X-ray Emission from Magnetically Torqued Disks of Oe/Be Stars

We focus attention on the Oe/Be stars to test the concept that the disks of these stars form by magnetic channeling of wind material toward the equator. Calculations are made of the X-rays expected from the Magnetically Torqued Disk (MTD) model for Be stars discussed by Cassinelli et al. (2002), by Maheswaran (2003), and by Brown et al. (2004). The dominant parameters in the model are the $\beta$ value of the velocity law, the rotation rate of the star, $S_o$, and the ratio of the magnetic field energy density to the disk gravitational energy density, $\gamma$. The model predictions are compared with the $ROSAT$ observations obtained for an O9.5 star $\zeta$ Oph from \Berghofer et al. (1996) and for 7 Be stars from Cohen et al. (1997). Extra considerations are also given here to the well studied Oe star $\zeta$ Oph for which we have $Chandra$ observations of the X-ray line profiles of the triad of He-like lines from the ion Mg XI.Comment: 28 pages with 6 figures. Accepted for publication in Ap

New Challenges For Wind Shock Models: The Chandra Spectrum Of The Hot Star Delta Orionis

The Chandra spectrum of delta Ori A shows emission lines from hydrogen- and helium-like states of Si, Mg, Ne, and O, along with N VII Lyalpha and lines from ions in the range Fe XVII-Fe XXI In contrast to the broad lines seen in zeta Pup and zeta Ori (850 +/- 40 and 1000 +/- 240 km s(-1) half-width at half-maximum [HWHM], respectively), these lines are broadened to only 430 +/- 60 km s(-1) HWHM. This is much lower than the measured wind terminal velocity of 2000 km s(-1). The forbidden, intercombination, and resonance (fir) lines from He-like ions indicate that the majority of the X-ray line emission does not originate at the base of the wind, in agreement with the standard wind shock models for these objects. However, in that model the X-ray emission is distributed throughout an expanding, X-ray-absorbing wind, and it is therefore surprising that the emission lines appear relatively narrow, unshifted, and symmetric. We compare the observed line profiles to recent detailed models for X-ray line pro le generation in hot stars, but none of them offers a fully satisfactory explanation for the observed line profiles

The 5'-3' exoribonuclease Pacman (Xrn1) regulates expression of the heat shock protein Hsp67Bc and the microRNA miR-277-3p in Drosophila wing imaginal discs

Pacman/Xrn1 is a highly conserved exoribonuclease known to play a critical role in gene regulatory events such as control of mRNA stability, RNA interference and regulation via miRNAs. Although Pacman has been well studied in Drosophila tissue culture cells, the biologically relevant cellular pathways controlled by Pacman in natural tissues are unknown. This study shows that a hypomorphic mutation in pacman (pcm5) results in smaller wing imaginal discs. These tissues, found in the larva, are known to grow and differentiate to form wing and thorax structures in the adult fly. Using microarray analysis, followed by quantitative RT-PCR, we show that eight mRNAs were increased in level by >2 fold in the pcm5 mutant wing discs compared to the control. The levels of pre mRNAs were tested for five of these mRNAs; four did not increase in the pcm5 mutant, showing that they are regulated at the post-transcriptional level and therefore could be directly affected by Pacman. These transcripts include one that encodes the heat-shock protein Hsp67Bc, which is upregulated 11.9-fold at the post-transcriptional level and 2.3-fold at the protein level. One miRNA, miR-277-3p, is 5.6-fold downregulated at the post-transcriptional level in mutant discs, suggesting that Pacman affects its processing in this tissue. Together, these data show that a relatively small number of mRNAs and miRNAs substantially change in abundance in pacman mutant wing imaginal discs. Since Hsp67Bc is known to regulate autophagy and protein synthesis, it is possible that Pacman may control the growth of wing imaginal discs by regulating these processes

Identification of furfural resistant strains of Saccharomyces cerevisiae and Saccharomyces paradoxus from a collection of environmental and industrial isolates

Background Fermentation of bioethanol using lignocellulosic biomass as a raw material provides a sustainable alternative to current biofuel production methods by utilising waste food streams as raw material. Before lignocellulose can be fermented it requires physical, chemical and enzymatic treatment in order to release monosaccharides, a process that causes the chemical transformation of glucose and xylose into the cyclic aldehydes furfural and hydroxyfurfural. These furan compounds are potent inhibitors of Saccharomyces fermentation, and consequently furfural tolerant strains of Saccharomyces are required for lignocellulosic fermentation. Results This study investigated yeast tolerance to furfural and hydroxyfurfural using a collection of 71 environmental and industrial isolates of the baker’s yeast Saccharomyces cerevisiae and its closest relative Saccharomyces paradoxus. The Saccharomyces strains were initially screened for growth on media containing 100 mM glucose and 1.5 mg ml-1 furfural. Five strains were identified that showed a significant tolerance to growth in the presence of furfural and these were then screened for growth and ethanol production in the presence of increasing amounts (0.1-4 mg ml-1) of furfural. Conclusions Of the five furfural tolerant strains S. cerevisiae NCYC 3451 displayed the greatest furfural resistance, and was able to grow in the presence of up to 3.0 mg ml-1 furfural. Furthermore, ethanol production in this strain did not appear to be inhibited by furfural, with the highest ethanol yield observed at 3.0 mg ml-1 furfural. Although furfural resistance was not found to be a trait specific to any one particular lineage or population, three of the strains were isolated from environments where they might be continually exposed to low levels of furfural through the on-going natural degradation of lignocelluloses, and would therefore develop elevated levels of resistance to these furan compounds. Thus these strains represent good candidates for future studies of genetic variation relevant to understanding and manipulating furfural resistance and in the development of tolerant ethanologenic yeast strains for use in bioethanol production from lignocellulose processing

