Ultra Vires Doctrine in the Legal Framework of the United Nations Organization

The doctrine of ultra vires denotes that legal institutions must function in the preconditioned framework of competences which have been envisaged for them. This doctrine has a well-established place in the law of international organizations. In this realm, the legal superiority of the United Nations has been the dominant discourse since middle of the 20th century. By considering this legal status, fears of transgression of authority and competence by the principal organs of the United Nations (General Assembly, Security Council, Economic and Social Council, Trusteeship Council, International Court of Justice and Secretariat) will exacerbate in a way that is quite incomparable with any other international organization.The purpose of this essay is to carry out an in-depth analysis about the application of this doctrine in the legal realm of the United Nations, which involves library research process of collecting information and legal dogmatic approach in way of analyzing the issue. The particular essence of the ultra vires doctrine has a direct nexus with relative legal personality of international organizations, including the United Nations with the absolute rule of international law over their acts and decisions

Pharmacogenetics of anticancer drug sensitivity and toxicity in colorectal cancer

Inter-individual differences in drug response are an important cause of failure in anticancer treatment and adverse drug events in cancer patients. Gene polymorphisms related to these outcomes have been investigated in an effort to find new genetic biomarkers to predict toxicity and response to anticancer drugs. Evaluating the value single nucleotide polymorphisms (SNPs) in the genes involved in transportation, activation and metabolism of anticancer drugs provides a promising approach to select the appropriate therapeutic regimes with at least adverse reactions. This review summarizes the current knowledge about the relationship between of SNPs involved in the transportation, activation and metabolism of anticancer drugs and treatment outcomes in colorectal cancer (CRC) patients

Investigating and Analyzing Nima Yooshij’s Two New Collections “Navāy-e Kārvān" and "Sad Sāl-e Degar" based on His Theories on Poetry

Nima Yooshij's theories about poetry and poet are in his previously published collections, and the process of his poetic developments can be drawn from them; moreover, there are many other poems of Nima Yooshij in the last two books, which are very important in the analysis of his poetic developments. In the current research, we have examined these two collections by considering the most important theories of Nima, including paying attention to symbolism, declamation and the natural process of speech, descriptive and narrative pattern, objectivity and subjectivity, harmony, and transubstantiation. The results show that Nima has a great interest in classical literature in addition to Western literature in order to achieve symbolism. In addition to the dramatic structure, Nima uses the capacity of "narrative" and "story" to express the content and tries to blend with nature and provide an objective and external description of it, unlike classical poetry. Nima does not see classical poetry as having a body-like unity and puts all the elements of the poem in the direction of creating a harmonious composition, which he calls "harmony" and "form".Keywords: Nima Yooshij, Navāy-e Kārvān, Sad Sāl-e Degar, Objectivity and Subjectivity, Harmony, Contemporary Poetry. IntroductionThe evolution of Nima's poetry and the transformation of his poetry can be seen and analyzed in the collection edited by Siros Tahbaz. Therefore, Nima's early experiences and some of his other unpublished poems, which can show the transformations of his poetry step by step, are recious works that show the infinite suffering and hardship of the "Father of Modern Persian Poetry".Research question: What features do the two published collections of Nima Yooshij show in his poetry? Literature ReviewAlthough Nima has created significant pieces, there are differences of opinion among critics, researchers, and even his students and followers. Terms such as "subjective" and "objective", "declamation" and "natural expression", "new point of view", "absorption", "transubstantiation" and "harmony" and etc. include most of his theories and it can be admitted that neither Nima was able to express them unambiguously, nor his students and critics have the same opinions about all of them. From this point of view, we see that Akhavan Sales and some other critics consider the "Mādar-e Bedathā-ye Nimā" in "prosodic meter", while Nima himself does not believe in this matter. Nima Yooshij's two newly published collections, entitled "Sad Sāl-e Degar" and "Navāy-e Kārvān", which contain his significant poems, are a great opportunity to examine Nima's ideas and theories more closely. In the present research, the two collections have been investigated by considering Nima Yooshij’s theories. MethodologyThe research method in this article is descriptive-analytical and based on library studies. First, from this point of view, Nima’s most important ideas about poems and poetry have been examined, and then, taking into consideration his two recent collections, some points about Nima's ideas have been examined. In this study, an attempt has been made to discuss the opinions of other critics. ResultsAccording to the last two collections of Nima Yooshij, it was concluded that:He was able to achieve his desired symbolism by paying attention to Western literature, mystical symbols, and allegories. His poem "Vampire" is derived from European literature. Some of his other poems are also derived from native elements.Nima has several poems with a dramatic structure, which shows his special attention to the "dramatic structure of poetry", which is also mentioned in the introduction of the legend.Nima uses the elements of narration and description for the story structure of his poems, and by creating a complete harmony of all linguistic elements, he presents a poem that has a body-like composition. This feature makes his poetry achieve the "form" or "harmony" that he wants.Another artistic feature of Nima's poetry is the absorption and analysis of the environment and objects. This point prevents him from repeating what others have said. In fact, creating a link between the outer and inner world and "being one with the object" creates a new and individual view of the poet in the poetic images that Nima has emphasized many times.Nima’s two collections of classical poems are an unsuccessful imitation of great poets such as Nezami, Sa'di, and Rumi; the evolution of his poetry is in Nimai's free verses. Some of Nima's poems in this collection can be among his most brilliant works among his other successful poems

