The Impact of Urban Removal from a Child\u27s Point of View

It is the premise of this paper that forced urban resettlement has more devastating consequences for children and their families than the usual voluntary moving process. The moving process, whether forced or voluntary, involves the following phases: a decision to change the place of residence, an exploration of housing opportunities in various areas, the final selection of one of these, activities associated with making the move, and activities associated with getting settled in the new house and neighborhood

Toward the Democratization of the Social Policy Process

The purpose of this paper is to reflect on the nature of social policies and the public policymaking process. It is demonstrated that public social policies tend to accrue an aura or ideology of benevolence that is only partially warranted, and that may be quite misleading to policy analysts and citizenry. The major thrust of the paper is to consider the social policy process as a strategy for public decision-making. As such, properly organized, it can provide an alternative and complementary strategy to electoral politics and protest movements. To be effective as a strategy, three major barriers must be overcome: the lack of openness in the public policy process, the active discouragement of citizen participation, and the failure to evaluate policy outcomes. Some notions are advanced about how social policy analysts and researchers can improve their work and thereby assist in the democratization of the process

Some Critical Questions in the Political Economy of Social Welfare - The Carter Welfare Reform Proposals

The purpose of this paper is to discuss President Carter\u27s welfare reform proposals, appropriately titled, The Program for Better Jobs and Income. If these proposals are adopted by Congress, they will guide the Administration in its stance toward and its work with the lowest income sectors of the nation: the welfare poor--those who cannot work and must be supported by the government, and the working poor--those who are able to support themselves, but whose yearly income is less than the poverty level. Consequently, the paper starts with an analysis of what the government documents have to tell us about the scope and nature of poverty in the United States. Then we proceed with a discussion of the current welfare reform proposals--what the Administration intends to do about the persistent entrenched poverty that plagues the nation. Finally, we ask: will the Carter welfare reforms work? We return to the key question posed at the beginning of the paper: Is it possible for the federal government to institute reforms that will result in better jobs and better distribution of income so that the welfare poor and the working poor can maintain a standard of living above abject poverty

The Relative Effectiveness of Legislative Campaigning in a School of Social Work

There are three interrelated strategies commonly used by social workers for coping with the conservative attack on social welfare institutions: client advocacy, electoral, and policy strategies. The paper evaluates the relative effectiveness of the policy strategy when 532 members of a school of social work were asked to write their legislators in support of progressive legislation. Five indicators of the relative effectiveness of this campaign were identified and assessed. The campaign is adjudged relatively effective from the standpoint of enlisting and motivating participants ready for service or action\u27 (action potential); in implementing a formal plan or organization--a connected series of operations to bring about a particular result (organization potential); in activizing a leadership cadre for current and future campaigns (leadership potential); and in disseminating information relevant to the campaign (information potential). The evidence on outcome effectiveness -- for producing a decided, decisive, and desired result -- was inconclusive. The advantages and disadvantages of the policy strategy are discussed

Toward Partisan Politics in a Professional Association: Utility of the Candidates Poll

The purpose of this paper is to describe the initial efforts of one local chapter, The Puget Sound Chapter; to engage in partisan politics by the conduct of a poll of candidates for election to the Washington State Legislature in 1974. Properly speaking, the Chapter endorsed no candidates, merely rated them from weak to outstanding on their agreement with NASW policies on relevant programs and their social welfare attitudes. Thus, it is a mild form of partisan politics that will be considered. The paper will analyze the social and organizational context in which the candidates\u27 poll occurred, and then report on the advantages and shortcomings of the poll as a technique for the assessment of political candidates. Finally, there will be a brief commentary on the functions of the professional association in the politicalization of the activities of organized social workers

The South Asian genome

Genetics of disease Microarrays Variant genotypes Population genetics Sequence alignment AllelesThe genetic sequence variation of people from the Indian subcontinent who comprise one-quarter of the world's population, is not well described. We carried out whole genome sequencing of 168 South Asians, along with whole-exome sequencing of 147 South Asians to provide deeper characterisation of coding regions. We identify 12,962,155 autosomal sequence variants, including 2,946,861 new SNPs and 312,738 novel indels. This catalogue of SNPs and indels amongst South Asians provides the first comprehensive map of genetic variation in this major human population, and reveals evidence for selective pressures on genes involved in skin biology, metabolism, infection and immunity. Our results will accelerate the search for the genetic variants underlying susceptibility to disorders such as type-2 diabetes and cardiovascular disease which are highly prevalent amongst South Asians.Whole genome sequencing to discover genetic variants underlying type-2 diabetes, coronary heart disease and related phenotypes amongst Indian Asians. Imperial College Healthcare NHS Trust cBRC 2011-13 (JS Kooner [PI], JC Chambers)

