50 research outputs found

    NWCSAF/High Resolution Winds AMV Software for Geostationary and Polar satellites Status in 2021

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    Ponencia presentada en: 15th International Winds Workshop celebrada del 12 al 16 de abril de 2021

    NWCSAF/High Resolution Winds AMV Software for Geostationary and Polar satellites Status in 2023

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    Ponencias presentadas en: 16th International Winds Workshop celebradas Montreal, Canadá, del 8-12 de mayo de 2023.The High Resolution Winds (NWC/GEO-HRW) software is developed by the EUMETSAT Satellite Application Facility on Support to Nowcasting and Very Short Range Forecasting (NWCSAF). It is part of a stand-alone software package for the calculation of meteorological products with geostationary satellite data (NWC/GEO). NWCSAF High Resolution Winds provides a detailed calculation of Atmospheric Motion Vectors (AMVs) and Trajectories, locally and in near real time, using as input geostationary satellite image data, NWP model data, and OSTIA sea surface temperature data. The whole NWC/GEO software package can be obtained after registration at the NWCSAF Helpdesk, www.nwcsaf.org, where users also find support and help for its use. NWC/GEO v2018.1 software version, available since autumn 2019, is able to process MSG, Himawari-8/9, GOES-N, and GOES-R satellite series images, so that AMVs and trajectories can be calculated all throughout the planet Earth with the same algorithm and quality. Considering other equivalent meteorological products, in the ‘2014 and 2018 AMV Intercomparison Studies’ NWCSAF High Resolution Winds compared very positively with six other AMV algorithms for both MSG and Himawari-8/9 satellites. Finally, the Coordination Group for Meteorological Satellites (CGMS) recognized in its ‘2012 Meeting Report’: (1) NWCSAF High Resolution Winds fulfills the requirements to be a portable stand-alone AMV calculation software due to its easy installation and usability. (2) It has been successfully adopted by some CGMS members and serves as an important tool for development. It is modular, well documented, and well suited as stand-alone AMV software. (3) Although alternatives exist as portable stand-alone AMV calculation software, they are not as advanced in terms of documentation and do not have an existing Helpdesk

    Impact of AVHRR channel 3b noise on climate data records: filtering method applied to the CM SAF CLARA-A2 data record

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    A method for reducing the impact of noise in the 3.7 micron spectral channel in climate data records derived from coarse resolution (4 km) global measurements from the Advanced Very High Resolution Radiometer (AVHRR) data is presented. A dynamic size-varying median filter is applied to measurements guided by measured noise levels and scene temperatures for individual AVHRR sensors on historic National Oceanic and Atmospheric Administration (NOAA) polar orbiting satellites in the period 1982–2001. The method was used in the preparation of the CM SAF cLoud, Albedo and surface RAdiation dataset from AVHRR data—Second Edition (CLARA-A2), a cloud climate data record produced by the EUMETSAT Satellite Application Facility for Climate Monitoring (CM SAF), as well as in the preparation of the corresponding AVHRR-based datasets produced by the European Space Agency (ESA) Climate Change Initiative (CCI) project ESA-CLOUD-CCI. The impact of the noise filter was equivalent to removing an artificial decreasing trend in global cloud cover of 1–2% per decade in the studied period, mainly explained by the very high noise levels experienced in data from the first satellites in the series (NOAA-7 and NOAA-9). View Full-Tex

    Spatial and temporal investigations of reported movements, births and deaths of cattle and pigs in Sweden

