No quantum gravity signature from the farthest quasars

Context: Strings and other alternative theories describing the quantum properties of space-time suggest that space-time could present a foamy structure and also that, in certain cases, quantum gravity (QG) may manifest at energies much below the Planck scale. One of the observable effects could be the degradation of the diffraction images of distant sources. Aims: We searched for this degradation effect, caused by QG fluctuations, in the light of the farthest quasars (QSOs) observed by the Hubble Space Telescope with the aim of setting new limits on the fluctuations of the space-time foam and QG models. Methods: We developed a software that estimates and compares the phase variation in the interference patterns of the high-redshift QSOs, taken from the snapshot survey of HST-SDSS, with those of stars that are expected to not be affected by QG effects. We used a two-parameter function to determine, for each test star and QSO, the maximum of the diffraction pattern and to calculate the Strehl ratio. Results: Our results go far beyond those already present in the literature. By adopting the most conservative approach where the correction terms, that describe the possibility for space-time fluctuations cumulating across long distances and partially compensate for the effects of the phase variations, are taken into account. We exclude the random walk model and most of the holographic models of the space-time foam. Without considering these correction terms, all the main QG scenarios are excluded. Finally, our results show the absence of any directional dependence of QG effects and the validity of the cosmological principle with an independent method; that is, viewed on a large scale, the properties of the Universe are the same for all observers, including the effects of space-time fluctuations.Comment: 5 pages 6 figure

White-light flares on cool stars in the Kepler Quarter 1 Data

We present the results of a search for white light flares on the ~23,000 cool dwarfs in the Kepler Quarter 1 long cadence data. We have identified 373 flaring stars, some of which flare multiple times during the observation period. We calculate relative flare energies, flare rates and durations, and compare these with the quiescent photometric variability of our sample. We find that M dwarfs tend to flare more frequently but for shorter durations than K dwarfs, and that they emit more energy relative to their quiescent luminosity in a given flare than K dwarfs. Stars that are more photometrically variable in quiescence tend to emit relatively more energy during flares, but variability is only weakly correlated with flare frequency. We estimate distances for our sample of flare stars and find that the flaring fraction agrees well with other observations of flare statistics for stars within 300 pc above the Galactic Plane. These observations provide a more rounded view of stellar flares by sampling stars that have not been pre-selected by their activity, and are informative for understanding the influence of these flares on planetary habitability.Comment: 42 pages, 10 figures, 2 tables; Accepted for publication in the Astronomical Journa

Child mortality in eastern and southern Africa

High rates of infant mortality in Africa continue to be a major public health concern today, despite the fact that most deaths can be prevented from well known, relatively low cost technologies. Using multiple years of DHS from four countries, we estimate the change in the relative risk of death as well as the main contributions to the change in mortality over time. We find significant declines in the mortality hazard in each of the 4 countries, with the largest declines in Malawi (44 percent) and Tanzania (22 percent) between the mid 1990s to mid 2000s, although there is significant variation by age group in the hazard rate across time. In Zambia for example, the hazard increased for children ages 25-60 months in spite of on overall decline in mortality, while in Mozambique the largest decline in mortality was exactly among this age group. The decomposition analysis illustrates that some of the main correlates of mortality did not contribute to overall declines over time, because the levels of these correlates did not change during the study period. This is particularly true for birth spacing, attended births and breastfeeding. The analysis also demonstrates the overall lack of explanatory power of the individual and household level variables available for use in the DHS, indicating the need to collect complementary supply side information, through community questionnaires for example, that can be linked to DHS households and thus expand the set of covariates available for modeling child survival and other health outcomes.http://www.populationreview.com

Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules

The programming of cellular networks to achieve new biological functions depends on the development of genetic tools that link the presence of a molecular signal to gene-regulatory activity. Recently, a set of engineered RNA controllers was described that enabled predictable tuning of gene expression in the yeast Saccharomyces cerevisiae through directed cleavage of transcripts by an RNase III enzyme, Rnt1p. Here, we describe a strategy for building a new class of RNA sensing-actuation devices based on direct integration of RNA aptamers into a region of the Rnt1p hairpin that modulates Rnt1p cleavage rates. We demonstrate that ligand binding to the integrated aptamer domain is associated with a structural change sufficient to inhibit Rnt1p processing. Three tuning strategies based on the incorporation of different functional modules into the Rnt1p switch platform were demonstrated to optimize switch dynamics and ligand responsiveness. We further demonstrated that these tuning modules can be implemented combinatorially in a predictable manner to further improve the regulatory response properties of the switch. The modularity and tunability of the Rnt1p switch platform will allow for rapid optimization and tailoring of this gene control device, thus providing a useful tool for the design of complex genetic networks in yeast

Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early Rheumatoid Arthritis: an observational study.

