The effects of hypophysectomy on osmoregulation in the euryhaline flounder Platichthys flesus (L.)

Euryhaline teleostean fish. Inhabit a range of aquatic environments in which the external osmolality varies from less than Im0sm/kg in freshwater to circa l000m0sm/kg in sea water. Teleosts in hypoosmotic media are subject to an osmotic influx of water and a passive efflux of electrolytes, whereas in hyperosmotic conditions these fluxes operate in the reverse direction. Against these adverse effects euryhaline teleosts are able to maintain a regulated internal osmolality within the region of 300m0sm/kg. A homeostatic control of water content and electrolyte composition is achieved by the activities of the three osmo(iono-)regulatory organs - the gill, gut and kidney. A scheme for teleostean osmoregulation was proposed originally by Smith (1930, 1932) and Krogh (l939). Comprehensive reviews of more recent advances in this field are available (Black, 1957; Potts and Parry, 1964; Parry, 1966; Maetz, 1968,1970a; Potts, 1968; Conte, 1969; Hickman and Trump, 1969; Holmes and Donaldson, 1969). In sea water teleosts an osmotic efflux of water is compensated by the drinking and subsequent intestinal absorption of the external medium. Monovalent ions absorbed from the gut are excreted at the gill and divalent ions are lost primarily via the kidney, which also conserves water. In freshwater teleosts drinking is reduced and the osmotic influx of water is excreted by the kidney, which conserves ions to 2 produce a copious, dilute urine. The passive efflux and renal depletion of ions is compensated by their active absorption by the gill from the external medium

Multi-layer and heterogeneous integrated photonics

Integrated photonic circuits are the optical analog to the ubiquitous electronic integrated circuits that are found in many everyday items. Much like their electronic analog, photonic integrated circuits have enabled the miniaturization of many complex optical systems and result in smaller size, less power consumption, reduced cost, and larger bandwidths. As the field of integrated photonics has matured, the complexity, desired capabilities, and library of material platforms have expanded. This expanded library of materials has allowed certain materials to be used for specific applications based on the strengths of their intrinsic properties. Such an approach inevitably leads to design trade-offs because any complex optical system will require optimal performance in a variety of optical properties. In this thesis, I will explore heterogeneous design via multi-layer integration using mature integrated photonic material platforms. I will demonstrate that a heterogeneous platform realized through multi-layer integration enables linear and nonlinear performance that cannot be achieved using a single-layer approach through various nonlinear optical demonstrations such as high-speed optical parametric gain, ring resonator enhanced four-wave mixing, and photon-pair generation via spontaneous four-wave mixing. In the second part of this thesis, I will add to the current library of integrated photonic material platforms through the investigation of a new material platform, niobium-tantalum oxide, for integrated photonics. I will demonstrate the utility of this material for linear and nonlinear optical applications and show that it is an ideal material for heterogeneous multi-layer integration

What is the effect of alcohol consumption on the risk of chronic widespread pain? : A Mendelian randomisation study using UK Biobank

This research has been conducted using the UK Biobank resource, application no. 1144, and was funded by the University of Aberdeen. MF is funded by the EU FP7 project PainOmics (contract #602736). The authors have no conflicts of interest to declarePeer reviewedPostprin

Quantifying and predicting the effect of anti-TNF therapy on axSpA-related fatigue : Results from the BSRBR-AS registry and meta-analysis

We are grateful to the staff of the British Society for Rheumatology Biologics Register in Axial Spondyloarthritis register and to the recruiting staff at the clinical centres, details of which are available at: https://www.abdn.ac.uk/iahs/research/epidemiology/spondyloarthritis.php#panel1011. Funding: This work was supported by the British Society for Rheumatology (BSR) who have funded the BSRBR-AS. The BSR received funding for this from Pfizer, AbbVie and UCB. These companies receive advance copies of manuscripts for comments but have no input in to the topics for analysis in the register nor the work involved in undertaking analysis. Analysis of data was supported by the Versus Arthritis/Medical Research Council Centre for Musculoskeletal Health and Work [grant number 20665].Peer reviewedPublisher PD

Maintaining musculoskeletal health using a behavioural therapy approach : a population-based randomised controlled trial (the MAmMOTH Study)

