Effect of piroxicam on lipid membranes : Drug encapsulation and gastric toxicity aspects

Uptake of piroxicam, a non-steroidal anti-inflammatory drug, from the intestines after oral intake is limited due to its low solubility and its wide use is associated with several side effects related to the gastrointestinal tract. In this study, all-atom molecular dynamics (MD) simulations and fluorescent spectroscopy were employed to investigate the interaction of piroxicam in neutral, zwitterionic, and cationic forms with lipid bilayers composed of phosphatidylcholine, cholesterol, and PEGylated lipids. Our study was aimed to assess the potential for encapsulation of piroxicam in liposomal carriers and to shed more light on the process of gastrointestinal tract injury by the drug. Through both the MD simulations and laser scanning confocal microscopy, we have demonstrated that all forms of piroxicam can associate with the lipid bilayers and locate close to the water-membrane interface. Conventional liposomes used in drug delivery are usually stabilized by the addition of cholesterol and have their bloodstream lifetime extended through the inclusion of PEGylated lipids in the formulation to create a protective polymer corona. For this reason, we tested the effect of these two modifications on the behavior of piroxicam in the membrane. When the bilayer was PEGylated, piroxicam localize to the PEG layer and within the lipid headgroup region. This suggests that PEGylated liposomes are capable of carrying a larger quantity of piroxicam than the conventional ones. (C) 2017 Elsevier B.V. All rights reserved.Peer reviewe

Forewarned is forearmed : harmonized approaches for early detection of potentially invasive pests and pathogens in sentinel plantings

This work was supported by COST Action Global Warning (FP1401). DLM and YB contribution was also supported by the Russian Foundation for Basic Research (Grant No. 17-04-01486). MG was supported by Ministry of Education, Science and Technological Development of the Republic of Serbia, Grant III43002. MKA was supported by the Ministry of Science and Higher Education of the Republic of Poland. NK was supported by Le Studium foundation (France) and RFBR (Grant No. 19-04-01029). RE, IF and MK contribution was also supported by CABI with core financial support from its member countries (see http://www.cabi.org/about-cabi/who-we-work-with/key-donors/ for details). IF contribution was further supported through a grant from the Swiss State Secretariat for Science, Education and Research (Grant C15.0081, awarded to RE).Peer reviewedPublisher PD

Global Geographic Distribution and Host Range of Fusarium circinatum, the Causal Agent of Pine Pitch Canker

Funding: This study was financially supported by COST Action FP1406 (PINESTRENGTH), the Estonian Science Foundation grant PSG136, the Forestry Commission, United Kingdom, the Phytophthora Research Centre Reg. No. CZ.02.1.01/0.0/0.0/15_003/0000453, a project co-financed by the European Regional Development Fund. ANSES is supported by a grant managed by the French National Research Agency (ANR) as part of the “Investissements d’Avenir” programme (ANR-11-LABX-0002-01, Laboratory of ExcellenceARBRE). SW was partly supported by BBSRC Grant reference BB/L012251/1 “Promoting resilience of UK tree species to novel pests & pathogens: ecological & evolutionary solutions (PROTREE)” jointly funded by BBSRC, Defra, ESRC, the Forestry Commission, NERC and the Scottish Government, under the Tree Health and Plant Biosecurity Initiative. Annual surveys in Switzerland were financially supported by the Swiss Federal Office for the Environment FOEN. Acknowledgments: Andrea Kunova and Cristina Pizzatti are acknowledged for the assistance in the sampling. Thanks are due to Dina Ribeiro and Helena Marques from ICNF-Portuguese Forest Authority for providing location coordinates. We thank three anonymous reviwers for valuable corrections and suggestions.Peer reviewedPublisher PD

Lamenting the church? Bishop Andrzej Krzycki and early reformation polemic

Copyright Natalia Nowakowska 201

Papacy and piety in the career of Cardinal Fryderyk Jagiellon, prince of Poland, 1468-1503

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Kazik and Kazia: A symbolic gender change in the midst of the fight for independence of Poland

Wanda Gertz was one of thirty Polish women who rushed to the frontlines of WW I in male disguise. The author asks what could have provoked such behavior by analyzing archival sources on Wanda Gertz, as well as facts mistakenly associated with her. This paper aims at showing patriotism as one among many motivations for symbolic gender change and joining the army. It also tackles the question of the perception of female soldiers who pass for men, then and now.Wanda Gertz była jedną z 30 kobiet, które wyruszyły na front I wojny światowej w męskim przebraniu. Autorka artykułu zastanawia się, co mogło kryć się za wykonaniem takiego kroku, analizuje przy tym zachowane źródła archiwalne dotyczące Wandy Gertz, a także te mylnie z nią kojarzone. Celem artykułu jest pokazanie, iż patriotyzm nie był jedynym kryterium podjęcia decyzji o symbolicznej zmianie płci i wstąpieniu do wojska. Porusza również aspekt odbioru przebranych żołnierek przez ówczesne otoczenie i dziś

The Japanese nourishing pattern based on questionnaire research

INTRODUCTION the purpose of the research paper is the evaluation of the Japanese nourishing pattern with consideration of 6 groups foodstuffs division. THE MATERIAL AND THE METHOD the questionnaire research taken into consideration selected products the uptake was carried out among 60 Japanese men residing in Japan permanently. THE RESULTS the frequency of selected products uptake was employed in the evaluation of eating habits in the tested group. CONCLUSIONS 1. The analysis corollas of the selected alimentary products consumed by the Japanese confirms characteristic and different for this group nourishing pattern. 2. Nourishing pattern in the tested group can be acknowledge to comply with proper nourishment commendations. 3. It is worth to use selected parts of Japanese nutrition in Polish diet as an example of proper nutrition.WSTĘP Celem pracy jest ocena sposobu odżywiania Japończyków, z uwzględnieniem podziału na 6 grup produktów spożywczych. MATERIAŁ I METODY Badania ankietowe uwzględniające spożycia wybranych produktów przeprowadzono wśród 60 Japończyków na stałe zamieszkałych w Japonii. WYNIKI Częstość spożycia wybranych produktów wykorzystano w ocenie nawyków żywieniowych badanej grupy. WNIOSKI 1. Analiza wybranych produktów spożywanych przez Japończyków potwierdza charakterystyczny i odmienny sposób żywienia tej grupy 2. Sposób żywienia badanej grupy można uznać za zgodny z zaleceniami prawidłowego żywienia. 3. Wybrane elementy żywienia Japończyków warto wykorzystać, w miarę możliwości, w diecie Polaków jako przykład prawidłowego żywienia

The effect of the biostimulator Goteo on the rooting of ninebark stem cuttings

As a consequence of restrictions on the use of preparations containing synthetic auxins in nursery production, there is a necessity to replace them with more environmentally friendly biopreparations efficiently stimulating plant growth. The aim of the presented experiment was to compare the effects of the synthetic auxin indole-3-butyric acid (IBA) and the biostimulator Goteo on the rooting of ninebark stem cuttings (Physocarpus opulifolius ‘Dart’s Gold’ and ‘Red Baron’) and to get some insight into the latter’s mechanisms of action in plants. Applications of the biostimulator Goteo produced comparable or slightly weaker effects compared to the treatments with IBA. Goteo stimulated elongation in new growth of cuttings when applied in watering or two-fold spraying methods. Application of the biostimulator resulted in increased levels of chlorophyll, soluble sugars and indole derivatives, while the contents of free amino acids and polyphenolic acids decreased. The above results indicate that, if necessary, Goteo may replace the synthetic auxin IBA in the propagation of ninebark in the future