INTRODUCTION: Neovascularization contributes to the development of sustained synovial inflammation in the early stages of Rheumatoid Arthritis. Ultrasound (US) provides an indirect method of assessing synovial blood flow and has been shown to correlate with clinical disease activity in patients with Rheumatoid Arthritis. This study examines the relationship of US determined synovitis with synovial vascularity, angiogenic/lymphangiogenic factors and cellular mediators of inflammation in a cohort of patients with early Rheumatoid Arthritis (RA) patients prior to therapeutic intervention with disease modifying therapy or corticosteroids. METHODS: An ultrasound guided synovial biopsy of the supra-patella pouch was performed in 12 patients with early RA prior to treatment. Clinical, US and biochemical assessments were undertaken prior to the procedure. Ultrasound images and histological samples were obtained from the supra-patella pouch. Histological samples were stained for Factor VIII and a-SMA (a-smooth muscle actin). Using digital imaging analysis a vascular area score was recorded. QT-PCR (quantitative-PCR) of samples provided quantification of angiogenic and lymphangiogenic gene expression and immunohistochemistry stained tissue was scored for macrophage, T cell and B cell infiltration using an existing semi-quantitative score. RESULTS: Power Doppler showed a good correlation with histological vascular area (Spearman r--0.73) and angiogenic factors such as vascular endothelial growth factor-A (VEGF-A), Angiopoietin 2 and Tie-2. In addition, lymphangiogenic factors such as VEGF-C and VEGF-R3 correlated well with US assessment of synovitis. A significant correlation was also found between power Doppler and synovial thickness, pro-inflammatory cytokines and sub-lining macrophage infiltrate. Within the supra-patella pouch there was no significant difference in US findings, gene expression or inflammatory cell infiltrate between any regions of synovium biopsied. CONCLUSION: Ultrasound assessment of synovial tissue faithfully reflects synovial vascularity. Both grey scale and power Doppler synovitis in early RA patients correlate with a pro-angiogenic and lymphangiogenic gene expression profile. In early RA both grey scale and power Doppler synovitis are associated with a pro-inflammatory cellular and cytokine profile providing considerable validity in its use as an objective assessment of synovial inflammation in clinical practice

A wide angle view of the Sagittarius dwarf Spheroidal Galaxy. I: VIMOS photometry and radial velocities across Sgr dSph major and minor axis

The Sagittarius dwarf Spheroidal Galaxy (Sgr dSph) provides us with a unique possibility of studying a dwarf galaxy merging event while still in progress. Due to its low distance (25 kpc), the main body of Sgr dSph covers a vast area in the sky (roughly 15 x 7 degrees). Available photometric and spectroscopic studies have concentrated either on the central part of the galaxy or on the stellar stream, but the overwhelming majority of the galaxy body has never been probed. The aim of the present study is twofold. On the one hand, to produce color magnitude diagrams across the extension of Sgr dSph to study its stellar populations, searching for age and/or composition gradients (or lack thereof). On the other hand, to derive spectroscopic low-resolution radial velocities for a subsample of stars to determine membership to Sgr dSph for the purpose of high resolution spectroscopic follow-up. We used VIMOS-VLT to produce V and I photometry and spectroscopy on 7 fields across the Sgr dSph minor and major axis, plus 3 more centered on the associated globular clusters Terzan 7, Terzan 8 and Arp 2. A last field has been centered on M 54, lying in the center of Sgr dSph. We present photometry for 320,000 stars across the main body of Sgr dSph, one of the richest, and safely the most wide-angle sampling ever produced for this fundamental object. We also provide robust memberships for more than one hundred stars, whose high resolution spectroscopic analysis will be the object of forthcoming papers. Sgr dSph appears remarkably uniform among the observed fields. We confirm the presence of a main Sgr dSph population characterized roughly by the same metallicity of 47 Tuc, but we also found the presence of multiple populations on the peripheral fields of the galaxy, with a metallicity spanning from [Fe/H]=-2.3 to a nearly solar value.Comment: 10 pages, 12 figures, accepted for publication in A&

Interfacial charge transfer in nanoscale polymer transistors

Interfacial charge transfer plays an essential role in establishing the relative alignment of the metal Fermi level and the energy bands of organic semiconductors. While the details remain elusive in many systems, this charge transfer has been inferred in a number of photoemission experiments. We present electronic transport measurements in very short channel ($L < 100$ nm) transistors made from poly(3-hexylthiophene) (P3HT). As channel length is reduced, the evolution of the contact resistance and the zero-gate-voltage conductance are consistent with such charge transfer. Short channel conduction in devices with Pt contacts is greatly enhanced compared to analogous devices with Au contacts, consistent with charge transfer expectations. Alternating current scanning tunneling microscopy (ACSTM) provides further evidence that holes are transferred from Pt into P3HT, while much less charge transfer takes place at the Au/P3HT interface.Comment: 19 preprint pages, 6 figure

A High Energy X-ray Imager for Inertial Confinement Fusion at the National Ignition Facility

X-ray imaging is a fundamental diagnostic tool for inertial confinement fusion (ICF) research, and provides data on the size and the shape of the core in implosions. We report on the feasibility and performance analysis of an ignition x-ray imager to be used on cryogenic DT implosions at the National Ignition Facility. The system is intended to provide time-integrated, broadband, moderate-energy x-ray core images of imploding ICF capsules. It is optimized with respect to spatial-resolution, signal-to-background and signal-to-noise ratios, taking into account the extreme operating conditions expected at NIF due to high expected neutrons yields, gamma-rays, and x-rays from laser-plasma interactions