Energy Performance Certification of Faculty Buildings in Spain: The gap between estimated and real energy consumption

A systematic method has been established to perform and analyse in detail the Energy Performance Certification of 21 Faculty Buildings located at the University of Zaragoza (Spain), according to the transposition of Directive 2010/31/EU. First of all, the problem background and a review of the state-of-the-art of the energy certification in buildings is outlined, regarding both the actual state of the Government regulations and the studies undertaken in several countries to assess the energy performance of different types of buildings, residential and non-residential. A summary of the causes found in other studies for the discrepancies between the estimated (by simulation) and actual energy consumption is shown which is afterwards tested and compared with the results found in the present study. Thereafter, the method followed to undertake the buildings’ Energy Performance Certification is explained, and the main results found together with the discussion are detailed, comparing actual vs. estimated energy consumption in the different case studies and proposing reasons for these deviations. The energy consumption breakdown by uses for several buildings is also analysed, and potential improvements for the simulation software are assessed

A Phase I/II Clinical Trial to evaluate the efficacy of baricitinib to prevent respiratory insufficiency progression in onco-hematological patients affected with COVID19: a structured summary of a study protocol for a randomised controlled trial

Objectives: Baricitinib is supposed to have a double effect on SARS-CoV2 infection. Firstly, it reduces the inflammatory response through the inhibition of the Januse-Kinase signalling transducer and activator of transcription (JAK-STAT) pathway. Moreover, it reduces the receptor mediated viral endocytosis by AP2-associated protein kinase 1 (AAK1) inhibition. We propose the use of baricinitib to prevent the progression of the respiratory insufficiency in SARS-CoV2 pneumonia in onco-haematological patients. In this phase Ib/II study, the primary objective in the safety cohort is to describe the incidence of severe adverse events associated with baricitinib administration. The primary objective of the randomized phase (baricitinib cohort versus standard of care cohort) is to evaluate the number of patients who did not require mechanical oxygen support since start of therapy until day +14 or discharge (whichever it comes first). The secondary objectives of the study (only randomized phase of the study) are represented by the comparison between the two arms of the study in terms of mortality and toxicity at day+30. Moreover, a description of the immunological related changes between the two arms of the study will be reported. Trial design: The trial is a phase I/II study with a safety run-in cohort (phase 1) followed by an open label phase II randomized controlled trial with an experimental arm compared to a standard of care arm

Malformations of the craniocervical junction (chiari type I and syringomyelia: classification, diagnosis and treatment)

Chiari disease (or malformation) is in general a congenital condition characterized by an anatomic defect of the base of the skull, in which the cerebellum and brain stem herniate through the foramen magnum into the cervical spinal canal. The onset of Chiari syndrome symptoms usually occurs in the second or third decade (age 25 to 45 years). Symptoms may vary between periods of exacerbation and remission. The diagnosis of Chiari type I malformation in patients with or without symptoms is established with neuroimaging techniques. The most effective therapy for patients with Chiari type I malformation/syringomyelia is surgical decompression of the foramen magnum, however there are non-surgical therapy to relieve neurophatic pain: either pharmacological and non-pharmacological. Pharmacological therapy use drugs that act on different components of pain. Non-pharmacological therapies are primarly based on spinal or peripheral electrical stimulation

Aportaciones corológicas al catálogo valenciano de especies de flora amenazada

Se aportan nuevas citas o precisiones sobre otras prece- dentes, para 24 especies vegetales incluidas en el Catálogo Valenciano de Especies de Flora Amenazada (Decreto 70/2009, DOCV de 22.05.2009), tanto para la categoría legal autonómica ¿En Peligro de Extinción¿ (EP) co- mo ¿Vulnerable¿ (VU). Los datos aportados se refieren a Achillea santoli- noides (EP), Antirrhinum valentinum (VU), Biarum dispar (VU), Campa- nula mollis (VU), Carex elata (VU), Cheirolophus lagunae (VU), Coelo- glossum viride (VU), Euphorbia nevadensis subsp. nevadensis (VU), Kos- teletzkya pentacarpa (VU), Limonium mansanetianum (VU), Lupinus ma- riae-josephae (VU), Odontites valentinus (EP), Ophioglossum lusitanicum (VU), Orchis conica (VU), O. papilionacea (EP), O. purpurea (VU), Pa- rentucellia viscosa (EP), Pinguicula vallisnerifolia (VU), Serapias lingua (VU), Silene diclinis (VU), Sternbergia colchiciflora (VU), Teucrium le- picephalum (VU), Thymus lacaitae (VU) y Utricularia australis (EP). La mayoría de nuevas citas derivan del rastreo técnico intensivo y de la cola- boración de agentes medioambientales de la Generalitat Valenciana e in- formadores voluntarios.New records of 24 plant species included in the Va- lencian Catalogue of Threatened Plant Species (Decree 70/2009, DOCV 22.05.2009), both for regional categories 'Threatened to Extinction (EP)' and 'Vulnerable (VU)' are presented. Data refer to Achillea santolinoides (EP), Antirrhinum valentinum (VU), Biarum dispar (VU), Campanula mo- llis (VU), Carex elata (VU), Cheirolophus lagunae (VU), Coeloglossum viride (VU), Euphorbia nevadensis subsp. nevadensis (VU), Kosteletzkya pentacarpa (VU), Limonium mansanetianum (VU), Lupinus mariae-jose- phae (VU), Odontites valentinus (EP), Ophioglossum lusitanicum (VU), Orchis conica (VU), O. papilionacea (EP), O. purpurea (VU), Parentu- cellia viscosa (EP), Pinguicula vallisnerifolia (VU), Serapias lingua (VU), Silene diclinis (VU), Sternbergia colchiciflora (VU), Teucrium lepice- phalum (VU), Thymus lacaitae (VU) and Utricularia australis (EP). Most of the new records come from the intensive field survey carried out by technicians and forest rangers from Generalitat Valenciana as well as vo- lunteers

Inventory of long and short term future needs of food chain users for future functions of internet

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f(R) theories

Over the past decade, f(R) theories have been extensively studied as one of the simplest modifications to General Relativity. In this article we review various applications of f(R) theories to cosmology and gravity - such as inflation, dark energy, local gravity constraints, cosmological perturbations, and spherically symmetric solutions in weak and strong gravitational backgrounds. We present a number of ways to distinguish those theories from General Relativity observationally and experimentally. We also discuss the extension to other modified gravity theories such as Brans-Dicke theory and Gauss-Bonnet gravity, and address models that can satisfy both cosmological and local gravity constraints.Comment: 156 pages, 14 figures, Invited review article in Living Reviews in Relativity, Published version, Comments are welcom

Multiwavelength studies of MHD waves in the solar chromosphere: An overview of recent results

The chromosphere is a thin layer of the solar atmosphere that bridges the relatively cool photosphere and the intensely heated transition region and corona. Compressible and incompressible waves propagating through the chromosphere can supply significant amounts of energy to the interface region and corona. In recent years an abundance of high-resolution observations from state-of-the-art facilities have provided new and exciting ways of disentangling the characteristics of oscillatory phenomena propagating through the dynamic chromosphere. Coupled with rapid advancements in magnetohydrodynamic wave theory, we are now in an ideal position to thoroughly investigate the role waves play in supplying energy to sustain chromospheric and coronal heating. Here, we review the recent progress made in characterising, categorising and interpreting oscillations manifesting in the solar chromosphere, with an impetus placed on their intrinsic energetics.Comment: 48 pages, 25 figures, accepted into Space Science Review