Experiencias colaborativas en entornos virtuales 2D y 3D

Se presenta la experiencia realizada en la asignatura Análisis y diseño de sistemas I (ADS I), materia del tercer año de las carreras informáticas de la Universidad Nacional del Noroeste de Buenos Aires (UNNOBA), donde se utilizaron herramientas colaborativas y entornos virtuales para el desarrollo de los contenidos que contempla trabajo virtual y presencial. Se muestran datos de la experiencia como así también resultados y consideraciones para trabajos futuros. Esta práctica se planifica en el marco de la propuesta de tesis para el Magister en Tecnología Informática aplicada a la educación, que tiene como objetivo describir estrategias para el rol tutorial de los avatares en los mundos virtuales 3D aplicables en el marco universitario [1]; y como trabajo experimental de una beca alumno de la UNNOBA.Tema: Experiencia Docente.Red de Universidades con Carreras en Informátic

Experiencias colaborativas en entornos virtuales 2D y 3D

Se presenta la experiencia realizada en la asignatura Análisis y diseño de sistemas I (ADS I), materia del tercer año de las carreras informáticas de la Universidad Nacional del Noroeste de Buenos Aires (UNNOBA), donde se utilizaron herramientas colaborativas y entornos virtuales para el desarrollo de los contenidos que contempla trabajo virtual y presencial. Se muestran datos de la experiencia como así también resultados y consideraciones para trabajos futuros. Esta práctica se planifica en el marco de la propuesta de tesis para el Magister en Tecnología Informática aplicada a la educación, que tiene como objetivo describir estrategias para el rol tutorial de los avatares en los mundos virtuales 3D aplicables en el marco universitario [1]; y como trabajo experimental de una beca alumno de la UNNOBA.Tema: Experiencia Docente.Red de Universidades con Carreras en Informátic

Experiencias colaborativas en entornos virtuales 2D y 3D

Se presenta la experiencia realizada en la asignatura Análisis y diseño de sistemas I (ADS I), materia del tercer año de las carreras informáticas de la Universidad Nacional del Noroeste de Buenos Aires (UNNOBA), donde se utilizaron herramientas colaborativas y entornos virtuales para el desarrollo de los contenidos que contempla trabajo virtual y presencial. Se muestran datos de la experiencia como así también resultados y consideraciones para trabajos futuros. Esta práctica se planifica en el marco de la propuesta de tesis para el Magister en Tecnología Informática aplicada a la educación, que tiene como objetivo describir estrategias para el rol tutorial de los avatares en los mundos virtuales 3D aplicables en el marco universitario [1]; y como trabajo experimental de una beca alumno de la UNNOBA.Tema: Experiencia Docente.Red de Universidades con Carreras en Informátic

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

Sphingosine kinase (SK) 1 catalyzes the formation of the bioactive lipid sphingosine 1-phosphate, and has been implicated in several biological processes in mammalian cells, including enhanced proliferation, inhibition of apoptosis, and oncogenesis. Human SK (hSK) 1 possesses high instrinsic catalytic activity which can be further increased by a diverse array of cellular agonists. We have shown previously that this activation occurs as a direct consequence of extracellular signal–regulated kinase 1/2–mediated phosphorylation at Ser225, which not only increases catalytic activity, but is also necessary for agonist-induced translocation of hSK1 to the plasma membrane. In this study, we report that the oncogenic effects of overexpressed hSK1 are blocked by mutation of the phosphorylation site despite the phosphorylation-deficient form of the enzyme retaining full instrinsic catalytic activity. This indicates that oncogenic signaling by hSK1 relies on a phosphorylation-dependent function beyond increasing enzyme activity. We demonstrate, through constitutive localization of the phosphorylation-deficient form of hSK1 to the plasma membrane, that hSK1 translocation is the key effect of phosphorylation in oncogenic signaling by this enzyme. Thus, phosphorylation of hSK1 is essential for oncogenic signaling, and is brought about through phosphorylation-induced translocation of hSK1 to the plasma membrane, rather than from enhanced catalytic activity of this enzyme

Avatares como tutores virtuales

Este trabajo muestra los avances realizados en la investigación que tiene como tema central la definición del rol tutorial docente con la utilización de avatares en entornos virtuales, más aún en entornos virtuales 3D; tema presentado en la propuesta de tesis para el Magister en tecnología informática aplicada a la educación, carrera de posgrado de la Universidad Nacional de la Plata (UNLP).Eje: Educación en Tecnología.Red de Universidades con Carreras en Informática (RedUNCI

