Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Evolutionary Selection of a Set of Association Rules Considering Biological Constraints Describing the Prevalent Elements in Bacterial Vaginosis

Bacterial Vaginosis is a common disease and recurring public health problem. Additionally, this infection can trigger other sexually transmitted diseases. In the medical field, not all possible combinations among the pathogens of a possible case of Bacterial Vaginosis are known to allow a diagnosis at the onset of the disease. It is important to contribute to this line of research, so this study uses a dataset with information from sexually active women between 18 and 50 years old, including 17 numerical attributes of microorganisms and bacteria with positive and negative results for BV. These values were semantically categorized for the Apriori algorithm to create the association rules, using support, confidence, and lift as statistical metrics to evaluate the quality of the rules, and incorporate those results in the objective function of the DE algorithm. To guide the evolutionary process we also incorporated the knowledge of a human expert represented as a set of biologically meaningful constraints. Thus, we were able to compare the performance of the rand/1/bin and best/1/bin versions from Differential Evolution to analyze the results of 30 independent executions. Therefore the experimental results allowed a reduced subset of biologically meaningful association rules by their executions, dimension, and DE version to be selected

Data from: Connecting genomic patterns of local adaptation and niche suitability in teosintes

The central-abundance hypothesis predicts that local adaptation is a function of the distance to the center of a species’ geographic range. To test this hypothesis, we gathered genomic diversity data from 49 populations, 646 individuals and 33,464 SNPs of two wild relatives of maize, the teosintes Zea mays ssp. parviglumis and Zea. mays. ssp. mexicana. We examined the association between the distance to their climatic and geographic centroids and the enrichment of SNPs bearing signals of adaptation. We identified candidate adaptive SNPs in each population by combining neutrality tests and cline analyzes. By applying linear regression models, we found that the number of candidate SNPs is positively associated with niche suitability, while genetic diversity is reduced at the limits of the geographic distribution. Our results suggest that overall, populations located at the limit of the species’ niches are adapting locally. We argue that local adaptation to this limit could initiate ecological speciation processes and facilitate adaptation to global change

SNPdata_Aguirre_Liguori_etal_SNPdata

The SNPdata_Aguirre_Liguori_etal.txt file contains the genotypes exported from GenomeStudio. SNPs were genotyped using the Illumina MaizeSNP50 Genotyping BeadChip. Loci are in rows and individuals are in columns. Each column is named as the population and individual separated by “_”. For example “Mochitlan_Mochitlan_9” indicates that the individual comes from the site Mochitlan in the Mochitlan “Municipio” and corresponds to the 9th individual. Sample information (Population, coordinates and the subspecies) is found in the sample_information_Aguirre_Liguori_etal.txt file and in the manuscript. Genotypes downloaded from Pyhäjärvi et al. (2013) can be found in the following link http://datadryad.org/resource/doi:10.5061/dryad.8m648/

Sample information of teosintes

The sample_information_Aguirre_Liguori_etal.txt file contains the geographic coordinates and the subspecies information of each of the populations sampled

Chromosome-scale <i>Salvia hispanica</i> (chia) genome assembly reveals rampant <i>Salvia </i>interspecies introgressions

Genome and annotation files for Salvia hispanica </p