New Insights into the Control of Pulsatile GnRH Release: The Role of Kiss1/Neurokinin B Neurons

Gonadotropin-releasing hormone (GnRH) is the ultimate output signal of an intricate network of neuroendocrine factors that, acting on the pituitary, trigger gonadotropin release. In turn, gonadotropins exert their trophic action on the gonads to stimulate the synthesis of sex steroids thus completing the gonadotropic axis through feedback regulatory mechanisms of GnRH release. These feedback loops are predominantly inhibitory in both sexes, leading to tonic pulsatile release of GnRH from puberty onward. However, in the female, rising levels of estradiol along the estrous cycle evoke an additional positive feedback that prompts a surge-like pattern of GnRH release prior to ovulation. Kisspeptins, secreted from hypothalamic Kiss1 neurons, are poised as major conduits to regulate this dual secretory pathway. Kiss1 neurons are diverse in origin, nature, and function, convening distinct neuronal populations in two main hypothalamic nuclei: the arcuate nucleus (ARC) and the anteroventral periventricular nucleus. Recent studies from our group and others point out Kiss1 neurons in the ARC as the plausible generator of GnRH pulses through a system of pulsatile kisspeptin release shaped by the coordinated action of neurokinin B (NKB) and dynorphin A (Dyn) that are co-expressed in Kiss1 neurons (so-called KNDy neurons). In this review, we aim to document the recent findings and working models directed toward the identification of the Kiss1-dependent mechanisms of GnRH release through a synoptic overview of the state-of-the-art in the field

Temporary Language Adaptation Classrooms: One of the Great Unknowns for Future Primary School teachers

El presente estudio pretende indagar en la opinión sobre la formación universitaria recibida por los futuros maestros de educación primaria en relación con la atención al alumnado inmigrante en las escuelas y, particularmente, con las aulas temporales de adaptación lingüística (ATAL) andaluzas. Se discuten los datos arrojados del análisis de un cuestionario formado por diez ítems, que combinaron tanto preguntas de índole cuantitativa como cualitativa, al que respondieron 54 estudiantes del último curso del Grado en Educación Primaria de la Universidad de Almería (España). Según los resultados, al acabar la carrera, las estrategias y el aprendizaje adquirido se muestran insuficientes de acuerdo con la naturaleza multicultural que presenta la mayoría de los centros educativos españoles, mientras que se aprecia gran interés por cursar estudios de posgrado sobre enseñanza del español como segunda lengua. En conclusión, con el propósito de lograr una integración auténtica del alumnado inmigrante, se reivindica una conexión efectiva entre la formación académica de grado y la realidad multicultural y multilingüe de las aulas en la sociedad española actual.The present study aims to look into the opinion of prospective primary school teachers about their training for assisting migrant students. Special attention is drawn to their views on the linguistic adaptation temporary classes (ATAL) in Andalusia. The data obtained from the analysis of a questionnaire are discussed. This questionnaire consists of ten items, which combined both quantitative and qualitative questions, and was completed by 54 students in the last year of the Degree in Primary Education at University of Almería (Spain). According to the results, upon completion of training, the knowledge and strategies developed appear to be insufficient for the multicultural nature of most Spanish schools. At the same time, respondents show a great interest in postgraduate courses on teaching Spanish as a second language. In conclusion, in order to achieve the integration of migrant students, a more effective connection between teacher training programs and the multicultural and multilingual reality of Spanish schools nowadays is needed

Classroom communication skills: the need to fill a gap in the training of teachers of Spanish as a foreign language

This paper sets out the necessity of examining the communication skills of teachers of Spanish as a foreign language as conducted in other socio-educative contexts. According to this objective, the paper begins with a review of theoretical efforts that have been made during recent years referring to research methodology (such as instruments), and to their main results. This leads to a discussion of the training needs that teachers of Spanish as a foreign language presently face for the development of their communication s kills in the classroom and, in general terms, the paper discusses the different types of ideas and strategies that must be considered during teachers’ instruction. Finally, this brief proposal expects to be the seed of future research projects that impact positively on the improvement of teachers’ communication competence, whereby the ideas discussed here are taken as a nuclear component in the frame of future teaching competence

Spatial Adaptive Speckle Filtering Driven by Temporal Polarimetric Statistics and Its Application to PSI

