Intestinal neuromuscular function after preservation and transplantation

While it is well known that prolonged preservation of the intestinal graft causes severe mucosal damage after transplantation, little is known about the effect on neuromuscular function. The entire small intestine of adult hound dogs was flushed and preserved with cold lactated Ringer's solution and autotransplanted either immediately (n = 6) or after 24 hr (n = 6). Animals undergoing sham operation (n = 4) were used as a control. Fasting motility and the response of the intestinal smooth muscle and enteric nerves to bethanechol (100 μg/kg/0.5 hr, iv) and cisapride (0.5 mg/kg, iv) were determined by a multiple strain gauge method on Postoperative Days 2, 4, 7, 14, 21, and 28. Compared to the control, immediately transplanted grafts and those preserved for 24 hr developed delayed reappearance of migrating myoelectric complexes (MMC), hypercontractile activity, and reduced response to bethanechol and cisapride administration. Animals in the preservation group developed more abnormal fasting motility after transplantation, but responses to bethanechol and cisapride stimulation were not markedly different from those of the immediate group. The reappearance of MMC occurred 3 weeks postoperatively in the preservation group compared to 2 days in the immediate group. The results of our study indicate that intestinal dysmotility is augmented in prolonged-preservation grafts compared to those with brief preservation. The dysmotility was transient and normalized 3 to 4 weeks after surgery. Preservation and reperfusion injury to the neuromuscular system of intestinal grafts are reversible and are attenuated by simple hypothermia

Toward a Deterministic Model of Planetary Formation VI: Dynamical Interaction and Coagulation of Multiple Rocky Embryos and Super-Earth Systems around Solar Type Stars

Radial velocity and transit surveys indicate that solar-type stars bear super-Earths, with mass and period up to ~ 20 M_E and a few months, are more common than those with Jupiter-mass gas giants. In many cases, these super-Earths are members of multiple-planet systems in which their mutual dynamical interaction has influenced their formation and evolution. In this paper, we modify an existing numerical population synthesis scheme to take into account protoplanetary embryos' interaction with their evolving natal gaseous disk, as well as their close scatterings and resonant interaction with each other. We show that it is possible for a group of compact embryos to emerge interior to the ice line, grow, migrate, and congregate into closely-packed convoys which stall in the proximity of their host stars. After the disk-gas depletion, they undergo orbit crossing, close scattering, and giant impacts to form multiple rocky Earths or super-Earths in non-resonant orbits around ~ 0.1AU with moderate eccentricities of ~0.01-0.1. We suggest that most refractory super-Earths with period in the range of a few days to weeks may have formed through this process. These super-Earths differ from Neptune-like ice giants by their compact sizes and lack of a substantial gaseous envelope.Comment: 37 pages, 10 figures, accepted for publication in Ap

Tidal Limits to Planetary Habitability

The habitable zones of main sequence stars have traditionally been defined as the range of orbits that intercept the appropriate amount of stellar flux to permit surface water on a planet. Terrestrial exoplanets discovered to orbit M stars in these zones, which are close-in due to decreased stellar luminosity, may also undergo significant tidal heating. Tidal heating may span a wide range for terrestrial exoplanets and may significantly affect conditions near the surface. For example, if heating rates on an exoplanet are near or greater than that on Io (where tides drive volcanism that resurface the planet at least every 1 Myr) and produce similar surface conditions, then the development of life seems unlikely. On the other hand, if the tidal heating rate is less than the minimum to initiate plate tectonics, then CO_2 may not be recycled through subduction, leading to a runaway greenhouse that sterilizes the planet. These two cases represent potential boundaries to habitability and are presented along with the range of the traditional habitable zone for main sequence, low-mass stars. We propose a revised habitable zone that incorporates both stellar insolation and tidal heating. We apply these criteria to GJ 581 d and find that it is in the traditional habitable zone, but its tidal heating alone may be insufficient for plate tectonics.Comment: 13 pages, 2 figures, accepted to ApJ Letters. A version with full resolution images is available at http://www.astro.washington.edu/users/rory/publications/bjgr09.pd

