Prizes from the borderlands

What is "the state of the art" as regards the study of literature and oral tradition? That question will have as many answers as there are people to respond. The point most worth making may be that though the battle was lost, the war has been won. By "the battle," what I mean is the heroic attempt made by Milman Parry, Albert B. Lord, and many other scholars during the mid-twentieth century to determine the mode of composition, whether oral or written, of the Homeric epics, Beowulf, and works of a similar character deriving from the ancient or medieval world.Not

Bending Tests of Circular Cylinders of Corrugated Aluminum-alloy Sheet

Bending tests were made of two circular cylinders of corrugated aluminum-alloy sheet. In each test failure occurred by bending of the corrugations in a plane normal to the skin. It was found, after analysis of the effect of short end bays, that the computed stress on the extreme fiber of a corrugated cylinder is in excess of that for a flat panel of the same basic pattern and panel length tested as a pin-ended column. It is concluded that this increased strength was due to the effects of curvature of the pitch line. It is also concluded from the tests that light bulkheads closely spaced strengthen corrugated cylinders very materially

Congestion-clearing payments to passengers

This paper reports on a project that considers whether the goals of (de)congestion pricing could be achieved in whole or in part by incentivizing mode-shift rather than using charging to force it: buying rather than selling decongestion. The project developed a method for estimating the net present value of the costs and benefits of a permanent ITS-enabled program of paying people to travel as passengers rather than as drivers-to reduce existing congestion in a target corridor to a target maximum level of delay-taking into account the mix of the traffic and the potential impact of latent demand and induced trips. This is relevant for making better use of existing infrastructure (a build nothing alternative to expansion, but not a do nothing one), for decarbonizing transport, and in the run up to automated vehicles where the possibility exists that new infrastructure investments in the 1-20-year timeframe will become stranded assets under some future scenarios. The project incorporated: a thorough review of the literature; focus groups; and a survey in a case study corridor in California to test the theory, develop the method, and determine the likely costs and benefits. The main insights include 1) the significance of an \u27intra-peak demand shift\u27 that would occur if congestion was removed; 2) the need for four major components in a congestion-clearing payments program: a) incentives to switch from driving to being a passenger, b) incentives to travel at less preferred times, c) park and ride/pool facilities near the bottleneck to ease the passenger switch, and d) some limitation on single-occupant vehicle travel in the peak-of-the-peak in order to reserve space for vehicles carrying passengers; and 3) the possible need for different land-use regulations in a successful payments to passengers environment where the amount of traffic might no longer be an obvious constraint for expanding the local economy. The case study benefit cost analysis delivers a benefit cost ratio of 4.5 to 1

Congestion-Clearing Payments to Passengers

Peak period motor vehicle traffic volume congests roads all over the world. This project hypothesizes implementing congestion- clearing payments to passengers as a permanent congestion-management solution. Ongoing congestion-free travel would be achieved by removing existing congestion, and absorbing (re)generated demand, at costs that would be expected to increase as the total number of travelers increases over time. The project develops a comprehensive, step-by-step methodology to calculate the benefits and costs of paying for drivers to become passengers at a congestion-clearing level and to maintain this level over time. The method is derived from the literature, analysis by the project team, and development of a case study. The case study, based on a long-standing bottleneck location in California, enabled the project team to think through the real challenges of developing and evaluating such a solution. The project finds that the conceptual underpinning of the solution is sound. Based on a survey, the case study finds that there is a level of payment that could clear congestion and maintain free-flow for twenty years, with benefits that outweigh costs on a net present value basis by about four to one—though calibration is required. After the initial reward clears the queue at the bottleneck, a significant intra-peak demand shift would occur as existing and new travelers depart home at times that are more to their liking, potentially causing the queue to re-form. A second incentive manages time of travel, rewarding people for traveling as passengers earlier (or later) than the preferred high demand peak-of-the-peak. In the case study, the high proportion of people who say they will only drive alone would eventually result in some periods of single-occupant-vehicle-only traffic during peak, which is an unintended and undesirable consequence. For the case study route, a limit on single-occupant-vehicle travel during the peak- of-the-peak would ensure that high-occupancy-vehicle travel is given preference and would reduce the overall cost of the solution. For the case study, the cost of the congestion-clearing payments-to-passengers solution on a net present value basis is within the estimated range of costs of the alternative of expanding the facility, and the benefits are expected to be greater than for facility expansion. Congestion-clearing payments to passengers can be implemented much sooner and will have greater positive long-term economic impacts. Facility expansion would provide lower and shorter-term benefits and would be expected to return to congested conditions within a year. The project team proposes a pilot project on the case study route to test and calibrate the solution, as well as recommending development of further case study routes to find out how different routes vary and determine the causes of any variations

