The effects of graded motor imagery and its components on chronic pain: A systematic review and meta-analysis

This is the post-print version of the final paper published in The Journal of Pain. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2013 The American Pain Society.Graded motor imagery (GMI) is becoming increasingly used in the treatment of chronic pain conditions. The objective of this systematic review was to synthesize all evidence concerning the effects of GMI and its constituent components on chronic pain. Systematic searches were conducted in 10 electronic databases. All randomized controlled trials (RCTs) of GMI, left/right judgment training, motor imagery, and mirror therapy used as a treatment for chronic pain were included. Methodological quality was assessed using the Cochrane risk of bias tool. Six RCTs met our inclusion criteria, and the methodological quality was generally low. No effect was seen for left/right judgment training, and conflicting results were found for motor imagery used as stand-alone techniques, but positive effects were observed for both mirror therapy and GMI. A meta-analysis of GMI versus usual physiotherapy care favored GMI in reducing pain (2 studies, n = 63; effect size, 1.06 [95% confidence interval, .41, 1.71]; heterogeneity, I2 = 15%). Our results suggest that GMI and mirror therapy alone may be effective, although this conclusion is based on limited evidence. Further rigorous studies are needed to investigate the effects of GMI and its components on a wider chronic pain population.NHMR

Reconstructing emission from pre-reionization sources with cosmic infrared background fluctuation measurements by the JWST

We present new methodology to use cosmic infrared background (CIB) fluctuations to probe sources at 10<z<30 from a JWST/NIRCam configuration that will isolate known galaxies to 28 AB mag at 0.5--5 micron. At present significant mutually consistent source-subtracted CIB fluctuations have been identified in the Spitzer and Akari data at 2--5 micron, but we demonstrate internal inconsistencies at shorter wavelengths in the recent CIBER data. We evaluate CIB contributions from remaining galaxies and show that the bulk of the high-z sources will be in the confusion noise of the NIRCam beam, requiring CIB studies. The accurate measurement of the angular spectrum of the fluctuations and probing the dependence of its clustering component on the remaining shot noise power would discriminate between the various currently proposed models for their origin and probe the flux distribution of its sources. We show that the contribution to CIB fluctuations from remaining galaxies is large at visible wavelengths for the current instruments precluding probing the putative Lyman-break of the CIB fluctuations. We demonstrate that with the proposed JWST configuration such measurements will enable probing the Lyman break. We develop a Lyman-break tomography method to use the NIRCam wavelength coverage to identify or constrain, via the adjacent two-band subtraction, the history of emissions over 10<z<30 as the Universe comes out of the 'Dark Ages'. We apply the proposed tomography to the current Spitzer/IRAC measurements at 3.6 and 4.5 micron, to find that it already leads to interestingly low upper limit on emissions at z>30.Comment: ApJ, in press. Minor revisions/additions to match the version in proof

Correlations in Systems of Complex Directed Macromolecules

An ensemble of directed macromolecules on a lattice is considered, where the constituting molecules are chosen as a random sequence of N different types. The same type of molecules experiences a hard-core (exclusion) interaction. We study the robustness of the macromolecules with respect to breaking and substituting individual molecules, using a 1/N expansion. The properties depend strongly on the density of macromolecules. In particular, the macromolecules are robust against breaking and substituting at high densities.Comment: 9 pages, 4 figure

Cooperative Set Function Optimization Without Communication or Coordination

We introduce a new model for cooperative agents that seek to optimize a common goal without communication or coordination. Given a universe of elements V, a set of agents, and a set function f, we ask each agent i to select a subset Si ⊂ V such that the size of Si is constrained (i.e., |Si| < k). The goal is for the agents to cooperatively choose the sets Si to maximize the function evaluated at the union of these sets, ∪iSi; we seek max f(∪iSi). We assume the agents can neither communicate nor coordinate how they choose their sets. This model arises naturally in many real-world settings such as swarms of surveillance robots and colonies of foraging insects. Even for simple classes of set functions, there are strong lower bounds on the achievable performance of coordinating deterministic agents. We show, surprisingly, that for the fundamental class of submodular set functions, there exists a near-optimal distributed algorithm for this problem that does not require communication. We demonstrate that our algorithm performs nearly as well as recently published algorithms that allow full coordination

Estimating the upper limit of prehistoric peak ground acceleration using an in situ, intact and vulnerable stalagmite from Plavecka priepast cave (Detrekoi-zsomboly), Little Carpathians, Slovakia-first results

