The role of binocularity in anisometropic amblyopia

Anisometropic amblyopia is unilateral by definition and current treatment recommendations reflect that characteristic. However, recent research suggests a binocular component that deserves consideration. The aim of this review is to consider the levels of anisometropia deemed amblyogenic, and the cortical changes that occur in the presence of anisometropic amblyopia. Particular attention is given to cortical changes that impact the binocularity of these individuals. Knowledge of binocular deficits in anisometropic amblyopia has implications for current, accepted treatment regimens which are monocular in nature. Therefore, the integrity of binocular function in anisometropic amblyopia and its impact on the visual outcome will be evaluated. Given the rise in binocular treatments under clinical trial for amblyopia, this review also aims to evaluate the evidence of potentially enhanced benefits to anisometropic amblyopes from proposed new binocular therapies

Effect of post processing on the creep performance of laser powder bed fused Inconel 718

In this study, the creep performance of laser powder bed fusion manufactured Inconel 718 specimens is studied in detail and compared with conventional hot-rolled specimens alongside as-built then heat-treated and as-built then hot-isostatic pressed specimens. Hot-rolled specimens showed the best creep resistance, while the hot-isostatic pressed specimens yielded the worst performance, inferior to the as-built condition. Creep testing of all samples showed increased secondary creep rate was consistently correlated with a reduced life. Fractography revealed intergranular fracture was the primary failure mode for all as-built samples. Preferential intergranular precipitation in the case of the hot-isostatic pressed specimens during hot-isostatic pressing extensive intergranular cracking as the primary failure mechanism. Heat-treated specimens possessed only sparse intergranular precipitates, thereby explaining an improved creep lifetime. The hot-rolled specimens, having smallest grain size, showed the least extensive cracking, particularly in locations of finest grains, explaining avoidance of intergranular fracture as a key creep mechanism, thereby explaining the ductile creep fracture surfaces in the case of the hot-rolled samples

Interactions between Nuclear Polyhedrosis Virus and Three Larval Parasitoids of Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae)

Interactions between a Helicoverpa nuclear polyhedrosis virus (NPV) and three larval parasitoids of H. armigera were recorded in laboratory studies. the parasitoids Microplitis demolitor, Cotesia kazak and Hyposoter didymator required a time advantage of at least 3 d at 25°C before the host was exposed to NPV to ensure successful completion of development. Helicoverpa larvae parasitised by C. kazak died from NPV after the parasitoids emerged from the host, and thus could provide a source of virus inoculum for secondary spread of the disease. On the other hand, as the interval between parasitisation and host exposure to NPV increased, the proportion of hosts parasitised by M. demolitor which died from NPV after emergence of the parasitoid decreased. It was also shown that as the time interval between host parasitisation by M. demolitor and exposure to virus increased, higher virus doses were required to kill parasitised hosts than were required for nonparasitised hosts of the same age

Spectral curves and the mass of hyperbolic monopoles

The moduli spaces of hyperbolic monopoles are naturally fibred by the monopole mass, and this leads to a nontrivial mass dependence of the holomorphic data (spectral curves, rational maps, holomorphic spheres) associated to hyperbolic multi-monopoles. In this paper, we obtain an explicit description of this dependence for general hyperbolic monopoles of magnetic charge two. In addition, we show how to compute the monopole mass of higher charge spectral curves with tetrahedral and octahedral symmetries. Spectral curves of euclidean monopoles are recovered from our results via an infinite-mass limit.Comment: 43 pages, LaTeX, 3 figure

Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk

<p><b>Objective:</b> The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD).</p> <p><b>Methods and Results:</b> In the PROSPER (PROspective Study of Pravastatin in the Elderly at Risk) cohort, we related baseline concentrations of circulating IL-10 to risk of CVD events in a nested case (n=819)-control (n=1618) study of 3.2 years of follow-up. Circulating IL-10 showed few strong associations with classical risk factors but was positively correlated with IL-6 and C-reactive protein. IL-10 was positively associated with risk of CVD events (odds ratio [OR] 1.17, 95% CI 1.05 to 1.31 per unit increase in log IL-10) after adjusting for classical risk factors and C-reactive protein. Furthermore, IL-10 was associated more strongly with CVD risk among those with no previous history of CVD (OR 1.42, 95% CI 1.18 to 1.70), compared with those with previous CVD (OR 1.04, 95% CI 0.90 to 1.19; P=0.018). Overall, IL-10 showed a modest ability to add discrimination to classical risk factors (C-statistic +0.005, P=0.002).</p> <p><b>Conclusion:</b> Baseline circulating levels of the antiinflammatory IL-10 are positively associated with risk of CVD among the elderly without prior CVD events, although the association is less evident in those with a history of CVD. Additional epidemiological and mechanistic studies investigating the role of IL-10 in CVD are warranted.</p&gt

