13,081 research outputs found

    Shock-Wave Heating Model for Chondrule Formation: Prevention of Isotopic Fractionation

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    Chondrules are considered to have much information on dust particles and processes in the solar nebula. It is naturally expected that protoplanetary disks observed in present star forming regions have similar dust particles and processes, so study of chondrule formation may provide us great information on the formation of the planetary systems. Evaporation during chondrule melting may have resulted in depletion of volatile elements in chondrules. However, no evidence for a large degree of heavy-isotope enrichment has been reported in chondrules. In order to meet this observed constraint, the rapid heating rate at temperatures below the silicate solidus is required to suppress the isotopic fractionation. We have developed a new shock-wave heating model taking into account the radiative transfer of the dust thermal continuum emission and the line emission of gas molecules and calculated the thermal history of chondrules. We have found that optically-thin shock waves for the thermal continuum emission from dust particles can meet the rapid heating constraint, because the dust thermal emission does not keep the dust particles high temperature for a long time in the pre-shock region and dust particles are abruptly heated by the gas drag heating in the post-shock region. We have also derived the upper limit of optical depth of the pre-shock region using the radiative diffusion approximation, above which the rapid heating constraint is not satisfied. It is about 1 - 10.Comment: 58 pages, including 5 tables and 15 figures, accepted for publication in The Astrophysical Journa

    Microbial diversity in individuals and their household contacts following typical antibiotic courses.

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    BackgroundAntibiotics are a mainstay of treatment for bacterial infections worldwide, yet the effects of typical antibiotic prescriptions on human indigenous microbiota have not been thoroughly evaluated. We examined the effects of the two most commonly prescribed antibiotics (amoxicillin and azithromycin) in the USA to discern whether short-term antibiotic courses may have prolonged effects on human microbiota.ResultsWe sampled the feces, saliva, and skin specimens from a cohort of unrelated, cohabitating individuals over 6 months. An individual in each household was given an antibiotic, and the other a placebo to discern antibiotic impacts on microbiota, as well as determine whether antibiotic use might reshape the microbiota of each household. We observed household-specific patterns of microbiota on each body surface, which persevered despite antibiotic perturbations. While the gut microbiota within an individual became more dissimilar over time, there was no evidence that the use of antibiotics accelerated this process when compared to household members. There was a significant change in microbiota diversity in the gut and mouth in response to antibiotics, but analogous patterns were not observed on the skin. Those who received 7 days of amoxicillin generally had greater reductions in diversity compared to those who received 3 days, in contrast to those who received azithromycin.ConclusionsAs few as 3 days of treatment with the most commonly prescribed antibiotics can result in sustained reductions in microbiota diversity, which could have implications for the maintenance of human health and resilience to disease

    Testing LSST dither strategies for Survey Uniformity and Large-Scale Structure Systematics

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    The Large Synoptic Survey Telescope (LSST) will survey the southern sky from 2022{2032 with unprecedented detail. Since the observing strategy can lead to artifacts in the data, we investigate the eects of telescope-pointing osets (called dithers) on the r-band coadded 5 depth yielded after the 10-year survey. We analyze this survey depth for several geometric patterns of dithers (e.g.,random, hexagonal lattice, spiral) with amplitude as large as the radius of the LSST eld-of-view, implemented on dierent timescales (per season, per night, per visit). Our results illustrate that per night and per visit dither assignments are more eective than per season. Also, we find that some dither geometries (e.g., hexagonal lattice) are particularly sensitive to the timescale on whichthe dithers are implemented, while others like random dithers perform well on all timescales. We then model the propagation of depth variations to articial uctuations in galaxy counts, which are a systematic for large-scale structure studies. We calculate the bias in galaxy counts caused by the observing strategy, accounting for photometric calibration uncertainties, dust extinction, and magnitude cuts; uncertainties in this bias limit our ability to account for structure induced by the observing strategy. We nd that after 10 years of the LSST survey, the best dither strategies lead to uncertainties in this bias smaller than the minimum statistical floor for a galaxy catalog as deep asr<27.5. A few of these strategies bring the uncertainties close to the statistical floor for r<25.7 after only one year of survey.Fil: Awan, Humna. Rutgers University; Estados UnidosFil: Gawiser, Eric. Rutgers University; Estados UnidosFil: Kurczynski, Peter. Rutgers University; Estados UnidosFil: Lynne Jones, R.. University of Washington; Estados UnidosFil: Zhan, Hu. Chinese Academy of Sciences; República de ChinaFil: Padilla, Nelson David. Pontificia Universidad Católica de Chile; ChileFil: Muñoz Arancibia, Alejandra M.. Pontificia Universidad Católica de Chile; ChileFil: Orsi, Alvaro. Centro de Estudios de Fisica del Cosmos de Aragon; EspañaFil: Cora, Sofia Alejandra. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica la Plata; ArgentinaFil: Yoachim, Peter. University of Washington; Estados Unido

    Isolation and characterization of the full-length cDNA encoding a member of a novel cytochrome p450 family (CYP320A1) from the tropical freshwater snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni

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    Cytochrome p450s (cyp450s) are a family of structurally related proteins, with diverse functions, including steroid synthesis and breakdown of toxins. This paper reports the full-length sequence of a novel cyp450 gene, the first to be isolated from the tropical freshwater snail Biomphalaria glabrata, an important intermediate host of Schistosoma mansoni. The nucleotide sequence is 2291 bp with a predicted amino acid sequence of 584aa. The sequence demonstrates conserved cyp450 structural motifs, but is sufficiently different from previously reported cyp450 sequences to be given a new classification, CYP320A1. Initially identified as down-regulated in partially resistant snails in response to S. mansoni infection, amplification of this gene using RT-PCR in both totally resistant or susceptible snail lines when exposed to infection, and all tissues examined, suggests ubiquitous expression. Characterization of the first cyp450 from B. glabrata is significant in understanding the evolution of these metabolically important proteins

    Implementation of a Deutsch-like quantum algorithm utilizing entanglement at the two-qubit level, on an NMR quantum information processor

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    We describe the experimental implementation of a recently proposed quantum algorithm involving quantum entanglement at the level of two qubits using NMR. The algorithm solves a generalisation of the Deutsch problem and distinguishes between even and odd functions using fewer function calls than is possible classically. The manipulation of entangled states of the two qubits is essential here, unlike the Deutsch-Jozsa algorithm and the Grover's search algorithm for two bits.Comment: 4 pages, two eps figure

    Rental Discrimination in the Multi-ethnic Metropolis: Evidence from Sydney

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    © 2016 Editorial Board, Urban Policy and Research. Investigating differential treatment in rental housing markets is important to ensure that renters are not discriminated against based on their personal characteristics. However, little Australian research has focused systematically on this question. This paper reports the results of a study that used paired tests to estimate the extent of differential treatment of Anglo, Indian, and Muslim Middle Eastern renters in the Sydney metropolitan housing market. We find statistically significant differences in treatment on several measures, including the likelihood an agent will offer an individual appointment, will provide additional information about other housing, will provide additional information about completing the application form, and will contact a prospective renter after an inspection

    The effect of type I migration on the formation of terrestrial planets in hot-Jupiter systems

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    Context: Our previous models of a giant planet migrating through an inner protoplanet/planetesimal disk find that the giant shepherds a portion of the material it encounters into interior orbits, whilst scattering the rest into external orbits. Scattering tends to dominate, leaving behind abundant material that can accrete into terrestrial planets. Aims: We add to the possible realism of our model by simulating type I migration forces which cause an inward drift, and strong eccentricity and inclination damping of protoplanetary bodies. This extra dissipation might be expected to enhance shepherding at the expense of scattering, possibly modifying our previous conclusions. Methods: We employ an N-body code that is linked to a viscous gas disk algorithm capable of simulating: gas accretion onto the central star; gap formation in the vicinity of the giant planet; type II migration of the giant planet; type I migration of protoplanets; and the effect of gas drag on planetesimals. We use the code to re-run three scenarios from a previous work where type I migration was not included. Results: The additional dissipation introduced by type I migration enhances the inward shepherding of material but does not severely reduce scattering. We find that > 50% of the solids disk material still survives the migration in scattered exterior orbits: most of it well placed to complete terrestrial planet formation at < 3 AU. The shepherded portion of the disk accretes into hot-Earths, which survive in interior orbits for the duration of our simulations. Conclusions: Water-rich terrestrial planets can form in the habitable zones of hot-Jupiter systems and hot-Earths and hot-Neptunes may also be present. These systems should be targets of future planet search missions.Comment: Accepted by A&A. 15 pages, 14 figures. Higher resolution pdf available at http://www.users.globalnet.co.uk/~mfogg/7950fogg.pd

    Incomplete reversibility of estimated glomerular filtration rate decline following tenofovir disoproxil fumarate exposure.

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    BACKGROUND: Tenofovir disoproxil fumarate (TDF) has been linked to renal impairment, but the extent to which this impairment is reversible is unclear. We aimed to investigate the reversibility of renal decline during TDF therapy. METHODS: Cox proportional hazards models assessed factors associated with discontinuing TDF in those with an exposure duration of >6 months. In those who discontinued TDF therapy, linear piecewise regression models estimated glomerular filtration rate (eGFR) slopes before initiation of, during, and after discontinuation of TDF therapy. Factors associated with not achieving eGFR recovery 6 months after discontinuing TDF were assessed using multivariable logistic regression. RESULTS: We observed declines in the eGFR during TDF exposure (mean slopes, -15.7 mL/minute/1.73 m(2)/year [95% confidence interval {CI}, -20.5 to -10.9] during the first 3 months and -3.1 mL/minute/1.73 m(2)/year [95% CI, -4.6 to -1.7] thereafter) and evidence of eGFR increases following discontinuation of TDF therapy (mean slopes, 12.5 mL/minute/1.73 m(2)/year [95% CI, 8.9-16.1] during the first 3 months and 0.8 mL/minute/1.73 m(2)/year [95% CI,.1-1.5] thereafter). Following TDF discontinuation, 38.6% of patients with a decline in the eGFR did not experience recovery. A higher eGFR at baseline, a lower eGFR after discontinuation of TDF therapy, and more-prolonged exposure to TDF were associated with an increased risk of incomplete recovery 6 months after discontinuation of TDF therapy. CONCLUSIONS: This study shows that a decline in the eGFR during TDF therapy was not fully reversible in one third of patients and suggests that prolonged TDF exposure at a low eGFR should be avoided
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