Acknowledgements: The study was funded by Arthritis Research UK (now Versus Arthritis) grant number: 20748. Costs for delivery of the intervention were provided by NHS Grampian, NHS Greater Glasgow and Clyde, and NHS Highland. The funder of the study had no role in the study design, data collection, data analysis, data interpretation, or writing of the report. We acknowledge the contribution of the trial steering committee to the successful conduct of the study. The members were Professor Ernest Choy (Cardiff University), Professor Tamar Pincus (Royal Holloway, University of London) and Gordon Taylor (Bath University). We thank Brian Taylor and Mark Forrest from the Centre for Healthcare Randomised Trials (CHaRT) at the University of Aberdeen for their technical assistance and Professor Graeme MacLennan, Director of CHaRT, for methodological input. Professor John Norrie (originally University of Aberdeen now University of Edinburgh) and Dr. Majid Artus (originally Keele University, now the Osmaston surgery, Derbyshire) were study investigators at the time of grant award but subsequently left the study. We thank Kathy Longley (a representative of Fibromyalgia Action UK) for her input to the grant application and the project as well as from members of the public on the University of Aberdeen College of Life Sciences and Medicine Research Interest Group. The prioritisation of “Prevention of chronic pain” arose from a 2012 meeting of the Arthritis Research UK Clinical Study Group in Pain to which patients contributed.Peer reviewedPostprintsupplementary_datasupplementary_dat

Therapists’ experiences of remotely delivering cognitive-behavioural or graded-exercise interventions for fatigue: a qualitative evaluation

Objectives: Fatigue is a challenging feature of all inflammatory rheumatic diseases. LIFT (Lessening the Impact of Fatigue in inflammatory rheumatic diseases: a randomised Trial) included remotely delivered personalised exercise programme (PEP) or cognitive-behavioural approach (CBA) interventions. The aim of this nested qualitative evaluation was to understand rheumatology health professionals (therapists’) perspectives of delivering the interventions in the LIFT trial. Methods: A subgroup of therapists who had delivered the PEP and CBA interventions took part in semi-structured telephone interviews. Results: Seventeen therapists (13 women, 4 men) who delivered PEP (n = 8) or CBA (n = 9) interventions participated. Five themes were identified: In ‘The benefits of informative, structured training’, therapists described how they were able to practice their skills, and the convenience of having the LIFT manual to refer to. When ‘Getting into the swing of it’, supporting patients gave therapists the confidence to tailor the content of the manual to each patient. Clinical supervision supported therapists to gain feedback and request assistance when required. In ‘Delivering the intervention’ therapists reported that patients valued the opportunity to address their fatigue and challenge their own beliefs. ‘Challenges in delivering the LIFT intervention’ therapists struggled to work collaboratively with patients who lacked motivation or stopped engaging. Finally, ‘Lift developing clinical skills’ therapists gained confidence and professional satisfaction seeing patients’ fatigue improve. Conclusion: Findings support the value of skills training for rheumatology health professionals to deliver a remote fatigue management intervention tested in the LIFT trial. These insights can inform service provision and clinical practice Lay summary What does this mean for patients ? Fatigue can be a challenge in inflammatory rheumatic diseases (IRDs). The LIFT study (Lessening the Impact of Fatigue in inflammatory rheumatic diseases: a randomized Trial) explored interventions to support people with fatigue. These were: a cognitive-behavioural approach (CBA), a personalized exercise programme (PEP), or usual care. People with IRDs were chosen randomly to take part in seven sessions of CBA, seven sessions of PEP or usual care. All sessions (aside from the first PEP session) were delivered over the phone. The aim of this study was to explore therapists' experiences of delivering the intervention. Seventeen therapists (13 women and 4 men) took part; eight had delivered the PEP intervention, and 9 delivered the CBA intervention. Therapists who delivered LIFT told us they enjoyed the chance to practice their skills, and that the LIFT manual gave them the confidence to tailor the intervention to each patient. Clinical supervision was valued. Therapists also shared that LIFT improved their skills and they were happy to see patients' fatigue improve over time. These new results can inform clinical practice, and how services are provided

