25 research outputs found
Multi-centre point-prevalence survey of hospital-acquired infections in Ghana
Background: There is a paucity of data describing hospital-acquired infections (HAIs) in Africa. Objective: To describe the prevalence and distribution of HAIs in acute care hospitals in Ghana. Methods: Between September and December 2016, point-prevalence surveys were conducted in participating hospitals using protocols of the European Centre for Disease Prevention and Control. Medical records of eligible inpatients at or before 8am on the survey date were reviewed to identify HAIs present at the time of the survey. Findings: Ten hospitals were surveyed, representing 32.9% of all acute care beds in government hospitals. Of 2107 inpatients surveyed, 184 HAIs were identified among 172 patients, corresponding to an overall prevalence of 8.2%. The prevalence values in hospitals ranged from 3.5% to 14.4%, with higher proportions of infections in secondary and tertiary care facilities. The most common HAIs were surgical site infections (32.6%), bloodstream infections (19.5%), urinary tract infections (18.5%) and respiratory tract infections (16.3%). Device-associated infections accounted for 7.1% of HAIs. For 12.5% of HAIs, a micro-organism was reported; the most commonly isolated micro-organism was Escherichia coli. Approximately 61% of all patients surveyed were on antibiotics; 89.5% of patients with an HAI received at least one antimicrobial agent on the survey date. The strongest independent predictors for HAI were the presence of an invasive device before onset of infection and duration of hospital stay. Conclusion: A low HAI burden was found compared with findings from other low- and middle-income countries
Early life child micronutrient status, maternal reasoning, and a nurturing household environment have persistent influences on child cognitive development at age 5 years: Results from MAL-ED
Background: Child cognitive development is influenced by early-life insults and protective factors. To what extent these factors have a long-term legacy on child development and hence fulfillment of cognitive potential is unknown. Objective: The aim of this study was to examine the relation between early-life factors (birth to 2 y) and cognitive development at 5 y. Methods: Observational follow-up visits were made of children at 5 y, previously enrolled in the community-based MAL-ED longitudinal cohort. The burden of enteropathogens, prevalence of illness, complementary diet intake, micronutrient status, and household and maternal factors from birth to 2 y were extensively measured and their relation with the Wechsler Preschool Primary Scales of Intelligence at 5 y was examined through use of linear regression. Results: Cognitive T-scores from 813 of 1198 (68%) children were examined and 5 variables had significant associations in multivariable models: mean child plasma transferrin receptor concentration (ÎČ: â1.81, 95% CI: â2.75, â0.86), number of years of maternal education (ÎČ: 0.27, 95% CI: 0.08, 0.45), maternal cognitive reasoning score (ÎČ: 0.09, 95% CI: 0.03, 0.15), household assets score (ÎČ: 0.64, 95% CI: 0.24, 1.04), and HOME child cleanliness factor (ÎČ: 0.60, 95% CI: 0.05, 1.15). In multivariable models, the mean rate of enteropathogen detections, burden of illness, and complementary food intakes between birth and 2 y were not significantly related to 5-y cognition. Conclusions: A nurturing home context in terms of a healthy/clean environment and household wealth, provision of adequate micronutrients, maternal education, and cognitive reasoning have a strong and persistent influence on child cognitive development. Efforts addressing aspects of poverty around micronutrient status, nurturing caregiving, and enabling home environments are likely to have lasting positive impacts on child cognitive development.publishedVersio
Invited review: Large-scale indirect measurements for enteric methane emissions in dairy cattle: A review of proxies and their potential for use in management and breeding decisions
Publication history: Accepted - 7 December 2016; Published online - 1 February 2017.Efforts to reduce the carbon footprint of milk production through selection and management of low-emitting
cows require accurate and large-scale measurements of
methane (CH4) emissions from individual cows. Several
techniques have been developed to measure CH4 in a research setting but most are not suitable for large-scale
recording on farm. Several groups have explored proxies (i.e., indicators or indirect traits) for CH4; ideally
these should be accurate, inexpensive, and amenable
to being recorded individually on a large scale. This
review (1) systematically describes the biological basis
of current potential CH4 proxies for dairy cattle; (2)
assesses the accuracy and predictive power of single
proxies and determines the added value of combining
proxies; (3) provides a critical evaluation of the relative
merit of the main proxies in terms of their simplicity,
cost, accuracy, invasiveness, and throughput; and (4)
discusses their suitability as selection traits. The proxies range from simple and low-cost measurements such
as body weight and high-throughput milk mid-infrared
spectroscopy (MIR) to more challenging measures such
as rumen morphology, rumen metabolites, or microbiome profiling. Proxies based on rumen samples are generally poor to moderately accurate predictors of CH4,
and are costly and difficult to measure routinely onfarm. Proxies related to body weight or milk yield and
composition, on the other hand, are relatively simple,
inexpensive, and high throughput, and are easier to
implement in practice. In particular, milk MIR, along
with covariates such as lactation stage, are a promising
option for prediction of CH4 emission in dairy cows.