Isotopic Branchpoints : Linkages and Efficiencies in Carbon and Water Budgets

Forests pass water and carbon through while converting portions to streamflow, soil organic matter, wood production, and other ecosystem services. The efficiencies of these transfers are but poorly quantified. New theory and new instruments have made it possible to use stable isotope composition to provide this quantification of efficiencies wherever there is a measurable difference between the branches of a branchpoint. We present a linked conceptual model that relies on isotopes of hydrogen, carbon, and oxygen to describe these branchpoints along the pathway from precipitation to soil and biomass carbon sequestration and illustrate how it can be tested and generalized. Plain Language Summary The way a forest works can be described in terms of carbon and water budgets, which describe the ways that carbon and water flow through the forest. The paths of such flows are frequently branched and the branches are often different in their stable isotope composition. This means that stable isotopes can be used to describe the branching events. We present isotopic methods of quantifying several such events, then link them in a chain that begins with the evaporation of water and ends with biomass production.Non peer reviewe

Setting our sights on infectious diseases

In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings

Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development

Mood stabilising drugs such as lithium (LiCl) and valproic acid (VPA) are the first line agents for treating conditions such as Bipolar disorder and Epilepsy. However, these drugs have potential developmental effects that are not fully understood. This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. Treatment with VPA and LiCl resulted in the differential expression of 331 and 164 genes respectively. In the subset of VPA targeted genes, 114 were downregulated whilst 217 genes were upregulated. In the subset of LiCl targeted genes, 73 were downregulated and 91 were upregulated. Gene ontology (GO) term enrichment analysis was used to highlight the most relevant GO terms associated with a given gene list following toxin exposure. In addition, in order to phenotypically anchor the gene expression data, changes in the heterogeneity of cell subtype populations and cell cycle phase were monitored using flow cytometry. Whilst LiCl exposure did not significantly alter the proportion of cells expressing markers for stem cells/undifferentiated cells (Oct4, SSEA4), neurons (Neurofilament M), astrocytes (GFAP) or cell cycle phase, the drug caused a 1.4-fold increase in total cell number. In contrast, exposure to VPA resulted in significant upregulation of Oct4, SSEA, Neurofilament M and GFAP with significant decreases in both G2/M phase cells and cell number. This neurosphere model might provide the basis of a human-based cellular approach for the regulatory exploration of developmental impact of potential toxic chemicals

First report of the ectomycorrhizal status of boletes on the Northern Yucatan Peninsula, Mexico determined using isotopic methods

Despite their prominent role for tree growth, few studies have examined the occurrence of ectomycorrhizal fungi in lowland, seasonally dry tropical forests (SDTF). Although fruiting bodies of boletes have been observed in a dry tropical forest on the Northern Yucatan Peninsula, Mexico, their occurrence is rare and their mycorrhizal status is uncertain. To determine the trophic status (mycorrhizal vs. saprotrophic) of these boletes, fruiting bodies were collected and isotopically compared to known saprotrophic fungi, foliage, and soil from the same site. Mean δ15N and δ13C values differed significantly between boletes and saprotrophic fungi, with boletes 8.0‰ enriched and 2.5‰ depleted in 15N and 13C, respectively relative to saprotrophic fungi. Foliage was depleted in 13C relative to both boletes and saprotrophic fungi. Foliar δ15N values, on the other hand, were similar to saprotrophic fungi, yet were considerably lower relative to bolete fruiting bodies. Results from this study provide the first isotopic evidence of ectomycorrhizal fungi in lowland SDTF and emphasize the need for further research to better understand the diversity and ecological importance of ectomycorrhizal fungi in these forested ecosystems

Farmers’ perceptions of climate change : identifying types

Ambitious targets to reduce greenhouse gas (GHG) emissions from agriculture have been set by both national governments and their respective livestock sectors. We hypothesize that farmer self-identity influences their assessment of climate change and their willingness to im- plement measures which address the issue. Perceptions of climate change were determined from 286 beef/sheep farmers and evaluated using principal component analysis (PCA). The analysis elicits two components which evaluate identity (productivism and environmental responsibility), and two components which evaluate behavioral capacity to adopt mitigation and adaptation measures (awareness and risk perception). Subsequent Cluster Analyses reveal four farmer types based on the PCA scores. ‘The Productivist’ and ‘The Countryside Steward’ portray low levels of awareness of climate change, but differ in their motivation to adopt pro-environmental behavior. Conversely, both ‘The Environmentalist’ and ‘The Dejected’ score higher in their awareness of the issue. In addition, ‘The Dejected’ holds a high sense of perceived risk; however, their awareness is not conflated with an explicit understanding of agricultural GHG sources. With the exception of ‘The Environmentalist’, there is an evident disconnect between perceptions of agricultural emission sources and their contribution towards GHG emissions amongst all types. If such linkages are not con- ceptualized, it is unlikely that behavioral capacities will be realized. Effective communication channels which encour- age action should target farmers based on the groupings depicted. Therefore, understanding farmer types through the constructs used in this study can facilitate effective and tai- lored policy development and implementation