Improved movie recommendations based on a hybrid feature combination method

Recommender systems help users find relevant items efficiently based on their interests and historical interactions with other users. They are beneficial to businesses by promoting the sale of products and to user by reducing the search burden. Recommender systems can be developed by employing different approaches, including collaborative filtering (CF), demographic filtering (DF), content-based filtering (CBF) and knowledge-based filtering (KBF). However, large amounts of data can produce recommendations that are limited in accuracy because of diversity and sparsity issues. In this paper, we propose a novel hybrid method that combines user–user CF with the attributes of DF to indicate the nearest users, and compare four classifiers against each other. This method has been developed through an investigation of ways to reduce the errors in rating predictions based on users’ past interactions, which leads to improved prediction accuracy in all four classification algorithms. We applied a feature combination method that improves the prediction accuracy and to test our approach, we ran an offline evaluation using the 1M MovieLens dataset, well-known evaluation metrics and comparisons between methods with the results validating our proposed method

Does Spending Matter in Improving Healthcare Across MENA Region

This study addresses the impact of healthcare spending on quality of health. Particularly, it investigates the impact of health budget allocation, health system performance, a nation’s income, and demographic aspects on prompting health quality across the MENA region. The yearly data sample used covers the period 1995–2016. The estimated model is tested using the appropriate GLS random effects method. The findings do not show support for public spending on healthcare to improve healthcare quality across the MENA region. However, higher private spending on healthcare leads to lower infant mortality rates, thus improving healthcare quality. The results also show that the improvement in income per-capita for oil-exporting countries leads to improved quality of healthcare as well as in non-oil-exporting countries, however the marginal benefit is lower for oil-exporting countries, compared to non-oil-exporting countries. This might suggest that oil-exporting countries have already reached a significant floor level of infant mortality rate that cannot be improved. However, non-oil-exporting countries still have potential to reduce the infant mortality rate and improve the quality of healthcare

Optimization of sol-immobilized bimetallic Au–Pd/TiO2 catalysts: reduction of 4-nitrophenol to 4-aminophenol for wastewater remediation

A sol-immobilization method is used to synthesize a series of highly active and stable AuxPd1−x/TiO2 catalysts (where x = 0, 0.13, 0.25, 0.5, 0.75, 0.87 and 1) for wastewater remediation. The catalytic performance of the materials was evaluated for the catalytic reduction of 4-nitrophenol, a model wastewater contaminant, using NaBH4 as the reducing agent under mild reaction conditions. Reaction parameters such as substrate/metal and substrate/reducing agent molar ratios, reaction temperature and stirring rate were investigated. Structure-activity correlations were studied using a number of complementary techniques including X-ray powder diffraction, X-ray photoelectron spectroscopy and transmission electron microscopy. The sol-immobilization route provides very small Au–Pd alloyed nanoparticles, with the highest catalytic performance shown by the Au0.5Pd0.5/TiO2 catalyst.This article is part of a discussion meeting issue ‘Science to enable the circular economy’

Magnetic and Optical properties of strained films of multiferroic GdMnO3

The effects of strain on a film of mulitferroic GdMnO3 are investigated using both magnetometry and magneto-optic spectroscopy. Optical spectra, in the energy range 1.5eV - 3.5eV, were taken in Faraday geometry in an applied magnetic field and also at remanence. This yielded rich information on the effects of strain on the spin ordering in these films. Epitaxial films of GdMnO3 were grown on SrTiO3 and LaAlO3 substrates. The LaAlO3 was twinned and so produced a highly strained film whereas the strain was less for the film grown on SrTiO3. The Ne\'el temperatures and coercive fields were measured using zero field data and hysteresis loops obtained using a SQUID magnetometer. Optical absorption data agreed with earlier work on bulk materials. The two well known features in the optical spectrum, the charge transfer transition between Mn d states at ~2eV and the band edge transition from the oxygen p band to the d states at ~3eV are observed in the magnetic circular dichroism; however they behaved very differently both as a function of magnetic field and temperature. This is interpreted in terms of the magnetic ordering of the Mn spins.Comment: 9 pages of text including figure

ROLE OF THE PHYSICAL ACTIVITY IN THE IMPROVEMENT OF CARDIAC MEASURES AND DECLINING OF COMORBIDITIES.

Background: Regular physical activity (PA) can prevent many non-communicable diseases, such as cardiovascular disease (CVD) and diabetes mellitus (DM). The present study aimed to assess the health benefits of physical activities including blood pressure and comorbid conditions. Methodology: This is a prospective cohort case-control study that recruited 300 Saudi volunteers living in the city ofHail, Northern Saudi Arabia. Results: Out of 300 participants 155(51.7%) were males and 145 (48.3%) were females. There were 111(37%) participants committed to regular physical activity and the remaining 189(63%) without a defined commitment to physical activity (Uncommitted). Among 111 persons who claimed a commitment to regular physical activity (committed), 61(55%) were males and 50(45%) were females. The majority of committed individuals were at the age group 21-25 years followed by age group 26-30 and 31-35 years representing 32, 30, and 20 persons, respectively. The physical activity was highly practiced at the age range 21-30 years and this was found to be statistically significant P < 0.001. Conclusion: There is a low prevalence of physical activity in Hail region, particularly among females, which necessitates the suggestion of appropriate awareness programs. Younger and elder populations are in much need to be targeted with PA awareness programs

A switching multi-level method for the long tail recommendation problem

Recommender systems are decision support systems that play an important part in generating a list of product or service recommendations for users based on the past experiences and interactions. The most popular recommendation method is Collaborative Filtering (CF) that is based on the users’ rating history to generate the recommendation. Although, recommender systems have been applied successfully in different areas such as e-Commerce and Social Networks, the popularity bias is still one of the challenges that needs to be further researched. Therefore, we propose a multi-level method that is based on a switching approach which solves the long tail recommendation problem (LTRP) when CF fails to find the target case. We have evaluated our method using two public datasets and the results show that it outperforms a number of bases lines and state-of-the-art alternatives with a further reduce of the recommendation error rates for items found in the long tail

Reproducibility of experiments in recommender systems evaluation

© IFIP International Federation for Information Processing 2018 Published by Springer International Publishing AG 2018. All Rights Reserved. Recommender systems evaluation is usually based on predictive accuracy metrics with better scores meaning recommendations of higher quality. However, the comparison of results is becoming increasingly difficult, since there are different recommendation frameworks and different settings in the design and implementation of the experiments. Furthermore, there might be minor differences on algorithm implementation among the different frameworks. In this paper, we compare well known recommendation algorithms, using the same dataset, metrics and overall settings, the results of which point to result differences across frameworks with the exact same settings. Hence, we propose the use of standards that should be followed as guidelines to ensure the replication of experiments and the reproducibility of the results

Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/Bis-2(1H)-Quinolinone Hybrids

A series of novel 1,2,3-triazoles hybridized with two quinolin-2-ones, was designed and synthesized through click reactions. The structures of the synthesized compounds were elucidated by NMR, IR, and mass spectra in addition to elemental analysis. The synthesized compounds were assessed for their antiapoptotic activity in testis, as testicular torsion is the main cause of male infertility. This effect was studied in light of decreasing tissue damage induced by I/R in the testis of rats using N-acetylcysteine (NAC) as an antiapoptotic reference. Compounds 6a–c were the most active antiapoptotic hybrids with significant measurements for malondialdehyde (MDA) and total antioxidant capacity (TAC) and the apoptotic biomarkers (testicular testosterone, TNFα, and caspase-3) in comparison to the reference. A preliminary mechanistic study was performed to improve the antiapoptotic activity through caspase-3 inhibition. A compound assigned as 6-methoxy-4-(4-(((2-oxo-1,2-dihydroquinolin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)quinolin-2(1H)-one (6c) was selected as a representative of the most active hybrids in comparison to NAC. Assay of cytochrome C for 6c revealed an attenuation of cytochrome C level about 3.54 fold, comparable to NAC (4.13 fold). In caspases-3,8,9 assays, 6c was found to exhibit more potency and selectivity toward caspase-3 than other caspases. The testicular histopathological investigation was carried out on all targeted compounds 6a–g, indicating a significant improvement in the spermatogenesis process for compounds 6a–c if compared to the reference relative to the control. Finally, molecular docking studies were done at the caspase-3 active site to suggest possible binding modes. Hence, it could conceivably be hypothesized that compounds 6a–c could be considered good lead candidate compounds as antiapoptotic agents

