The Effectiveness of Digital Marketing: A Case Study of One Bowl Soup MSMEs

Digital marketing is a key factor in facing business competition in the current era. Effective digital marketing strategy implementation could lead MSMEs to maximize the market potential available in social media. Therefore, this research is conducted to investigate the effectiveness of digital marketing implemented for One Bowl Soup. As previous research doesn’t show an actual comparison regarding before and after the suggested strategy implemented, this research does not only overcome the referred limitation, but is not limited to only 2 social medias and comprised of major social medias which has highest active users in Indonesia simultaneously. A qualitative approach is utilized, and customers of One Bowl Soup are collected as samples for this research. It was found that social media usage by enterprises, including MSMEs, would improve the brand awareness of residents towards said enterprise. Moreover, for Instagram, which majority of interviewed sample uses Instagram in their daily life, including searching about local culinary options. After using social media, One Bowl Soup has improved visibility or brand awareness in Batam City, Indonesia, which can be seen from profile traffic insights provided by each social media

Financial Literacy terhadap Financial Satisfaction: Peran Financial Risk Attitude sebagai Variabel Mediasi

Kemampuan seseorang untuk mengelola keuangan pribadinya adalah kunci utama untuk mencapai kepuasan finansial untuk individual. Tingkat keberhasilan pengelolaan keuangan secara pribadi juga dipengaruhi oleh faktor individual seperti literasi keuangan dan sikap terhadap risiko dalam keuangan. Oleh karena itu, dilakukan penelitian untuk menguji faktor-faktor yang memengaruhi kepuasan finansial seseorang. Penelitian ini memperoleh 118 responden sebagai sampel yang berasal dari Kota Batam dan telah berpenghasilan. Data penelitian bersifat primer karena dihasilkan dari kuesioner tertutup yang disajikan dalam google form. Data yang terkumpul dianalisis menggunakan metode partial least square dengan bantuan program SmartPLS. Berdasarkan hasil analisis, ditemukan bahwa financial literacy memengaruhi financial risk attitude secara positif, namun tidak memengaruhi financial satisfaction. Selain itu, financial risk attitude ditemukan tidak memengaruhi financial satisfaction. Penelitian ini juga menguji pengaruh tidak langsung dan tidak menemukan adanya pengaru dari financial literacy terhadap financial satisfaction melalui intervensi financial risk attitude

Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation

Aims: Atrial fibrillation (AF) is increased in patients with heart failure resulting from myocardial infarction (MI). We aimed to determine the effects of chronic ventricular MI in rabbits on the susceptibility to AF, and underlying atrial electrophysiological and Ca2+-handling mechanisms. Methods and results: In Langendorff-perfused rabbit hearts, under beta-adrenergic-stimulation with isoproterenol (1 µM; ISO), 8 weeks MI decreased AF threshold, indicating increased AF-susceptibility. This was associated with increased atrial action potential duration-alternans at 90% repolarisation, by 147%, and no significant change in mean APD or atrial global conduction velocity (n=6-13 non-MI hearts, 5-12 MI). In atrial isolated myocytes, also under beta-stimulation, L-type Ca2+ current (ICaL) density and intracellular Ca2+-transient amplitude were decreased by MI, by 35% and 41%, respectively, and the frequency of spontaneous depolarisations (SDs) was substantially increased. MI increased atrial myocyte size and capacity, and markedly decreased transverse-tubule density. In non-MI hearts perfused with ISO, the ICaL-blocker nifedipine, at a concentration (0.02 µM) causing an equivalent ICaL-reduction (35%) to that from the MI, did not affect AF-susceptibility, and decreased APD. Conclusion: chronic MI in rabbits remodels atrial structure, electrophysiology and intracellular Ca2+-handling. Increased susceptibility to AF by MI, under beta-adrenergic-stimulation, may result from associated production of atrial APD-alternans and SDs, since steady-state APD and global conduction velocity were unchanged under these conditions, and may be unrelated to the associated reduction in whole-cell ICaL. Future studies may clarify potential contributions of local conduction changes, and cellular and sub-cellular mechanisms of alternans, to the increased AF-susceptibility

The Age of the Galactic Disk

I review different methods devised to derive the age of the Galactic Disk, namely the Radio-active Decay (RD), the Cool White Dwarf Luminosity Function (CWDLF), old opne clusters (OOC) and the Color Magnitude Diagram (CMD) of the stars in the solar vicinity. I argue that the disk is likely to be 8-10 Gyr old. Since the bulk of globulars has an age around 13 Gyr, the possibility emerges that the Galaxy experienced a minimum of Star Formation at the end of the halo/bulge formation. This minimum might reflect the time at which the Galaxy started to acquire material to form the disk inside-out.Comment: 10 pages, 4 figure, invited review, in "The chemical evolution of the Milky Way : Stars vs Clusters, Vulcano (Italy), 20-24 September 199

Thick disk kinematics from RAVE and the solar motion

Radial velocity surveys such as the Radial Velocity Experiment (RAVE) provide us with measurements of hundreds of thousands of nearby stars most of which belong to the Galactic thin, thick disk or halo. Ideally, to study the Galactic disks (both thin and thick) one should make use of the multi-dimensional phase-space and the whole pattern of chemical abundances of their stellar populations. In this paper, with the aid of the RAVE Survey, we study the thin and thick disks of the Milky Way, focusing on the latter. We present a technique to disentangle the stellar content of the two disks based on the kinematics and other stellar parameters such as the surface gravity of the stars. Using the Padova Galaxy Model, we checked the ability of our method to correctly isolate the thick disk component from the Galaxy mixture of stellar populations. We introduce selection criteria in order to clean the observed radial velocities from the Galactic differential rotation and to take into account the partial sky coverage of RAVE. We developed a numerical technique to statistically disentangle thin and thick disks from their mixture. We deduce the components of the solar motion relative to the Local Standard of Rest (LSR) in the radial and vertical direction, the rotational lag of the thick disk component relative to the LSR, and the square root of the absolute value of the velocity dispersion tensor for the thick disk alone. The analysis of the thin disk is presented in another paper. We find good agreement with previous independent parameter determinations. In our analysis we used photometrically determined distances. In the Appendix we show that similar values can be found for the thick disk alone as derived in the main sections of our paper even without the knowledge of photometric distances.Comment: accepted on A&A, please see companion paper "THIN disk kinem...

Re-visiting the relations: Galactic thin disc age-velocity dispersion relation

The velocity dispersion of stars in the solar neighbourhood thin disc increases with time after star formation. Nordstrom et al. (2004) is the most recent observational attempt to constrain the age-velocity dispersion relation. They fitted the age-velocity dispersion relations of each Galactic cardinal direction space velocity component, U (towards the Galactic centre), V (in the direction of Galactic rotation) and W (towards the North Galactic Pole), with power laws and interpreted these as evidence for continuous heating of the disc in all directions throughout its lifetime. We re-visit these relations with their data and use Famaey et al. (2005) to show that structure in the local velocity distribution function distorts the in-plane (U and V) velocity distributions away from Gaussian so that a dispersion is not an adequate parametrization of their functions. The age-sigma(W) relation can however be constrained because the sample is well phase-mixed vertically. We do not find any local signature of the stellar warp in the Galactic disc. Vertical disc heating does not saturate at an early stage. Our new result is that a power law is not required by the data: disc heating models that saturate after ~ 4.5 Gyr are equally consistent with observations.Comment: Accepted for publication in MNRAS, 24 pages, 20 figure

Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth

The second most commonly mutated gene in primary microcephaly (MCPH) patients is wd40-repeat protein 62 (wdr62), but the relative contribution of WDR62 function to the growth of major brain lineages is unknown. Here, we use Drosophila models to dissect lineagespecific WDR62 function(s). Interestingly, although neural stem cell (neuroblast)-specific depletion of WDR62 significantly decreased neuroblast number, brain size was unchanged. In contrast, glial lineage-specific WDR62 depletion significantly decreased brain volume. Moreover, loss of function in glia not only decreased the glial population but also non-autonomously caused neuroblast loss.We further demonstrated that WDR62 controls brain growth through lineage-specific interactions with master mitotic signaling kinase, AURKA. Depletion of AURKA in neuroblasts drives brain overgrowth, which was suppressed by WDR62 co-depletion. In contrast, glial-specific depletion of AURKA significantly decreased brain volume, which was further decreased by WDR62 co-depletion. Thus, dissecting relative contributions of MCPH factors to individual neural lineages will be critical for understanding complex diseases such as microcephaly

Activation of a novel natriuretic endocrine system in humans with heart failure

Proguanylin and prouroguanylin are the inactive precursors of guanylin and uroguanylin, natriuretic peptides involved in the regulation of sodium balance. Urinary uroguanylin levels have been found previously to be elevated in patients with HF (heart failure). The aim of the present study was to investigate whether plasma proguanylin and prouroguanylin levels are increased in patients with HF and to evaluate their relationship with cardiac and renal function. In this prospective observational study, we recruited 243 patients with HF (151 men) and 72 healthy controls. In patients with HF, plasma levels of proguanylin [median, 7.2 (range, 0.9–79.0) μg/l] and prouroguanylin [8.3 (1.7–53.0 μg/l)] were both significantly (P<0.0005) higher compared with levels in healthy controls [5.5 (0.4–22.3 μg/l) for proguanylin and 6.3 (2.5–16.9) μg/l for prouroguanylin]. In patients with HF, increased age, a history of hypertension, diabetes and atrial fibrillation, use of diuretics, a higher NYHA (New York Heart Association) class and a lower eGFR (estimated glomerular filtration rate) were significant univariate predictors of proguanylin and prouroguanylin levels. In multivariate analysis, a history of hypertension and low eGFR both had strong independent associations with proguanylin and prouroguanylin levels. Proguanylin and prouroguanylin varied significantly between NYHA class with a trend of increasing plasma concentrations with worsening severity of symptoms. In conclusion, plasma proguanylin and prouroguanylin are elevated in patients with HF. Elevated plasma proguanylin and prouroguanylin levels are associated with hypertension, renal impairment and increasing severity of HF. This novel endocrine system may contribute to the pathophysiology of HF

Tracing the vertical composition of disc galaxies through colour gradients

(Abbreviated) Optical observations of a statistically complete sample of edge-on disc galaxies are used to study the intrinsic vertical colour gradients in the galactic discs, to constrain the effects of population gradients, residual dust extinction and gradients in the galaxies' metal abundance. It appears that the intrinsic vertical colour gradients are either non-existent, or small and relatively constant as a function of position along the galaxies' major axes. Our results are consistent with the absence of any vertical colour gradient in the discs of the early-type sample galaxies. In most galaxies small-scale variations in the magnitude and even the direction of the vertical gradient are observed: at larger galactocentric distances they generally display redder colours with increasing z height, whereas the opposite is often observed in and near the galactic centres. For a significant fraction of our sample galaxies another mechanism in addition to the effects of stellar population gradients is required to explain the magnitude of the observed gradients. The non-zero colour gradients in a significant fraction of our sample galaxies are likely (at least) partially due to residual dust extinction at these z heights, as is also evidenced from the sometimes significant differences between the vertical colour gradients measured on either side of the galactic planes. We suggest that initial vertical metallicity gradients, if any, have likely not been accentuated by accretion or merging events over the lifetimes of our sample galaxies. On the other hand, they may have weakened any existing vertical metallicity gradients, although they also may have left the existing correlations unchanged.Comment: 17 pages LaTeX, incl. 5 embedded postscript figures, resubmitted to MNRAS (referee's comments taken into account