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

The mechanisms that generate itch are poorly understood at both the molecular and cellular levels despite its clinical importance. To explore the peripheral neuronal mechanisms underlying itch, we assessed the behavioral responses (scratching) produced by s.c. injection of various pruritogens in PLCβ3- or TRPV1-deficient mice. We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCβ3 and the TRPV1 channel; 2) serotonin, or a selective agonist, α-methyl-serotonin (α-Me-5-HT), requires the presence of PLCβ3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCβ3 or TRPV1. To determine whether the activity of these molecules is represented in a particular subpopulation of sensory neurons, we examined the behavioral consequences of selectively eliminating 2 nonoverlapping subsets of nociceptors. The genetic ablation of MrgprD^+ neurons that represent ≈90% of cutaneous nonpeptidergic neurons did not affect the scratching responses to a number of pruritogens. In contrast, chemical ablation of the central branch of TRPV1+ nociceptors led to a significant behavioral deficit for pruritogens, including α-Me-5-HT and ET-1, that is, the TRPV1-expressing nociceptor was required, whether or not TRPV1 itself was essential. Thus, TRPV1 neurons are equipped with multiple signaling mechanisms that respond to different pruritogens. Some of these require TRPV1 function; others use alternate signal transduction pathways

Distribution of Accreting Gas and Angular Momentum onto Circumplanetary Disks

We investigate gas accretion flow onto a circumplanetary disk from a protoplanetary disk in detail by using high-resolution three-dimensional nested-grid hydrodynamic simulations, in order to provide a basis of formation processes of satellites around giant planets. Based on detailed analyses of gas accretion flow, we find that most of gas accretion onto circumplanetary disks occurs nearly vertically toward the disk surface from high altitude, which generates a shock surface at several scale heights of the circumplanetary disk. The gas that has passed through the shock surface moves inward because its specific angular momentum is smaller than that of the local Keplerian rotation, while gas near the midplane in the protoplanetary disk cannot accrete to the circumplanetary disk. Gas near the midplane within the planet's Hill sphere spirals outward and escapes from the Hill sphere through the two Lagrangian points L$_1$ and L$_2$. We also analyze fluxes of accreting mass and angular momentum in detail and find that the distributions of the fluxes onto the disk surface are well described by power-law functions and that a large fraction of gas accretion occurs at the outer region of the disk, i.e., at about 0.1 times the Hill radius. The nature of power-law functions indicates that, other than the outer edge, there is no specific radius where gas accretion is concentrated. These source functions of mass and angular momentum in the circumplanetary disk would provide us with useful constraints on the structure and evolution of the circumplanetary disk, which is important for satellite formation.Comment: 22pages, 17 figures, accepted for publication in Ap

Near-infrared transit photometry of the exoplanet HD 149026b

The transiting exoplanet HD 149026b is an important case for theories of planet formation and planetary structure, because the planet's relatively small size has been interpreted as evidence for a highly metal-enriched composition. We present observations of 4 transits with the Near Infrared Camera and Multi-Object Spectrometer on the Hubble Space Telescope, within a wavelength range of 1.1--2.0 $\mu$m. Analysis of the light curve gives the most precise estimate yet of the stellar mean density, $\rho_\star = 0.497^{+0.042}_{-0.057}$ g cm$^{-3}$. By requiring agreement between the observed stellar properties (including $\rho_\star$) and stellar evolutionary models, we refine the estimate of the stellar radius: $R_\star = 1.541^{+0.046}_{-0.042}$ R_\sun. We also find a deeper transit than has been measured at optical and mid-infrared wavelengths. Taken together, these findings imply a planetary radius of $R_p = 0.813^{+0.027}_{-0.025}$ $R_{\rm Jup}$, which is larger than earlier estimates. Models of the planetary interior still require a metal-enriched composition, although the required degree of metal enrichment is reduced. It is also possible that the deeper NICMOS transit is caused by wavelength-dependent absorption by constituents in the planet's atmosphere, although simple model atmospheres do not predict this effect to be strong enough to account for the discrepancy. We use the 4 newly-measured transit times to compute a refined transit ephemeris.Comment: 18 pages, 13 figures, accepted for publication in Ap

