456 research outputs found
Intestinal neuromuscular function after preservation and transplantation
While it is well known that prolonged preservation of the intestinal graft causes severe mucosal damage after transplantation, little is known about the effect on neuromuscular function. The entire small intestine of adult hound dogs was flushed and preserved with cold lactated Ringer's solution and autotransplanted either immediately (n = 6) or after 24 hr (n = 6). Animals undergoing sham operation (n = 4) were used as a control. Fasting motility and the response of the intestinal smooth muscle and enteric nerves to bethanechol (100 μg/kg/0.5 hr, iv) and cisapride (0.5 mg/kg, iv) were determined by a multiple strain gauge method on Postoperative Days 2, 4, 7, 14, 21, and 28. Compared to the control, immediately transplanted grafts and those preserved for 24 hr developed delayed reappearance of migrating myoelectric complexes (MMC), hypercontractile activity, and reduced response to bethanechol and cisapride administration. Animals in the preservation group developed more abnormal fasting motility after transplantation, but responses to bethanechol and cisapride stimulation were not markedly different from those of the immediate group. The reappearance of MMC occurred 3 weeks postoperatively in the preservation group compared to 2 days in the immediate group. The results of our study indicate that intestinal dysmotility is augmented in prolonged-preservation grafts compared to those with brief preservation. The dysmotility was transient and normalized 3 to 4 weeks after surgery. Preservation and reperfusion injury to the neuromuscular system of intestinal grafts are reversible and are attenuated by simple hypothermia
Toward a Deterministic Model of Planetary Formation VI: Dynamical Interaction and Coagulation of Multiple Rocky Embryos and Super-Earth Systems around Solar Type Stars
Radial velocity and transit surveys indicate that solar-type stars bear
super-Earths, with mass and period up to ~ 20 M_E and a few months, are more
common than those with Jupiter-mass gas giants. In many cases, these
super-Earths are members of multiple-planet systems in which their mutual
dynamical interaction has influenced their formation and evolution. In this
paper, we modify an existing numerical population synthesis scheme to take into
account protoplanetary embryos' interaction with their evolving natal gaseous
disk, as well as their close scatterings and resonant interaction with each
other. We show that it is possible for a group of compact embryos to emerge
interior to the ice line, grow, migrate, and congregate into closely-packed
convoys which stall in the proximity of their host stars. After the disk-gas
depletion, they undergo orbit crossing, close scattering, and giant impacts to
form multiple rocky Earths or super-Earths in non-resonant orbits around ~
0.1AU with moderate eccentricities of ~0.01-0.1. We suggest that most
refractory super-Earths with period in the range of a few days to weeks may
have formed through this process. These super-Earths differ from Neptune-like
ice giants by their compact sizes and lack of a substantial gaseous envelope.Comment: 37 pages, 10 figures, accepted for publication in Ap
Development of a novel integrated iontophoresis electrode consisting of metallic and drug-loaded layers
Tidal Limits to Planetary Habitability
The habitable zones of main sequence stars have traditionally been defined as
the range of orbits that intercept the appropriate amount of stellar flux to
permit surface water on a planet. Terrestrial exoplanets discovered to orbit M
stars in these zones, which are close-in due to decreased stellar luminosity,
may also undergo significant tidal heating. Tidal heating may span a wide range
for terrestrial exoplanets and may significantly affect conditions near the
surface. For example, if heating rates on an exoplanet are near or greater than
that on Io (where tides drive volcanism that resurface the planet at least
every 1 Myr) and produce similar surface conditions, then the development of
life seems unlikely. On the other hand, if the tidal heating rate is less than
the minimum to initiate plate tectonics, then CO_2 may not be recycled through
subduction, leading to a runaway greenhouse that sterilizes the planet. These
two cases represent potential boundaries to habitability and are presented
along with the range of the traditional habitable zone for main sequence,
low-mass stars. We propose a revised habitable zone that incorporates both
stellar insolation and tidal heating. We apply these criteria to GJ 581 d and
find that it is in the traditional habitable zone, but its tidal heating alone
may be insufficient for plate tectonics.Comment: 13 pages, 2 figures, accepted to ApJ Letters. A version with full
resolution images is available at
http://www.astro.washington.edu/users/rory/publications/bjgr09.pd
TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms
The mechanisms that generate itch are poorly understood at both the molecular and cellular levels despite its clinical importance. To explore the peripheral neuronal mechanisms underlying itch, we assessed the behavioral responses (scratching) produced by s.c. injection of various pruritogens in PLCβ3- or TRPV1-deficient mice. We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCβ3 and the TRPV1 channel; 2) serotonin, or a selective agonist, α-methyl-serotonin (α-Me-5-HT), requires the presence of PLCβ3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCβ3 or TRPV1. To determine whether the activity of these molecules is represented in a particular subpopulation of sensory neurons, we examined the behavioral consequences of selectively eliminating 2 nonoverlapping subsets of nociceptors. The genetic ablation of MrgprD^+ neurons that represent ≈90% of cutaneous nonpeptidergic neurons did not affect the scratching responses to a number of pruritogens. In contrast, chemical ablation of the central branch of TRPV1+ nociceptors led to a significant behavioral deficit for pruritogens, including α-Me-5-HT and ET-1, that is, the TRPV1-expressing nociceptor was required, whether or not TRPV1 itself was essential. Thus, TRPV1 neurons are equipped with multiple signaling mechanisms that respond to different pruritogens. Some of these require TRPV1 function; others use alternate signal transduction pathways
Distribution of Accreting Gas and Angular Momentum onto Circumplanetary Disks
We investigate gas accretion flow onto a circumplanetary disk from a
protoplanetary disk in detail by using high-resolution three-dimensional
nested-grid hydrodynamic simulations, in order to provide a basis of formation
processes of satellites around giant planets. Based on detailed analyses of gas
accretion flow, we find that most of gas accretion onto circumplanetary disks
occurs nearly vertically toward the disk surface from high altitude, which
generates a shock surface at several scale heights of the circumplanetary disk.
The gas that has passed through the shock surface moves inward because its
specific angular momentum is smaller than that of the local Keplerian rotation,
while gas near the midplane in the protoplanetary disk cannot accrete to the
circumplanetary disk. Gas near the midplane within the planet's Hill sphere
spirals outward and escapes from the Hill sphere through the two Lagrangian
points L and L. We also analyze fluxes of accreting mass and angular
momentum in detail and find that the distributions of the fluxes onto the disk
surface are well described by power-law functions and that a large fraction of
gas accretion occurs at the outer region of the disk, i.e., at about 0.1 times
the Hill radius. The nature of power-law functions indicates that, other than
the outer edge, there is no specific radius where gas accretion is
concentrated. These source functions of mass and angular momentum in the
circumplanetary disk would provide us with useful constraints on the structure
and evolution of the circumplanetary disk, which is important for satellite
formation.Comment: 22pages, 17 figures, accepted for publication in Ap
Near-infrared transit photometry of the exoplanet HD 149026b
The transiting exoplanet HD 149026b is an important case for theories of
planet formation and planetary structure, because the planet's relatively small
size has been interpreted as evidence for a highly metal-enriched composition.
We present observations of 4 transits with the Near Infrared Camera and
Multi-Object Spectrometer on the Hubble Space Telescope, within a wavelength
range of 1.1--2.0 m. Analysis of the light curve gives the most precise
estimate yet of the stellar mean density, g cm. By requiring agreement between the
observed stellar properties (including ) and stellar evolutionary
models, we refine the estimate of the stellar radius: R_\sun. We also find a deeper transit than has been
measured at optical and mid-infrared wavelengths. Taken together, these
findings imply a planetary radius of , which is larger than earlier estimates. Models of the planetary interior
still require a metal-enriched composition, although the required degree of
metal enrichment is reduced. It is also possible that the deeper NICMOS transit
is caused by wavelength-dependent absorption by constituents in the planet's
atmosphere, although simple model atmospheres do not predict this effect to be
strong enough to account for the discrepancy. We use the 4 newly-measured
transit times to compute a refined transit ephemeris.Comment: 18 pages, 13 figures, accepted for publication in Ap
On the Origin of HD149026b
The high density of the close-in extrasolar planet HD149026b suggests the
presence of a huge core in the planet, which challenges planet formation
theory. We first derive constraints on the amount of heavy elements and
hydrogen/helium present in the planet: We find that preferred values of the
core mass are between 50 and 80 M_E. We then investigate the possibility of
subcritical core accretion as envisioned for Uranus and Neptune and find that
the subcritical accretion scenario is unlikely in the case of HD149026b for at
least two reasons: (i) Subcritical planets are such that the ratio of their
core mass to their total mass is above ~0.7, in contradiction with constraints
for all but the most extreme interior models of HD149026b; (ii) High accretion
rates and large isolation mass required for the formation of a subcritical core
of 30 M_E are possible only at specific orbital distances in a disk with a
surface density of dust equal to at least 10 times that of the minimum mass
solar nebula. This value climbs to 30 when considering a 50 M_E core. These
facts point toward two main routes for the formation of this planet: (i) Gas
accretion that is limited by a slow viscous inflow of gas in an evaporating
disk; (ii) A significant modification of the composition of the planet after as
accretion has stopped. These two routes are not mutually exclusive.
