Resonant Diffraction Radiation and Smith-Purcell Effect

An approach has been developed where the Smith-Purcell radiation (SPR), i.e. emission of electrons moving close to a periodic structure, is treated as the resonant diffraction radiation. Simple formulas have been designed for the SPR intensity for a grating having perfectly conducting strips spaced by a vacuum gap. The results have been compared with those obtained via other techniques. It has been shown that the intensity of radiation for the said gratings for a relativistic case sufficiently exceeds the SPR intensity for the grating made up by a periodically deformed continuous surface.Comment: 9 pages, LATEX, 3 Postscript figures, uses epsf.sty, submitted to Phys.Letters

In-plane magnetic reorientation in coupled ferro- and antiferromagnetic thin films

By studying coupled ferro- (FM) and antiferromagnetic (AFM) thin film systems, we obtain an in-plane magnetic reorientation as a function of temperature and FM film thickness. The interlayer exchange coupling causes a uniaxial anisotropy, which may compete with the intrinsic anisotropy of the FM film. Depending on the latter the total in-plane anisotropy of the FM film is either enhanced or reduced. Eventually a change of sign occurs, resulting in an in-plane magnetic reorientation between a collinear and an orthogonal magnetic arrangement of the two subsystems. A canted magnetic arrangement may occur, mediating between these two extremes. By measuring the anisotropy below and above the N\'eel temperature the interlayer exchange coupling can be determined. The calculations have been performed with a Heisenberg-like Hamiltonian by application of a two-spin mean-field theory.Comment: 4 pages, 4 figure

Strong peoples - strong country: Indigenous heritage monitoring framework summary report

The report titled 'Monitoring Indigenous Heritage within the Reef 2050 Integrated Monitoring and Reporting Program: Final report of the Indigenous Heritage Expert Group' can be viewed through this repository at http://hdl.handle.net/11017/3535This is a summary report of the Strong peoples – Strong country framework, which details information on the framework. The methodology and processes of the expert group are found in, Monitoring Indigenous Heritage within the Reef 2050 Integrated Monitoring and Reporting Program: Final report of the Indigenous Heritage Expert Group (Jarvis, Hill, Buissereth et al. 2019). This summary presents the key elements of the Indigenous heritage monitoring framework for the Great Barrier Reef: Strong peoples – Strong country. It's been extracted from the Indigenous Heritage Expert Group report, which outlines a proposed design for monitoring of the Indigenous heritage theme under the Reef 2050 Integrated Monitoring and Reporting Program

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Does congenital deafness affect the structural and functional architecture of primary visual cortex?

Deafness results in greater reliance on the remaining senses. It is unknown whether the cortical architecture of the intact senses is optimized to compensate for lost input. Here we performed widefield population receptive field (pRF) mapping of primary visual cortex (V1) with functional magnetic resonance imaging (fMRI) in hearing and congenitally deaf participants, all of whom had learnt sign language after the age of 10 years. We found larger pRFs encoding the peripheral visual field of deaf compared to hearing participants. This was likely driven by larger facilitatory center zones of the pRF profile concentrated in the near and far periphery in the deaf group. pRF density was comparable between groups, indicating pRFs overlapped more in the deaf group. This could suggest that a coarse coding strategy underlies enhanced peripheral visual skills in deaf people. Cortical thickness was also decreased in V1 in the deaf group. These findings suggest deafness causes structural and functional plasticity at the earliest stages of visual cortex

Localization of the murine cholecystokinin A and B receptor genes

We have determined the chromosomal locations of the two cholecystokinin (CCK) receptor genes in the mouse. Genetic localization utilized an interspecific backcross panel formed from the cross (C57BL/6J x Mus spretus ) F 1 x Mus spretus . Genomic DNAs from 94 individuals in the backcross were analyzed by Southern hybridization with rat CCK A and CCK B receptor cDNA probes. Unique map positions were determined by haplotype analysis with 650 previously mapped loci in the mouse backcross. The CCK A receptor gene ( Cckar ) mapped to mouse Chromosome (Chr) 5, in tight linkage with the DNA marker D5Bir8 . The CCK B receptor gene ( Cckbr ) mapped to mouse Chr 7, tightly linked to the β-hemoglobin locus ( Hbb ). This localization places Cckbr in the same region as the mouse obesity mutation tubby ( tub ), which also maps near Hbb (2.4±1.4 cM). Since CCK can function as a satiety factor when administered to rodents, localization of Cckbr near the tub mutation identifies this receptor as a possible candidate gene for this obesity mutation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47021/1/335_2004_Article_BF00352408.pd

Age at first birth in women is genetically associated with increased risk of schizophrenia

Prof. Paunio on PGC:n jäsenPrevious studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.Peer reviewe