State Court Power to Enjoin Federal Judicial Proceedings: Donovan v. City of Dallas Revisited

In this Article, we do not intend to suggest that a state court may enjoin federal court proceedings merely upon a showing of a lack of federal jurisdiction over the parties or the subject matter. The injunctive power is that of a court of equity. An applicant would be required not only to show that the federal court was devoid of power to hear the case, but also to demonstrate the existence of whatever state law might require to justify injunctive relief. Thus, the rather limited focus here is the demonstration that there is no federal constitutional ban on state court injunctions against federal proceedings, pending or impending, once a state equity court determines that the federal court lacks jurisdiction

Tributes to Professor Alan Hornstein

Tributes to Professor Alan Hornstein upon his retirement from the University of Maryland School of Law

Energy Loss of a Heavy Fermion in an Anisotropic QED Plasma

We compute the leading-order collisional energy loss of a heavy fermion propagating in a QED plasma with an electron distribution function which is anisotropic in momentum space. We show that in the presence of such anisotropies there can be a significant directional dependence of the heavy fermion energy loss with the effect being quite large for highly-relativistic velocities. We also repeat the analysis of the isotropic case more carefully and show that the final result depends on the intermediate scale used to separate hard and soft contributions to the energy loss. We then show that the canonical isotropic result is obtained in the weak-coupling limit. For intermediate-coupling we use the residual scale dependence as a measure of our theoretical uncertainty. We also discuss complications which could arise due to the presence of unstable soft photonic modes and demonstrate that the calculation of the energy loss is safe.Comment: 19 pages, 18 figures. v2 - Correction to normalization of numerical results; some figures modified as a result; discussion of role of unstable modes added along with two new figure

Back-gated Nb-doped MoS2 junctionless field-effect-transistors

Electrical measurements were carried out to measure the performance and evaluate the characteristics of MoS2 flakes doped with Niobium (Nb). The flakes were obtained by mechanical exfoliation and transferred onto 85 nm thick SiO2 oxide and a highly doped Si handle wafer. Ti/Au (5/45 nm) deposited on top of the flake allowed the realization of a back-gate structure, which was analyzed structurally through Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). To best of our knowledge this is the first cross-sectional TEM study of exfoliated Nb-doped MoS2 flakes. In fact to date TEM of transition-metal-dichalcogenide flakes is extremely rare in the literature, considering the recent body of work. The devices were then electrically characterized by temperature dependent Ids versus Vds and Ids versus Vbg curves. The temperature dependency of the device shows a semiconductor behavior and, the doping effect by Nb atoms introduces acceptors in the structure, with a p-type concentration 4.3 × 1019 cm−3 measured by Hall effect. The p-type doping is confirmed by all the electrical measurements, making the structure a junctionless transistor. In addition, other parameters regarding the contact resistance between the top metal and MoS2 are extracted thanks to a simple Transfer Length Method (TLM) structure, showing a promising contact resistivity of 1.05 × 10−7 Ω/cm2 and a sheet resistance of 2.36 × 102 Ω/sq

Coarse-Graining and Self-Dissimilarity of Complex Networks

Can complex engineered and biological networks be coarse-grained into smaller and more understandable versions in which each node represents an entire pattern in the original network? To address this, we define coarse-graining units (CGU) as connectivity patterns which can serve as the nodes of a coarse-grained network, and present algorithms to detect them. We use this approach to systematically reverse-engineer electronic circuits, forming understandable high-level maps from incomprehensible transistor wiring: first, a coarse-grained version in which each node is a gate made of several transistors is established. Then, the coarse-grained network is itself coarse-grained, resulting in a high-level blueprint in which each node is a circuit-module made of multiple gates. We apply our approach also to a mammalian protein-signaling network, to find a simplified coarse-grained network with three main signaling channels that correspond to cross-interacting MAP-kinase cascades. We find that both biological and electronic networks are 'self-dissimilar', with different network motifs found at each level. The present approach can be used to simplify a wide variety of directed and nondirected, natural and designed networks.Comment: 11 pages, 11 figure

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and 'easy to use' oral drugs. Previously, we reported the discovery of the triazolopyrimidine (TP) class as selective kinetoplastid proteasome inhibitors with in vivo efficacy in mouse models of leishmaniasis, Chagas Disease and African trypanosomiasis (HAT). For the treatment of HAT, development compounds need to have excellent penetration to the brain to cure the meningoencephalic stage of the disease. Here we describe detailed biological and pharmacological characterization of triazolopyrimidine compounds in HAT specific assays. The TP class of compounds showed single digit nanomolar potency against Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense strains. These compounds are trypanocidal with concentration-time dependent kill and achieved relapse-free cure in vitro. Two compounds, GNF6702 and a new analog NITD689, showed favorable in vivo pharmacokinetics and significant brain penetration, which enabled oral dosing. They also achieved complete cure in both hemolymphatic (blood) and meningoencephalic (brain) infection of human African trypanosomiasis mouse models. Mode of action studies on this series confirmed the 20S proteasome as the target in T. brucei. These proteasome inhibitors have the potential for further development into promising new treatment for human African trypanosomiasis

