RMDM: A Multilabel Fakenews Dataset for Vietnamese Evidence Verification

In this study, we present a novel and challenging multilabel Vietnamese dataset (RMDM) designed to assess the performance of large language models (LLMs), in verifying electronic information related to legal contexts, focusing on fake news as potential input for electronic evidence. The RMDM dataset comprises four labels: real, mis, dis, and mal, representing real information, misinformation, disinformation, and mal-information, respectively. By including these diverse labels, RMDM captures the complexities of differing fake news categories and offers insights into the abilities of different language models to handle various types of information that could be part of electronic evidence. The dataset consists of a total of 1,556 samples, with 389 samples for each label. Preliminary tests on the dataset using GPT-based and BERT-based models reveal variations in the models' performance across different labels, indicating that the dataset effectively challenges the ability of various language models to verify the authenticity of such information. Our findings suggest that verifying electronic information related to legal contexts, including fake news, remains a difficult problem for language models, warranting further attention from the research community to advance toward more reliable AI models for potential legal applications.Comment: ISAILD@KSE 202

Antibiotic Resistance Profile and Methicillin-Resistant Encoding Genes of Staphylococcus aureus Strains Isolated from Bloodstream Infection Patients in Northern Vietnam

Background:  Evaluating the antibiotic susceptibility and resistance genes is essential in the clinical management of bloodstream infections (BSIs). Nevertheless, there are still limited studies in Northern Vietnam. AIM: This study aimed to determine the antibiotic resistance profile and methicillin-resistant encoding genes of Staphylococcus aureus (S. aureus) causing BSIs in Northern Vietnam. METHODS: The cross-sectional study was done from December 2012 to June 2014 in two tertiary hospitals in Northern Vietnam. Tests performed at the lab of the hospital. RESULTS:  In 43 S. aureus strains isolating, 53.5 % were MRSA. Distribution of gene for overall, MRSA, and MSSA strains were following: mecA gene (58.1 %; 95.7%, and 15%), femA gene (48.8%, 47.8%, and 50%), femB gene (88.4%, 82.6%, and 95%). Antibiotic resistance was highest in penicillin (100%), followed by erythromycin (65.1%) and clindamycin (60.5%). Several antibiotics were susceptible (100%), including vancomycin, tigecycline, linezolid, quinupristin/dalfopristin. Quinolone group was highly sensitive, include ciprofloxacin (83.7%), levofloxacin (86%) and moxifloxacin (86%). CONCLUSION:  In S. aureus causing BSIs, antibiotic resistance was higher in penicillin, erythromycin, and clindamycin. All strains were utterly susceptible to vancomycin, tigecycline, linezolid, quinupristin/dalfopristin

Antibiotic Resistance Profile and Diversity of Subtypes Genes in Escherichia coli Causing Bloodstream Infection in Northern Vietnam

BACKGROUND: Evaluating the antibiotic susceptibility and resistance genes is essential in the clinical management of bloodstream infections (BSIs). But there are still limited studies in Northern Vietnam. AIM: The aim of the study was to determine the antibiotic resistance profile and characteristics of subtypes genes in Escherichia coli causing BSIs in Northern Vietnam. METHODS: The cross-sectional study was done in the period from December 2012 to June 2014 in two tertiary hospitals in Northern Vietnam. Tests were performed at the lab of the hospital. RESULTS: In 56 E. coli strains isolating 39.29 % produced ESBL. 100% of the isolates harbored blaTEM gene, but none of them had the blaPER gene. The prevalence of ESBL producers and ESBL non-producers in blaCTX-M gene was 81.82%, and 73.53%, in blaSHV gene was 18.18% and 35.29%. Sequencing results showed three blaTEM subtypes (blaTEM 1, 79, 82), four blaCTX-M subtypes (blaCTX-M-15, 73, 98, 161), and eight blaSHV subtypes (blaSHV 5, 7, 12, 15, 24, 33, 57, 77). Antibiotic resistance was higher in ampicillin (85.71%), trimethoprim/sulfamethoxazole (64.29%) and cephazolin (50%). Antibiotics were still highly susceptible including doripenem (96.43%), ertapenem (94.64%), amikacin (96.43%), and cefepime (89.29%). CONCLUSION: In Escherichia coli causing BSIs, antibiotic resistance was higher in ampicillin, trimethoprim/sulfamethoxazole and cephazolin. Antibiotics was highly susceptible including doripenem, ertapenem, amikacin, and cefepime

Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries

Background: The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most dengue infections are asymptomatic, patients can present with a wide spectrum of clinical symptoms ranging from mild febrile illness through to severe manifestations of bleeding, organ impairment, and hypovolaemic shock due to a systemic vascular leak syndrome. Clinical diagnosis of dengue and identification of which patients are likely to develop severe disease remain challenging. This study aims to improve diagnosis and clinical management through approaches designed a) to differentiate between dengue and other common febrile illness within 72 h of fever onset, and b) among patients with dengue to identify markers that are predictive of the likelihood of evolving to a more severe disease course. Method/Design: This is a prospective multi-centre observational study aiming to enrol 7–8000 participants aged ≥ 5 years presenting with a febrile illness consistent with dengue to outpatient health facilities in 8 countries across Asia and Latin America. Patients presenting within 72 h of fever onset who do not exhibit signs of severe disease are eligible for the study. A broad range of clinical and laboratory parameters are assessed daily for up to 6 days during the acute illness, and also at a follow up visit 1 week later. Discussion: Data from this large cohort of patients, enrolled early with undifferentiated fever, will be used to develop a practical diagnostic algorithm and a robust clinical case definition for dengue. Additionally, among patients with confirmed dengue we aim to identify simple clinical and laboratory parameters associated with progression to a more severe disease course. We will also investigate early virological and serological correlates of severe disease, and examine genetic associations in this large heterogeneous cohort. In addition the results will be used to assess the new World Health Organization classification scheme for dengue in practice, and to update the guidelines for “Integrated Management of Childhood Illness” used in dengue-endemic countries. Trial registration: NCT01550016. Registration Date: March 7, 201

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Poprawa badań sejsmicznych w poszukiwaniu ropy naftowej i hydratów gazu w Wietnamie

Located in Southeast Asia, Vietnam has a diverse and complex geology. Seismic methods have solved many different geological tasks such as interpreting geological structure, petroleum and mineral exploration, research gas hydrate, etc. In this report, we present some achievements using Seismic methods for petroleum exploration to find not only structural traps but also stratigraphic traps in sedimentary basins, in non-traditional fractured granite basement reservoirs, and in the initial stage of gas -hydrate exploration. Seismic acquisition methods such as 3D / 4C have been applied effectively. Advanced seismic processing and interpretation methods have been used, such as applying seismic filters (T-P, Radon, SRMA…), seismic imaging (Pre-stack Migration/PSTM, Control Beam Migration/CBM), Seismic Inversion (SI), Amplitude Versus Offset Analysis (AVO), Seismic Sequence Stratigraphy, Seismic Attributies, Artificial Neural Network (ANN), etc. The results seismic interpretation, thereby which lead to enhansed effectiveness of oil and gas exploration programs.Położony w Azji Południowo-Wschodniej Wietnam ma różnorodną i złożoną geologię. Metodami sejsmicznymi rozwiązano wiele różnych zadań geologicznych, takich jak interpretacja struktury geologicznej, poszukiwania ropy naftowej i minerałów, hydratów gazu itp. W niniejszym artykule przedstawiono niektóre osiągnięcia w których wykorzystano metody sejsmiczne do poszukiwań ropy naftowej, w celu określenia zaburzeń strukturalnych, a także stratygraficznych w basenach osadowych, w nietradycyjnych zbiornikach granitowych oraz w początkowej fazie eksploracji gazu i hydratów. Skutecznie zastosowano metody akwizycji sejsmicznej 3D/4C. Zastosowano zaawansowane metody przetwarzania i interpretacji danych sejsmicznych, takie jak stosowanie filtrów sejsmicznych (TP, Radon, SRMA), obrazowanie sejsmiczne (Migracja / PSTM, Migracja wiązki kontrolnej / CBM), Inwersja sejsmiczna (SI), Amplituda kontra przesunięcie (AVO), stratygrafia sekwencji sejsmicznych, atrybuty sejsmiczne, sztuczna sieć neuronowa (ANN) itp. Wyniki interpretacji sejsmicznej pozwalają na osiągnięcie zwiększonej skuteczności programów poszukiwania ropy i gazu

Assessment of Microalbuminuria for Early Diagnosis and Risk Prediction in Dengue Infections

