152 research outputs found
Relic Gravitational Waves and Their Detection
The range of expected amplitudes and spectral slopes of relic (squeezed)
gravitational waves, predicted by theory and partially supported by
observations, is within the reach of sensitive gravity-wave detectors. In the
most favorable case, the detection of relic gravitational waves can be achieved
by the cross-correlation of outputs of the initial laser interferometers in
LIGO, VIRGO, GEO600. In the more realistic case, the sensitivity of advanced
ground-based and space-based laser interferometers will be needed. The specific
statistical signature of relic gravitational waves, associated with the
phenomenon of squeezing, is a potential reserve for further improvement of the
signal to noise ratio.Comment: 25 pages, 9 figures included, revtex. Based on a talk given at
"Gyros, Clocks, and Interferometers: Testing General Relativity in Space"
(Germany, August 99
Casimir energy in multiply connected static hyperbolic Universes
We generalize a previously obtained result, for the case of a few other
static hyperbolic universes with manifolds of nontrivial topology as spatial
sections.Comment: accepted for publicatio
The Sensitivity of Ligo to a Stochastic Background, and its Dependance on the Detector Orientations
We analyze the sensitivity of a network of interferometer gravitational-wave
detectors to the gravitational-wave stochastic background, and derive the
dependence of this sensitivity on the orientations of the detector arms. We
build on and extend the recent work of Christensen, but our conclusion for the
optimal choice of orientations of a pair of detectors differs from his. For a
pair of detectors (such as LIGO) that subtends an angle at the center of the
earth of \,\alt 70^\circ, we find that the optimal configuration is for each
detector to have its arms make an angle of (modulo ) with
the arc of the great circle that joins them. For detectors that are farther
separated, each detector should instead have one arm aligned with this arc. We
also describe in detail the optimal data-analysis algorithm for searching for
the stochastic background with a detector network, which is implicit in earlier
work of Michelson. The LIGO pair of detectors will be separated by . The minimum detectable stochastic energy-density for these
detectors with their currently planned orientations is greater than
what it would be if the orientations were optimal.Comment: 56 pages, 10 figures, Caltech preprint GRP-347, submitted to Phys Rev
D, uses revtex macro
Ecosystem-based management for military training, biodiversity, carbon storage and climate resiliency on a complex coastal land/water-scape
The Defense Coastal/Estuarine Research Program (DCERP) was a 10-year multi-investigator project funded by the Department of Defense to improve understanding of ecosystem processes and their interactions with natural and anthropogenic stressors at the Marine Corps Base Camp Lejeune (MCBCL) located in coastal North Carolina. The project was aimed at facilitating ecosystem-based management (EBM) at the MCBCL and other coastal military installations. Because of its scope, interdisciplinary character, and duration, DCERP embodied many of the opportunities and challenges associated with EBM, including the need for explicit goals, system models, long-term perspectives, systems complexity, change inevitability, consideration of humans as ecosystem components, and program adaptability and accountability. We describe key elements of this program, its contributions to coastal EBM, and its relevance as an exemplar of EBM
Gravitational Radiation From Cosmological Turbulence
An injection of energy into the early Universe on a given characteristic
length scale will result in turbulent motions of the primordial plasma. We
calculate the stochastic background of gravitational radiation arising from a
period of cosmological turbulence, using a simple model of isotropic
Kolmogoroff turbulence produced in a cosmological phase transition. We also
derive the gravitational radiation generated by magnetic fields arising from a
dynamo operating during the period of turbulence. The resulting gravitational
radiation background has a maximum amplitude comparable to the radiation
background from the collision of bubbles in a first-order phase transition, but
at a lower frequency, while the radiation from the induced magnetic fields is
always subdominant to that from the turbulence itself. We briefly discuss the
detectability of such a signal.Comment: 20 pages. Corrections for an errant factor of 2 in all the gravity
wave characteristic amplitudes. Accepted for publication in Phys. Rev.
Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to unexplained genetic variance. To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European ancestry. We found exome-wide significant (P<5×10-7) evidence for two loci not previously highlighted by common variant GWAS: GLP1R (p.Ala316Thr, minor allele frequency (MAF)=1.5%) influencing FG levels, and URB2 (p.Glu594Val, MAF = 0.1%) influencing FI levels. Coding variant associations can highlight potential effector genes at (non-coding) GWAS signals. At the G6PC2/ABCB11 locus, we identified multiple coding variants in G6PC2 (p.Val219Leu, p.His177Tyr, and p.Tyr207Ser) influencing FG levels, conditionally independent of each other and the non-coding GWAS signal. In vitro assays demonstrate that these associated coding alleles result in reduced protein abundance via proteasomal degradation, establishing G6PC2 as an effector gene at this locus. Reconciliation of single-variant associations and functional effects was only possible when haplotype phase was considered. In contrast to earlier reports suggesting that, paradoxically, glucose-raising alleles at this locus are protective against type 2 diabetes (T2D), the p.Val219Leu G6PC2 variant displayed a modest but directionally consistent association with T2D risk. Coding variant associations for glycemic traits in GWAS signals highlight PCSK1, RREB1, and ZHX3 as likely effector transcripts. These coding variant association signals do not have a major impact on the trait variance explained, but they do provide valuable biological insights
Identification of common genetic risk variants for autism spectrum disorder
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared with other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD.Peer reviewe
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