Physiological responses to an intensified period of rugby league competition

This study investigated the physiological responses to an intensified period of rugby league competition and the subsequent impact on match performance. The participants were 7 rugby league players competing in an international student tournament. The tournament involved three 80-minute games over a 5-day period, with 48 hours between each match. Baseline measures of upper and lower body neuromuscular functions via a plyometric press-up (PP) and countermovement jump (CMJ), respectively (peak power and peak force were measured), blood creatine kinase (CK), and perceptions of well-being were assessed with a questionnaire. These measures were repeated every morning of the competition; neuromuscular fatigue and CK were additionally assessed within 2 hours after the cessation of each game. During each match, player movements were recorded via global positioning system units. There were meaningful reductions in upper (effect size [ES] = 20.55) and lower body (ES = 20.73) neuromuscular functions, and perceptual well-being (ES = 21.56) and increases in blood CK (ES = 2.32) after game 1. These changes increased in magnitude as the competition progressed. There were large reductions in the relative distance covered in high-speed running (ES = 21.49) and maximal accelerations (ES = 20.85) during game 3. Additionally, moderate reductions in the percentage of successful tackles completed were observed during game 3 (ES = 20.59). Collectively, these results demonstrate that during an intensified period of rugby league competition, characterized by only 48 hours between matches, fatigue will accumulate. This cumulative fatigue may compromise highintensity match activities such as high-speed running, accelerations, and tackling. Furthermore, CMJs and PPs appear to be sensitive measures for monitoring neuromuscular function in rugby league players

International variation in neighborhood walkability, transit, and recreation environments using geographic information systems: The IPEN adult study

Background: The World Health Organization recommends strategies to improve urban design, public transportation, and recreation facilities to facilitate physical activity for non-communicable disease prevention for an increasingly urbanized global population. Most evidence supporting environmental associations with physical activity comes from single countries or regions with limited variation in urban form. This paper documents variation in comparable built environment features across countries from diverse regions. Methods: The International Physical Activity and the Environment Network (IPEN) study of adults aimed to measure the full range of variation in the built environment using geographic information systems (GIS) across 12 countries on 5 continents. Investigators in Australia, Belgium, Brazil, Colombia, the Czech Republic, Denmark, China, Mexico, New Zealand, Spain, the United Kingdom, and the United States followed a common research protocol to develop internationally comparable measures. Using detailed instructions, GIS-based measures included features such as walkability (i.e., residential density, street connectivity, mix of land uses), and access to public transit, parks, and private recreation facilities around each participant's residential address using 1-km and 500-m street network buffers. Results: Eleven of 12 countries and 15 cities had objective GIS data on built environment features. We observed a 38-fold difference in median residential densities, a 5-fold difference in median intersection densities and an 18-fold difference in median park densities. Hong Kong had the highest and North Shore, New Zealand had the lowest median walkability index values, representing a difference of 9 standard deviations in GIS-measured walkability. Conclusions: Results show that comparable measures can be created across a range of cultural settings revealing profound global differences in urban form relevant to physical activity. These measures allow cities to be ranked more precisely than previously possible. The highly variable measures of urban form will be used to explain individuals' physical activity, sedentary behaviors, body mass index, and other health outcomes on an international basis. Present measures provide the ability to estimate dose-response relationships from projected changes to the built environment that would otherwise be impossible

The Cold Peace: Russo-Western Relations as a Mimetic Cold War

In 1989–1991 the geo-ideological contestation between two blocs was swept away, together with the ideology of civil war and its concomitant Cold War played out on the larger stage. Paradoxically, while the domestic sources of Cold War confrontation have been transcended, its external manifestations remain in the form of a ‘legacy’ geopolitical contest between the dominant hegemonic power (the United States) and a number of potential rising great powers, of which Russia is one. The post-revolutionary era is thus one of a ‘cold peace’. A cold peace is a mimetic cold war. In other words, while a cold war accepts the logic of conflict in the international system and between certain protagonists in particular, a cold peace reproduces the behavioural patterns of a cold war but suppresses acceptance of the logic of behaviour. A cold peace is accompanied by a singular stress on notions of victimhood for some and undigested and bitter victory for others. The perceived victim status of one set of actors provides the seedbed for renewed conflict, while the ‘victory’ of the others cannot be consolidated in some sort of relatively unchallenged post-conflict order. The ‘universalism’ of the victors is now challenged by Russia's neo-revisionist policy, including not so much the defence of Westphalian notions of sovereignty but the espousal of an international system with room for multiple systems (the Schmittean pluriverse)