Persistent scatterer (PS) interferometry (PSI) techniques are designed to measure ground deformations using satellite synthetic aperture radar (SAR) data. They rely on the identification of pixels not severely affected by spatial or temporal decorrelation, which, in general, correspond to pointlike PSs commonly found in urban areas. However, in urban areas, we can find not only PSs but also distributed scatterers (DSs) whose phase information may be exploited for PSI applications. Estimation of DS parameters requires speckle filtering to be applied to the complex SAR data, but conventional speckle filtering approaches tend to mask PS information due to spatial averaging. In the context of single-polarization PSI, adaptive speckle filtering strategies based on the exploitation of amplitude temporal statistics have been proposed, which seek to avoid spatial filtering on nonhomogeneous areas. Given the growing interest on polarimetric PSI techniques, i.e., those using polarimetric diversity to increase performance over conventional single-polarization PSI, in this paper, we propose an adaptive spatial filter driven by polarimetric temporal statistics, rather than single-polarization amplitudes. The proposed approach is able to filter DS while preserving PS information. In addition, a new methodology for the joint processing of PS and DS in the context of PSI is introduced. The technique has been tested for two different urban data sets: 41 dual-polarization TerraSAR-X images of Murcia (Spain) and 31 full-polarization Radarsat-2 images of Barcelona (Spain). Results show an important improvement in terms of number of pixels with valid deformation information, hence denser area coverage.This work was supported in part by the Spanish Ministerio de Economía y Competitividad and in part by the European Union FEDER funds under Project TEC2011-28201-C02-02

Adaptive runtime-assisted block prefetching on chip-multiprocessors

Memory stalls are a significant source of performance degradation in modern processors. Data prefetching is a widely adopted and well studied technique used to alleviate this problem. Prefetching can be performed by the hardware, or be initiated and controlled by software. Among software controlled prefetching we find a wide variety of schemes, including runtime-directed prefetching and more specifically runtime-directed block prefetching. This paper proposes a hybrid prefetching mechanism that integrates a software driven block prefetcher with existing hardware prefetching techniques. Our runtime-assisted software prefetcher brings large blocks of data on-chip with the support of a low cost hardware engine, and synergizes with existing hardware prefetchers that manage locality at a finer granularity. The runtime system that drives the prefetch engine dynamically selects which cache to prefetch to. Our evaluation on a set of scientific benchmarks obtains a maximum speed up of 32 and 10 % on average compared to a baseline with hardware prefetching only. As a result, we also achieve a reduction of up to 18 and 3 % on average in energy-to-solution.Peer ReviewedPostprint (author's final draft

Polarimetric Approaches for Persistent Scatterers Interferometry

In previous works, a general framework to exploit polarimetric diversity to optimize the results of persistent scatterers interferometry (PSI) was presented, but tested only with dual-pol data. In this paper, the performance of these algorithms is assessed using fully polarimetric data, acquired by the Radarsat-2 satellite over the urban area of Barcelona, Spain. In addition, two new highly efficient polarimetric optimization methods, mean intensity polarimetric optimization and joint diagonalization-based polarimetric optimization, are introduced and evaluated. Given the variety of dual-pol configurations provided by current polarimetric satellites, such as TerraSAR-X and Radarsat-2, and the upcoming launch of Sentinel-1, ALOS-2, and Radarsat Constellation Mission, a study has been also carried out to determine the best performing dual-pol configurations for polarimetric PSI. Subsidence maps of the area of study are computed for single-pol, dual-pol, and full-pol data, which show the increase in pixel density with valid deformation results as more polarimetric information is made available. In particular, for full-pol data we get an increase of up to 2.5 times more pixels for coherence-based PSI techniques (degraded resolution), and over four times more for amplitude-based approaches (full resolution), in comparison with single-pol data. Both higher density and quality of pixels yield better results in terms of coverage and accuracy.This work was supported in part by the Spanish Ministerio de Economía y Competitividad and European Union FEDER funds under Project TEC2011-28201-C02-02

Neuroprotective Effects of Exercise Treatments After Injury : The Dual Role of Neurotrophic Factors

Shared connections between physical activity and neuroprotection have been studied for decades, but the mechanisms underlying this effect of specific exercise were only recently brought to light. Several evidences suggest that physical activity may be a reasonable and beneficial method to improve functional recovery in both peripheral and central nerve injuries and to delay functional decay in neurodegenerative diseases. In addition to improving cardiac and immune functions, physical activity may represent a multifunctional approach not only to improve cardiocirculatory and immune functions, but potentially modulating trophic factors signaling and, in turn, neuronal function and structure at times that may be critical for neurodegeneration and regeneration. Research content related to the effects of physical activity and specific exercise programs in normal and injured nervous system have been reviewed. Sustained exercise, particularly if applied at moderate intensity and early after injury, exerts anti-inflammatory and pro-regenerative effects, and may boost cognitive and motor functions in aging and neurological disorders. However, newest studies show that exercise modalities can differently affect the production and function of brain-derived neurotrophic factor and other neurotrophins involved in the generation of neuropathic conditions. These findings suggest the possibility that new exercise strategies can be directed to nerve injuries with therapeutical benefits. Considering the growing burden of illness worldwide, understanding of how modulation of neurotrophic factors contributes to exercise-induced neuroprotection and regeneration after peripheral nerve and spinal cord injuries is a relevant topic for research, and represents the beginning of a new non-pharmacological therapeutic approach for better rehabilitation of neural disorders

