Revisão de literatura da produção acadêmica brasileira sobre a inserção internacional da China (2000-2022)

O presente trabalho busca traçar o panorama da produção acadêmica nacional sobre a inserção internacional Chinesa, através das perspectivas política, securitária e econômica, indicando os principais temas e resultados convergentes. Além disso, se busca identificar o perfil da academia brasileira, apontando os pólos de publicações, o volume de trabalhos ao longo do tempo e o tipo de pesquisa mais frequente. Como metodologia utilizou-se de análise quali-quantitativa para realizar uma varredura digital no material recolhido, construindo gráficos e nuvens de palavras. Como resultados, encontrou-se uma predominância das regiões Sul e Sudeste no número de trabalhos, um crescimento volumétrico exponencial ao longo do tempo e um maior interesse de pesquisas na ascensão chinesa por meio do desenvolvimento econômico. No eixo político, há a predominância de temas sobre as ações chinesas em instituições internacionais e nas relações Sul-Sul. No eixo securitário, o destaque fica com os teatros de operação na Região da Península Coreana e no Mar do Sul. Por último, o eixo econômico se mostrou o mais evidente, priorizando compreender o peso do mercado chinês e seus efeitos no mundo e na política econômica brasileira.The present study aims to provide an overview of national academic production on China's international insertion, focusing on political, security, and economic perspectives, while indicating the main themes and convergent results. Additionally, the study seeks to identify the profile of Brazilian academia by pointing out the publication poles, the volume of works over time, and the most frequent type of research. Qualitative and quantitative analysis were used as the methodology to conduct a digital scan of the collected material, constructing graphs and word clouds. The results indicate a predominance of the South and Southeast regions in the number of works, exponential growth over time, and a greater interest in research on Chinese ascension through economic development. Regarding the political axis, there is a predominance of themes on Chinese actions in international institutions and in South-South relations. In the security axis, the emphasis is on theaters of operation in the Korean Peninsula region and the South China Sea. Lastly, the economic axis is the most evident, prioritizing an understanding of the weight of the Chinese market and its effects on the world and Brazilian economic policy

Circadian sleep propensity and alcohol interaction at the wheel

Study Objectives: The study was aimed at estimating the effect of alcohol consumption, time of day, and their interaction on traffic crashes in a real regional context. Methods: Blood alcohol concentration (BAC) data were collected from drivers involved in traffic accidents during one year in an Italian region and in a control group of drivers over the same road network. Mean circadian sleep propensity was estimated from a previous study as function of time of day. Accident risk was analyzed by logistic regression as function of BAC and circadian sleep propensity. Results: BAC values greater than zero were found in 72.0% of the drivers involved in crashes and in 40.4% of the controls. Among the former 23.6% of the drivers exceeded the BAC legal threshold of 0.05 g/dL, while illegal values were found in 10.4% of the controls. The relative risk showed a significant increase with both BAC and circadian sleep propensity (as estimated from time of day) and their interaction was significant. Conclusions: Due to the significant interaction, even low BAC levels strongly increased accident risk when associated with high sleep propensity

Technical analysis of a renewable woody biomass generator/electrolyzer poly-generative system

In the REPowerEU plan, the European Commission has envisaged a rapid reduction in dependence on fossil fuels, an acceleration of the green transition and has shown its willingness to tackle the climate crisis by resorting to greater and better use of renewable energy sources. Furthermore, from 2035 the “Fit for 55” climate package aims to reduce emissions of pollutants and climate-altering gas emissions and to encourage the diffusion of new pure electric or fuel cell hybrid electric vehicles. In this context, this article deals with a poly-generative energy system for the production of H2, electric and thermal powers. It is able to satisfy the new vehicles needs and/or the electric/thermal loads of a rural building located in Rende (Italy, Lat. 39.3°N) on two typical winter and summer days. The poly-generative system is mainly composed of an energy system fed by woody biomass in a cogenerative arrangement, a photovoltaic system and a PEM electrolyzer. Technical analysis of the system shows that for the mixed fleet of 30 vehicles the output electrical and thermal powers and hydrogen production are respectively of about 50 kW, 97 kW and 9.23 kg. Furthermore, the system covers totally the electric load on summer days and the thermal load for hot water production in the summer and winter days

The SNAP-tag technology revised: an effective chemo-enzymatic approach by using a universal azide-based substrate

SNAP-tag ® is a powerful technology for the labelling of protein/enzymes by using benzyl-guanine (BG) derivatives as substrates. Although commercially available or ad hoc produced, their synthesis and purification are necessary, increasing time and costs. To address this limitation, here we suggest a revision of this methodology, by performing a chemo-enzymatic approach, by using a BG-substrate containing an azide group appropriately distanced by a spacer from the benzyl ring. The SNAP-tag ® and its relative thermostable version (SsOGT-H5 ) proved to be very active on this substrate. The stability of these tags upon enzymatic reaction makes possible the exposition to the solvent of the azide-moiety linked to the catalytic cysteine, compatible for the subsequent conjugation with DBCO-derivatives by azide-alkyne Huisgen cycloaddition. Our studies propose a strengthening and an improvement in terms of biotechnological applications for this self-labelling protein-tag