Illustrating the second route, we show that for a wide range of impact
parameters, giant impacts lead to a loss of the gas component of the planet and
thus may lead to planets that are highly enriched in heavy elements. In the
giant impact scenario, we expect an outer giant planet to be present.
Observational studies by imaging, astrometry and long term interferometry of
this system are needed to better narrow down the ensemble of possibilities.Comment: 29 pages, 8 figures, to appear in the 10 October 2006 issue of Ap
Analysis of new high-precision transit light curves of WASP-10 b: starspot occultations, small planetary radius, and high metallicity
The WASP-10 planetary system is intriguing because different values of radius
have been reported for its transiting exoplanet. The host star exhibits
activity in terms of photometric variability, which is caused by the rotational
modulation of the spots. Moreover, a periodic modulation has been discovered in
transit timing of WASP-10 b, which could be a sign of an additional body
perturbing the orbital motion of the transiting planet. We attempt to refine
the physical parameters of the system, in particular the planetary radius,
which is crucial for studying the internal structure of the transiting planet.
We also determine new mid-transit times to confirm or refute observed anomalies
in transit timing. We acquired high-precision light curves for four transits of
WASP-10 b in 2010. Assuming various limb-darkening laws, we generated best-fit
models and redetermined parameters of the system. The prayer-bead method and
Monte Carlo simulations were used to derive error estimates. Three transit
light curves exhibit signatures of the occultations of dark spots by the planet
during its passage across the stellar disk. The influence of stellar activity
on transit depth is taken into account while determining system parameters. The
radius of WASP-10 b is found to be no greater than 1.03 Jupiter radii, a value
significantly smaller than most previous studies indicate. We calculate
interior structure models of the planet, assuming a two-layer structure with
one homogeneous envelope atop a rock core. The high value of the WASP-10 b's
mean density allows one to consider the planet's internal structure including
270 to 450 Earth masses of heavy elements. Our new mid-transit times confirm
that transit timing cannot be explained by a constant period if all literature
data points are considered. They are consistent with the ephemeris assuming a
periodic variation of transit timing...Comment: Accepted for publication in A&
ESPRESSO Mass determination of TOI-263b: An extreme inhabitant of the brown dwarf desert
The TESS mission has reported a wealth of new planetary systems around bright
and nearby stars amenable for detailed characterization of the planet
properties and their atmospheres. However, not all interesting TESS planets
orbit around bright host stars. TOI-263b is a validated ultra-short period
substellar object in a 0.56-day orbit around a faint (V=18.97) M3.5 dwarf star.
The substellar nature of TOI-263b was explored using multi-color photometry,
which determined a true radius of 0.87+-0.21 Rj, establishing TOI-263b's nature
ranging from an inflated Neptune to a brown dwarf. The orbital period-radius
parameter space occupied by TOI-263b is quite unique, which prompted a further
characterization of its true nature. Here, we report radial velocity
measurements of TOI-263 obtained with 3 VLT units and the ESPRESSO spectrograph
to retrieve the mass of TOI-263b. We find that TOI-263b is a brown dwarf with a
mass of 61.6+-4.0 Mj. Additionally, the orbital period of the brown dwarf is
found to be synchronized with the rotation period of the host star, and the
system is found to be relatively active, possibly revealing a star--brown dwarf
interaction. All these findings suggest that the system's formation history
might be explained via disc fragmentation and later migration to close-in
orbits. If the system is found to be unstable, TOI-263 is an excellent target
to test the migration mechanisms before the brown dwarf becomes engulfed by its
parent star.Comment: Accepted for Publication in Astronomy and Astrophysic
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