Tidal Signatures in the Faintest Milky Way Satellites: The Detailed Properties of Leo V, Pisces II and Canes Venatici II

We present deep wide-field photometry of three recently discovered faint Milky Way satellites: Leo V, Pisces II, and Canes Venatici II. Our main goals are to study the structure and star formation history of these dwarfs; we also search for signs of tidal disturbance. The three satellites have similar half-light radii ($\sim 60-90$ pc) but a wide range of ellipticities. Both Leo V and CVn II show hints of stream-like overdensities at large radii. An analysis of the satellite color-magnitude diagrams shows that all three objects are old ($>$ 10 Gyr) and metal-poor ([Fe/H] $\sim -2$), though neither the models nor the data have sufficient precision to assess when the satellites formed with respect to cosmic reionization. The lack of an observed younger stellar population (\la 10 Gyr) possibly sets them apart from the other satellites at Galactocentric distances \ga 150 kpc. We present a new compilation of structural data for all Milky Way satellite galaxies and use it to compare the properties of classical dwarfs to the ultra-faints. The ellipticity distribution of the two groups is consistent at the $\sim$2-$\sigma$ level. However, the faintest satellites tend to be more aligned toward the Galactic center, and those satellites with the highest ellipticity (\ga 0.4) have orientations ($\Delta \theta_{GC}$) in the range $20^{\circ} \lesssim \Delta \theta_{GC} \lesssim 40^{\circ}$. This latter observation is in rough agreement with predictions from simulations of dwarf galaxies that have lost a significant fraction of their dark matter halos and are being tidally stripped.Comment: 25 pages, 7 figures, ApJ accepted; version updated to match ApJ accepte

International Veterinary Epilepsy Task Force consensus proposal: Medical treatment of canine epilepsy in Europe

In Europe, the number of antiepileptic drugs (AEDs) licensed for dogs has grown considerably over the last years. Nevertheless, the same questions remain, which include, 1) when to start treatment, 2) which drug is best used initially, 3) which adjunctive AED can be advised if treatment with the initial drug is unsatisfactory, and 4) when treatment changes should be considered. In this consensus proposal, an overview is given on the aim of AED treatment, when to start long-term treatment in canine epilepsy and which veterinary AEDs are currently in use for dogs. The consensus proposal for drug treatment protocols, 1) is based on current published evidence-based literature, 2) considers the current legal framework of the cascade regulation for the prescription of veterinary drugs in Europe, and 3) reflects the authors’ experience. With this paper it is aimed to provide a consensus for the management of canine idiopathic epilepsy. Furthermore, for the management of structural epilepsy AEDs are inevitable in addition to treating the underlying cause, if possible

Pharmaceuticals and personal care products in the environment: What are the big questions?

Background: Over the past 10-15 years, a substantial amount of work has been done by the scientific, regulatory, and business communities to elucidate the effects and risks of pharmaceuticals and personal care products (PPCPs) in the environment. Objective: This review was undertaken to identify key outstanding issues regarding the effects of PPCPs on human and ecological health in order to ensure that future resources will be focused on the most important areas. Data sources: To better understand and manage the risks of PPCPs in the environment, we used the "key question" approach to identify the principle issues that need to be addressed. Initially, questions were solicited from academic, government, and business communities around the world. A list of 101 questions was then discussed at an international expert workshop, and a top-20 list was developed. Following the workshop, workshop attendees ranked the 20 questions by importance. Data synthesis: The top 20 priority questions fell into seven categories: a) prioritization of substances for assessment, b) pathways of exposure, c) bioavailability and uptake, d) effects characterization, e) risk and relative risk, f) antibiotic resistance, and g) risk management. Conclusions: A large body of information is now available on PPCPs in the environment. This exercise prioritized the most critical questions to aid in development of future research programs on the topic.Centro de Investigaciones del Medioambient

Implementation salvage experiences from the Melbourne diabetes prevention study

Background Many public health interventions based on apparently sound evidence from randomised controlled trials encounter difficulties when being scaled up within health systems. Even under the best of circumstances, implementation is exceedingly difficult. In this paper we will describe the implementation salvage experiences from the Melbourne Diabetes Prevention Study, which is a randomised controlled trial of the effectiveness and cost-effectiveness nested in the state-wide Life! Taking Action on Diabetes program in Victoria, Australia.Discussion The Melbourne Diabetes Prevention Study sits within an evolving larger scale implementation project, the Life! program. Changes that occurred during the roll-out of that program had a direct impact on the process of conducting this trial. The issues and methods of recovery the study team encountered were conceptualised using an implementation salvage strategies framework. The specific issues the study team came across included continuity of the state funding for Life! program and structural changes to the Life! program which consisted of adjustments to eligibility criteria, referral processes, structure and content, as well as alternative program delivery for different population groups. Staff turnover, recruitment problems, setting and venue concerns, availability of potential participants and participant characteristics were also identified as evaluation roadblocks. Each issue and corresponding salvage strategy is presented.Summary The experiences of conducting such a novel trial as the preliminary Melbourne Diabetes Prevention Study have been invaluable. The lessons learnt and knowledge gained will inform the future execution of this trial in the coming years. We anticipate that these results will also be beneficial to other researchers conducting similar trials in the public health field. We recommend that researchers openly share their experiences, barriers and challenges when conducting randomised controlled trials and implementation research. We encourage them to describe the factors that may have inhibited or enhanced the desired outcomes so that the academic community can learn and expand the research foundation of implementation salvage.<br /

The New Testament in the Christian church : eight lectures /

Includes bibliographical references and index.The authorities of the early church -- The witness of the earliest Christian literature to the New Testament -- The New Testament at the end of the second century -- The closing of the canon in the West -- The closing of the canon in the East -- The Renaissance and the Reformation -- The canonization and the origin of Church government -- The canonization and the beginnings of the history of doctrine -- The idea of authority in the Christian church.Mode of access: Internet

Exercise Guidelines for Pregnant Women

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74599/1/j.1547-5069.1994.tb00332.x.pd