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    <p>Abstract</p> <p>Background</p> <p>Livestock movements can affect the spread and control of contagious diseases and new data recording systems enable analysis of these movements. The results can be used for contingency planning, modelling of disease spread and design of disease control programs.</p> <p>Methods</p> <p>Data on the Swedish cattle and pig populations during the period July 2005 until June 2006 were obtained from databases held by the Swedish Board of Agriculture. Movements of cattle and pigs were investigated from geographical and temporal perspectives, births and deaths of cattle were investigated from a temporal perspective and the geographical distribution of holdings was also investigated.</p> <p>Results</p> <p>Most movements of cattle and pigs were to holdings within 100 km, but movements up to 1200 km occurred. Consequently, the majority of movements occurred within the same county or to adjacent counties. Approximately 54% of the cattle holdings and 45% of the pig holdings did not purchase any live animals. Seasonal variations in births and deaths of cattle were identified, with peaks in spring. Cattle movements peaked in spring and autumn. The maximum number of holdings within a 3 km radius of one holding was 45 for cattle and 23 for pigs, with large variations among counties. Missing data and reporting bias (digit preference) were detected in the data.</p> <p>Conclusion</p> <p>The databases are valuable tools in contact tracing. However since movements can be reported up to a week after the event and some data are missing they cannot replace other methods in the acute phase of an outbreak. We identified long distance transports of cattle and pigs, and these findings support an implementation of a total standstill in the country in the case of an outbreak of foot-and-mouth disease. The databases contain valuable information and improvements in data quality would make them even more useful.</p

    The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.

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    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM -/- patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors

    The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

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    Abstract: Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors

    Population growth : analysis of an age structure population model

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    This report presents an analysis of a partial differential equation, resulting from population model with age structure. The existence and uniqueness of a solution to the equation are proved. We look at stability of the solution. The asymptotic behaviour of the solution is treated. The report also contains a section about the connection between the solution to the age structure population model and a simple model without age structure

    Network analysis and optimization of animal transports

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    This thesis is about animal transports and their effect on animal welfare. Transports are needed in today’s system of livestock farming. Long transports are stressful for animals and infectious diseases can spread via animal transports. With optimization methods transport times can be minimized, but there is a trade-off between short distances for the animals and short distances for the trucks. The risk of disease spread in the transport system and disease occurrence at farms can be studied with models and network analysis. The animal transport data and the quality of the data in the Swedish national database of cattle and pig transports are investigated in the thesis. The data is analyzed regarding number of transports, number of farms, seasonality, geographical properties, transport distances, network measures of individual farms and network measures of the system. The data can be used as input parameters in epidemic models. Cattle purchase reports are double reported and we found that there are incorrect and missing reports in the database. The quality is improving over the years i.e. 5% of cattle purchase reports were not correctly double reported in 2006, 3% in 2007 and 1% in 2008. In the reports of births and deaths of cattle we detected date preferences; more cattle births and deaths are reported on the 1st, 10th and 20th each month. This is because when we humans don’t remember the exact number we tend to pick nice numbers (like 1, 10 and 20). This implies that the correct date is not always reported. Network analysis and network measures are suggested as tools to estimate risk for disease spread in transport systems and risk of disease introduction to individual holdings. Network generation algorithms can be used together with epidemic models to test the ability of network measures to predict disease risks. I have developed, and improved, a network generation algorithm that generates a large variety of structures. In my thesis I also suggest a method, the good choice heuristic, for generating non-optimal routes. Today coordination of animal transports is neither optimal nor random. In epidemic simulations we need to model routes as close to the actual driven routes as possible and the good choice heuristic can model that. The heuristic is tuned by two parameters and creates coordination of routes from completely random to almost as good as the Clarke and Wright heuristic. I also used the method to make the rough estimate that transport distances for cattle can be reduced by 2-24% with route-coordination optimization of transports-to-slaughter. Different optimization methods can be used to minimize the transport times for animal-transports in Sweden. For transports-to-slaughter the strategic planning of “which animals to send where” is the first step to optimize. I investigated data from 2008 and found that with strategic planning, given the slaughterhouse capacity, transport distances can be decreased by about 25% for pigs and 40% for cattle. The slaughterhouse capacity and placement are limiting the possibility to minimize transport times for the animals. The transport distances could be decreased by 60% if all animals were sent to the closest slaughterhouse 2008. Small-scale and mobile slaughterhouses have small effect on total transport work (total transport distance for all the animals) but are important for the transport distances of the animals that travel the longest
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