Reasons why Hypertensive Patients Admission to Emergency Services and their Chronic Illness Care Management

The study sample was composed of 200 individuals with hypertension who were admitted to the emergency department of a government hospital. Of the participants, 36.5% presented to the emergency department. Of the participants, those who were older, who had a low education level, who consumed salt without restriction, coffee drinkers, who were not on a diet and who did not receive health education obtained lower scores from the Patient Assessment of Chronic Illness Care scale. Effective discharge planning from hospital to home, home visits and counselling provided by primary health care departments will contribute to a reduction in emergency admissions and to successful chronic disease management.</p

Hybrid approach: an alternative prior to corrective surgery in a patient with arch hypoplasia and complete atrioventricular septal defect

The hybrid approach is mostly preferred in patients with hypoplastic left heart syndrome or univentricular physiology. Here, the hybrid approach is applied as a palliative procedure prior to corrective surgery in a patient with complete atrioventricular septal defect associated with arcus hypoplasia and results are discussed according to the literature

Synthesis, Antibacterial and Antioxidant Activities of Some New Nsubstituted Azachalcone, Schiff base and Pyrazole Derivatives

WOS: 000561219600010Pyrazoles, Schiff bases and the quaternary ammonium compounds (QAC) such as N-alkyl substituted azachalcones are the important group of chemical individuals with widespread usage in many fields of science. in particular, these compounds have proven biological activities. in addition, the emergence of resistance against antibiotics used is the cause of an increasing necessity of new effective substances. Therefore, new N-alkyl substituted derivatives (4-7), 1,3,5-trisubstituted-2-pyrazoles (8-10) and Schiff bases (11-13) with biological activities such as phenolic. antioxidants or QAC were synthesized, starting from azachalcones. the structures of the compounds were elucidated with spectral methods including IR, 1H-NMR, 13C-NMR, COSY spectral data and elemental analyses. the prepared compounds were evaluated for antibacterial activity against four Gram-positive bacteria, and four Gram-negative bacteria. the minimum inhibitory concentration (MIC) of the N-alkylated azachalcone derivatives 5 and 7 (7.8 mg/mL) showed strong antimicrobial activities, especially against Bacillus cereus. Antioxidant capacities of the synthesized compounds were determined by using CU-PRAC and FRAP methods. As a result, compound 9 was observed to be more effective than other compounds

Stem cells combined 3D electrospun nanofibrous and macrochannelled matrices: a preliminary approach in repair of rat cranial bones

Bolgen, Nimet/0000-0003-3162-0803; Meydanli, E. Elif Guzel/0000-0001-9072-3322; Cetinkaya, Duygu Uckan/0000-0003-3593-6493; KILIC, Emine/0000-0003-2984-7638; Weeks, Jason/0000-0001-5537-6927WOS: 000463175200003PubMed: 30942631Repair of cranial bone defects is an important problem in the clinical area. The use of scaffolds combined with stem cells has become a focus in the reconstruction of critical-sized bone defects. Electrospinning became a very attracting method in the preparation of tissue engineering scaffolds in the last decade, due to the unique nanofibrous structure of the electrospun matrices. However, they have a limitation for three dimensional (3D) applications, due to their two-dimensional structure and pore size which is smaller than a cellular diameter which cannot allow cell migration within the structure. In this study, electrospun poly(epsilon-caprolactone) (PCL) membranes were spirally wounded to prepare 3D matrices composed of nanofibers and macrochannels. Mesenchymal stromal/stem cells were injected inside the scaffolds after the constructs were implanted in the cranial bone defects in rats. New bone formation, vascularisation and intramembranous ossification of the critical size calvarial defect were accelerated by using mesenchymal stem cells combined 3D spiral-wounded electrospun matrices.Turkish Academy of SciencesTurkish Academy of SciencesThis study was performed in the context of the EU-FP6-NoE Expertissues Project. Erhan Piskin is supported by Turkish Academy of Sciences as a Honorary Member. This study was a part of PhD thesis of smail Alper isoglu. The thesis was supervised by Erhan Piskin

Development of a Colorimetric Urease Test Based on Au NPS Capped with Anthocyanin for the Rapid Detection of Helicobacter pylori through Multiple Readouts