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum

Procollagen requires COPII coat proteins for export from the endoplasmic reticulum (ER). SEC24 is the major component of the COPII proteins that selects cargo during COPII vesicle assembly. There are four paralogs (A to D) of SEC24 in mammals, which are classified into two subgroups. Pathological mutations in SEC24D cause osteogenesis imperfecta with craniofacial dysplasia in humans and sec24d mutant fish also recapitulate this phenotypes. Consistent with the skeletal phenotypes, the secretion of collagen was severely defective in mutant fish, emphasizing the importance of SEC24D in collagen secretion. However, SEC24D patient derived fibroblasts show only a mild secretion phenotype, suggesting tissue-specificity in the secretion process. To explore this possibility, we generated Sec24d knockout (KO) mice. Homozygous KO mice died prior to bone development. When we analyzed embryonic and extraembryonic tissues of mutant animals, we observed tissue-dependent defects of procollagen processing and ER export. The spacial patterns of these defects mirrored with SEC24B deficiency. By systematically knocking down the expression of Sec24 paralogs, we determined that, in addition to SEC24C and SEC24D, SEC24A and SEC24B also contribute to collagen secretion. In contrast, fibronectin 1 preferred either SEC24C or SEC24D. On the basis of our results, we propose that procollagen interacts with multiple SEC24 paralogs for efficient export from the ER, and that this is the basis for tissue-specific phenotypes resulting from SEC24 paralog deficiency

Informática y tecnologías emergentes

Nuestro entorno se va transformando por cambios que se producen con el avance de las tecnologías con un fuerte impacto en nuestra vida cotidiana. En este contexto ¿Qué son las Tecnologías Emergentes? “Tecnologías emergentes (TE) son innovaciones en desarrollo que como su nombre lo dice en un futuro cambiarán la forma de vivir del ser humano brindándole mayor facilidad a la hora de realizar sus actividades, conforme la tecnología vaya cambiando estas también irán evolucionando logrando complementarse con la tecnología más moderna para brindar servicios que harán la vida del hombre mucho más segura y sencilla.” Por lo tanto decimos que una TE es el producto que se obtiene al renovar la tecnología que ya antes se ha desarrollado con el fin de obtener mayores beneficios, esto está acompañado de un elevado margen de incertidumbre. La clave para utilizar al máximo las TE será saber cómo integrarlas de manera efectiva en los productos, procesos o servicios que impactan en nuestra calidad de vida para hacerlos cada vez más personalizados y eficientes. Este Proyecto de I+D+i es continuación de proyectos anteriores. Se propone identificar, contextualizar, evaluar, desarrollar y aplicar herramientas informáticas usando TE, las cuales tendrán un impacto en contextos heterogéneos.Eje: Innovación en Sistemas de Software.Red de Universidades con Carreras en Informátic

Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults : Results from a meta-analysis and exploratory meta-regression analysis

Frailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs)+/- 95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total of 31,343 participants were meta-analyzed. Using estimates from 10 cross-sectional cohorts, both frailty and pre-frailty were associated with higher odds of CVD than robust participants. Longitudinal data were obtained from 6 prospective cohort studies. After a median follow-up of 4.4 years, we identified an increased risk for faster onset of any type CVD in the frail (HR= 1.70 [95%CI, 1.18-2.45]; I-2 = 66%) and pre-frail (HR= 1.23 [95%CI, 1.07-1.36]; I-2 = 67%) vs. robust groups. Similar results were apparent for time to CVD mortality in the frail and pre-frail groups. In conclusion, frailty and pre-frailty constitute addressable and independent risk factors for CVD in older adults. (C) 2017 Elsevier B.V. All rights reserved.Peer reviewe

REBALANCING DISRUPTIVE BUSINESS OF MULTINATIONAL CORPORATIONS AND GLOBAL VALUE CHAINS WITHIN DEMOCRATIC AND INCLUSIVE CITIZENSHIP PROCESSES- REVIEW WORKING PAPER

The purpose of this working paper is to conduct a comprehensive review of existing literature that explores the relationship between business organizations and democracy. This review draws from various fields, including management, business ethics, sociology, international law, and other relevant disciplines for this Project and has several objectives. Firstly, it aims to provide insight into prior research on how democratic institutions regulate economic actors and how these actors, particularly large multinational corporations (MNCs), resist such regulation. Additionally, it examines how these economic actors develop behaviors and economic models that pose challenges to democratic governance, such as business-related human rights violations. In the initial part of the review, we delve into the historical and contemporary aspects of the relationship between business and democracy. Furthermore, the report explores how companies can contribute to shaping a more democratic future by addressing gaps in governance, especially in cases where populist governments fail to protect the rights of their citizens. It also considers the development of alternative business models, such as social enterprises and cross-sector partnerships. Moreover, it looks into how businesses can actively engage in democratic governance and promote principles of participation. The final section of the working paper involves a bibliometric analysis, including co authorship, co-citation, and keyword co-occurrence maps. This analysis is based on key references used by team members in their literature reviews and is designed to examine the connections that exist among various strands of research that support the research questions of the Rebalance Project

Invisible interpretations: reflections on the digital humanities and intellectual history

Much has been made of the digital humanities, yet it remains an underexplored field in relation to intellectual history. This paper aims to add to the little literature which does exist by offering a survey of the ideas and issues facing would-be practitioners. This includes: an overview of what the digital humanities are; reflections on what they offer intellectual history and how they may be problematic in regard to, first, accessing texts, and second, analysing source material; a conclusion with three reflections on future best practices – to be sceptical of digital sources, to be reflective of methodologies and how they may need to be modified when engaging with the digital humanities, and to embrace more directly the methodological, statistical, and technical aspects behind digital humanities. The aim is not to provide all the answers – at this stage that is impossible – but to be part of an emerging and ongoing discussion