EXTREMO: An Eclipse plugin for modelling and meta-modelling assistance

Modelling is a core activity in software development paradigms like Model-driven Engineering (MDE). Therefore, the quality of (meta-)models is crucial for the success of software projects. However, many times, modelling becomes a purely manual activity, which does not take advantage of information embedded in heterogeneous information sources, such as XML documents, ontologies, or other models and meta-models. In order to improve this situation, we present EXTREMO, an Eclipse plugin aimed at gathering the information stored in heterogeneous sources in a common data model, to facilitate the reuse of information chunks in the model being built. The tool covers the steps needed to incorporate this knowledge within an external modelling tool, supporting the uniform query of the heterogeneous sources and the evaluation of constraints. Flexibility of the main features (e.g., supported data formats, queries)is achieved by means of extensible mechanisms. To illustrate the usefulness of EXTREMO, we describe a practical case study in the financial domain and evaluate its performance and scalabilityThis work was partially supported by the Ministry of Education of Spain (FPU grant FPU13/02698), the Spanish Ministry of Science (RTI2018-095255-B-I00), and the R&D programme of the Madrid Region (S2018/TCS-4314

Modelling assistants based on information reuse: a user evaluation for language engineering

This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10270-023-01094-5Model-driven engineering (MDE) uses models as first-class artefacts during the software development lifecycle. MDE often relies on domain-specific languages (DSLs) to develop complex systems. The construction of a new DSL implies a deep understanding of a domain, whose relevant knowledge may be scattered in heterogeneous artefacts, like XML documents, (meta-)models, and ontologies, among others. This heterogeneity hampers their reuse during (meta-)modelling processes. Under the hypothesis that reusing heterogeneous knowledge helps in building more accurate models, more efficiently, in previous works we built a (meta-)modelling assistant called Extremo. Extremo represents heterogeneous information sources with a common data model, supports its uniform querying and reusing information chunks for building (meta-)models. To understand how and whether modelling assistants—like Extremo—help in designing a new DSL, we conducted an empirical study, which we report in this paper. In the study, participants had to build a meta-model, and we measured the accuracy of the artefacts, the perceived usability and utility and the time to completion of the task. Interestingly, our results show that using assistance did not lead to faster completion times. However, participants using Extremo were more effective and efficient, produced meta-models with higher levels of completeness and correctness, and overall perceived the assistant as useful. The results are not only relevant to Extremo, but we discuss their implications for future modelling assistantsWe would like to thank the reviewers for their valuable comments. This work was supported by the Ministry of Education of Spain (FPU Grant FPU13/02698 and stay EST17/00803); the Spanish Ministry of Science and Innovation (PID2021-122270OB-I00); the R&D programme of the Madrid Region (P2018/TCS-4314); and the Austrian Federal Ministry for Digital and Economic Affairs and the National Foundation for Research, Technology and Development (CDG

Automated modelling assistance by integrating heterogeneous information sources

Model-Driven Engineering (MDE) uses models as its main assets in the software development process. The structure of a model is described through a metamodel. Even though modelling and meta-modelling are recurrent activities in MDE and a vast amount of MDE tools exist nowadays, they are tasks typically performed in an unassisted way. Usually, these tools cannot extract useful knowledge available in heterogeneous information sources like XML, RDF, CSV or other models and meta-models. We propose an approach to provide modelling and meta-modelling assistance. The approach gathers heterogeneous information sources in various technological spaces, and represents them uniformly in a common data model. This enables their uniform querying, by means of an extensible mechanism, which can make use of services, e.g., for synonym search and word sense analysis. The query results can then be easily incorporated into the (meta-)model being built. The approach has been realized in the Extremo tool, developed as an Eclipse plugin. Extremo has been validated in the context of two domains { production systems and process modelling { taking into account a large and complex industrial standard for classi cation and product description. Further validation results indicate that the integration of Extremo in various modelling environments can be achieved with low e ort, and that the tool is able to handle information from most existing technological spacesThis work was supported by the Ministry of Education of 1256 Spain (FPU grant FPU13/02698); the Spanish MINECO (TIN2014-52129-R);1257 the R&D programme of the Madrid Region (S2013/ICE-3006); the Austrian 1258 agency for international mobility and cooperation in education, science and re1259 search (OeAD) by funds from the Austrian Federal Ministry of Science, Research 1260 and Economy - BMWFW (ICM-2016-04969

PTL: A Model Transformation Language based on Logic Programming

In this paper we present a model transformation language based on logic programming. The language, called PTL (Prolog based Transformation Language), can be considered as a hybrid language in which ATL (Atlas Transformation Language)-style rules are combined with logic rules for defining transformations. ATL-style rules are used to define mappings from source models to target models while logic rules are used as helpers. The implementation of PTL is based on the encoding of the ATL-style rules by Prolog rules. Thus, PTL makes use of Prolog as a transformation engine. We have provided a declarative semantics to PTL and proved the semantics equivalent to the encoded program. We have studied an encoding of OCL (Object Constraint Language) with Prolog goals in order to map ATL to PTL. Thus a subset of PTL can be considered equivalent to a subset of ATL. The proposed language can be also used for model validation, that is, for checking constraints on models and transformations. We have equipped our language with debugging and tracing capabilities which help developers to detect programming errors in PTL rules. Additionally, we have developed an Eclipse plugin for editing PTL programs, as well as for debugging, tracing and validation. Finally, we have evaluated the language with several transformation examples as well as tested the performance with large models

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Medio ambiente, sociedad, ética, auditoría y educación. La Investigación Contable en UNIMINUTO Virtual y a Distancia: Contexto y Oportunidades.

En los últimos años la educación a distancia ha mostrado ser capaz de reducir la brecha de inequidad social, de capacitar personas en lugares remotos, de brindar la posibilidad a la comunidad discapacitada y de permitirle a quienes no cuentan con suficientes recursos económicos acceder a la educación superior, la presente investigación da cuenta de los aspectos clave asociados a la decisión de matricularse en el programa de Contaduría Pública en la modalidad distancia tradicional. Se realizó un análisis de las narrativas basado en los resultados de un instrumento aplicado a 150 estudiantes. Para el análisis de datos se empleó la herramienta SenseMaker®. Los resultados evidencian aspectos personales, sociales y culturales que posicionan la oferta de educación en la modalidad a distancia como la institución que permite resignificar la vida de las persona

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries