2,584 research outputs found
Mandibular Actinomyces osteomyelitis complicating florid cemento-osseous dysplasia: case report
Abstract
Background
Apart from neoplastic processes, chronic disfiguring and destructive diseases of the mandible are uncommon.
Case Presentation
We report, perhaps for the first time, the simultaneous occurrence of two such conditions in one patient, in a case that emphasizes the importance of bone biopsy in establishing the correct diagnosis. Florid cemento-osseous dysplasia (FCOD) is a chronic, disfiguring condition of the maxillofacial region. This relatively benign disease is primarily observed in middle-aged women of African ancestry. Cervicofacial actinomycosis is an uncommon and progressive infection caused by bacilli of the Actinomyces genus that typically involves intraoral soft tissues but may also involve bone. The accurate diagnosis of actinomycosis is critical for successful treatment. A diagnosis of osteomyelitis caused by Actinomyces bacteria was diagnosed by bone biopsy in a 53 year-old African-American woman with a longstanding history of FCOD after she presented with a new draining ulcer overlying the mandible.
Conclusions
Clinicians should be aware of the possibility of actinomycosis arising in the setting of FCOD, and the importance of bone biopsy and cultures in arriving at a definitive and timely diagnosis.http://deepblue.lib.umich.edu/bitstream/2027.42/112686/1/12903_2011_Article_189.pd
SN 2010jl in UGC 5189: Yet another luminous type IIn supernova in a metal-poor galaxy
We present ASAS data starting 25 days before the discovery of the recent type
IIn SN 2010jl, and we compare its light curve to other luminous IIn SNe,
showing that it is a luminous (M_I ~ -20.5) event. Its host galaxy, UGC 5189,
has a low gas-phase oxygen abundance (12 + log(O/H) = 8.2), which reinforces
the emerging trend that over-luminous core-collapse supernovae are found in the
low-metallicity tail of the galaxy distribution, similar to the known trend for
the hosts of long GRBs. We compile oxygen abundances from the literature and
from our own observations of UGC 5189, and we present an unpublished spectrum
of the luminous type Ic SN 2010gx that we use to estimate its host metallicity.
We discuss these in the context of host metallicity trends for different
classes of core-collapse objects. The earliest generations of stars are known
to be enhanced in [O/Fe] relative to the Solar mixture; it is therefore likely
that the stellar progenitors of these overluminous supernovae are even more
iron-poor than they are oxygen-poor. A number of mechanisms and massive star
progenitor systems have been proposed to explain the most luminous
core-collapse supernovae; any successful theory will need to include the
emerging trend that points towards low-metallicity for the massive progenitor
stars. This trend for very luminous supernovae to strongly prefer
low-metallicity galaxies should be taken into account when considering various
aspects of the evolution of the metal-poor early universe. (abridged)Comment: 27 pages, 7 figures, 2 tables. Accepted for publication in Ap
Measuring the Quantum State of a Large Angular Momentum
We demonstrate a general method to measure the quantum state of an angular
momentum of arbitrary magnitude. The (2F+1) x (2F+1) density matrix is
completely determined from a set of Stern-Gerlach measurements with (4F+1)
different orientations of the quantization axis. We implement the protocol for
laser cooled Cesium atoms in the 6S_{1/2}(F=4) hyperfine ground state and apply
it to a variety of test states prepared by optical pumping and Larmor
precession. A comparison of input and measured states shows typical
reconstruction fidelities of about 0.95.Comment: 4 pages, 6 figures, submitted to PR
The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.
Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously. Group 1 allergens of house dust mites (HDM) are meaningful targets in this quest because they are globally prevalent and clinically important triggers of allergic asthma. Group 1 HDM allergens are cysteine peptidases whose proteolytic activity triggers essential steps in the allergy cascade. Using the HDM allergen Der p 1 as an archetype for structure-based drug discovery, we have identified a series of novel, reversible inhibitors. Potency and selectivity were manipulated by optimizing drug interactions with enzyme binding pockets, while variation of terminal groups conferred the physicochemical and pharmacokinetic attributes required for inhaled delivery. Studies in animals challenged with the gamut of HDM allergens showed an attenuation of allergic responses by targeting just a single component, namely, Der p 1. Our findings suggest that these inhibitors may be used as novel therapies for allergic asthma
"Author! Author!" : Shakespeare and biography
Original article can be found at: http://www.informaworld.com/smpp/title~content=t714579626~db=all Copyright Informa / Taylor & Francis Group. DOI: 10.1080/17450910902764454Since 1996, not a year has passed without the publication of at least one Shakespeare biography. Yet for many years the place of the author in the practice of understanding literary works has been problematized, and even on occasions eliminated. Criticism reads the “works”, and may or may not refer to an author whose “life” contributed to their meaning. Biography seeks the author in the works, the personality that precedes the works and gives them their characteristic shape and meaning. But the form of literary biography addresses the unusual kind of “life” that puts itself into “works”, and this is particularly challenging where the “works” predominate massively over the salient facts of the “life”. This essay surveys the current terrain of Shakespeare biography, and considers the key questions raised by the medium: can we know anything of Shakespeare's “personality” from the facts of his life and the survival of his works? What is the status of the kind of speculation that inevitably plays a part in biographical reconstruction? Are biographers in the end telling us as much about themselves as they tell us about Shakespeare?Peer reviewe
Status of the GEO600 gravitational wave detector
The GEO600 laser interferometric gravitational wave detector is approaching the end of its commissioning phase which started in 1995.During a test run in January 2002 the detector was operated for 15 days in a power-recycled michelson configuration. The detector and environmental data which were acquired during this test run were used to test the data analysis code. This paper describes the subsystems of GEO600, the status of the detector by August 2002 and the plans towards the first science run
A blind detection of a large, complex, Sunyaev--Zel'dovich structure
We present an interesting Sunyaev-Zel'dovich (SZ) detection in the first of
the Arcminute Microkelvin Imager (AMI) 'blind', degree-square fields to have
been observed down to our target sensitivity of 100{\mu}Jy/beam. In follow-up
deep pointed observations the SZ effect is detected with a maximum peak
decrement greater than 8 \times the thermal noise. No corresponding emission is
visible in the ROSAT all-sky X-ray survey and no cluster is evident in the
Palomar all-sky optical survey. Compared with existing SZ images of distant
clusters, the extent is large (\approx 10') and complex; our analysis favours a
model containing two clusters rather than a single cluster. Our Bayesian
analysis is currently limited to modelling each cluster with an ellipsoidal or
spherical beta-model, which do not do justice to this decrement. Fitting an
ellipsoid to the deeper candidate we find the following. (a) Assuming that the
Evrard et al. (2002) approximation to Press & Schechter (1974) correctly gives
the number density of clusters as a function of mass and redshift, then, in the
search area, the formal Bayesian probability ratio of the AMI detection of this
cluster is 7.9 \times 10^4:1; alternatively assuming Jenkins et al. (2001) as
the true prior, the formal Bayesian probability ratio of detection is 2.1
\times 10^5:1. (b) The cluster mass is MT,200 = 5.5+1.2\times 10^14h-1M\odot.
(c) Abandoning a physical model with num- -1.3 70 ber density prior and instead
simply modelling the SZ decrement using a phenomenological {\beta}-model of
temperature decrement as a function of angular distance, we find a central SZ
temperature decrement of -295+36 {\mu}K - this allows for CMB primary
anisotropies, receiver -15 noise and radio sources. We are unsure if the
cluster system we observe is a merging system or two separate clusters.Comment: accepted MNRAS. 12 pages, 9 figure
Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva
BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life. DNA methylation may be the underlying association between prenatal cortisol exposure and health effects. We investigated associations between maternal CRH levels and epigenome-wide DNA methylation of cord blood in offsprings and evaluated whether these associations persisted into mid-childhood.MethodsWe investigated mother-child pairs enrolled in the prospective Project Viva pre-birth cohort. We measured DNA methylation in 257 umbilical cord blood samples using the HumanMethylation450 Bead Chip. We tested associations of maternal CRH concentration with cord blood cells DNA methylation, adjusting the model for maternal age at enrollment, education, maternal race/ethnicity, maternal smoking status, pre-pregnancy body mass index, parity, gestational age at delivery, child sex, and cell-type composition in cord blood. We further examined the persistence of associations between maternal CRH levels and DNA methylation in children's blood cells collected at mid-childhood (n = 239, age: 6.7-10.3 years) additionally adjusting for the children's age at blood drawn.ResultsMaternal CRH levels are associated with DNA methylation variability in cord blood cells at 96 individual CpG sites (False Discovery Rate <0.05). Among the 96 CpG sites, we identified 3 CpGs located near the LEP gene. Regional analyses confirmed the association between maternal CRH and DNA methylation near LEP. Moreover, higher maternal CRH levels were associated with higher blood-cell DNA methylation of the promoter region of LEP in mid-childhood (P < 0.05, β = 0.64, SE = 0.30).ConclusionIn our cohort, maternal CRH was associated with DNA methylation levels in newborns at multiple loci, notably in the LEP gene promoter. The association between maternal CRH and LEP DNA methylation levels persisted into mid-childhood
Multiplicity Structure of the Hadronic Final State in Diffractive Deep-Inelastic Scattering at HERA
The multiplicity structure of the hadronic system X produced in
deep-inelastic processes at HERA of the type ep -> eXY, where Y is a hadronic
system with mass M_Y< 1.6 GeV and where the squared momentum transfer at the pY
vertex, t, is limited to |t|<1 GeV^2, is studied as a function of the invariant
mass M_X of the system X. Results are presented on multiplicity distributions
and multiplicity moments, rapidity spectra and forward-backward correlations in
the centre-of-mass system of X. The data are compared to results in e+e-
annihilation, fixed-target lepton-nucleon collisions, hadro-produced
diffractive final states and to non-diffractive hadron-hadron collisions. The
comparison suggests a production mechanism of virtual photon dissociation which
involves a mixture of partonic states and a significant gluon content. The data
are well described by a model, based on a QCD-Regge analysis of the diffractive
structure function, which assumes a large hard gluonic component of the
colourless exchange at low Q^2. A model with soft colour interactions is also
successful.Comment: 22 pages, 4 figures, submitted to Eur. Phys. J., error in first
submission - omitted bibliograph
Differential (2+1) Jet Event Rates and Determination of alpha_s in Deep Inelastic Scattering at HERA
Events with a (2+1) jet topology in deep-inelastic scattering at HERA are
studied in the kinematic range 200 < Q^2< 10,000 GeV^2. The rate of (2+1) jet
events has been determined with the modified JADE jet algorithm as a function
of the jet resolution parameter and is compared with the predictions of Monte
Carlo models. In addition, the event rate is corrected for both hadronization
and detector effects and is compared with next-to-leading order QCD
calculations. A value of the strong coupling constant of alpha_s(M_Z^2)=
0.118+- 0.002 (stat.)^(+0.007)_(-0.008) (syst.)^(+0.007)_(-0.006) (theory) is
extracted. The systematic error includes uncertainties in the calorimeter
energy calibration, in the description of the data by current Monte Carlo
models, and in the knowledge of the parton densities. The theoretical error is
dominated by the renormalization scale ambiguity.Comment: 25 pages, 6 figures, 3 tables, submitted to Eur. Phys.
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