Higher Spin Gravitational Couplings and the Yang--Mills Detour Complex

Gravitational interactions of higher spin fields are generically plagued by inconsistencies. We present a simple framework that couples higher spins to a broad class of gravitational backgrounds (including Ricci flat and Einstein) consistently at the classical level. The model is the simplest example of a Yang--Mills detour complex, which recently has been applied in the mathematical setting of conformal geometry. An analysis of asymptotic scattering states about the trivial field theory vacuum in the simplest version of the theory yields a rich spectrum marred by negative norm excitations. The result is a theory of a physical massless graviton, scalar field, and massive vector along with a degenerate pair of zero norm photon excitations. Coherent states of the unstable sector of the model do have positive norms, but their evolution is no longer unitary and their amplitudes grow with time. The model is of considerable interest for braneworld scenarios and ghost condensation models, and invariant theory.Comment: 19 pages LaTe

Multi-serotype pneumococcal nasopharyngeal carriage prevalence in vaccine naïve Nepalese children, assessed using molecular serotyping.

Invasive pneumococcal disease is one of the major causes of death in young children in resource poor countries. Nasopharyngeal carriage studies provide insight into the local prevalence of circulating pneumococcal serotypes. There are very few data on the concurrent carriage of multiple pneumococcal serotypes. This study aimed to identify the prevalence and serotype distribution of pneumococci carried in the nasopharynx of young healthy Nepalese children prior to the introduction of a pneumococcal conjugate vaccine using a microarray-based molecular serotyping method capable of detecting multi-serotype carriage. We conducted a cross-sectional study of healthy children aged 6 weeks to 24 months from the Kathmandu Valley, Nepal between May and October 2012. Nasopharyngeal swabs were frozen and subsequently plated on selective culture media. DNA extracts of plate sweeps of pneumococcal colonies from these cultures were analysed using a molecular serotyping microarray capable of detecting relative abundance of multiple pneumococcal serotypes. 600 children were enrolled into the study: 199 aged 6 weeks to <6 months, 202 aged 6 months to < 12 months, and 199 aged 12 month to 24 months. Typeable pneumococci were identified in 297/600 (49.5%) of samples with more than one serotype being found in 67/297 (20.2%) of these samples. The serotypes covered by the thirteen-valent pneumococcal conjugate vaccine were identified in 44.4% of samples containing typeable pneumococci. Application of a molecular serotyping approach to identification of multiple pneumococcal carriage demonstrates a substantial prevalence of co-colonisation. Continued surveillance utilising this approach following the introduction of routine use of pneumococcal conjugate vaccinates in infants will provide a more accurate understanding of vaccine efficacy against carriage and a better understanding of the dynamics of subsequent serotype and genotype replacement

A comparison of match demands using ball-in-play versus whole match data in professional soccer players of the English Championship

This is the first study to report the Whole Match, ball-in-play (BiP), ball-out-of-play (BoP), and Max BiP (worst case scenario phases of play) demands of professional soccer players competing in the English Championship. Effective playing time per soccer game is typically 90 s) providing precise peak match demands. Whole-match demands recorded were compared to BiP and Max BiP, and BiP data excluded data from all match stoppages, providing a more precise analysis of match demands. Whole-match metrics were significantly lower than BiP metrics (p 90 s. No significant differences were found between positions. Ball-in-play analysis allows an accurate representation of the game and physical demands imposed on professional soccer players. Through having a clearer understanding of maximum game demands in professional soccer, will enable practitioners to design highly specific training methods

Gravity, Two Times, Tractors, Weyl Invariance and Six Dimensional Quantum Mechanics

Fefferman and Graham showed some time ago that four dimensional conformal geometries could be analyzed in terms of six dimensional, ambient, Riemannian geometries admitting a closed homothety. Recently it was shown how conformal geometry provides a description of physics manifestly invariant under local choices of unit systems. Strikingly, Einstein's equations are then equivalent to the existence of a parallel scale tractor (a six component vector subject to a certain first order covariant constancy condition at every point in four dimensional spacetime). These results suggest a six dimensional description of four dimensional physics, a viewpoint promulgated by the two times physics program of Bars. The Fefferman--Graham construction relies on a triplet of operators corresponding, respectively to a curved six dimensional light cone, the dilation generator and the Laplacian. These form an sp(2) algebra which Bars employs as a first class algebra of constraints in a six-dimensional gauge theory. In this article four dimensional gravity is recast in terms of six dimensional quantum mechanics by melding the two times and tractor approaches. This "parent" formulation of gravity is built from an infinite set of six dimensional fields. Successively integrating out these fields yields various novel descriptions of gravity including a new four dimensional one built from a scalar doublet, a tractor vector multiplet and a conformal class of metrics.Comment: 27 pages, LaTe