Development of SARS-CoV-2 specific IgG and IgA antibodies in serum and milk with different SARS-COV-2 vaccines in lactating women

Background: Our main objective was to determine the evolution of IgG and IgA antibodies directed against SARS-CoV-2 protein S in the blood of lactating women and in breast milk. Methods: A cohort of 110 uninfected and vaccinated breastfeeding women was followed-up for 6 months at the Marqués de Valdecilla University Hospital, Spain, in 2020. An additional group of 23 breastfeeding mothers who had no previously documented infection and had not been vaccinated against SARS-CoV-2 were included as a control group. The antibodies in blood and breast milk and their evolution at 6 months post-vaccination were analysed. Results: One hundred ten breastfeeding mothers were included; 70 women (63.6%) were vaccinated with two doses of BNT162b2, 20 women (18.2%) received two doses of mRNA-1273, and 20 women (18.2%) received a single dose of ChAdOx1-S. No evidence of differences between concentrations of antibodies was found according to the type of vaccine, with the exception of serum IgA antibodies, which was higher in women vaccinated with mRNA-1273: mean [95%CI]: 0.05 AU/mL [0.03,0.06] with mRNA-1273, 0.02 AU/mL [0.01,0.03] with BNT162b2 and 0.01 AU/mL [0.00,0.03] with ChAdOx1-S, ANOVA p value = 0.03. The lack of difference between vaccines was also found when anti-S1 specific IgG in serum and breast milk were measured. Conclusions: In lactating women vaccinated against COVID-19, anti-SARS-CoV-2 antibodies can be detected in both serum and breastmilk 6 months after receiving the second dose, although their concentrations decreased when compared with concentrations reached immediately after vaccination.Project Nextval 2021/23 is funded by Fundación Instituto de Investigación Marqués de Valdecill

Influence of socioeconomic status on SARS-CoV-2 infection in spanish pregnant women. The MOACC-19 Cohort

Little is known on socio-economic factors associated with SARS-CoV-2 infection in pregnant women. Here, we analyze the relationship between educational, occupational, and housing variables with SARS-CoV-2 infection in a cohort of 988 pregnant women in Spain. Pregnant women were recruited at the University Hospital Marques de Valdecilla, Santander, Spain, among those delivering from 23 March 2020 onwards or consulting for their 12th week of pregnancy from 26 May 2020 onwards. Information on occupational variables and housing characteristics was self-reported. Pregnant women were tested for a current or past infection of SARS-CoV-2 using both PCR and antibodies detection (ELISA). Logistic regression models were used to analyze factors associated with SARS-CoV-2 infection, adjusting for age and country of origin. Infection by SARS-CoV-2 was not associated with educational level or occupational variables, except for where the pregnant woman was a healthcare worker (odds ratio (OR) = 2.87, 95% confidence interval (CI): 0.84-9.79). Housing with four or more rooms (OR = 2.07, 95% CI: 0.96-4.47), four or more people in the household (OR = 1.91, 95% CI: 0.89-4.14), lack of heating (OR = 2.81, 95% CI: 1.24-6.34) and less than 23 square meters per person (OR = 3.97, 95% CI: 1.43-11.1) were the housing characteristics associated with SARS-CoV-2 infection. Housing characteristics, but not occupational or educational variables, were associated with SARS-CoV-2 infection. Guidelines on the prevention of COVID-19 should reinforce household measures to prevent pregnant women from becoming infected by their relatives.Funding: This research was funded by the Spanish Instituto de Salud Carlos III grant number COV20/00923

La televisión on-line en la Formación del Profesorado: un recurso educativo multilingüe y multidisciplinar

Jornadas de Innovación Docente de la Universidad de Oviedo (12ª, 2020, Oviedo)Este proyecto interdisciplinar y multilingüe ha sido diseñado con el objetivo de poner en funcionamiento un canal de televisión on-line para la Facultad de Formación del Profesorado y Educación y poner en valor los productos audiovisuales del alumnado. Para ello utiliza una metodología de enseñanza-aprendizaje colaborativa centrada en el alumnado. Los vídeos están grabados con dispositivos móviles, reforzando así la importancia del m-learning o aprendizaje con dispositivos móviles. El canal de tv, denominado DIDACTICTAC TV, no es sólo un elemento de comunicación e inter-relación entre el alumnado y el profesorado de dicha facultad sino que, además, ha generado un puente de unión con otras universidades nacionales y extranjeras y con centros escolares de Primaria y Secundaria. En el proyecto se han implicado un elevado número de docentes de la Facultad de Formación del Profesorado y Educación de la Universidad de Oviedo, además de docentes de otras tres universidades (Universidad de León-España, Kio University-Japón y Marie Curie Sklodowska University-Polonia) y de treinta y un centros de Educación Primaria y Secundaria. La evaluación del proyecto, en su primer año de vida, se ha realizado utilizado cuatro tipos de cuestionarios on-line para todo el profesorado y el alumnado implicado yse han realizado numeroso grupos de discusión con el alumnado. Los resultados parciales muestran un alto grado de satisfacción con el desarrollo del proyecto así como algunos aspectos a mejorar en su segundo año de desarroll

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Development of SARS-CoV-2 specific IgG and IgA antibodies in serum and milk with different SARS-COV-2 vaccines in lactating women

