79 research outputs found
A tough egg to crack: recreational boats as vectors for invasive goby eggs and transdisciplinary management approaches
Non-native invasive species are a major threat to biodiversity, especially in freshwater ecosystems. Freshwater ecosystems are naturally rather isolated from one another. Nonetheless, invasive species often spread rapidly across water sheds. This spread is to a large extent realized by human activities that provide vectors. For example, recreational boats can carry invasive species propagules as âaquatic hitch-hikersâ within and across water sheds. We used invasive gobies in Switzerland as a case study to test the plausibility that recreational boats can serve as vectors for invasive fish and that fish eggs can serve as propagules. We found that the peak season of boat movements across Switzerland and the goby spawning season overlap temporally. It is thus plausible that goby eggs attached to boats, anchors or gear may be transported across watersheds. In experimental trials we found that goby eggs show resistance to physical removal (90mN attachment strength of individual eggs) and stay attached if exposed to rapid water flow (2.8m s-138 for 1h). When exposing the eggs to air, we found that hatching success remained high (>95%) even after eggs had been out of water for up to 24h. It is thus plausible that eggs survive during pick up, within water and overland transport by boats. We complemented the experimental plausibility tests with a survey on how decision makers from inside and outside academia rate the feasibility of managing recreational boats as vectors. We found consensus that an installation of a preventive boat vector management is considered an effective and urgent measure. This study advances our understanding of the potential of recreational boats to serve as vectors for invasive vertebrate species, and demonstrates that preventive management of recreational boats is considered feasible by relevant decision makers in- and outside academia
Multifragmentation of a very heavy nuclear system (II): bulk properties and spinodal decomposition
The properties of fragments and light charged particles emitted in
multifragmentation of single sources formed in central 36AMeV Gd+U collisions
are reviewed. Most of the products are isotropically distributed in the
reaction c.m. Fragment kinetic energies reveal the onset of radial collective
energy. A bulk effect is experimentally evidenced from the similarity of the
charge distribution with that from the lighter 32AMeV Xe+Sn system. Spinodal
decomposition of finite nuclear matter exhibits the same property in simulated
central collisions for the two systems, and appears therefore as a possible
mechanism at the origin of multifragmentation in this incident energy domain.Comment: 28 pages including 14 figures; submitted to Nucl. Phys.
Study of intermediate velocity products in the Ar+Ni collisions between 52 and 95 A.MeV
Intermediate velocity products in Ar+Ni collisions from 52 to 95 A.MeV are
studied in an experiment performed at the GANIL facility with the 4
multidetector INDRA. It is shown that these emissions cannot be explained by
statistical decays of the quasi-projectile and the quasi-target in complete
equilibrium. Three methods are used to isolate and characterize intermediate
velocity products. The total mass of these products increases with the violence
of the collision and reaches a large fraction of the system mass in mid-central
collisions. This mass is found independent of the incident energy, but strongly
dependent on the geometry of the collision. Finally it is shown that the
kinematical characteristics of intermediate velocity products are weakly
dependent on the experimental impact parameter, but strongly dependent on the
incident energy. The observed trends are consistent with a
participant-spectator like scenario or with neck emissions and/or break-up.Comment: 37 pages, 13 figure
Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease
BACKGROUND: Acute graft-versus-host disease (GVHD) remains a major limitation of allogeneic stem-cell transplantation; not all patients have a response to standard glucocorticoid treatment. In a phase 2 trial, ruxolitinib, a selective Janus kinase (JAK1 and JAK2) inhibitor, showed potential efficacy in patients with glucocorticoid-refractory acute GVHD. METHODS: We conducted a multicenter, randomized, open-label, phase 3 trial comparing the efficacy and safety of oral ruxolitinib (10 mg twice daily) with the investigator's choice of therapy from a list of nine commonly used options (control) in patients 12 years of age or older who had glucocorticoid-refractory acute GVHD after allogeneic stem-cell transplantation. The primary end point was overall response (complete response or partial response) at day 28. The key secondary end point was durable overall response at day 56. RESULTS: A total of 309 patients underwent randomization; 154 patients were assigned to the ruxolitinib group and 155 to the control group. Overall response at day 28 was higher in the ruxolitinib group than in the control group (62% [96 patients] vs. 39% [61]; odds ratio, 2.64; 95% confidence interval [CI], 1.65 to 4.22; P<0.001). Durable overall response at day 56 was higher in the ruxolitinib group than in the control group (40% [61 patients] vs. 22% [34]; odds ratio, 2.38; 95% CI, 1.43 to 3.94; P<0.001). The estimated cumulative incidence of loss of response at 6 months was 10% in the ruxolitinib group and 39% in the control group. The median failure-free survival was considerably longer with ruxolitinib than with control (5.0 months vs. 1.0 month; hazard ratio for relapse or progression of hematologic disease, non-relapse-related death, or addition of new systemic therapy for acute GVHD, 0.46; 95% CI, 0.35 to 0.60). The median overall survival was 11.1 months in the ruxolitinib group and 6.5 months in the control group (hazard ratio for death, 0.83; 95% CI, 0.60 to 1.15). The most common adverse events up to day 28 were thrombocytopenia (in 50 of 152 patients [33%] in the ruxolitinib group and 27 of 150 [18%] in the control group), anemia (in 46 [30%] and 42 [28%], respectively), and cytomegalovirus infection (in 39 [26%] and 31 [21%]). CONCLUSIONS: Ruxolitinib therapy led to significant improvements in efficacy outcomes, with a higher incidence of thrombocytopenia, the most frequent toxic effect, than that observed with control therapy
New mesogens with cubic phases: hydrogen-bonded bipyridines and siloxane-containing benzoic acids I. Preparation and phase behaviour
A Cd radioisotopic study of the electrodeposition of cadmium on lead in sulphuric solutions
PIN5 INTEREST OF MULTI-CRITERIA MODELING APPROACH IN ASSESSMENT OF YELLOW FEVER EPIDEMIC RISK
352 PERMIXON LIPIDOSTEROLIC EXTRACT OF SERENOA REPENS MODIFIES PROSTATE INFLAMMATORY STATUS
Un cas de dyslexie développementale avec trouble isolé de l'empan visuo-attentionnel
National audienc
What do we really know about the impacts of one of the 100 worst invaders in Europe? A reality check
Invasive species are one of the greatest threats to biodiversity worldwide, and to successfully manage their introductions is a major challenge for society. Knowledge on the impacts of an invasive species is essential for motivating decision makers and optimally allocating management resources. We use a prominent invasive fish species, the round goby (Neogobius melanostomus) to objectively quantify the state of scientific knowledge on its impacts. Focusing on how native fish species are affected by round goby invasions, we analyzed 113 peer-reviewed papers and found that impacts are highly ecosystem and time scale dependent. We discovered round goby impacts to be profound, but surprisingly complex. Even if identical native species were affected, the impacts remained less comparable across ecosystems than expected. Acknowledging the breadth but also limitations in scientific knowledge on round goby impacts would greatly improve scientistsâ ability to conduct further research and inform management measures
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