Design, Synthesis, and Molecular Docking of Paracyclophanyl-Thiazole Hybrids as Novel CDK1 Inhibitors and Apoptosis Inducing Anti-Melanoma Agents

Three new series of paracyclophanyl-dihydronaphtho[2,3-d]thiazoles and paracyclophanyl-thiazolium bromides were designed, synthesized, and characterized by their spectroscopic data, along with X-ray analysis. One-dose assay results of anticancer activity indicated that 3a–e had the highest ability to inhibit the proliferation of different cancer cell lines. Moreover, the hybrids 3c–e were selected for five-dose analyses to demonstrate a broad spectrum of antitumor activity without apparent selectivity. Interestingly, series I compounds (Z)-N-substituted-4,9-dihydronaphtho[2,3-d]thiazol-3(2H)-yl)-4′-[2.2]paracyclophanylamide) that are carrying 1,4-dihydronaphthoquinone were more active as antiproliferative agents than their naphthalene-containing congeners (series II: substituted 2-(4′-[2.2]paracyclophanyl)hydrazinyl)-4-(naphth-2-yl)-thiazol-3-ium bromide hybrids) and (series III: 3-(4′-[2.2]paracyclophanyl)amido-2-(cyclopropylamino)-4-(naphth-2-yl)thiazol-3-ium bromide) toward the SK-MEL-5 melanoma cell line. Further antiproliferation investigations of 3c and 3e on the healthy, normal unaffected SK-MEL-5 cell line indicated their relative safety. Compound 3c showed an inhibition of eight isoforms of cyclin-dependent kinases (CDK); however, it exhibited the lowest IC50 of 54.8 nM on CDK1 in comparison to Dinaciclib as a reference. Additionally, compound 3c revealed a remarkable downregulation of phospho-Tyr15 with a level (7.45 pg/mL) close to the reference. 3c mainly showed cell cycle arrest in the pre-G1 and G2/M phases upon analysis of the SK-MEL-5 cell line. The sequential caspase-3 assay for 3c indicated a remarkable overexpression level. Finally, a molecular docking study was adopted to elucidate the binding mode and interactions of the target compounds with CDK1

Extraintestinal Manifestations Of Ulcerative Colitis In Saudi Arabia: Systematic Review

Background: Inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), exhibits varied clinical presentations and extraintestinal manifestations (EIMs) that impact the overall well-being of affected individuals. This systematic review aims to consolidate recent studies conducted in Saudi Arabia to comprehensively analyze the sociodemographic characteristics and clinical features of UC patients, with a specific focus on bone-related complications. Objective: To systematically review Extraintestinal Manifestations of Ulcerative Colitis in Saudi Arabia Methodology: Using the PRISMA guidelines, a comprehensive A systematic search was conducted to identify relevant studies published between 2014 and 2023 on PubMed in English that investigated UC in Saudi Arabia. resulting in the inclusion of seven studies with a collective participant count of 1580. Sociodemographic characteristics &amp; Clinical characteristics, particularly the prevalence of bone-related complications, were examined across these studies. Results: The sociodemographic analysis of 1580 participants from seven studies highlighted variations in extraintestinal manifestations in IBD. Due to the inflammatory nature of the UC disease, and increased glucocorticoids concentrations, bone-related complications, including osteoporosis and osteopenia, were prevalent in UC patients, with distinct patterns observed in different studies. Arthropathy emerged as one of the most common extraintestinal manifestation. Moreover, renal stones are another issue for these patients. Finally, all of these manifestations contribute to the prevalence of anxiety and depression symptoms that was identified among UC patients, that indicated that fifth of these cohort suffer from, psychological disease. Conclusion: This systematic review provides a comprehensive overview of recent studies on UC in Saudi Arabia, emphasizing the prevalence of bone-related complications as predominant extra intestinal manifestations. The findings underscore the importance of addressing these complications in the management of UC patients, necessitating regular testing of the bone density in these patients and provide supplements and other necessary treatments for these patients. Moreover, it is important to consider the psychological impact of such disease on the quality of life of patients. Comprehensive multi-disciplinary medical teams need to work together to address various clinical aspects regarding Ulcerative colitis. This does not only include gastroenterologist, nephrologists and general internists, but also include psychologists/therapists to ensure all patients needs are addressed. Finally, further research is needed to have comprehensive view of UC in Saudi Populations and improve the overall quality of care