Recurrent Coding Sequence Variation Explains only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Whilst common genetic variation in many non-coding genomic regulatory regions are known to impart risk of colorectal cancer (CRC), much of the heritability of CRC remains unexplained. To examine the role of recurrent coding sequence variation in CRC aetiology, we genotyped 12,638 CRCs cases and 29,045 controls from six European populations. Single-variant analysis identified a coding variant (rs3184504) in SH2B3 (12q24) associated with CRC risk (OR = 1.08, P = 3.9 × 10-7), and novel damaging coding variants in 3 genes previously tagged by GWAS efforts; rs16888728 (8q24) in UTP23 (OR = 1.15, P = 1.4 × 10-7); rs6580742 and rs12303082 (12q13) in FAM186A (OR = 1.11, P = 1.2 × 10-

Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

Regular aspirin use is associated with reduced risk of colorectal cancer (CRC). Variation in aspirin’s chemoprevention efficacy has been attributed to the presence of single nucleotide polymorphisms (SNPs). We conducted a meta-analysis using two large population-based case-control datasets, the UK-Leeds Colorectal Cancer Study Group and the NIH-Colon Cancer Family Registry, having a combined total of 3325 cases and 2262 controls. The aim was to assess 42 candidate SNPs in 15 genes whose association with colorectal cancer risk was putatively modified by aspirin use, in the literature. Log odds ratios (ORs) and standard errors were estimated for each dataset separately using logistic regression adjusting for age, sex and study site, and dataset-specific results were combined using random effects meta-analysis. Meta-analysis showed association between SNPs rs6983267, rs11694911 and rs2302615 with CRC risk reduction (All P<0.05). Association for SNP rs6983267 in the CCAT2 gene only was noteworthy after multiple test correction (P = 0.001). Site-specific analysis showed association between SNPs rs1799853 and rs2302615 with reduced colon cancer risk only (P = 0.01 and P = 0.004, respectively), however neither reached significance threshold following multiple test correction. Meta-analysis of SNPs rs2070959 and rs1105879 in UGT1A6 gene showed interaction between aspirin use and CRC risk (Pinteraction = 0.01 and 0.02, respectively); stratification by aspirin use showed an association for decreased CRC risk for aspirin users having a wild-type genotype (rs2070959 OR = 0.77, 95% CI = 0.68–0.86; rs1105879 OR = 0.77 95% CI = 0.69–0.86) compared to variant allele cariers. The direction of the interaction however is in contrast to that published in studies on colorectal adenomas. Both SNPs showed potential site-specific interaction with aspirin use and colon cancer risk only (Pinteraction = 0.006 and 0.008, respectively), with the direction of association similar to that observed for CRC. Additionally, they showed interaction between any non-steroidal anti-inflammatory drugs (including aspirin) use and CRC risk (Pinteraction = 0.01 for both). All gene x environment (GxE) interactions however were not significant after multiple test correction. Candidate gene investigation indicated no evidence of GxE interaction between genetic variants in genes involved in aspirin pathways, regular aspirin use and colorectal cancer risk

Negative feedback regulation of the ERK1/2 MAPK pathway

The extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signalling pathway regulates many cellular functions, including proliferation, differentiation, and transformation. To reliably convert external stimuli into specific cellular responses and to adapt to environmental circumstances, the pathway must be integrated into the overall signalling activity of the cell. Multiple mechanisms have evolved to perform this role. In this review, we will focus on negative feedback mechanisms and examine how they shape ERK1/2 MAPK signalling. We will first discuss the extensive number of negative feedback loops targeting the different components of the ERK1/2 MAPK cascade, specifically the direct posttranslational modification of pathway components by downstream protein kinases and the induction of de novo gene synthesis of specific pathway inhibitors. We will then evaluate how negative feedback modulates the spatiotemporal signalling dynamics of the ERK1/2 pathway regarding signalling amplitude and duration as well as subcellular localisation. Aberrant ERK1/2 activation results in deregulated proliferation and malignant transformation in model systems and is commonly observed in human tumours. Inhibition of the ERK1/2 pathway thus represents an attractive target for the treatment of malignant tumours with increased ERK1/2 activity. We will, therefore, discuss the effect of ERK1/2 MAPK feedback regulation on cancer treatment and how it contributes to reduced clinical efficacy of therapeutic agents and the development of drug resistance

Author Correction: The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data

The following authors were omitted from the original version of this Data Descriptor: Markus Reichstein and Nicolas Vuichard. Both contributed to the code development and N. Vuichard contributed to the processing of the ERA-Interim data downscaling. Furthermore, the contribution of the co-author Frank Tiedemann was re-evaluated relative to the colleague Corinna Rebmann, both working at the same sites, and based on this re-evaluation a substitution in the co-author list is implemented (with Rebmann replacing Tiedemann). Finally, two affiliations were listed incorrectly and are corrected here (entries 190 and 193). The author list and affiliations have been amended to address these omissions in both the HTML and PDF versions