Ngrams and Engrams: the use of structural and conceptual features to discriminate between English translations of religious texts

In this paper, we present experiments using the Linguistic Inquiry and Word Count (LIWC) program, a ‘closed-class keyword’ (CCK) analysis and a ‘correspondence analysis’ (CA) to examine whether the Scientology texts of L. Ron Hubbard are linguistically and conceptually like those of other religions. A Kruskal–Wallis test comparing the frequencies of LIWC category words in the Scientology texts and the English translations of the texts of five other religions showed that there were eighteen categories for which the Scientology texts differed from the others, and between one and seventeen for the other religions. In the CCK experiment, keywords typical of each religion were found, both by comparing the religious texts with one another and with the Brown corpus of general English. The most typical keywords were looked up in a concordancer and were manually coded with conceptual tags. The set of categories found for the Scientology texts showed little overlap with those found for the others. Our CA experiments produced fairly clear clusters of texts by religion. Scientology texts were seen at one pole on the first factor, with Christian and Islamic texts at the other. It appears that, in several ways, the Scientology texts are dissimilar to the texts of some of the world's major religions

A quantitative genetic approach to assess the evolutionary potential of a coastal marine fish to ocean acidification

Assessing the potential of marine organisms to adapt genetically to increasing oceanic CO2 levels requires proxies such as heritability of fitness-related traits under ocean acidification (OA). We applied a quantitative genetic method to derive the first heritability estimate of survival under elevated CO2 conditions in a metazoan. Specifically, we reared offspring, selected from a wild coastal fish population (Atlantic silverside, Menidia menidia), at high CO2 conditions (~2300 μatm) from fertilization to 15 days posthatch, which significantly reduced survival compared to controls. Perished and surviving offspring were quantitatively sampled and genotyped along with their parents, using eight polymorphic microsatellite loci, to reconstruct a parent–offspring pedigree and estimate variance components. Genetically related individuals were phenotypically more similar (i.e., survived similarly long at elevated CO2 conditions) than unrelated individuals, which translated into a significantly nonzero heritability (0.20 ± 0.07). The contribution of maternal effects was surprisingly small (0.05 ± 0.04) and nonsignificant. Survival among replicates was positively correlated with genetic diversity, particularly with observed heterozygosity. We conclude that early life survival of M. menidia under high CO2 levels has a significant additive genetic component that could elicit an evolutionary response to OA, depending on the strength and direction of future selection

On the Influence of Noise on the Critical and Oscillatory Behavior of a Predator-Prey Model: Coherent Stochastic Resonance at the Proper Frequency

Noise induced changes in the critical and oscillatory behavior of a Prey-Predator system are studied using power spectrum density and Spectral Amplification Factor (SAF) analysis. In the absence of external noise, the population densities exhibit three kinds of asymptotic behavior, namely: Absorbing State, Fixed Point (FP) and an Oscillatory Regime (OR) with a well defined proper (natural) frequency. The addition of noise destabilizes the FP phase inducing a transition to a new OR. Surprisingly, it is found that when a periodic signal is added to the control parameter, the system responds robustly, without relevant changes in its behavior. Nevertheless, the "Coherent Stochastic Resonance" phenomenon is found only at the proper frequency. Also, a method based on SAF allows us to locate very accurately the transition points between the different regimes.Comment: RevTex, 18 pgs, 6 figures. Submitted to Physics Letters A (2000

The Evolution of Sunspot Magnetic Fields Associated with a Solar Flare

Solar flares occur due to the sudden release of energy stored in active-region magnetic fields. To date, the pre-cursors to flaring are still not fully understood, although there is evidence that flaring is related to changes in the topology or complexity of an active region's magnetic field. Here, the evolution of the magnetic field in active region NOAA 10953 was examined using Hinode/SOT-SP data, over a period of 12 hours leading up to and after a GOES B1.0 flare. A number of magnetic-field properties and low-order aspects of magnetic-field topology were extracted from two flux regions that exhibited increased Ca II H emission during the flare. Pre-flare increases in vertical field strength, vertical current density, and inclination angle of ~ 8degrees towards the vertical were observed in flux elements surrounding the primary sunspot. The vertical field strength and current density subsequently decreased in the post-flare state, with the inclination becoming more horizontal by ~7degrees. This behaviour of the field vector may provide a physical basis for future flare forecasting efforts.Comment: Accepted for Publication in Solar Physics. 16 pages, 4 figure