In this work, we have reported use of anthocyanin capped gold nanoparticles (Ant@Au NPs)-incorporated colorimetric urease test for rapid, sensitive and economic detection of Helicobacter pylori (H. pylori). This test containing Ant@Au NPs, urea, sodium phosphate buffer (PBS) and sodium azide (NaN3) was prepared at pH 5 with red solution owing to dispersity of Ant@Au NPs, urease enzyme secreted from H. pylori cause production of ammonia (NH3) via hydrolysis of urea, then which makes reaction environment alkaline (pH 8.2). The limit of detection for this Ant@Au NPs based urease test was determined to be to 102 CFU/mL with proportional to increasing incubation time. However, distinct color change was observed with 104 CFU/mL H. pylori suspensions in 15 min. The anthocyanin molecules existing on surface of Ant@Au NPs were easily deprotonated from hydroxyl groups in the alkaline condition, which caused various changes on Ant@Au NPs including quite much negative charges on the surface of Ant@Au NPs analyzed by Zeta potential, aggregation of Ant@Au NPs demonstrated by STEM, DLS and spectrophotometer, and turning the color of test solution to purple evaluated by a naked eye and digital process imaging system

Stem Cells Combined 3D Electrospun Nanofibrous And Macrochannelled Matrices: A Preliminary Approach In Repair Of Rat Cranial Bones

Repair of cranial bone defects is an important problem in the clinical area. The use of scaffolds combined with stem cells has become a focus in the reconstruction of critical-sized bone defects. Electrospinning became a very attracting method in the preparation of tissue engineering scaffolds in the last decade, due to the unique nanofibrous structure of the electrospun matrices. However, they have a limitation for three dimensional (3D) applications, due to their two-dimensional structure and pore size which is smaller than a cellular diameter which cannot allow cell migration within the structure. In this study, electrospun poly(epsilon-caprolactone) (PCL) membranes were spirally wounded to prepare 3D matrices composed of nanofibers and macrochannels. Mesenchymal stromal/stem cells were injected inside the scaffolds after the constructs were implanted in the cranial bone defects in rats. New bone formation, vascularisation and intramembranous ossification of the critical size calvarial defect were accelerated by using mesenchymal stem cells combined 3D spiral-wounded electrospun matrices.WoSScopu

A study exploring the autism awareness of first grade nursing and medical students in Istanbul, Turkey

Objective: To assess the level of awareness about childhood autism among first-grade nursing and medical students

Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA)

Introduction: The results of standard chemotherapy in lung cancer are not very satisfactory, so it is important to identify genetic mutations that provide targeted therapies. Recent reports have suggested influences of racial difference on the frequency of mutation in lung cancer. We aimed to determine the frequency and regional distribution of genetic mutations of non-small cell lung cancer (NSCLC) in Turkey

Prevalence of Anosmia in 10.157 Pediatric COVID-19 Cases: Multicenter Study from Turkey.

Introduction: COVID-19-related anosmia is a remarkable and disease-specific finding. With this multicenter cohort study, we aimed to determine the prevalence of anosmia in pediatric cases with COVID-19 from Turkey and make an objective assessment with a smell awareness questionnaire. Material and Methods: This multicenter prospective cohort study was conducted with pediatric infection clinics in 37 centers in 19 different cities of Turkey between October 2020 and March 2021. The symptoms of 10.157 COVID-19 cases 10-18 years old were examined. Age, gender, other accompanying symptoms, and clinical severity of the disease of cases with anosmia and ageusia included in the study were recorded. The cases were interviewed for the smell awareness questionnaire at admission and one month after the illness. Results: Anosmia was present in 12.5% (1.266/10.157) of COVID-19 cases 10-18 years of age. The complete records of 1053 patients followed during the study period were analyzed. The most common symptoms accompanying symptoms with anosmia were ageusia in 885 (84%) cases, fatigue in 534 cases (50.7%), and cough in 466 cases (44.3%). Anosmia was recorded as the only symptom in 84 (8%) of the cases. One month later, it was determined that anosmia persisted in 88 (8.4%) cases. In the smell awareness questionnaire, the score at admission was higher than the score one month later (P < 0.001). Discussion: With this study, we have provided the examination of a large case series across Turkey. Anosmia and ageusia are specific symptoms seen in cases of COVID-19. With the detection of these symptoms, it should be aimed to isolate COVID-19 cases in the early period and reduce the spread of the infection. Such studies are important because the course of COVID-19 in children differs from adults and there is limited data on the prevalence of anosmia