Assessment of the Relationship between Fear and Self-efficacy of Childbirth during Labor in Primipara Women

Fear of childbirth is an important and prevalent problem during pregnancy and delivery. Self-efficacy of childbirth is one of the factors playing an important role in the fear of delivery. This study aimed to determine the relationship between the fear and self-efficacy of childbirth during labor in primipara women. This descriptive and analytical study was conducted on 100 primipara women in Ommolbanin Hospital, Mashhad, Iran, during 2017. Data were analyzed in SPSS software using descriptive statistics and Pearson’s correlation coefficient. According to the results, the mean scores of fear and self-efficacy of delivery were reported to be 48.9±14.2 and 220.5±54.9, respectively. In addition, there was a reverse association between the scores of fear of childbirth and self-efficacy of delivery using Pearson’s results (r=-0.44,

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Funding: F Carvalho and E Fernandes acknowledge support from Fundação para a Ciência e a Tecnologia, I.P. (FCT), in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy i4HB; FCT/MCTES through the project UIDB/50006/2020. J Conde acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006.proofepub_ahead_of_prin

Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019

Background: Updated data on chronic respiratory diseases (CRDs) are vital in their prevention, control, and treatment in the path to achieving the third UN Sustainable Development Goals (SDGs), a one-third reduction in premature mortality from non-communicable diseases by 2030. We provided global, regional, and national estimates of the burden of CRDs and their attributable risks from 1990 to 2019. Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we estimated mortality, years lived with disability, years of life lost, disability-adjusted life years (DALYs), prevalence, and incidence of CRDs, i.e. chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease and pulmonary sarcoidosis, and other CRDs, from 1990 to 2019 by sex, age, region, and Socio-demographic Index (SDI) in 204 countries and territories. Deaths and DALYs from CRDs attributable to each risk factor were estimated according to relative risks, risk exposure, and the theoretical minimum risk exposure level input. Findings: In 2019, CRDs were the third leading cause of death responsible for 4.0 million deaths (95% uncertainty interval 3.6–4.3) with a prevalence of 454.6 million cases (417.4–499.1) globally. While the total deaths and prevalence of CRDs have increased by 28.5% and 39.8%, the age-standardised rates have dropped by 41.7% and 16.9% from 1990 to 2019, respectively. COPD, with 212.3 million (200.4–225.1) prevalent cases, was the primary cause of deaths from CRDs, accounting for 3.3 million (2.9–3.6) deaths. With 262.4 million (224.1–309.5) prevalent cases, asthma had the highest prevalence among CRDs. The age-standardised rates of all burden measures of COPD, asthma, and pneumoconiosis have reduced globally from 1990 to 2019. Nevertheless, the age-standardised rates of incidence and prevalence of interstitial lung disease and pulmonary sarcoidosis have increased throughout this period. Low- and low-middle SDI countries had the highest age-standardised death and DALYs rates while the high SDI quintile had the highest prevalence rate of CRDs. The highest deaths and DALYs from CRDs were attributed to smoking globally, followed by air pollution and occupational risks. Non-optimal temperature and high body-mass index were additional risk factors for COPD and asthma, respectively. Interpretation: Albeit the age-standardised prevalence, death, and DALYs rates of CRDs have decreased, they still cause a substantial burden and deaths worldwide. The high death and DALYs rates in low and low-middle SDI countries highlights the urgent need for improved preventive, diagnostic, and therapeutic measures. Global strategies for tobacco control, enhancing air quality, reducing occupational hazards, and fostering clean cooking fuels are crucial steps in reducing the burden of CRDs, especially in low- and lower-middle income countries