No single proxy was found to accurately predict CH4,
and combinations of 2 or more proxies are likely to be
a better solution. Combining proxies can increase the
accuracy of predictions by 15 to 35%, mainly because
different proxies describe independent sources of variation in CH4 and one proxy can correct for shortcomings
in the other(s). The most important applications of
CH4 proxies are in dairy cattle management and breeding for lower environmental impact. When breeding for
traits of lower environmental impact, single or multiple
proxies can be used as indirect criteria for the breeding
objective, but care should be taken to avoid unfavorable correlated responses. Finally, although combinations of proxies appear to provide the most accurate
estimates of CH4, the greatest limitation today is the
lack of robustness in their general applicability. Future
efforts should therefore be directed toward developing
combinations of proxies that are robust and applicable
across diverse production systems and environments.Technical and financial support from the COST Action FA1302 of the European Union
Recommended from our members
The bii4africa dataset of faunal and floral population intactness estimates across Africaâs major land uses
Sub-Saharan Africa is under-represented in global biodiversity datasets, particularly regarding the impact of land use on speciesâ population abundances. Drawing on recent advances in expert elicitation to ensure data consistency, 200 experts were convened using a modified-Delphi process to estimate âintactness scoresâ: the remaining proportion of an âintactâ reference population of a species group in a particular land use, on a scale from 0 (no remaining individuals) to 1 (same abundance as the reference) and, in rare cases, to 2 (populations that thrive in human-modified landscapes). The resulting bii4africa dataset contains intactness scores representing terrestrial vertebrates (tetrapods: ±5,400 amphibians, reptiles, birds, mammals) and vascular plants (±45,000 forbs, graminoids, trees, shrubs) in sub-Saharan Africa across the regionâs major land uses (urban, cropland, rangeland, plantation, protected, etc.) and intensities (e.g., large-scale vs smallholder cropland). This dataset was co-produced as part of the Biodiversity Intactness Index for Africa Project. Additional uses include assessing ecosystem condition; rectifying geographic/ taxonomic biases in global biodiversity indicators and maps; and informing the Red List of Ecosystems
The bii4africa dataset of faunal and floral population intactness estimates across Africaâs major land uses
Sub-Saharan Africa is under-represented in global biodiversity datasets, particularly regarding the impact of land use on speciesâ population abundances. Drawing on recent advances in expert elicitation to ensure data consistency, 200 experts were convened using a modified-Delphi process to estimate âintactness scoresâ: the remaining proportion of an âintactâ reference population of a species group in a particular land use, on a scale from 0 (no remaining individuals) to 1 (same abundance as the reference) and, in rare cases, to 2 (populations that thrive in human-modified landscapes). The resulting bii4africa dataset contains intactness scores representing terrestrial vertebrates (tetrapods: ±5,400 amphibians, reptiles, birds, mammals) and vascular plants (±45,000 forbs, graminoids, trees, shrubs) in sub-Saharan Africa across the regionâs major land uses (urban, cropland, rangeland, plantation, protected, etc.) and intensities (e.g., large-scale vs smallholder cropland). This dataset was co-produced as part of the Biodiversity Intactness Index for Africa Project. Additional uses include assessing ecosystem condition; rectifying geographic/taxonomic biases in global biodiversity indicators and maps; and informing the Red List of Ecosystems