Engineering direct-indirect band gap transition in wurtzite GaAs nanowires through size and uniaxial strain

Electronic structures of wurtzite GaAs nanowires in the [0001] direction were studied using first-principles calculations. It was found that the band gap of GaAs nanowires experience a direct-to-indirect transition when the diameter of the nanowires is smaller than ~28 {\AA}. For those thin GaAs nanowires with an indirect band gap, it was found that the gap can be tuned to be direct if a moderate external uniaxial strain is applied. Both tensile and compressive strain can trigger the indirect-to-direct gap transition. The critical strains for the gap-transition are determined by the energy crossover of two states in conduction bands.Comment: 4 pages, 4 figure

Multidimensional Methods for the Formulation of Bipharmaceuticals and Vaccines

Determining and preserving the higher order structural integrity and conformational stability of proteins, plasmid DNA and macromolecular complexes such as viruses, virus-like particles and adjuvanted antigens is often a significant barrier to the successful stabilization and formulation of biopharmaceutical drugs and vaccines. These properties typically must be investigated with multiple lower resolution experimental methods, since each technique monitors only a narrow aspect of the overall conformational state of a macromolecular system. This review describes the use of empirical phase diagrams (EPDs) to combine large amounts of data from multiple high-throughput instruments and construct a map of a target macromolecule's physical state as a function of temperature, solvent conditions, and other stress variables. We present a tutorial on the mathematical methodology, an overview of some of the experimental methods typically used, and examples of some of the previous major formulation applications. We also explore novel applications of EPDs including potential new mathematical approaches as well as possible new biopharmaceutical applications such as analytical comparability, chemical stability, and protein dynamics

The cellular and synaptic architecture of the mechanosensory dorsal horn

The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR-recipient zone (LTMR-RZ), a role for LTMR-RZ processing in tactile perception, and the basic logic of LTMR-RZ organization. We found an unexpectedly high degree of neuronal diversity in the LTMR-RZ: seven excitatory and four inhibitory subtypes of interneurons exhibiting unique morphological, physiological, and synaptic properties. Remarkably, LTMRs form synapses on between four and 11 LTMR-RZ interneuron subtypes, while each LTMR-RZ interneuron subtype samples inputs from at least one to three LTMR classes, as well as spinal cord interneurons and corticospinal neurons. Thus, the LTMR-RZ is a somatosensory processing region endowed with a neuronal complexity that rivals the retina and functions to pattern the activity of ascending touch pathways that underlie tactile perception

Role of the Kelvin-Helmholtz instability in the evolution of magnetized relativistic sheared plasma flows

We explore, via analytical and numerical methods, the Kelvin-Helmholtz (KH) instability in relativistic magnetized plasmas, with applications to astrophysical jets. We solve the single-fluid relativistic magnetohydrodynamic (RMHD) equations in conservative form using a scheme which is fourth order in space and time. To recover the primitive RMHD variables, we use a highly accurate, rapidly convergent algorithm which improves upon such schemes as the Newton-Raphson method. Although the exact RMHD equations are marginally stable, numerical discretization renders them unstable. We include numerical viscosity to restore numerical stability. In relativistic flows, diffusion can lead to a mathematical anomaly associated with frame transformations. However, in our KH studies, we remain in the rest frame of the system, and therefore do not encounter this anomaly. We use a two-dimensional slab geometry with periodic boundary conditions in both directions. The initial unperturbed velocity peaks along the central axis and vanishes asymptotically at the transverse boundaries. Remaining unperturbed quantities are uniform, with a flow-aligned unperturbed magnetic field. The early evolution in the nonlinear regime corresponds to the formation of counter-rotating vortices, connected by filaments, which persist in the absence of a magnetic field. A magnetic field inhibits the vortices through a series of stages, namely, field amplification, vortex disruption, turbulent breakdown, and an approach to a flow-aligned equilibrium configuration. Similar stages have been discussed in MHD literature. We examine how and to what extent these stages manifest in RMHD for a set of representative field strengths. To characterize field strength, we define a relativistic extension of the Alfvénic Mach number M(A). We observe close complementarity between flow and magnetic field behavior. Weaker fields exhibit more vortex rotation, magnetic reconnection, jet broadening, and intermediate turbulence. Sufficiently strong fields (M(A)<6) completely suppress vortex formation. Maximum jet deceleration, and viscous dissipation, occur for intermediate vortex-disruptive fields, while electromagnetic energy is maximized for the strongest fields which allow vortex formation. Highly relativistic flows destabilize the system, supporting modes with near-maximum growth at smaller wavelengths than the shear width of the velocity. This helps to explain early numerical breakdown of highly relativistic simulations using numerical viscosity, a long-standing problem. While magnetic fields generally stabilize the system, we have identified many features of the complex and turbulent reorganization that occur for sufficiently weak fields in RMHD flows, and have described the transition from disruptive to stabilizing fields at M(A)≈6. Our results are qualitatively similar to observations of numerous jets, including M87, whose knots may exhibit vortex-like behavior. Furthermore, in both the linear and nonlinear analyses, we have successfully unified the HD, MHD, RHD, and RMHD regimes

Cognitive Inertia: How Loops Among Attention, Representation, and Decision Making Distort Reality

The decisions we make in our everyday lives often require us to navigate through a barrage of information, so that we can base our decisions only on information that is relevant to our goals. Selectively attending only to goal-relevant dimensions of information can help us efficiently navigate this barrage of information, but can also lead us into ``traps" where we fail to learn which information is most relevant, or fail to notice information that becomes relevant later in time. Here, we investigate the dynamic interactions between attention, learning, and memory that unfold as learners seek to identify dimensions of information that will help them make consistently accurate decisions. Using a multi-pronged approach, we identify the cyclical links between decision making, attention, and representation that best explain human category learning. We then show how the structure of these relationships paradoxically causes both accelerated learning and leads learners into different types of learning traps

Chloroquine increases phosphorylation of AMPK and Akt in myotubes

Aims: There are reports that ataxia telangiectasia mutated (ATM) can activate the AMP-activated protein kinase (AMPK) and also Akt, two kinases that play integral parts in cardioprotection and metabolic function. We hypothesized that chloroquine and resveratrol, both known ATM activators, would also activate AMPK and Akt. Main methods: Phosphorylation of AMPK and Akt was assessed after C2C12 myotubes were exposed to chloroquine or resveratrol. Additional experiments were done in cells expressing shRNA against ATM or in the presence of the ATM inhibitor KU55933. The effects of chloroquine on intracellular calcium were assessed with the fluorescent probe Calcium Green-1 AM. Key findings: 0.5 mM chloroquine increased AMPK phosphorylation by nearly four-fold (P 50% concomitant with a decrease in glucose transport. Significance: These ATM-independent effects of chloroquine on AMPK and Akt and the additional effect to decrease intracellular calcium are likely to partially underlie the positive metabolic effects of chloroquine that have been reported in the literature