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990-2021: findings from the Global Burden of Disease Study 2021

Background Anaemia is a major health problem worldwide. Global estimates of anaemia burden are crucial for developing appropriate interventions to meet current international targets for disease mitigation. We describe the prevalence, years lived with disability, and trends of anaemia and its underlying causes in 204 countries and territories. Methods We estimated population-level distributions of haemoglobin concentration by age and sex for each location from 1990 to 2021. We then calculated anaemia burden by severity and associated years lived with disability (YLDs). With data on prevalence of the causes of anaemia and associated cause-specific shifts in haemoglobin concentrations, we modelled the proportion of anaemia attributed to 37 underlying causes for all locations, years, and demographics in the Global Burden of Disease Study 2021. Findings In 2021, the global prevalence of anaemia across all ages was 24·3% (95% uncertainty interval [UI] 23·9–24·7), corresponding to 1·92 billion (1·89–1·95) prevalent cases, compared with a prevalence of 28·2% (27·8–28·5) and 1·50 billion (1·48–1·52) prevalent cases in 1990. Large variations were observed in anaemia burden by age, sex, and geography, with children younger than 5 years, women, and countries in sub-Saharan Africa and south Asia being particularly affected. Anaemia caused 52·0 million (35·1–75·1) YLDs in 2021, and the YLD rate due to anaemia declined with increasing Socio-demographic Index. The most common causes of anaemia YLDs in 2021 were dietary iron deficiency (cause-specific anaemia YLD rate per 100 000 population: 422·4 [95% UI 286·1–612·9]), haemoglobinopathies and haemolytic anaemias (89·0 [58·2–123·7]), and other neglected tropical diseases (36·3 [24·4–52·8]), collectively accounting for 84·7% (84·1–85·2) of anaemia YLDs. Interpretation Anaemia remains a substantial global health challenge, with persistent disparities according to age, sex, and geography. Estimates of cause-specific anaemia burden can be used to design locally relevant health interventions aimed at improving anaemia management and prevention. Funding Bill & Melinda Gates Foundation

The Effectiveness of Cognitive Rehabilitation of Working Memory in Reducing Sleep Disorders and Behavioral Symptoms of Children with Attention Deficit/Hyperactivity Disorder

The aim of this study was to measure the effectiveness of cognitive rehabilitation of working memory in reducing sleep disorders and behavioral symptom of children with Attention Deficit/hyperactivity Disorder (ADHD). The present study was semi-experimental design with pre-test and post-test with control group. In this study, children aged 7 to 12 years who were diagnosed with (ADHD) by psychological experts of the counseling center of Kermanshah were selected. The Conners-Parent's Questionnaire and the Petersburg Sleep Inventory by parents and the Conners-Teacher Form by teachers were completed. 20 people who had the weakest performance in a working memory test were randomly divided into two groups. The experimental group was subjected to 12 sessions of The Captain's Log Mind Power Builder and the control group did not receive treatment. After the last session of treatment, both groups were re-evaluated. The findings showed that cognitive rehabilitation of working memory was effective in reducing sleep problems (P <0.001) and behavioral symptoms of attention deficit/ hyperactivity disorder (P <0.001). Therefore, it can be concluded that cognitive rehabilitation of working memory is effective on the reduce of sleep problems and behavioral symptoms in ADHD. It is suggested that cognitive therapy for cognitive-psychological rehabilitation in health centers to use by mental health professionals to reduce sleep problems and behavioral symptoms in children with ADHD