Substrate reduction therapy with Miglustat in pediatric patients with GM1 type 2 gangliosidosis delays neurological involvement: A multicenter experience

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Development and implementation of the AIDA International Registry for patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis syndrome

Objective: Aim of this paper is to illustrate the methodology, design, and development of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to patients with the Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome. Methods: This is a physician-driven, non-population- and electronic-based registry proposed to gather real-world demographics, clinical, laboratory, instrumental and socioeconomic data from PFAPA patients. Data recruitment is realized through the on-line Research Electronic Data Capture (REDCap) tool. This registry is thought to collect standardized information for clinical research leading to solid real-life evidence. The international scope and the flexibility of the registry will facilitate the realization of cutting-edge study projects through the constant updating of variables and the possible merging and transfer of data between current and future PFAPA registries. Results: A total of 112 centers have already been involved from 23 countries and 4 continents starting from August 24th, 2021, to April 6th, 2022. In total 56/112 have already obtained the formal approval from their local Ethics Committees. The platform counts 321 users (113 principal investigators, 203 site investigators, two lead investigators, and three data managers). The registry collects retrospective and prospective data using 3,856 fields organized into 25 instruments, including PFAPA patient's demographics, medical histories, symptoms, triggers/risk factors, therapies, and impact on the healthcare systems. Conclusions: The development of the AIDA International Registry for PFAPA patients will enable the on-line collection of standardized data prompting real-life studies through the connection of worldwide groups of physicians and researchers. This project can be found on NCT 05200715

Efficacy of canakinumab in patients with Still's disease across different lines of biologic therapy: real-life data from the International AIDA Network Registry for Still's Disease

Introduction: The effectiveness of canakinumab may change according to the different times it is used after Still's disease onset. This study aimed to investigate whether canakinumab (CAN) shows differences in short- and long-term therapeutic outcomes, according to its use as different lines of biologic treatment.Methods: Patients included in this study were retrospectively enrolled from the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to Still's disease. Seventy-seven (51 females and 26 males) patients with Still's disease were included in the present study. In total, 39 (50.6%) patients underwent CAN as a first-line biologic agent, and the remaining 38 (49.4%) patients were treated with CAN as a second-line biologic agent or subsequent biologic agent.Results: No statistically significant differences were found between patients treated with CAN as a first-line biologic agent and those previously treated with other biologic agents in terms of the frequency of complete response (p =0.62), partial response (p =0.61), treatment failure (p >0.99), and frequency of patients discontinuing CAN due to lack or loss of efficacy (p =0.2). Of all the patients, 18 (23.4%) patients experienced disease relapse during canakinumab treatment, 9 patients were treated with canakinumab as a first-line biologic agent, and nine patients were treated with a second-line or subsequent biologic agent. No differences were found in the frequency of glucocorticoid use (p =0.34), daily glucocorticoid dosage (p =0.47), or concomitant methotrexate dosage (p =0.43) at the last assessment during CAN treatment.Conclusion: Canakinumab has proved to be effective in patients with Still's disease, regardless of its line of biologic treatment

Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study

Two methods are currently available for left atrial (LA) strain measurement by speckle tracking echocardiography, with two different reference timings for starting the analysis: QRS (QRS-LASr) and P wave (P-LASr). The aim of MASCOT HIT study was to define which of the two was more reproducible, more feasible, and less time consuming. In 26 expert centers, LA strain was analyzed by two different echocardiographers (young vs senior) in a blinded fashion. The study population included: healthy subjects, patients with arterial hypertension or aortic stenosis (LA pressure overload, group 2) and patients with mitral regurgitation or heart failure (LA volume–pressure overload, group 3). Difference between the inter-correlation coefficient (ICC) by the two echocardiographers using the two techniques, feasibility and analysis time of both methods were analyzed. A total of 938 subjects were included: 309 controls, 333 patients in group 2, and 296 patients in group 3. The ICC was comparable between QRS-LASr (0.93) and P-LASr (0.90). The young echocardiographers calculated QRS-LASr in 90% of cases, the expert ones in 95%. The feasibility of P-LASr was 85% by young echocardiographers and 88% by senior ones. QRS-LASr young median time was 110 s (interquartile range, IR, 78-149) vs senior 110 s (IR 78-155); for P-LASr, 120 s (IR 80-165) and 120 s (IR 90-161), respectively. LA strain was feasible in the majority of patients with similar reproducibility for both methods. QRS complex guaranteed a slightly higher feasibility and a lower time wasting compared to the use of P wave as the reference