Abstract Background Our main objective was to determine the evolution of IgG and IgA antibodies directed against SARS-CoV-2 protein S in the blood of lactating women and in breast milk. Methods A cohort of 110 uninfected and vaccinated breastfeeding women was followed-up for 6 months at the Marqués de Valdecilla University Hospital, Spain, in 2020. An additional group of 23 breastfeeding mothers who had no previously documented infection and had not been vaccinated against SARS-CoV-2 were included as a control group. The antibodies in blood and breast milk and their evolution at 6 months post-vaccination were analysed. Results One hundred ten breastfeeding mothers were included; 70 women (63.6%) were vaccinated with two doses of BNT162b2, 20 women (18.2%) received two doses of mRNA-1273, and 20 women (18.2%) received a single dose of ChAdOx1-S. No evidence of differences between concentrations of antibodies was found according to the type of vaccine, with the exception of serum IgA antibodies, which was higher in women vaccinated with mRNA-1273: mean [95%CI]: 0.05 AU/mL [0.03,0.06] with mRNA-1273, 0.02 AU/mL [0.01,0.03] with BNT162b2 and 0.01 AU/mL [0.00,0.03] with ChAdOx1-S, ANOVA p value = 0.03. The lack of difference between vaccines was also found when anti-S1 specific IgG in serum and breast milk were measured. Conclusions In lactating women vaccinated against COVID-19, anti-SARS-CoV-2 antibodies can be detected in both serum and breastmilk 6 months after receiving the second dose, although their concentrations decreased when compared with concentrations reached immediately after vaccination

The state of climate in NW Iberia

Since 1974, there has been a significant increasing trend in land and sea surface temperatures of 0.5 and 0.24°C decade-1, respectively, in the NW Iberian Peninsula. Over the same period, annual precipitation does not show any trend, although some tendencies have been detected at seasonal scales. A significant positive trend, on average of 2 cm decade–1, was also observed in sea level rise from 1943 onwards. Ekman transport perpendicular to the coast (upwelling index) showed a decrease from 1975 to 2008 at both annual and seasonal scales. In addition, the flow of the Miño River (the main river in the area) has also decreased at a mean rate of 18 m3 s-1 decade-1 since 1970. At a synoptic scale, winter cyclone frequency and winter and spring blocking activity have decreased since the 1950s, which may partially explain the winter precipitation decline and the winter and spring temperature increases. These changes in synoptic systems are also in agreement with reported trends in the dominant variability modes of atmospheric circulation affecting NW Iberia, particularly a pronounced positive trend in the North Atlantic Oscillation from the 1970s to the 1990s.Ministerio de Educación y Ciencia | Ref. CTM2007-62546-C03-03Ministerio de Ciencia e Innovación | Ref. CGL2009-09143Ministerio de Ciencia e Innovación | Ref. INCITE09383278P

Premios Nacionales a la Innovación Educativa : 2002-2003 : experiencias del Principado de Asturias

Resumen basado en la publicaciónEste CD-Rom recoge cuatro trabajos realizados por profesorado asturiano presentados y premiados en la convocatoria de Premios Nacionales a la Innovación Educativa en los años 2002 y 2003: 1) 'El Agua'. Desarrollado en el IES de Cerdeño es el producto del trabajo realizado con el objetivo de trabajar de forma interdisciplinar sobre un tema común, intercambiando ideas y materiales para llegar a la elaboración de un manual didáctico interdisciplinar. Como tema central se selecciona 'El agua'. El producto final de la experiencia es el citado manual didáctico en formato CD-Rom con formato web y que consta de los siguientes apartados: cuatro unidades didácticas y un apartado de diccionario. 2) 'Introducción temprana del inglés como segunda lengua en clases multinivel de Educación Infantil en un Colegio Rural Agrupado'. El trabajo se lleva a cabo en el CRA del Alto Aller. Este apartado recoge la recopilación y creación de materiales específicos para trabajar las clases multinivel de Educación Infantil, con el fin de elaborar un proyecto más cómodo para desarrollar las clases en el nivel señalado. El trabajo se estructura en tres apartados: Proyecto, unidades didácticas y bibliografía. 3) 'Mi biografía-yo y mis circunstancias, para que no se pierda en mi memoria'. Esta experiencia se lleva a cabo en el IES Río Nora de Pola de Siero. Mediante la exposición del proyecto y el material 'Preguntas guía para la realización del trabajo', se presenta esta experiencia didáctica innovadora que trata de facilitar al alumnado que la realiza un conjunto variado de 'items - preguntas guía' pautadas, que le sirvan de orientación para el encuentro consigo mismo evolucionando hacia su autonomía vital en medio de un mundo con otros semejantes. 4) 'Por una escuela intercultural'. Presenta el proyecto intercultural llevado a cabo en el Colegio Nazaret de Oviedo. El proyecto se presenta con tres objetivos básicos: a) Conocer y analizar las diferentes culturas presentes en el centro, con el fin de descubrir lo que tienen de enriquecedor para todos. b) Conseguir la participación de las familias en actividades que favorezcan tanto la interrelación entre culturas como el respeto y la convivencia pacífica. c) Facilitar la integración de los niños inmigrantes en la comunidad respetando y conservando su propia identidad. Se continua haciendo una exposición detallada de las actividades desarrolladas en clase y distribuidas en tres niveles diferentes. Posteriormente se presenta como actividad final 'La semana Intercultural' y por último se realiza una evaluación de la experiencia.AsturiasUniversidad de Oviedo. Facultad de Ciencias de la Educación; Calle Aniceto Sela s. n.; 33005 Oviedo; +34985103215; +34985103214;ES