On The Reduced Canonical Quantization Of The Induced 2D-Gravity

The quantization of the induced 2d-gravity on a compact spatial section is carried out in three different ways. In the three approaches the supermomentum constraint is solved at the classical level but they differ in the way the hamiltonian constraint is imposed. We compare these approaches establishing an isomorphism between the resulting Hilbert spaces.Comment: 17 pages, plain LaTeX. FTUV/93-15, IFIC/93-10, Imperial-TP/93-94/1

L2C2: Last-level compressed-contents non-volatile cache and a procedure to forecast performance and lifetime

Several emerging non-volatile (NV) memory technologies are rising as interesting alternatives to build the Last-Level Cache (LLC). Their advantages, compared to SRAM memory, are higher density and lower static power, but write operations wear out the bitcells to the point of eventually losing their storage capacity. In this context, this paper presents a novel LLC organization designed to extend the lifetime of the NV data array and a procedure to forecast in detail the capacity and performance of such an NV-LLC over its lifetime. From a methodological point of view, although different approaches are used in the literature to analyze the degradation of an NV-LLC, none of them allows to study in detail its temporal evolution. In this sense, this work proposes a forecasting procedure that combines detailed simulation and prediction, allowing an accurate analysis of the impact of different cache control policies and mechanisms (replacement, wear-leveling, compression, etc.) on the temporal evolution of the indices of interest, such as the effective capacity of the NV-LLC or the system IPC. We also introduce L2C2, a LLC design intended for implementation in NV memory technology that combines fault tolerance, compression, and internal write wear leveling for the first time. Compression is not used to store more blocks and increase the hit rate, but to reduce the write rate and increase the lifetime during which the cache supports near-peak performance. In addition, to support byte loss without performance drop, L2C2 inherently allows N redundant bytes to be added to each cache entry. Thus, L2C2+N, the endurance-scaled version of L2C2, allows balancing the cost of redundant capacity with the benefit of longer lifetime. For instance, as a use case, we have implemented the L2C2 cache with STT-RAM technology. It has affordable hardware overheads compared to that of a baseline NV-LLC without compression in terms of area, latency and energy consumption, and increases up to 6-37 times the time in which 50% of the effective capacity is degraded, depending on the variability in the manufacturing process. Compared to L2C2, L2C2+6 which adds 6 bytes of redundant capacity per entry, that means 9.1% of storage overhead, can increase up to 1.4-4.3 times the time in which the system gets its initial peak performance degraded

Seasonal patterns of settlement and growth of introduced and native ascidians in bivalve cultures in the Ebro Delta (NE Iberian Peninsula)

Ascidians are important both as invasive species and as a fouling group in artificial marine habitats, causing negative impacts in aquaculture settings and the surrounding environment. The Ebro Delta is one of the major centres of bivalve production in the Mediterranean and is affected by proliferation of ascidian species (mostly introduced forms). Knowledge of the patterns of settlement and growth of the fouling species is mandatory to attempt mitigation measures. Settlement PVC plates were deployed from May to September 2015 at different depths (0.2, 1 and 2 m) in the Ebro Delta oyster aquaculture facilities. The occurrences of all species and the area cover of a selected subset of 6 species were monitored on a monthly basis from June 2015 to December 2016. Fifteen species were found, of which 10 are introduced. There were some differences between the deployed plates and the oyster ropes in species abundance and composition, likely due to differences in substrate complexity. For instance, Didemnum vexillum and Clavelina oblonga occurred in few plates in contrast to their abundance on oysters. The most abundant species were Styela plicata and Clavelina lepadiformis, which together with Ecteinascidia turbinata showed a preference to grow on plates deployed in May and June. Most of the species grew more at 0.2 m depth than at deeper plates. Thus, to minimise fouling on bivalves, spat immersion during fall and below 1 m depth is recommended. The number of occurrences and cover of the species was found to be similarly informative; suggesting that a periodic monitoring of species occurrence on replicate plates is sufficient for detecting new introduced species as soon as possible and will provide information useful for management