивне забарвлення цитоплазми. Це вказує на відсутність альтеративних процесів в організмі. Результати досліджень дозволяють зробити висновок, що включення 0,2% альфасорбу до складу корму, контамінованого мікотоксинами, значно зменшує їх негативний вплив на організм поросят, позитивно впливає на прирости, перебіг метаболічних процесів, також сприяє, зниженню у печінці середніх розмірів ядер гепатоцитів, стимулює біосинтетичні процеси у цих клітинах та забезпечує формування повної структури гістогематологічних бар’єрів у організмі

CLINICAL AND HISTOLOGIC FEATURES OF UTERINE MYOMA IN REPRODUCTIVE-AGE WOMEN UNDER THE TREATMENT BY SELECTIVE PROGESTERONE RECEPTOR MODULATORS

Aim of the study was to investigate the clinical features of reproductive age women with uterine body myoma and the production of vascular endothelial growth factor (VEGF) in the dominant myoma node and perifocal myometrium under the preoperative use of ulipristal acetate (UA). Material and methods. 140 samples of 35 women surgical material were studied, VEGF content in the incubation medium of samples of myoma and myometrium was measured using enzymelinked  immunosorbent assay.Results and discussion. The treatment by UA before myoma surgery according to the standard regimen per 5 mg daily for 13 weeks deals with significantly reduced production of VEGF in the dominant myoma node compared to perifocal myometrium (p < 0.001), which is similar to patients of the control group. However, when comparing tumor nodes, a significantly lower content of VEGF was revealed in the UA-group (p = 0.026); unlike the perifocal myometrium samples. Conclusion. The use of a selective modulator of progesterone receptors downregulates the production of VEGF by the cells of the myoma nodes and doesn’t impact on the perifocal myometrium

The relationship between sensory sensitivity and autistic traits in the general population.

Individuals with Autism Spectrum Disorders (ASDs) tend to have sensory processing difficulties (Baranek et al. in J Child Psychol Psychiatry 47:591–601, 2006). These difficulties include over- and under-responsiveness to sensory stimuli, and problems modulating sensory input (Ben-Sasson et al. in J Autism Dev Disorders 39:1–11, 2009). As those with ASD exist at the extreme end of a continuum of autistic traits that is also evident in the general population, we investigated the link between ASD and sensory sensitivity in the general population by administering two questionnaires online to 212 adult participants. Results showed a highly significant positive correlation (r = .775, p < .001) between number of autistic traits and the frequency of sensory processing problems. These data suggest a strong link between sensory processing and autistic traits in the general population, which in turn potentially implicates sensory processing problems in social interaction difficulties

The Economic Resource Receipt of New Mothers

U.S. federal policies do not provide a universal social safety net of economic support for women during pregnancy or the immediate postpartum period but assume that employment and/or marriage will protect families from poverty. Yet even mothers with considerable human and marital capital may experience disruptions in employment, earnings, and family socioeconomic status postbirth. We use the National Survey of Families and Households to examine the economic resources that mothers with children ages 2 and younger receive postbirth, including employment, spouses, extended family and social network support, and public assistance. Results show that many new mothers receive resources postbirth. Marriage or postbirth employment does not protect new mothers and their families from poverty, but education, race, and the receipt of economic supports from social networks do

Autism as a disorder of neural information processing: directions for research and targets for therapy

The broad variation in phenotypes and severities within autism spectrum disorders suggests the involvement of multiple predisposing factors, interacting in complex ways with normal developmental courses and gradients. Identification of these factors, and the common developmental path into which theyfeed, is hampered bythe large degrees of convergence from causal factors to altered brain development, and divergence from abnormal brain development into altered cognition and behaviour. Genetic, neurochemical, neuroimaging and behavioural findings on autism, as well as studies of normal development and of genetic syndromes that share symptoms with autism, offer hypotheses as to the nature of causal factors and their possible effects on the structure and dynamics of neural systems. Such alterations in neural properties may in turn perturb activity-dependent development, giving rise to a complex behavioural syndrome many steps removed from the root causes. Animal models based on genetic, neurochemical, neurophysiological, and behavioural manipulations offer the possibility of exploring these developmental processes in detail, as do human studies addressing endophenotypes beyond the diagnosis itself

A genome-wide scan for common alleles affecting risk for autism

Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10−8. When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10−8 threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C

Enzyme immunoassay of interleukin content in tumor supernatants in patients with multiple uterine myoma

The aim of the study was to determine the effects of a mixture of polyclonal activators on the interleukin production by dominant myomatous and myometrial tissue samples under treating by ulipristal acetate (UA), a selective modulator of progesterone receptors.Цель работы — изучить эффект поликлональных активаторов на продукцию интерлейкинов и 17-ОН-прогестерона в ткани доминирующего миоматозного узла и перифокального миометрия в условиях применения улипристала ацетата (УА), селективного модулятора прогестероновых рецепторо

Hyperactivity, impulsivity, and inattention in boys with cleft lip and palate: relationship to ventromedial prefrontal cortex morphology

The purpose of this study is to evaluate quantitative structural measures of the ventromedial prefrontal cortex (vmPFC) in boys with isolated clefts of the lip and/or palate (ICLP) relative to a comparison group and to associate measures of brain structure with quantitative measures of hyperactivity, impulsivity, and inattentiveness. A total of 50 boys with ICLP were compared to 60 healthy boys without clefts. Magnetic resonance imaging brain scans were used to evaluate vmPFC structure. Parents and teachers provided quantitative measures of hyperactivity, impulsivity, and inattentiveness using the Pediatric Behavior Scale. Boys with ICLP had significantly higher ratings of hyperactivity/impulsivity/inattention (HII) and significantly increased volume of the right vmPFC relative to the comparison group. There was a direct relationship between HII score and vmPFC volume in both the ICLP group and control group, but the relationship was in the opposite direction: in ICLP, the higher the vmPFC volume, the higher the HII score; for the comparison group, the lower the vmPFC volume, the greater the HII score. The vmPFC is a region of the brain that governs behaviors of hyperactivity, impulsivity and inattention (HII). In boys with ICLP, there are higher levels of HII compared to the controls and this is directly related to a significantly enlarged volume of the right vmPFC. Enlargement of this region of the brain is therefore considered to be pathological in the ICLP group and supports the notion that abnormal brain structure (from abnormal brain development) is the underlying etiology for the abnormal behaviors seen in this population