Earthquakes hit urban centres in Europe infrequently, but occasionally with disastrous effects. Obtaining an unbiased view of seismic hazard (and risk) is therefore very important. In principle, the best way to test probabilistic seismic hazard assessments (PSHAs) is to compare them with observations that are entirely independent of the procedure used to produce PSHA models. Arguably, the most valuable information in this context should be information on long-term hazard, namely maximum intensities (or magnitudes) occurring over time intervals that are at least as long as a seismic cycle. The new observations can provide information of maximum intensity (or magnitude) for long timescale as an input data for PSHA studies as well. Long-term information can be gained from intact stalagmites in natural caves. These formations survived all earthquakes that have occurred over thousands of years, depending on the age of the stalagmite. Their 'survival' requires that the horizontal ground acceleration (HGA) has never exceeded a certain critical value within that time period. Here, we present such a stalagmite-based case study from the Little Carpathians of Slovakia. A specially shaped, intact and vulnerable stalagmite in the Plavecka priepast cave was examined in 2013. This stalagmite is suitable for estimating the upper limit of horizontal peak ground acceleration generated by prehistoric earthquakes. The critical HGA values as a function of time going back into the past determined from the stalagmite that we investigated are presented. For example, at the time of Joko event (1906), the critical HGA value cannot have been higher than 1 and 1.3 m/s(2) at the time of the assumed Carnuntum event (similar to 340 AD), and 3000 years ago, it must have been lower than 1.7 m/s(2). We claimed that the effect of Joko earthquake (1906) on the location of the Plavecka priepast cave is consistent with the critical HGA value provided by the stalagmite we investigated. The approach used in this study yields significant new constraints on the seismic hazard, as tectonic structures close to Plavecka priepast cave did not generate strong earthquakes in the last few thousand years. The results of this study are highly relevant given that the two capitals, Vienna and Bratislava, are located within 40 and 70 km of the cave, respectively.Web of Science2151130111

A mid-infrared survey of the inner 2 × 1.5 degrees of the Galaxy with Spitzer/IRAC

We present a survey of Spitzer Space Telescope/IRAC observations of the central 2 × 1.5 degrees (265 × 200 pc) of the Galaxy at 3-8 μm. These data represent the highest spatial resolution and sensitivity large-scale map made to date of the Galactic Center (GC) at mid-infrared wavelengths. The IRAC data provide a census of the optically obscured stellar sources as well as a detailed map of the highly filamentary structure in the interstellar medium. The diffuse emission is dominated by PAH emission from small grains in star-forming regions. Dark clouds displaying a large variety of sizes and morphologies are imaged, many of which remain opaque at IRAC wavelengths. Using a multiwavelength comparison, we determine which objects are likely to be in the foreground and which are located at the GC. We find no counterparts at IRAC wavelengths to the unique system of linear, nonthermal radio filaments present at the GC

Could psoralen plus ultraviolet A1 (“PUVA1”) work? Depth penetration achieved by phototherapy lamps

Funding: PhD Studentship UK EPRSC EP/N509759/1.Psoralen and ultraviolet A (PUVA) is useful in treating various hand and foot skin diseases.1 Most cases of psoriasis respond well to phototherapy or PUVA. However, for some diseases, such as palmoplantar pustular psoriasis, PUVA is not always sufficient to produce therapeutic effect. If PUVA fails, it is sometimes necessary to progress to other treatments such as Grenz ray therapy (where available),2 systemic retinoid or systemic immunosuppression. Could “PUVA1” (psoralen combined with ultraviolet A1 long wavelength ultraviolet A [UVA]) work in cases where conventional PUVA (psoralen plus broadband UVA) has been inadequate?PostprintPeer reviewe

Characterization of a submillimeter high-angular-resolution camera with a monolithic silicon bolometer array for the Caltech Submillimeter Observatory

We constructed a 24-pixel bolometer camera operating in the 350- and 450-µm atmospheric windows for the Caltech Submillimeter Observatory (CSO). This instrument uses a monolithic silicon bolometer array that is cooled to approximately 300 mK by a single-shot 3 He refrigerator. First-stage amplification is provided by field-effect transistors at approximately 130 K. The sky is imaged onto the bolometer array by means of several mirrors outside the Dewar and a cold off-axis elliptical mirror inside the cryostat. The beam is defined by cold aperture and field stops, which eliminates the need for any condensing horns. We describe the instrument, present measurements of the physical properties of the bolometer array, describe the performance of the electronics and the data-acquisition system, and demonstrate the sensitivity of the instrument operating at the observatory. Approximate detector noise at 350 µm is 5 x 10^-15 W/√Hz, referenced to the entrance of the Dewar, and the CSO system noise-equivalent flux density is approximately 4 Jy/√Hz. These values are within a factor of 2.5 of the background limit