<div><h3>Background</h3><p>Dengue is the most important arboviral infection of humans. Following an initial febrile period, a small proportion of infected patients develop a vasculopathy, with children at particular risk for severe vascular leakage and shock. Differentiation between dengue and other common childhood illnesses is difficult during the early febrile phase, and risk prediction for development of shock is poor. The presence of microalbuminuria is recognized as a useful early predictor for subsequent complications in a number of other disorders with vascular involvement. Significant proteinuria occurs in association with dengue shock syndrome and it is possible that early-phase microalbuminuria may be helpful both for diagnosis of dengue and for identification of patients likely to develop severe disease.</p> <h3>Methodology/Principal Findings</h3><p>We measured formal urine albumin to creatinine ratios (UACRs) in daily samples obtained from a large cohort of children with suspected dengue recruited at two outpatient clinics in Ho Chi Minh City, Vietnam. Although UACRs were increased in the 465 confirmed dengue patients, with a significant time trend showing peak values around the critical period for dengue-associated plasma leakage, urine albumin excretion was also increased in the comparison group of 391 patients with other febrile illnesses (OFI). The dengue patients generally had higher UACRs than the OFI patients, but microalbuminuria, using the conventional cutoff of 30 mg albumin/g creatinine discriminated poorly between the two diagnostic groups in the early febrile phase. Secondly UACRs did not prove useful in predicting either development of warning signs for severe dengue or need for hospitalization.</p> <h3>Conclusion/Significance</h3><p>Low-level albuminuria is common, even in relatively mild dengue infections, but is also present in many OFIs. Simple point-of-care UACR tests are unlikely to be useful for early diagnosis or risk prediction in dengue endemic areas.</p> </div

Conversion of bipolar resistive switching and threshold switching by controlling conductivity behavior and porous volumes of UiO-66 thin films

In the age of big data, a memory with cross-bar array architecture is urgently required to facilitate high-density data storage. To eliminate the sneak path current of integrated circuits, threshold switching-based selectors have been utilized simultaneously with resistive switching memories. In this study, the successful absorption of uric acid (UA) into a UiO-66 matrix was realized at room temperature without any disruption of the host crystalline structure. Fourier transform infrared and Raman spectra revealed the presence of UA based on the interaction of its carbonyl group with the UiO-66 matrix, whereas the diffraction peaks in the X-ray diffraction spectra of the (111) and (200) index planes were slightly shifted to the lower 2θ values, demonstrating the interaction of the UA on the system is occupy porous cages and free volume structures. The occupation of UA in the porous volume of the framework has been estimated by the significant vanishing of surface area from 1299 to 950 cm3 g−1 as well as the almost dismission of UiO-66 porous cages of 12.5 Å by BET analysis. The electronic transitions from linkers to metals and intramolecular between nearest linkers of UA absorbed UiO-66 were heavily reduced via the evidence from photoluminescence spectroscopy. These changes in structural and electronic density lead to the change in the electrical conduction mechanism, operating voltage, and resistive switching characteristics from memory switching to threshold switching corresponding to Ag/UiO-66–PVA/Ag and Ag/UA@UiO-66–PVA/Ag device, respectively. The reduction and vanish of porous cages and free volume restrict the formation management of silver conducting filaments through the UA@UiO-66–PVA matrix. This study provides a new approach to controlling the conversion switching behavior between memory and threshold in metal–organic framework materials for high-density cross-bar architecture

A Prognostic Model for Development of Profound Shock among Children Presenting with Dengue Shock Syndrome

<div><p>Purpose</p><p>To identify risk factors and develop a prediction model for the development of profound and recurrent shock amongst children presenting with dengue shock syndrome (DSS)</p><p>Methods</p><p>We analyzed data from a prospective cohort of children with DSS recruited at the Paediatric Intensive Care Unit of the Hospital for Tropical Disease in Ho Chi Minh City, Vietnam. The primary endpoint was “profound DSS”, defined as ≥2 recurrent shock episodes (for subjects presenting in compensated shock), or ≥1 recurrent shock episodes (for subjects presenting initially with decompensated/hypotensive shock), and/or requirement for inotropic support. Recurrent shock was evaluated as a secondary endpoint. Risk factors were pre-defined clinical and laboratory variables collected at the time of presentation with shock. Prognostic model development was based on logistic regression and compared to several alternative approaches.</p><p>Results</p><p>The analysis population included 1207 children of whom 222 (18%) progressed to “profound DSS” and 433 (36%) had recurrent shock. Independent risk factors for both endpoints included younger age, earlier presentation, higher pulse rate, higher temperature, higher haematocrit and, for females, worse hemodynamic status at presentation. The final prognostic model for “profound DSS” showed acceptable discrimination (AUC=0.69 for internal validation) and calibration and is presented as a simple score-chart.</p><p>Conclusions</p><p>Several risk factors for development of profound or recurrent shock among children presenting with DSS were identified. The score-chart derived from the prognostic models should improve triage and management of children presenting with DSS in dengue-endemic areas.</p></div