On the Origin of HD149026b

The high density of the close-in extrasolar planet HD149026b suggests the presence of a huge core in the planet, which challenges planet formation theory. We first derive constraints on the amount of heavy elements and hydrogen/helium present in the planet: We find that preferred values of the core mass are between 50 and 80 M_E. We then investigate the possibility of subcritical core accretion as envisioned for Uranus and Neptune and find that the subcritical accretion scenario is unlikely in the case of HD149026b for at least two reasons: (i) Subcritical planets are such that the ratio of their core mass to their total mass is above ~0.7, in contradiction with constraints for all but the most extreme interior models of HD149026b; (ii) High accretion rates and large isolation mass required for the formation of a subcritical core of 30 M_E are possible only at specific orbital distances in a disk with a surface density of dust equal to at least 10 times that of the minimum mass solar nebula. This value climbs to 30 when considering a 50 M_E core. These facts point toward two main routes for the formation of this planet: (i) Gas accretion that is limited by a slow viscous inflow of gas in an evaporating disk; (ii) A significant modification of the composition of the planet after as accretion has stopped. These two routes are not mutually exclusive. Illustrating the second route, we show that for a wide range of impact parameters, giant impacts lead to a loss of the gas component of the planet and thus may lead to planets that are highly enriched in heavy elements. In the giant impact scenario, we expect an outer giant planet to be present. Observational studies by imaging, astrometry and long term interferometry of this system are needed to better narrow down the ensemble of possibilities.Comment: 29 pages, 8 figures, to appear in the 10 October 2006 issue of Ap

Analysis of new high-precision transit light curves of WASP-10 b: starspot occultations, small planetary radius, and high metallicity

The WASP-10 planetary system is intriguing because different values of radius have been reported for its transiting exoplanet. The host star exhibits activity in terms of photometric variability, which is caused by the rotational modulation of the spots. Moreover, a periodic modulation has been discovered in transit timing of WASP-10 b, which could be a sign of an additional body perturbing the orbital motion of the transiting planet. We attempt to refine the physical parameters of the system, in particular the planetary radius, which is crucial for studying the internal structure of the transiting planet. We also determine new mid-transit times to confirm or refute observed anomalies in transit timing. We acquired high-precision light curves for four transits of WASP-10 b in 2010. Assuming various limb-darkening laws, we generated best-fit models and redetermined parameters of the system. The prayer-bead method and Monte Carlo simulations were used to derive error estimates. Three transit light curves exhibit signatures of the occultations of dark spots by the planet during its passage across the stellar disk. The influence of stellar activity on transit depth is taken into account while determining system parameters. The radius of WASP-10 b is found to be no greater than 1.03 Jupiter radii, a value significantly smaller than most previous studies indicate. We calculate interior structure models of the planet, assuming a two-layer structure with one homogeneous envelope atop a rock core. The high value of the WASP-10 b's mean density allows one to consider the planet's internal structure including 270 to 450 Earth masses of heavy elements. Our new mid-transit times confirm that transit timing cannot be explained by a constant period if all literature data points are considered. They are consistent with the ephemeris assuming a periodic variation of transit timing...Comment: Accepted for publication in A&

ESPRESSO Mass determination of TOI-263b: An extreme inhabitant of the brown dwarf desert

The TESS mission has reported a wealth of new planetary systems around bright and nearby stars amenable for detailed characterization of the planet properties and their atmospheres. However, not all interesting TESS planets orbit around bright host stars. TOI-263b is a validated ultra-short period substellar object in a 0.56-day orbit around a faint (V=18.97) M3.5 dwarf star. The substellar nature of TOI-263b was explored using multi-color photometry, which determined a true radius of 0.87+-0.21 Rj, establishing TOI-263b's nature ranging from an inflated Neptune to a brown dwarf. The orbital period-radius parameter space occupied by TOI-263b is quite unique, which prompted a further characterization of its true nature. Here, we report radial velocity measurements of TOI-263 obtained with 3 VLT units and the ESPRESSO spectrograph to retrieve the mass of TOI-263b. We find that TOI-263b is a brown dwarf with a mass of 61.6+-4.0 Mj. Additionally, the orbital period of the brown dwarf is found to be synchronized with the rotation period of the host star, and the system is found to be relatively active, possibly revealing a star--brown dwarf interaction. All these findings suggest that the system's formation history might be explained via disc fragmentation and later migration to close-in orbits. If the system is found to be unstable, TOI-263 is an excellent target to test the migration mechanisms before the brown dwarf becomes engulfed by its parent star.Comment: Accepted for Publication in Astronomy and Astrophysic