Back-gated Nb-doped MoS2 junctionless field-effect-transistors

Electrical measurements were carried out to measure the performance and evaluate the characteristics of MoS2 flakes doped with Niobium (Nb). The flakes were obtained by mechanical exfoliation and transferred onto 85 nm thick SiO2 oxide and a highly doped Si handle wafer. Ti/Au (5/45 nm) deposited on top of the flake allowed the realization of a back-gate structure, which was analyzed structurally through Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). To best of our knowledge this is the first cross-sectional TEM study of exfoliated Nb-doped MoS2 flakes. In fact to date TEM of transition-metal-dichalcogenide flakes is extremely rare in the literature, considering the recent body of work. The devices were then electrically characterized by temperature dependent Ids versus Vds and Ids versus Vbg curves. The temperature dependency of the device shows a semiconductor behavior and, the doping effect by Nb atoms introduces acceptors in the structure, with a p-type concentration 4.3 × 1019 cm−3 measured by Hall effect. The p-type doping is confirmed by all the electrical measurements, making the structure a junctionless transistor. In addition, other parameters regarding the contact resistance between the top metal and MoS2 are extracted thanks to a simple Transfer Length Method (TLM) structure, showing a promising contact resistivity of 1.05 × 10−7 Ω/cm2 and a sheet resistance of 2.36 × 102 Ω/sq

The Eurace@Unibi Model: An Agent-Based Macroeconomic Model for Economic Policy Analysis

Dawid H, Gemkow S, Harting P, van der Hoog S, Neugart M. The Eurace@Unibi Model: An Agent-Based Macroeconomic Model for Economic Policy Analysis. Working Papers in Economics and Management. Vol 05-2012. Bielefeld: Bielefeld University, Department of Business Administration and Economics; 2012.This document provides a description of the modeling assumptions and economic features of the Eurace@Unibi model. Furthermore, the document shows typical patterns of the output generated by this model and compares it to empirically observable stylized facts. The Eurace@Unibi model provides a representation of a closed macroeconomic model with spatial structure. The main objective is to provide a micro-founded macroeconomic model that can be used as a unified framework for policy analysis in different economic policy areas and for the examination of generic macroeconomic research questions. In spite of this general agenda the model has been constructed with certain specific research questions in mind and therefore certain parts of the model, e.g. the mechanisms driving technological change, have been worked out in more detail than others. The purpose of this document is to give an overview over the model itself and its features rather than discussing how insights into particular economic issues can be obtained using the Eurace@Unibi model. The model has been designed as a framework for economic analysis in various domains of economics. A number of economic issues have been examined using (prior versions of) the model (see Dawid et al. (2008), Dawid et al. (2009), Dawid et al. (2011a), Dawid and Harting (2011), van der Hoog and Deissenberg (2011), Cincotti et al. (2010)) and recent extensions of the model have substantially extended its applicability in various economic policy domains, however results of such policy analyses will be reported elsewhere. Whereas the overall modeling approach, the different modeling choices and the economic rationale behind these choices is discussed in some detail in this document, no detailed description of the implementation is given. Such a detailed documentation is provided in the accompanying document Dawid et al. (2011b)

Melt generation, crystallization, and extraction beneath segmented oceanic transform faults

Author Posting. © American Geophysical Union, 2009. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 114 (2009): B11102, doi:10.1029/2008JB006100.We examine mantle melting, fractional crystallization, and melt extraction beneath fast slipping, segmented oceanic transform fault systems. Three-dimensional mantle flow and thermal structures are calculated using a temperature-dependent rheology that incorporates a viscoplastic approximation for brittle deformation in the lithosphere. Thermal solutions are combined with the near-fractional, polybaric melting model of Kinzler and Grove (1992a, 1992b, 1993) to determine extents of melting, the shape of the melting regime, and major element melt composition. We investigate the mantle source region of intratransform spreading centers (ITSCs) using the melt migration approach of Sparks and Parmentier (1991) for two end-member pooling models: (1) a wide pooling region that incorporates all of the melt focused to the ITSC and (2) a narrow pooling region that assumes melt will not migrate across a transform fault or fracture zone. Assuming wide melt pooling, our model predictions can explain both the systematic crustal thickness excesses observed at intermediate and fast slipping transform faults as well as the deeper and lower extents of melting observed in the vicinity of several transform systems. Applying these techniques to the Siqueiros transform on the East Pacific Rise we find that both the viscoplastic rheology and wide melt pooling are required to explain the observed variations in gravity inferred crustal thickness. Finally, we show that mantle potential temperature Tp = 1350°C and fractional crystallization at depths of 9–15.5 km fit the majority of the major element geochemical data from the Siqueiros transform fault system.This research was supported by WHOI Academic Programs Office (PMG), NSF grants OCE-0649103 and OCE-0623188 (MDB), and the Charles D. Hollister Endowed Fund for Support of Innovative Research at WHOI (J.L.)