A Novel Multi-Spacecraft Interplanetary Global Trajectory Optimization Transcription

As the frontier of space exploration continues to advance, so does the design complexity of future interplanetary missions. One avenue of this increasing complexity includes a class of designs known as "Distributed Spacecraft Missions"; missions where multiple spacecraft coordinate to perform shared objectives. Current approaches for the global trajectory optimization of these Multi-Vehicle Missions (MVMs) are prone to shortcomings including laborious iterative design, considerable human-in-the-loop effort, treatment of the multi-vehicle problem as multiple separate trajectory optimization subproblems (resulting in suboptimal solutions where the whole is less than the sum of its parts), and poor handling of coordination objectives and constraints. There are only a handful of software platforms in existence capable of fully-automated, rapid, interplanetary mission and systems global optimization including the Parallel Global Multiobjective Optimizer (PaGMO), the Gravity Assisted Low-thrust Local Optimization Program (GALLOP), and the Evolutionary Mission Trajectory Generator (EMTG). However, none of these tools is capable of performing such tasks for MVM designs. The work outlined in this paper lays the groundwork for a technique to begin addressing these shortcomings. We present a fully-automated technique which frames interplanetary MVMs as Multi-Objective, Multi-Agent Hybrid Optimal Control Problems (MOMA HOCP). First, the basic functionality of this technique is validated on the single-vehicle problem of reproducing the Cassini interplanetary cruise

A Novel Multi-Spacecraft Interplanetary Global Trajectory Optimization Transcription

As the frontier of space exploration continues to advance, so does the design complexity of future interplanetary missions. One avenue of this increasing complexity includes a class of designs known as ``Distributed Spacecraft Missions"; missions where multiple spacecraft coordinate to perform shared objectives. Current approaches for the global trajectory optimization of these Multi-Vehicle Missions (MVMs) are prone to shortcomings including laborious iterative design, considerable human-in-the-loop effort, treatment of the multi-vehicle problem as multiple separate trajectory optimization subproblems (resulting in suboptimal solutions where the whole is less than the sum of its parts), and poor handling of coordination objectives and constraints. There are only a handful of software platforms in existence capable of fully-automated, rapid, interplanetary mission and systems global optimization including the Parallel Global Multiobjective Optimizer (PaGMO), the Gravity Assisted Low-thrust Local Optimization Program (GALLOP), and the Evolutionary Mission Trajectory Generator (EMTG). However, none of these tools is capable of performing such tasks for MVM designs. The work outlined in this paper lays the groundwork for a technique to begin addressing these shortcomings. We present a fully-automated technique which frames interplanetary MVMs as Multi-Objective, Multi-Agent Hybrid Optimal Control Problems (MOMA HOCP). First, the basic functionality of this technique is validated on the single-vehicle problem of reproducing the Cassini interplanetary cruise

Characterization of a novel alpha-conotoxin TxID from Conus textile that potently blocks rat alpha3/beta4 nicotinic acetylcholine receptors

The alpha 3 beta 4 nAChRs are implicated in pain sensation in the PNS and addiction to nicotine in the CNS. We identified an alpha-4/6-conotoxin (CTx) TxID from Conus textile. The new toxin consists of 15 amino acid residues with two disulfide bonds. TxID was synthesized using solid phase methods, and the synthetic peptide was functionally tested on nAChRs heterologously expressed in Xenopus laevis oocytes. TxID blocked rat alpha 3 beta 4 nAChRs with a 12.5 nM IC50, which places it among the most potent alpha 3 beta 4 nAChR antagonists. TxID also blocked the closely related alpha 6/alpha 3 beta 4 with a 94 nM IC50 but showed little activity on other nAChR subtypes. NMR analysis showed that two major structural isomers exist in solution, one of which adopts a regular alpha-CTx fold but with different surface charge distribution to other 4/6 family members. alpha-CTx TxID is a novel tool with which to probe the structure and function of alpha 3 beta 4 nAChRs

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Overview of the DESI Legacy Imaging Surveys

The DESI Legacy Imaging Surveys (http://legacysurvey.org/) are a combination of three public projects (the Dark Energy Camera Legacy Survey, the Beijing–Arizona Sky Survey, and the Mayall z-band Legacy Survey) that will jointly image ≈14,000 deg2 of the extragalactic sky visible from the northern hemisphere in three optical bands (g, r, and z) using telescopes at the Kitt Peak National Observatory and the Cerro Tololo Inter-American Observatory. The combined survey footprint is split into two contiguous areas by the Galactic plane. The optical imaging is conducted using a unique strategy of dynamically adjusting the exposure times and pointing selection during observing that results in a survey of nearly uniform depth. In addition to calibrated images, the project is delivering a catalog, constructed by using a probabilistic inference-based approach to estimate source shapes and brightnesses. The catalog includes photometry from the grz optical bands and from four mid-infrared bands (at 3.4, 4.6, 12, and 22 μm) observed by the Wide-field Infrared Survey Explorer satellite during its full operational lifetime. The project plans two public data releases each year. All the software used to generate the catalogs is also released with the data. This paper provides an overview of the Legacy Surveys project

Search for intermediate mass black hole binaries in the first observing run of Advanced LIGO

International audienceDuring their first observational run, the two Advanced LIGO detectors attained an unprecedented sensitivity, resulting in the first direct detections of gravitational-wave signals produced by stellar-mass binary black hole systems. This paper reports on an all-sky search for gravitational waves (GWs) from merging intermediate mass black hole binaries (IMBHBs). The combined results from two independent search techniques were used in this study: the first employs a matched-filter algorithm that uses a bank of filters covering the GW signal parameter space, while the second is a generic search for GW transients (bursts). No GWs from IMBHBs were detected; therefore, we constrain the rate of several classes of IMBHB mergers. The most stringent limit is obtained for black holes of individual mass 100  M⊙, with spins aligned with the binary orbital angular momentum. For such systems, the merger rate is constrained to be less than 0.93  Gpc−3 yr−1 in comoving units at the 90% confidence level, an improvement of nearly 2 orders of magnitude over previous upper limits